LOCUS       NM_031394               4659 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus synaptotagmin-like 2 (Sytl2), transcript variant 3,
            mRNA.
ACCESSION   NM_031394 XM_006508363 XM_984785 XM_984812 XM_984850 XM_986891
            XM_986927 XM_986962
VERSION     NM_031394.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4659)
  AUTHORS   Boogerd,C.J., Perini,I., Kyriakopoulou,E., Han,S.J., La,P., van der
            Swaan,B., Berkhout,J.B., Versteeg,D., Monshouwer-Kloots,J. and van
            Rooij,E.
  TITLE     Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP
            inhibition during cardiac maturation
  JOURNAL   Nat Commun 14 (1), 4716 (2023)
   PUBMED   37543677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Jung,H., Park,H., Choi,Y., Kang,H., Lee,E., Kweon,H., Roh,J.D.,
            Ellegood,J., Choi,W., Kang,J., Rhim,I., Choi,S.Y., Bae,M.,
            Kim,S.G., Lee,J., Chung,C., Yoo,T., Park,H., Kim,Y., Ha,S.,
            Um,S.M., Mo,S., Kwon,Y., Mah,W., Bae,Y.C., Kim,H., Lerch,J.P.,
            Paik,S.B. and Kim,E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Khacho,M., Tarabay,M., Patten,D., Khacho,P., MacLaurin,J.G.,
            Guadagno,J., Bergeron,R., Cregan,S.P., Harper,M.E., Park,D.S. and
            Slack,R.S.
  TITLE     Acidosis overrides oxygen deprivation to maintain mitochondrial
            function and cell survival
  JOURNAL   Nat Commun 5, 3550 (2014)
   PUBMED   24686499
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4659)
  AUTHORS   Yasuda,T. and Fukuda,M.
  TITLE     Slp2-a controls renal epithelial cell size through regulation of
            Rap-ezrin signaling independently of Rab27
  JOURNAL   J Cell Sci 127 (Pt 3), 557-570 (2014)
   PUBMED   24284068
  REMARK    GeneRIF: Our findings indicate that Slp2-a controls renal cell size
            through regulation of Rap-ezrin signaling independently of Rab27.
REFERENCE   5  (bases 1 to 4659)
  AUTHORS   Yasuda,T., Saegusa,C., Kamakura,S., Sumimoto,H. and Fukuda,M.
  TITLE     Rab27 effector Slp2-a transports the apical signaling molecule
            podocalyxin to the apical surface of MDCK II cells and regulates
            claudin-2 expression
  JOURNAL   Mol Biol Cell 23 (16), 3229-3239 (2012)
   PUBMED   22767581
  REMARK    GeneRIF: Slp2-a is required for targeting of the signaling molecule
            podocalyxin to the apical membrane in a Rab27A-dependent manner.
REFERENCE   6  (bases 1 to 4659)
  AUTHORS   Kuroda,T.S. and Fukuda,M.
  TITLE     Rab27A-binding protein Slp2-a is required for peripheral melanosome
            distribution and elongated cell shape in melanocytes
  JOURNAL   Nat Cell Biol 6 (12), 1195-1203 (2004)
   PUBMED   15543135
  REMARK    GeneRIF: Loss of Slp2-a protein also induced a change in melanocyte
            morphology, from their normal elongated shape to a more rounded
            shape, which depended on the phospholipid-binding activity of
            Slp2-a
REFERENCE   7  (bases 1 to 4659)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   8  (bases 1 to 4659)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Synaptotagmin-like protein 2-a (Slp2-a) contains an
            N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of
            Slp2-a specifically and directly binds the GTP-bound form of
            Rab27A.
REFERENCE   9  (bases 1 to 4659)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem Biophys Res Commun 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   10 (bases 1 to 4659)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ165208.1, BB622234.1, BC052915.1, AC100322.8, BC060665.1,
            AK027924.1 and AK051653.1.
            
            On or before Jan 24, 2014 this sequence version replaced
            XM_006508363.1, NM_031394.2.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the central coding region, compared to variant 6, resulting
            in an isoform (3, also known as Slp2-a delta 2S-III) that is
            shorter than isoform 6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1261174.1,
                                           ERR3363658.4145644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               CJ165208.1         1-435
            436-471             BB622234.1         363-398
            472-688             BB622234.1         400-616
            689-1410            BC052915.1         33-754
            1411-1411           AC100322.8         37005-37005
            1412-2259           BC052915.1         756-1603
            2260-2325           BC060665.1         2131-2196
            2326-4108           AK027924.1         516-2298
            4109-4659           AK051653.1         2482-3032
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.54 cM"
     gene            1..4659
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /note="synaptotagmin-like 2"
                     /db_xref="GeneID:83671"
                     /db_xref="MGI:MGI:1933366"
     exon            1..389
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..855
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             755..3487
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     synaptotagmin-like protein 2; exophilin-4"
                     /codon_start=1
                     /product="synaptotagmin-like protein 2 isoform 3"
                     /protein_id="NP_113571.2"
                     /db_xref="CCDS:CCDS40017.1"
                     /db_xref="GeneID:83671"
                     /db_xref="MGI:MGI:1933366"
                     /translation="MIDLSFLTEEEQDAILKVLQRDAALKRAEEERVRHLPEKIKDDQ
                     QLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRRKKLPAAAEQNKDTAMRAKESWVNN
                     VNKDAVLPPEIAVVEEPEDDTDPAGPSSSLVDPASSVIDMSQESTRTPAVSLPKQRKN
                     PFNSPKLPEDHSLQQTKPEQSKTGKAGLFQISKEGELSESKEKSSIPDMPRQQLEKPK
                     QTVSTEPENASHTKAPIPKARKLIYKSNDLEKDDNQSFPRQRRDSLNARGAPRGILKR
                     NSSSSSTDSETLRLNYNLDPKSKILSPGLTIHERISEKEFSLEDDSSTSSLEPLKHVR
                     FSAVKNELPQSPRPVLGQEVGEFTVLESDQLQNGTEDAGDIEEFQNHPELSHKTPLSH
                     YQLVSSPSDSGREREQLMSSGSAPRDEIPCHSDILPTGPQCVESSSVINGQQEKSSHF
                     TKLPSELSKSPSDELTQCGEPEPSQTADHSFRDHRQGSEEEHSPVLKTLERRAARKLP
                     SKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVPSLPDNQF
                     SHPDKLKRMSKSVPAFLQDEASGSVMSVYSGDFGNLEVKGSVQFALDYVESLKELHVF
                     VAQCKDLAAADVKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIER
                     QFLKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDSKQNKQLKWYPLKRKTAPVAL
                     ETENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILP
                     DTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGL
                     RIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWVEATLPLRMLLIAKLSK"
     exon            856..1007
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1140
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1222
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1337
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..2141
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2213
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2315
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2369
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2417
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2512
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2682
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2785
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2956
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3035
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3135
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3341
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..4659
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4354..4359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /note="hexamer: AATAAA"
     polyA_site      4379
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /note="major polyA site"
ORIGIN      
        1 gctgccctcc cctccgcccg ccccgaacag cggcgacacc tgggtggcgc agccggctgc
       61 gagcgctggg cggcagagag aggttggcag cccggaggag gtagagcggg cagccggggc
      121 tgcggcggag actcggcgcg cgctctgggt gtgacttttc tgtctactgg cggtgtcgct
      181 gggactgctt tctggtcctg ctctgggtct tggagtagct ggaggagttg gtgtagagag
      241 agattttttt gttgtccttg ctatcctggc tgctacaacg tgaaccaccg gggcggcaac
      301 caacaagctt catccctcag tttctccttt agttaggagt tccttctgct gccctcgccg
      361 ccgtgtgtcc gcgaagctag ggacaccagg ttaaggatgc agcaaggagg ctgttgctca
      421 agatggtgat gagggtggag atactgtgtc taagactggt ccagagaagg tgcactgaag
      481 gaattctgct aaagacccaa gcaaggcatg catcctcctc ctgagacctg ttcatcctac
      541 agaccgctgc taccttgagg gaccttgctg tcacgacttt gatgtcatct gcctaaaatt
      601 tttgtggagc ccagataaga ctttcaccac caaataagat accatttact tttgcatcct
      661 gtaatcatcc tggctgtagt ctcagctgtt ttttgccgag aatcccaagc tacatttgtt
      721 acaattgttc cttttgtgga agctgtgctc caaaatgatc gacttaagtt tcctgacaga
      781 ggaggagcaa gacgccatct taaaggttct gcagagggat gctgccctga agagggctga
      841 agaggagaga gtcagacatc tgcctgaaaa aattaaggat gaccaacaac taaagaatat
      901 gagtggccaa tggttttatg aagctaaggc aaaaagacac agggacaaaa tccacggtgc
      961 tgacatcatc agagcatcca tgagaaggaa gaagctccca gcggcagctg agcagaataa
     1021 ggacacagca atgagggcaa aggagagctg ggtgaataat gttaacaaag atgctgtcct
     1081 tcctccagag atagctgttg tggaagagcc agaagatgac acagatcccg caggcccaag
     1141 ttccagtttg gtggatccag cttccagtgt gattgatatg tcccaggaaa gtacgaggac
     1201 tccagctgtg tctctgccca agcaaaggaa gaatccattc aacagcccca agctgccgga
     1261 agatcactcc ttgcaacaaa ccaaacccga gcagtcaaaa actggaaaag ctggtttatt
     1321 tcagatttca aaagagggtg agttgtcaga atcaaaagaa aagtcatcta tcccagatat
     1381 gccacgtcag cagttagaga aaccaaagca aactgtatcc acagagcctg aaaatgcgtc
     1441 tcataccaaa gctccaatcc ccaaagccag aaaactgatc tacaaatcaa atgacttaga
     1501 gaaagatgat aaccagtctt ttcccagaca acggagggac tccctgaatg cgagaggggc
     1561 tccaagaggg atcctaaagc gcaactccag ttccagcagc acggactcag agaccctccg
     1621 tttaaattac aaccttgatc cgaaaagcaa aatcctatca cctggcctaa ccatccacga
     1681 gagaatctct gagaaggaat tttctttaga agacgactct tccacaagct cactagagcc
     1741 gttaaagcac gtgagattct ctgccgtgaa gaatgagctt ccacaaagtc ctagacccgt
     1801 ccttggccag gaagtgggag aatttactgt tttagaatct gaccagttgc aaaatggaac
     1861 tgaagatgca ggggacatag aggagtttca gaatcaccca gagctctccc acaaaacacc
     1921 tttgtctcat tatcagttag tgtcaagccc aagcgattca ggaagggaaa gagaacagct
     1981 gatgtcttct gggtctgctc caagagatga gatcccttgt cattcagaca ttctacccac
     2041 aggacctcag tgtgttgaga gttcatccgt catcaatggg caacaagaga aatcatcaca
     2101 ttttacaaag cttccatcag aattgtccaa aagcccttcc gatgaactga ctcagtgtgg
     2161 tgagcctgag ccatcacaga cagcagacca cagttttaga gaccatcggc aaggttcaga
     2221 agaagagcac agccctgttt tgaaaactct ggaaagaaga gctgctagga aattgccttc
     2281 caaaagtcta gaagacattc catcagattc atcaaatcaa gcaaaagtag ataatctgcc
     2341 tgaagaatta gtgcgtagtg ctgaagatga tcaaaaagcc gaccaagaac cagatacaaa
     2401 tgaatgtata ccaggaattt ccacagtgcc ttcactgcct gataatcagt tttcccaccc
     2461 tgacaaactc aaaaggatga gcaagtccgt gccagcattt cttcaagatg aggcgagtgg
     2521 cagtgtgatg agcgtttaca gtggagactt tggcaaccta gaagtgaaag gaagcgtgca
     2581 gtttgcactc gactacgtgg agtccctgaa agagctgcat gtgtttgtgg cccagtgtaa
     2641 ggatttagca gcagcagatg ttaagaaaca gcgctcagat ccgtatgtaa agacctatct
     2701 gctaccagac aaaggcaaaa tgggcaagaa gaagacactc gtagtgaaga agaccttgaa
     2761 tcctgtatac aacgagatat tgcggtataa aattgaaagg caattcttaa agacgcagaa
     2821 gttgaacctg tccgtttggc atcgggatac atttaagcgc aacagctttc tgggggaggt
     2881 ggagctcgac ctggaaacgt gggattggga cagcaaacag aacaaacagc tgaagtggta
     2941 cccactgaag aggaagacag caccagttgc cctcgagaca gaaaacagag gtgaaatgaa
     3001 actagctctc cagtatgttc cggaaccaag ccctggcaaa aagcttccta caactggaga
     3061 agtccacatc tgggtgaagg aatgccttga cctcccactg ttgaggggca gccacctaaa
     3121 ttcttttgtt aaatgtacca tccttccaga taccagtaga aaaagtcgcc agaagacaag
     3181 agctgtaggg aaaaccacca accccgtctt caaccatacc atggtgtatg atgggttcag
     3241 gcctgaagat ctgatggaag cctgtgtaga actcacagtc tgggaccatt ataaactaac
     3301 caaccagttt ctgggaggtc tccggatcgg ctttggaaca ggaaaaagct acgggactga
     3361 agtggattgg atggattcta cttctgagga agttgctctc tgggagaaga tggtaaactc
     3421 tcccaacact tgggttgaag cgacgctgcc cctccggatg cttctgattg ccaagctttc
     3481 caagtgatcc tagtcagccg attccgccat caaaaactac gccccagggg catctgaact
     3541 ggagagttgg cctcatggac aaataccctc tcccgttgtc actaatgact tttagaagca
     3601 tgctcaactt aatctgcatg catttctttg gttgcacgac tcaagggagt taaacgatga
     3661 caagatgtac ggcccagaag aagtgtggcg tgatgccgac attcaaggag agagttgaac
     3721 aagctaggaa aactgaactg ttgcttccac accaaagaaa aagctagctt cacatgtttc
     3781 ctaccacaat ccgtgttgca gtgcaggcct gccgtttggt tattgaaatg cttgctgggc
     3841 ttctaagtaa gaaggttttg ggcaaagcaa tgaggaaact cctgggatgg ggtggagaga
     3901 gaaaggacag cggtgaagac aatgacctac ataatatgac gaatttactt agtaacctct
     3961 aatgaaacat tgaattccat gttagggcag taagactgac ttcactgctc ataaatctgc
     4021 cttgagaaat cccacacaca cccggactcc tgtaacctca ccttctcagt ctcaaatgga
     4081 ctttggtgcc acctactggc tgcatatgga attcagctct tggcttattt tggcttaatt
     4141 tttgctaaag tgggtggcaa gtctatattt tataagacta tgctaaaata ttgcatatag
     4201 ttgatggttt tcttatgatt ttactatata aaaacagcat taaagtattc acatatatgc
     4261 tttgctacaa agttttaatc agaatataaa ttgctcaact gtattggact tcctatgtat
     4321 aattttcata aggtcttttg taaaaaccct tagaataaat tatcatggtt taaattgcat
     4381 cagtagttta gcctgacttc ttatatttaa aaaaatacat tctgtaaaag caagctccaa
     4441 cttaatgtag gtaggaagtc tggatagtga gtaaatgtga aatctcataa agatgccatc
     4501 aaaaccttgt ggctcttgcc tataacccct gatctagaat atggaggcag gagaattgtt
     4561 gctagtctga ggctagcttg ggctacacag tgagagtggt ctaaaaacaa aaaaacaaac
     4621 caaacaaaac taaaaaattt aaataaataa gtaaaactg
//
