LOCUS       NM_183368               1504 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptotagmin-like 3 (Sytl3), transcript variant 3,
            mRNA.
ACCESSION   NM_183368 XM_975734 XM_977457
VERSION     NM_183368.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Fukuda,M.
  TITLE     The C2A domain of synaptotagmin-like protein 3 (Slp3) is an
            atypical calcium-dependent phospholipid-binding machine: comparison
            with the C2A domain of synaptotagmin I
  JOURNAL   Biochem J 366 (Pt 2), 681-687 (2002)
   PUBMED   12049610
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Synaptotagmin-like protein 3-a (Slp3-a) contains an
            N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of
            Slp3-a specifically and directly binds the GTP-bound form of
            Rab27A.
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem Biophys Res Commun 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168090.3, BC118936.2 and BB031741.2.
            
            On Oct 31, 2008 this sequence version replaced NM_183368.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks
            several exons in the 5' coding region, and uses a downstream
            translation start codon, compared to variant 1. The resulting
            isoform (b, also known as Slp3-b) is shorter at the N-terminus,
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is based
            on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB050743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC168090.3         119008-119187       c
            181-1296            BC118936.2         810-1925
            1297-1498           BB031741.2         467-668
            1499-1504           AC168090.3         86973-86978         c
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.33 cM"
     gene            1..1504
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /note="synaptotagmin-like 3"
                     /db_xref="GeneID:83672"
                     /db_xref="MGI:MGI:1933367"
     exon            1..189
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1296
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /note="isoform b is encoded by transcript variant 3;
                     synaptotagmin-like protein 3; exophilin-6"
                     /codon_start=1
                     /product="synaptotagmin-like protein 3 isoform b"
                     /protein_id="NP_899224.2"
                     /db_xref="CCDS:CCDS28373.2"
                     /db_xref="GeneID:83672"
                     /db_xref="MGI:MGI:1933367"
                     /translation="MTSEKHLLAMDPRQCVGHTERRSQSDTAVNVTSRKASTPDILKA
                     FHQEDPKHPPDPVLKQDTPPSSPTHSAVFSGGLRHGSLISINSTCTEMGNFDNANVTG
                     EIEFAIHYCVKSCSLEICIKTCKNLAYGEEKKRKCNPYVKTYLLPDRSSQGKRKTRVQ
                     KNTLDPTFEETLKYQVDPGQLMTRRLQVSVWHLGTLARRVFLGEVILPLAMWDFKDST
                     AQNARWYPLRAKAEKYEENIPQNNGELAVRAKLVLPAGPRKPQEAQEGQLALNGQLCL
                     VVLGAKNLPVRSDGTLNSFVKGCLTLPNQQKLRVKSPVLKKQACPQWKHSFVFNGVSS
                     SQLRQSTLELTVWDQAIFGMNDRLLGEARLGSKGGAAGCPDSGSQSKLQWHRVLSSPN
                     LWTDMTLVLH"
     exon            190..324
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            325..503
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..606
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            607..777
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            778..883
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            884..980
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1186
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1504
                     /gene="Sytl3"
                     /gene_synonym="A430092N21; mFLJ00307; Slp3; Slp3-a;
                     Slp3-b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagaaggct ccctctggtc ttggcaaagc ttgttgctct cgactgttcc cccttgtctc
       61 ctagagctct ccaagtccca gaatgacatg acctctgaga agcatcttct ggccatggac
      121 cccaggcagt gtgtgggaca cacggagagg cggagccagt cagacactgc agtcaacgtg
      181 acttccagga aggccagcac acccgatatt ctgaaagcat tccatcaaga agatcccaaa
      241 caccctcccg accctgtttt gaagcaagac actcccccgt ccagtccgac acacagcgct
      301 gtcttctctg gaggcttgag acacggaagc ttaattagca tcaacagcac ctgcacagag
      361 atgggtaatt ttgacaatgc taatgtcact ggagaaatag aatttgccat tcattactgc
      421 gttaaaagct gctctttaga gatatgcatc aagacctgta agaaccttgc ctatggagaa
      481 gaaaagaaaa gaaagtgcaa tccgtatgtc aagacctacc tgctgcctga caggtcttct
      541 cagggaaaac gcaagacacg agtccaaaag aacacgctgg acccgacttt cgaggaaacc
      601 ttgaagtatc aggtggaccc tggccagctg atgacccgga ggctgcaggt ctctgtgtgg
      661 cacctaggca cccttgcccg gagggtgttc ctcggagaag tgatccttcc actggccatg
      721 tgggacttta aggacagtac ggcacagaat gccagatggt atcctctgcg ggccaaggct
      781 gagaaatacg aagagaatat tcctcagaat aatggagaac ttgctgttcg agccaaattg
      841 gtccttcccg cagggccaag aaagccccag gaggcccaag aaggtcagct agcgcttaat
      901 ggtcaactgt gtctggttgt gttgggagcc aagaatttac cggtgaggtc agatggcacc
      961 ttaaactcat ttgttaaggg ctgtctcacc ctgccaaacc aacaaaagct gcgtgtgaag
     1021 tccccagtcc tgaagaagca ggcttgtccc cagtggaaac actcctttgt gtttaatggt
     1081 gtgagcagtt ctcagctgag acagtccacc ttggagctga ctgtctggga ccaggccatc
     1141 tttggtatga acgaccgtct gctcggggaa gccaggcttg gttcaaaggg aggtgctgcg
     1201 ggttgtcccg actcaggttc acagtccaag cttcagtggc acagagtcct ctccagccca
     1261 aacctgtgga cagacatgac cctcgtcctg cactgaggtg aagcccaagg cgactgcgaa
     1321 cccacaaagg tcaacaggaa gtgggatcat ggcagaatca gacacactgg atcaccaata
     1381 actgactaca gtaatgtgtg tcgttaggac acggaacaat tactgttacc caggcagtcg
     1441 gggaggctac tgtcaacaga tagatgtgga aatgttctga tctcaataaa cgctcaacac
     1501 tgtc
//
