LOCUS       NM_001368878            8033 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus synaptotagmin-like 2 (Sytl2), transcript variant 11,
            mRNA.
ACCESSION   NM_001368878 XM_006508355
VERSION     NM_001368878.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8033)
  AUTHORS   Boogerd,C.J., Perini,I., Kyriakopoulou,E., Han,S.J., La,P., van der
            Swaan,B., Berkhout,J.B., Versteeg,D., Monshouwer-Kloots,J. and van
            Rooij,E.
  TITLE     Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP
            inhibition during cardiac maturation
  JOURNAL   Nat Commun 14 (1), 4716 (2023)
   PUBMED   37543677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8033)
  AUTHORS   Jung,H., Park,H., Choi,Y., Kang,H., Lee,E., Kweon,H., Roh,J.D.,
            Ellegood,J., Choi,W., Kang,J., Rhim,I., Choi,S.Y., Bae,M.,
            Kim,S.G., Lee,J., Chung,C., Yoo,T., Park,H., Kim,Y., Ha,S.,
            Um,S.M., Mo,S., Kwon,Y., Mah,W., Bae,Y.C., Kim,H., Lerch,J.P.,
            Paik,S.B. and Kim,E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   3  (bases 1 to 8033)
  AUTHORS   Khacho,M., Tarabay,M., Patten,D., Khacho,P., MacLaurin,J.G.,
            Guadagno,J., Bergeron,R., Cregan,S.P., Harper,M.E., Park,D.S. and
            Slack,R.S.
  TITLE     Acidosis overrides oxygen deprivation to maintain mitochondrial
            function and cell survival
  JOURNAL   Nat Commun 5, 3550 (2014)
   PUBMED   24686499
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8033)
  AUTHORS   Yasuda,T. and Fukuda,M.
  TITLE     Slp2-a controls renal epithelial cell size through regulation of
            Rap-ezrin signaling independently of Rab27
  JOURNAL   J Cell Sci 127 (Pt 3), 557-570 (2014)
   PUBMED   24284068
  REMARK    GeneRIF: Our findings indicate that Slp2-a controls renal cell size
            through regulation of Rap-ezrin signaling independently of Rab27.
REFERENCE   5  (bases 1 to 8033)
  AUTHORS   Yasuda,T., Saegusa,C., Kamakura,S., Sumimoto,H. and Fukuda,M.
  TITLE     Rab27 effector Slp2-a transports the apical signaling molecule
            podocalyxin to the apical surface of MDCK II cells and regulates
            claudin-2 expression
  JOURNAL   Mol Biol Cell 23 (16), 3229-3239 (2012)
   PUBMED   22767581
  REMARK    GeneRIF: Slp2-a is required for targeting of the signaling molecule
            podocalyxin to the apical membrane in a Rab27A-dependent manner.
REFERENCE   6  (bases 1 to 8033)
  AUTHORS   Kuroda,T.S. and Fukuda,M.
  TITLE     Rab27A-binding protein Slp2-a is required for peripheral melanosome
            distribution and elongated cell shape in melanocytes
  JOURNAL   Nat Cell Biol 6 (12), 1195-1203 (2004)
   PUBMED   15543135
  REMARK    GeneRIF: Loss of Slp2-a protein also induced a change in melanocyte
            morphology, from their normal elongated shape to a more rounded
            shape, which depended on the phospholipid-binding activity of
            Slp2-a
REFERENCE   7  (bases 1 to 8033)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   8  (bases 1 to 8033)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Synaptotagmin-like protein 2-a (Slp2-a) contains an
            N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of
            Slp2-a specifically and directly binds the GTP-bound form of
            Rab27A.
REFERENCE   9  (bases 1 to 8033)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem Biophys Res Commun 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   10 (bases 1 to 8033)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158781.4 and AC100322.8.
            
            On Mar 6, 2019 this sequence version replaced XM_006508355.3.
            
            Transcript Variant: This variant (11) represents the longest
            transcript and encodes the longest isoform (9).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC158781.4         142702-143016
            316-781             AC158781.4         188700-189165
            782-933             AC158781.4         198406-198557
            934-1066            AC158781.4         200318-200450
            1067-1148           AC100322.8         33000-33081
            1149-1263           AC100322.8         34370-34484
            1264-2067           AC100322.8         36932-37735
            2068-5748           AC100322.8         41045-44725
            5749-5850           AC100322.8         46586-46687
            5851-5904           AC100322.8         49046-49099
            5905-5952           AC100322.8         50411-50458
            5953-6047           AC100322.8         53902-53996
            6048-6167           AC100322.8         56706-56825
            6168-6337           AC100322.8         58017-58186
            6338-6440           AC100322.8         60727-60829
            6441-6611           AC100322.8         62941-63111
            6612-6690           AC100322.8         64574-64652
            6691-6790           AC100322.8         68454-68553
            6791-6996           AC100322.8         69899-70104
            6997-8033           AC100322.8         70945-71981
FEATURES             Location/Qualifiers
     source          1..8033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.54 cM"
     gene            1..8033
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /note="synaptotagmin-like 2"
                     /db_xref="GeneID:83671"
                     /db_xref="MGI:MGI:1933366"
     exon            1..315
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..781
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             681..7142
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /note="isoform 9 is encoded by transcript variant 11;
                     synaptotagmin-like protein 2; exophilin-4"
                     /codon_start=1
                     /product="synaptotagmin-like protein 2 isoform 9"
                     /protein_id="NP_001355807.1"
                     /db_xref="CCDS:CCDS90269.1"
                     /db_xref="GeneID:83671"
                     /db_xref="MGI:MGI:1933366"
                     /translation="MIDLSFLTEEEQDAILKVLQRDAALKRAEEERVRHLPEKIKDDQ
                     QLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRRKKLPAAAEQNKDTAMRAKESWVNN
                     VNKDAVLPPEIAVVEEPEDDTDPAGPSSSLVDPASSVIDMSQESTRTPAVSLPKQRKN
                     PFNSPKLPEDHSLQQTKPEQSKTGKAGLFQISKEGELSESKEKSSIPDMPRQQLEKPK
                     QTVSTEPENASHTKAPIPKARKLIYKSNDLEKDDNQSFPRQRRDSLNARGAPRGILKR
                     NSSSSSTDSETLRLNYNLDPKSKILSPGLTIHERISEKEFSLEDDSSTSSLEPLKHVR
                     FSAVKNELPQSPRPVLGQEVGEFTVLESDQLQNGTEDAGDIEEFQNHPELSHKTPLSH
                     YQLVSSPSDSGREREQLMSSGSAPRDEIPCHSDILPTGPQCVESSSVINGQQEKSSHF
                     TKLPSELSKSPSDELTQCGEPEPSQTADHSFRDHRQGKPLLKALTAQTSSHVGPCATE
                     IRKTTDESISKVLDWFNRSSHTEDTMSSLQHLQGIDLKQQTDSKAQISNALMTDNTCL
                     EEDDSKVPMPTKVKLKPVRSDLAFQEEGAMLVSVTCQDSDALLKSNSENLSQQGTHKE
                     GPDTLQRFETYRIPSRRNENKGGSQGLESTEGVGTLPADGDDLLRALKRSDSEAQVPW
                     NTNHPESLGKEETEFHLPQKSKGSTHINSDSSVIVLGSILKDDTERKSKTKKTSLLKS
                     SLETENSALPLGAADNGSSWKKPEDQKEASEDPKNQVLREKYKRVSDRISFWEGGKAG
                     AKLKASQLTSSCSQQLSAKAHQPRKSQVMSLGSLSSGQSDYSEVTAKPVVFDEDGQAP
                     HLSRFDSSNKPETTRPLMSGLSKNYAVGNQSDKVTQLQTMGNETHPSLEKDRLVIDKS
                     NGSFKVLSLRERMDEPNTEQVYSHSQFENLRKFWGLGANVNSKHNDGNNTATNKQTSV
                     PLNIQKSKEFNAMKLSREKTQEVEEGRHLRQGNVIAAEEMEKLNFKCMPQEPPDETIF
                     PQKTLSIEPSKENEGKNTEYFGTQVIKKACSEQEIQESIVKTSILPKVSKDTFNDRLQ
                     KLLAEATLPASQTSGKEVHEQQALKVGVSENGKSFAKDEEEVTGLRESPKEPQRRNQQ
                     DCSVDKLLKESTRTPLSPLQSPLEAVTTRPISPLKDDLLFEKWMKENHSPSADQREIT
                     APFPQGVGILAGADLIQKDKHCNTEAMLQLAAEGSPPLAQLPHCFDGVSSSPADMSLS
                     WDAQLPSENGTLPSQKEISEAIEKVVLPSKPAATDVNAVLQKLLREAGEVDAKLPERE
                     QTAGTPSCPQRVSPLWPAPDPVVPNKDFHSFCTVPDTTHEGRSHLSARMSPSAHATMS
                     PTSTVTQYGQRLLQEVAETVRETVIQPKSQYPEFRAGLEKLLKETLQTSLSKDKKDTM
                     TISPSALTGSCEMSHQLSSEFHLTEIQETVEKAEAPSVTESSFDVGLEKLLKEMSEGP
                     CQLQASGRRDTLEKQPSQVEQAGFMGEIPHHILDGPGASKMKVSCSGLESQISQCDKQ
                     LGGDEAVTGPLIDVQDNKSGFEVPECSQLHEDHKIETNGTIQFVEDKGREKVITGETQ
                     ASQEPGFEEAPKEMSVSRNKHSIVLLETKGKAIKTREVKLVLATPYKRQEEEQGPEAC
                     SEYEFSDGNTSSNRENWRNTSSSEEEHSPVLKTLERRAARKLPSKSLEDIPSDSSNQA
                     KVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVPSLPDNQFSHPDKLKRMSKSVPA
                     FLQDESDDRETDTASESSYQLRRYKKSPSSLTNLSSSSGMTSLSSASGSVMSVYSGDF
                     GNLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKTYLLPDKGKMG
                     KKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVWHRDTFKRNSFLGEVELDLET
                     WDWDSKQNKQLKWYPLKRKTAPVALETENRGEMKLALQYVPEPSPGKKLPTTGEVHIW
                     VKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPE
                     DLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNS
                     PNTWVEATLPLRMLLIAKLSK"
     exon            782..933
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1066
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1148
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1263
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..2067
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..5748
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5749..5850
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..5904
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5905..5952
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5953..6047
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6048..6167
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6168..6337
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6338..6440
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6441..6611
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6612..6690
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6691..6790
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6791..6996
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6997..8033
                     /gene="Sytl2"
                     /gene_synonym="mKIAA1597; Slp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagaggt tggcagcccg gaggaggtag agcgggcagc cggggctgcg gcggagactc
       61 ggcgcgcgct ctgggtgtga cttttctgtc tactggcggt gtcgctggga ctgctttctg
      121 gtcctgctct gggtcttgga gtagctggag gagttggtgt agagagagat ttttttgttg
      181 tccttgctat cctggctgct acaacgtgaa ccaccggggc ggcaaccaac aagcttcatc
      241 cctcagtttc tcctttagtt aggagttcct tctgctgccc tcgccgccgt gtgtccgcga
      301 agctagggac accaggttaa ggatgcagca aggaggctgt tgctcaagat ggtgatgagg
      361 gtggagatac tgtgtctaag actggtccag agaaggtgca ctgaaggaat tctgctaaag
      421 acccaagcaa ggcatgcatc ctcctcctga gacctgttca tcctacagac cgctgctacc
      481 ttgagggacc ttgctgtcac gactttgatg tcatctgcct aaaatttttg tggagcccag
      541 ataagacttt caccaccaaa taagatacca tttacttttg catcctgtaa tcatcctggc
      601 tgtagtctca gctgtttttt gccgagaatc ccaagctaca tttgttacaa ttgttccttt
      661 tgtggaagct gtgctccaaa atgatcgact taagtttcct gacagaggag gagcaagacg
      721 ccatcttaaa ggttctgcag agggatgctg ccctgaagag ggctgaagag gagagagtca
      781 gacatctgcc tgaaaaaatt aaggatgacc aacaactaaa gaatatgagt ggccaatggt
      841 tttatgaagc taaggcaaaa agacacaggg acaaaatcca cggtgctgac atcatcagag
      901 catccatgag aaggaagaag ctcccagcgg cagctgagca gaataaggac acagcaatga
      961 gggcaaagga gagctgggtg aataatgtta acaaagatgc tgtccttcct ccagagatag
     1021 ctgttgtgga agagccagaa gatgacacag atcccgcagg cccaagttcc agtttggtgg
     1081 atccagcttc cagtgtgatt gatatgtccc aggaaagtac gaggactcca gctgtgtctc
     1141 tgcccaagca aaggaagaat ccattcaaca gccccaagct gccggaagat cactccttgc
     1201 aacaaaccaa acccgagcag tcaaaaactg gaaaagctgg tttatttcag atttcaaaag
     1261 agggtgagtt gtcagaatca aaagaaaagt catctatccc agatatgcca cgtcagcagt
     1321 tagagaaacc aaagcaaact gtatccacag agcctgaaaa tgcgtctcat accaaagctc
     1381 caatccccaa agccagaaaa ctgatctaca aatcaaatga cttagagaaa gatgataacc
     1441 agtcttttcc cagacaacgg agggactccc tgaatgcgag aggggctcca agagggatcc
     1501 taaagcgcaa ctccagttcc agcagcacgg actcagagac cctccgttta aattacaacc
     1561 ttgatccgaa aagcaaaatc ctatcacctg gcctaaccat ccacgagaga atctctgaga
     1621 aggaattttc tttagaagac gactcttcca caagctcact agagccgtta aagcacgtga
     1681 gattctctgc cgtgaagaat gagcttccac aaagtcctag acccgtcctt ggccaggaag
     1741 tgggagaatt tactgtttta gaatctgacc agttgcaaaa tggaactgaa gatgcagggg
     1801 acatagagga gtttcagaat cacccagagc tctcccacaa aacacctttg tctcattatc
     1861 agttagtgtc aagcccaagc gattcaggaa gggaaagaga acagctgatg tcttctgggt
     1921 ctgctccaag agatgagatc ccttgtcatt cagacattct acccacagga cctcagtgtg
     1981 ttgagagttc atccgtcatc aatgggcaac aagagaaatc atcacatttt acaaagcttc
     2041 catcagaatt gtccaaaagc ccttccgatg aactgactca gtgtggtgag cctgagccat
     2101 cacagacagc agaccacagt tttagagacc atcggcaagg taagcccctt ctcaaggctc
     2161 tcactgctca gacatcctca catgtgggtc catgtgctac agagataagg aagacaactg
     2221 acgagtccat atctaaagtc ctagactggt ttaaccgaag ttctcataca gaggacacta
     2281 tgtcatccct ccaacatctc caaggaatag atctcaaaca gcaaacagac tcaaaagcac
     2341 agattagcaa cgccttgatg acagacaata cctgtctgga agaagacgac tcaaaagtcc
     2401 caatgcccac taaagttaag ttgaagcctg tgaggtctga cttggcattc caagaagaag
     2461 gagctatgct ggtttctgta acttgccaag atagtgatgc acttctcaag tctaactctg
     2521 agaatttgtc ccaacaaggc acccacaagg aaggtccaga tacactgcaa cgatttgaaa
     2581 cctacagaat cccaagtcgc aggaatgaaa acaagggtgg tagccaaggt ttggagagta
     2641 cagaaggagt ggggaccctt cctgcagacg gtgacgacct gctcagggct ctgaaaaggt
     2701 ctgattcaga agcccaagtc ccatggaaca ctaaccatcc tgaaagctta ggtaaagaag
     2761 aaaccgaatt ccatctgcct caaaaaagta aggggagcac acatataaat tcagactctt
     2821 cagtaattgt cctaggctct attttgaaag atgatacaga gaggaaaagc aaaaccaaga
     2881 agacttccct cctaaaatct tccctagaga cagagaatag tgcattaccc cttggggctg
     2941 ccgacaatgg atcttcttgg aagaagcctg aggaccaaaa agaagccagt gaggacccca
     3001 agaaccaagt gctgagagag aaatacaagc gagtgagcga ccgaatatct ttttgggaag
     3061 gaggcaaagc tggtgctaag ttaaaggcat cacagctcac atcttcttgc agccagcagc
     3121 tttctgctaa agcacaccag cccaggaagt cacaagtcat gtccctgggc agtttatctt
     3181 caggtcaaag tgactatagt gaagtcacag ctaaaccagt ggtctttgat gaggatggcc
     3241 aagcacccca tctctcacgt tttgattcct caaataaacc tgaaacaacc aggcccctga
     3301 tgtcaggtct atccaaaaac tatgctgtag gtaaccagtc tgataaagta actcaacttc
     3361 aaactatggg gaatgaaaca cacccttctt tggagaaaga cagacttgtg attgataaat
     3421 caaatggcag cttcaaagtt ctgtccctaa gagaaagaat ggatgaaccc aatacagaac
     3481 aagtctatag tcactctcag tttgagaatc tgaggaagtt ttggggcctg ggagctaatg
     3541 taaacagtaa acacaatgat gggaataata cagcaacaaa caaacaaact tctgtgccac
     3601 tgaacatcca gaaatccaag gagtttaacg ccatgaaatt atcaagagaa aagacccagg
     3661 aagtagaaga aggaagacac ttaaggcagg gaaatgttat agctgcagaa gagatggaga
     3721 aattaaactt taagtgcatg cctcaagaac caccagatga aaccatattt ccgcaaaaaa
     3781 cactctcaat tgagccttca aaggaaaatg aaggaaaaaa tacagaatac tttggtactc
     3841 aggtgattaa aaaggcttgc tcagagcaag agattcaaga atccatagtg aaaacaagca
     3901 ttttgcctaa agtctcgaaa gacacgttca atgacaggtt acagaagttg ctggcagaag
     3961 ccacattacc agcaagccag acttctggca aggaagttca tgaacagcaa gcactcaaag
     4021 taggtgtttc tgaaaatggg aaaagttttg ccaaggatga ggaagaagtc acagggctca
     4081 gggagagccc caaagagccc caaagaagaa atcagcagga ctgtagtgta gacaaactcc
     4141 taaaggaatc aactagaact ccattgagtc ccttacaatc cccgctggaa gctgttacta
     4201 ctagacccat ctccccgctt aaagatgacc tattgtttga aaagtggatg aaagagaacc
     4261 acagtccttc agcagatcag agagagatca cagctccttt tccacagggt gttggaattt
     4321 tggcaggtgc agatctcatc cagaaggaca aacattgtaa cacagaagct atgcttcagt
     4381 tggctgcaga aggctctcct ccattggctc agcttcccca ttgttttgat ggagtttcca
     4441 gttctccagc agatatgtct ttatcttggg atgctcagct tccatctgag aacggcacgt
     4501 tgccttctca gaaggaaatt tcggaggcta tagagaaagt tgttcttcct tccaaaccag
     4561 cagcaactga tgtaaatgct gtgttacaaa agctacttag agaagctgga gaagtggacg
     4621 ccaagctccc tgaaagagag cagacagcag gtacaccctc atgtcctcag agagtgagtc
     4681 ccctatggcc tgctccagac cctgttgttc caaataagga cttccattct ttttgcacgg
     4741 ttcctgatac aactcatgaa ggtcggtctc acttatctgc cagaatgtca ccatcagcac
     4801 atgccactat gtcacccact tctactgtaa ctcagtatgg ccagaggcta cttcaggaag
     4861 tggcagagac agtgagggaa acagtcattc agcccaagtc acagtaccct gaattcaggg
     4921 ctggcttgga aaaactactg aaggaaacac tacaaacatc cctgtcaaaa gataaaaagg
     4981 atacaatgac tatttctcca tcagccttaa caggtagctg tgagatgtcc catcaacttt
     5041 cttctgaatt ccatcttaca gaaatacaag aaactgtaga gaaggctgag gctccatcag
     5101 taactgagag tagttttgat gttggtcttg agaaacttct taaagagatg tcggaaggac
     5161 cttgccagct ccaggcatca gggagaagag acactttaga gaagcagcct tcgcaagtag
     5221 agcaagcagg gttcatgggg gaaatacccc atcatatttt ggatggccca ggagcctcta
     5281 aaatgaaggt ttcatgtagt ggtttggaat ctcaaatcag ccagtgtgat aagcaattag
     5341 gaggagatga agctgtgact ggcccattga tagatgtcca ggataacaaa agtgggtttg
     5401 aggtccctga atgctcacaa cttcatgaag accataaaat agagaccaat ggaactatac
     5461 aatttgtaga ggacaaaggc agagaaaagg tcattacagg agaaacacag gcttcccagg
     5521 aaccaggctt tgaagaagct cctaaagaaa tgagtgtgtc cagaaataag cactccattg
     5581 ttcttctgga aacaaaagga aaggctataa aaacgaggga agttaagttg gtactagcaa
     5641 caccatataa gagacaagag gaagagcaag ggccagaggc atgctcagaa tatgagtttt
     5701 cagatgggaa caccagctct aaccgggaga actggagaaa tacctccagt tcagaagaag
     5761 agcacagccc tgttttgaaa actctggaaa gaagagctgc taggaaattg ccttccaaaa
     5821 gtctagaaga cattccatca gattcatcaa atcaagcaaa agtagataat ctgcctgaag
     5881 aattagtgcg tagtgctgaa gatgatcaaa aagccgacca agaaccagat acaaatgaat
     5941 gtataccagg aatttccaca gtgccttcac tgcctgataa tcagttttcc caccctgaca
     6001 aactcaaaag gatgagcaag tccgtgccag catttcttca agatgagagc gatgacagag
     6061 aaacagacac agcatcagag agcagctacc agctcaggag atacaagaag agccccagct
     6121 cattaaccaa tcttagcagc tcctctggca tgacgtcctt gtcctctgcg agtggcagtg
     6181 tgatgagcgt ttacagtgga gactttggca acctagaagt gaaaggaagc gtgcagtttg
     6241 cactcgacta cgtggagtcc ctgaaagagc tgcatgtgtt tgtggcccag tgtaaggatt
     6301 tagcagcagc agatgttaag aaacagcgct cagatccgta tgtaaagacc tatctgctac
     6361 cagacaaagg caaaatgggc aagaagaaga cactcgtagt gaagaagacc ttgaatcctg
     6421 tatacaacga gatattgcgg tataaaattg aaaggcaatt cttaaagacg cagaagttga
     6481 acctgtccgt ttggcatcgg gatacattta agcgcaacag ctttctgggg gaggtggagc
     6541 tcgacctgga aacgtgggat tgggacagca aacagaacaa acagctgaag tggtacccac
     6601 tgaagaggaa gacagcacca gttgccctcg agacagaaaa cagaggtgaa atgaaactag
     6661 ctctccagta tgttccggaa ccaagccctg gcaaaaagct tcctacaact ggagaagtcc
     6721 acatctgggt gaaggaatgc cttgacctcc cactgttgag gggcagccac ctaaattctt
     6781 ttgttaaatg taccatcctt ccagatacca gtagaaaaag tcgccagaag acaagagctg
     6841 tagggaaaac caccaacccc gtcttcaacc ataccatggt gtatgatggg ttcaggcctg
     6901 aagatctgat ggaagcctgt gtagaactca cagtctggga ccattataaa ctaaccaacc
     6961 agtttctggg aggtctccgg atcggctttg gaacaggaaa aagctacggg actgaagtgg
     7021 attggatgga ttctacttct gaggaagttg ctctctggga gaagatggta aactctccca
     7081 acacttgggt tgaagcgacg ctgcccctcc ggatgcttct gattgccaag ctttccaagt
     7141 gatcctagtc agccgattcc gccatcaaaa actacgcccc aggggcatct gaactggaga
     7201 gttggcctca tggacaaata ccctctcccg ttgtcactaa tgacttttag aagcatgctc
     7261 aacttaatct gcatgcattt ctttggttgc acgactcaag ggagttaaac gatgacaaga
     7321 tgtacggccc agaagaagtg tggcgtgatg ccgacattca aggagagagt tgaacaagct
     7381 aggaaaactg aactgttgct tccacaccaa agaaaaagct agcttcacat gtttcctacc
     7441 acaatccgtg ttgcagtgca ggcctgccgt ttggttattg aaatgcttgc tgggcttcta
     7501 agtaagaagg ttttgggcaa agcaatgagg aaactcctgg gatggggtgg agagagaaag
     7561 gacagcggtg aagacaatga cctacataat atgacgaatt tacttagtaa cctctaatga
     7621 aacattgaat tccatgttag ggcagtaaga ctgacttcac tgctcataaa tctgccttga
     7681 gaaatcccac acacacccgg actcctgtaa cctcaccttc tcagtctcaa atggactttg
     7741 gtgccaccta ctggctgcat atggaattca gctcttggct tattttggct taatttttgc
     7801 taaagtgggt ggcaagtcta tattttataa gactatgcta aaatattgca tatagttgat
     7861 ggttttctta tgattttact atataaaaac agcattaaag tattcacata tatgctttgc
     7921 tacaaagttt taatcagaat ataaattgct caactgtatt ggacttccta tgtataattt
     7981 tcataaggtc ttttgtaaaa acccttagaa taaattatca tggtttaaat tgc
//
