LOCUS       NM_031393               1940 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptotagmin-like 1 (Sytl1), mRNA.
ACCESSION   NM_031393
VERSION     NM_031393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Ramadass,M., Johnson,J.L., Marki,A., Zhang,J., Wolf,D.,
            Kiosses,W.B., Pestonjamasp,K., Ley,K. and Catz,S.D.
  TITLE     The trafficking protein JFC1 regulates Rac1-GTP localization at the
            uropod controlling neutrophil chemotaxis and in vivo migration
  JOURNAL   J Leukoc Biol 105 (6), 1209-1224 (2019)
   PUBMED   30748033
  REMARK    GeneRIF: results suggest that defective Rac1-GTP recycling from the
            uropod affects directionality and highlight JFC1-mediated Rac1
            trafficking as a potential target to regulate chemotaxis in
            inflammation and immunity.
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Kurz,A.R., Pruenster,M., Rohwedder,I., Ramadass,M., Schafer,K.,
            Harrison,U., Gouveia,G., Nussbaum,C., Immler,R., Wiessner,J.R.,
            Margraf,A., Lim,D.S., Walzog,B., Dietzel,S., Moser,M., Klein,C.,
            Vestweber,D., Haas,R., Catz,S.D. and Sperandio,M.
  TITLE     MST1-dependent vesicle trafficking regulates neutrophil
            transmigration through the vascular basement membrane
  JOURNAL   J Clin Invest 126 (11), 4125-4139 (2016)
   PUBMED   27701149
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Yokoyama,T., Nakatake,M., Kuwata,T., Couzinet,A., Goitsuka,R.,
            Tsutsumi,S., Aburatani,H., Valk,P.J., Delwel,R. and Nakamura,T.
  TITLE     MEIS1-mediated transactivation of synaptotagmin-like 1 promotes
            CXCL12/CXCR4 signaling and leukemogenesis
  JOURNAL   J Clin Invest 126 (5), 1664-1678 (2016)
   PUBMED   27018596
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Holt,O., Kanno,E., Bossi,G., Booth,S., Daniele,T., Santoro,A.,
            Arico,M., Saegusa,C., Fukuda,M. and Griffiths,G.M.
  TITLE     Slp1 and Slp2-a localize to the plasma membrane of CTL and
            contribute to secretion from the immunological synapse
  JOURNAL   Traffic 9 (4), 446-457 (2008)
   PUBMED   18266782
  REMARK    GeneRIF: These results suggest that both Slp1 and Slp2-a may form
            part of a docking complex, capturing secretory lysosomes at the
            immunological synapse.
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   9  (bases 1 to 1940)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Jfc1/synaptotagmin-like protein 1 (Slp1) contains an
            N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of
            Slp1/Jfc1 specifically and directly binds the GTP-bound form of
            Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
REFERENCE   10 (bases 1 to 1940)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA856092.1, AK131162.1 and AI553427.1.
            
            On Oct 31, 2007 this sequence version replaced NM_031393.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154176.1, AK078868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AA856092.1         1-43
            44-1918             AK131162.1         1-1875
            1919-1940           AI553427.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..1940
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /note="synaptotagmin-like 1"
                     /db_xref="GeneID:269589"
                     /db_xref="MGI:MGI:1933365"
     exon            1..101
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..330
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..479
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..555
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..601
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..689
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..784
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..898
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1065
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1162
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1321
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1400
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1500
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1706
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1925
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /note="hexamer: AATAAA"
     polyA_site      1919
                     /gene="Sytl1"
                     /gene_synonym="9030417L18; PSGL-1; Slp1"
                     /note="major polyA site"
ORIGIN      
        1 gcgagtcagc tttagtcccc acagcctttc tagtctctga actgtcttcc tggagagctg
       61 gagtcgcctt tgaagttgtc gtccctactg gacccttaca ggaagctaca tatgcccagc
      121 tggggcacaa ccccagctga tgccccagag aggccaccca tctcaggaga ggctttgggc
      181 cctgccctcc ctccccatgg cacatggacc aggatctgaa gctgaggggt tgctggacct
      241 cagcttcctg acagaggagg aacaggaggc catctctgat gtcctcaaac gagatgccca
      301 cctgcgccag ctggaggaag ggcgggtcag caagctccgg gcctccctgg aagacccctg
      361 gcagctgaag atcctgacag gggactggtt ccaagaagcg cgttcccaga ggcaccatca
      421 cgcccatttt ggttctgacc tcgtccgggc ttctatccga aggaagaaga gcccaaaggg
      481 ggaccaggct ctggggagtg atggtgaagc agaggctgct ggggaaaaca ccattgaagg
      541 agagccggag tccagggtct ccatagaggt ggcagctcca gagagaaaca ctgagaccca
      601 agggcctgat ttgttctcac catatgtacc ctcaaaggct tccgaaggtc aggaggagga
      661 gccccaggac caggaatgtg agctggaggc ccctggcgaa gggggtgtgc aggtggcaga
      721 ggcggaccca gagctggatc ctgagcagaa ggcggagcag gagtcccagc caactccagc
      781 ccagtccaag gcgacctcca agatcctgga gaatggagaa gaggccccgg ggctcggccc
      841 ctctcttgac cgcatgctca gcagcagctc ctctgtgtcc agcctcaatt cctctacgct
      901 gagcggcagc ctgatgagcc tatccgggga ggcagaggca ggcacggtgc aggtgcgagg
      961 ctccgtgctc ttctcgctgc gctacgagcc tggcacctct gagctgcgag tacaggtgat
     1021 ccagtgccag ggcctggccg ctgcccggcg acgccgctcc gatccctacg tgaaaagcta
     1081 cctcctcccg gataagcaga gcaagcgtaa gacgtcagtg aagaaacgga atctgaaccc
     1141 gatcttcaac gagactctgc ggcactctgt ccagcaggct gatctcccag gccgcgtgct
     1201 gagcctgtcc gtgtggcacc gggaaagtct gggtcgcaac atcttcctgg gagaagtaga
     1261 agtgccccta gacacatgga actgggactc tgaggctacc tggctccccc tgcagcctcg
     1321 ggttcctcca tctccagatg agcttcccag ccgtggactg ctgtctctgt cccttaagta
     1381 tgtccctgcc ggctcagagg gaggaggaca gcctcagagt ggggagttac acttctgggt
     1441 aaaggaagct cagagcctgg taccactgcg accaggatcc ctggacactt acattcaatg
     1501 ctcagtgctg cctgatgaca gtcgggccag ccgccaacgc acaagagtgg ttcgaagaag
     1561 tctcagccct gtgttcaacc acaccatggt ttatgacggc ttcgggcctg ctgacctacg
     1621 ccaggcctgt gccgagctct ccctgtggga ccatggggcc ctggccagtc gccagctggg
     1681 gggcacacgc ctcagccttg gtacaggcag cagttatggg cttcaggtgc cctggatgga
     1741 ttccacaccg gaggagaagc agctgtggca gacactcctg gagcggccct gtgagtgggt
     1801 ggatggcctt ctgcccctca gaaccaacct ggtccccagg gcatagcctt gtcaaaccct
     1861 tctgtggacc cccacctaaa gcacacccat ggccggaatc aataaagtct gtttacagag
     1921 ctactaaaaa aaaaaaaaaa
//
