LOCUS       NM_021889               3885 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus synaptotagmin IX (Syt9), transcript variant 1, mRNA.
ACCESSION   NM_021889
VERSION     NM_021889.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3885)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3885)
  AUTHORS   Rahman,M.M., Pathak,A., Schueler,K.L., Alsharif,H., Michl,A.,
            Alexander,J., Kim,J.A. and Bhatnagar,S.
  TITLE     Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to
            increase insulin secretion from pancreatic beta-cells improving
            glucose clearance
  JOURNAL   FASEB J 37 (8), e23075 (2023)
   PUBMED   37432648
  REMARK    GeneRIF: Genetic ablation of synaptotagmin-9 alters tomosyn-1
            function to increase insulin secretion from pancreatic beta-cells
            improving glucose clearance.
REFERENCE   3  (bases 1 to 3885)
  AUTHORS   Zhang,M., Yang,K., Wang,Q.H., Xie,L., Liu,Q., Wei,R., Tao,Y.,
            Zheng,H.L., Lin,N., Xu,H., Yang,L., Wang,H., Zhang,T., Xue,Z.,
            Cao,J.L. and Pan,Z.
  TITLE     The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral
            Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9
            Expression in Primary Sensory Neurons
  JOURNAL   J Neurosci 43 (17), 3009-3027 (2023)
   PUBMED   36898834
  REMARK    GeneRIF: The Cytidine N-Acetyltransferase NAT10 Participates in
            Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing
            SYT9 Expression in Primary Sensory Neurons.
REFERENCE   4  (bases 1 to 3885)
  AUTHORS   Seibert,M.J., Evans,C.S., Stanley,K.S., Wu,Z. and Chapman,E.R.
  TITLE     Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in
            Striatal Neurons by Regulating Substance P Secretion
  JOURNAL   J Neurosci 43 (9), 1475-1491 (2023)
   PUBMED   36732068
  REMARK    GeneRIF: Synaptotagmin 9 Modulates Spontaneous Neurotransmitter
            Release in Striatal Neurons by Regulating Substance P Secretion.
REFERENCE   5  (bases 1 to 3885)
  AUTHORS   Quadros,R.M., Miura,H., Harms,D.W., Akatsuka,H., Sato,T., Aida,T.,
            Redder,R., Richardson,G.P., Inagaki,Y., Sakai,D., Buckley,S.M.,
            Seshacharyulu,P., Batra,S.K., Behlke,M.A., Zeiner,S.A.,
            Jacobi,A.M., Izu,Y., Thoreson,W.B., Urness,L.D., Mansour,S.L.,
            Ohtsuka,M. and Gurumurthy,C.B.
  TITLE     Easi-CRISPR: a robust method for one-step generation of mice
            carrying conditional and insertion alleles using long ssDNA donors
            and CRISPR ribonucleoproteins
  JOURNAL   Genome Biol 18 (1), 92 (2017)
   PUBMED   28511701
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3885)
  AUTHORS   Fukuda,M.
  TITLE     Distinct developmental expression of synaptotagmin I and IX in the
            mouse brain
  JOURNAL   Neuroreport 17 (2), 179-182 (2006)
   PUBMED   16407767
REFERENCE   7  (bases 1 to 3885)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   8  (bases 1 to 3885)
  AUTHORS   Lee,B.H., Min,X., Heise,C.J., Xu,B.E., Chen,S., Shu,H.,
            Luby-Phelps,K., Goldsmith,E.J. and Cobb,M.H.
  TITLE     WNK1 phosphorylates synaptotagmin 2 and modulates its membrane
            binding
  JOURNAL   Mol Cell 15 (5), 741-751 (2004)
   PUBMED   15350218
REFERENCE   9  (bases 1 to 3885)
  AUTHORS   Tucker,W.C., Edwardson,J.M., Bai,J., Kim,H.J., Martin,T.F. and
            Chapman,E.R.
  TITLE     Identification of synaptotagmin effectors via acute inhibition of
            secretion from cracked PC12 cells
  JOURNAL   J Cell Biol 162 (2), 199-209 (2003)
   PUBMED   12860971
REFERENCE   10 (bases 1 to 3885)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127431.1 and AC164638.4.
            
            On Mar 22, 2023 this sequence version replaced NM_021889.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089115.1, BC137904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AC127431.1         9455-9880           c
            427-778             AC164638.4         96248-96599
            779-1325            AC164638.4         107476-108022
            1326-1446           AC164638.4         173294-173414
            1447-1618           AC164638.4         175363-175534
            1619-1748           AC164638.4         177690-177819
            1749-3885           AC164638.4         217721-219857
FEATURES             Location/Qualifiers
     source          1..3885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 56.33 cM"
     gene            1..3885
                     /gene="Syt9"
                     /note="synaptotagmin IX"
                     /db_xref="GeneID:60510"
                     /db_xref="MGI:MGI:1926373"
     exon            1..426
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1757
                     /gene="Syt9"
                     /note="synaptotagmin V; sytIX"
                     /codon_start=1
                     /product="synaptotagmin-9"
                     /protein_id="NP_068689.2"
                     /db_xref="CCDS:CCDS40078.1"
                     /db_xref="GeneID:60510"
                     /db_xref="MGI:MGI:1926373"
                     /translation="MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPR
                     LRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLFSGSKDNNQEPLNYT
                     DTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQPGGQENCAHAVRVQRQVTE
                     PTPSARHNSIRRQLNLSNPDFNIQQLQRQEQLTGIGRIKPELYKQRSLDNDDGRRSNS
                     KACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKV
                     HRKTLNPVFDEVFLFPVHYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFFDLADFP
                     RECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYV
                     KVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQIHLSIAVMDYDRVGHN
                     EVIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLMEKR"
     exon            427..778
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1325
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1446
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1618
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1748
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..3885
                     /gene="Syt9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3862..3867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt9"
                     /note="hexamer: AGTAAA"
     polyA_site      3877
                     /gene="Syt9"
     polyA_site      3885
                     /gene="Syt9"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcggag cgcggagagg cgcgctgggc tgtgcggcgc cgcctcccct ccgcgccgag
       61 ggagggacga ggggccgcgc gggagacgga gaaagcccga gcgagcggct ctccgagagc
      121 tgcatgcaac cggtgggagg ccgacccggc tggcgctgcg gctcgggtgg ggagcgcgga
      181 ccggccggtg gcggcggcgg cggcggcagc tctgagctgg caggcggagg gctttctccc
      241 gcgcccgcct gcccggcgcg gtccgaggat gcgggggggc gatgcccggg gccagggacg
      301 cgctctgtca ccaggcgctg cagctgctgg ccgagctctg tgcccgaggg gccctggagc
      361 acgacagctg ccaagatttc atctaccacc tgcgggaccg tgccagaccc cggctccgcg
      421 acccagatat ctctgtgagc ctgctaaccc tcgtggttac tgcctgtggt ctggcccttt
      481 ttggtgtctc tcttttcgtg tcttggaaac tgtgctgggt tccgtggcga gagcgaggcc
      541 tgttctctgg tagcaaagac aacaaccaag agcctcttaa ttacaccgac acagagacaa
      601 acgagcagga gaacagcgag gacttcctag acccacctac accctgccct gactcctcca
      661 tgaagataag ccacacttcc cccgacattc ccctctccac ccagccaggg ggccaggaga
      721 actgtgccca tgccgtccgt gtgcagcgac aagtcacaga gccaacacca tcagctcggc
      781 ataactcaat ccgaagacag ctcaacctgt cgaacccgga ctttaatatc cagcagcttc
      841 agaggcagga gcagctgact gggattggta gaattaaacc agagttatac aaacagaggt
      901 cactggacaa cgacgatggg cggaggagta acagcaaagc ctgcgggaaa ctgaacttca
      961 ttttaaaata tgactgcgac ttggaacagc tcattgtgaa gatccacaaa gccgtcaatc
     1021 tgcctgccaa ggacttctct gggacttcag atccttatgt caagatctac ttgcttcctg
     1081 accggaaaac aaaacaccag actaaagttc acaggaagac cctgaaccct gtgtttgatg
     1141 aggtgttttt atttcctgtt cactacaatg accttgaagc tcggaagctt cacttctctg
     1201 tgtatgactt tgacaggttc tctcgccatg acctgattgg tcaggtggtg gtggaccact
     1261 tcttcgactt ggccgacttc cccagggagt gcatcctttg gaaggatatc gagtatgtca
     1321 ccaacgataa tgtggatctg ggcgagctta tgttttcact ctgctatctt ccaacggctg
     1381 gcaggctgac catcaccatc ataaaagcaa ggaatttaaa ggcgatggac ataacaggag
     1441 catcagatcc ctacgtgaaa gtctcactga tgtgtgacgg ccggagactg aagaagagga
     1501 aaacctccac caagaggaac acgcttaatc ccgtttacaa tgaagccata gtcttcgacg
     1561 tccctcccga gagcatcgac cagatccact tgtccatagc cgtcatggac tatgaccgtg
     1621 taggtcacaa tgaggtcatt ggcgtgtgcc aagtaggaaa cgaggctgag cggctgggca
     1681 gagaccactg gagtgagatg ctgtcatatc ctcggaagcc catcgcacac tggcactctc
     1741 tgatggagaa acgatgacta tggagaagaa gactgcttgt gccaaggaca cagtcggaca
     1801 accatgtaac aaagatctgc agtaactttt cccacctagc aacacccaga tgactccagt
     1861 gaagaaatac tcagctgtaa ccacagcaat aactggccct ctttccaaat tggatgtggt
     1921 gaatctgaag ggttcatcta ttttcttcag gtggcccaag gtgatatgct ctagagaagc
     1981 tcctccctca ctgtcaaaag ccaagttgga ctgtggaaga gagcaagtgg catagtaagt
     2041 ggcttgagtg ccaagatggc ctttggttgg atgggcatga cactggtcct gacagtggtc
     2101 agtctaacat gcagtcattt gatttggatg ccctggaagg acagaatatt taaatatata
     2161 tccaggtgct aaataggcag cagatttcaa atcaaacttt actacctgtg agctaatgac
     2221 tgtcttcaga gaataattcc accccagaaa gtgttccagt tttccaagta atggcccaag
     2281 aaaatactag gctaagccag cctggaaaaa gtctcatgca aggcaggtca gttcatagca
     2341 aactcactgt cccttcccat gcacatggca gagtcccact tagccatggt cattcttcac
     2401 agaacccagg ttctgggatt ctaaaacatt atttccaagt agcctcttcc tttccagcag
     2461 tgatattact agagtgaaac gtgccatctt tgttagggac acttgcctcc cagtggaata
     2521 tgcatccagg aataatcttt cctggacaca gaagtgtgtg ttatgagata agatcactga
     2581 gagatgacac tggaaaaagg cacagctttt gggctttctt gacacagctg ccttctggct
     2641 gtttccatat gcaacagccc agggtataga cttgggcagc cacagaaaga ggctcttttc
     2701 cacctcagac acataccact tttgcagcac ttggggaatg gaaataccta caagaatgaa
     2761 ggccaagggc tctccccagg gtagctcatc cattacccag catcctcctg gaccagtcta
     2821 ctgccagttg tgcacctcat ccttcctgtg tctgcctcca ggaaatgaaa ccaaaggccc
     2881 cagtaccccc tgaatggact gggggctatt acctaaaggt cctctctcat cctgggtcta
     2941 gaagaccctc cccctgcatc actgttccac aattccattc ccctccagtc tctgtaacag
     3001 aacccagagt tgggttgcag ttaaccatcc tggagagcag cctctcttca tttcactttg
     3061 tttttcagtg taggttgcac ccgagggatg cagcattaca gcagatgttg gaaagttctg
     3121 gcttccatat acacctagta caagaaatcc tactgccaac gccagatctt gtcgtgtctt
     3181 aaaagggtgg agacctttgg ttgtataagg caatgttaat tcattcaagc ttagtgcatt
     3241 ccctggcctc ccagatccac tcccatctcc ttccaacttc atttgaaggg gttcaaaggg
     3301 aacctatgtt caaagttcag cctatgtcta ataaaatgag aaaaacacac cttccttgcc
     3361 catcccttcc attcagacat ccgccaccat atcagtattt agaaccaaag tatgaaggcc
     3421 aagtgccaac aggacaggga gcagaaatat tgtcactaga tccaggcaga tgtgcctaga
     3481 agaatggtcc caaagaaact agaatggctc cagcaaaaga ttatcaggca gccatcttat
     3541 taagctttga catgtccttg gcaatgggag ctcaggttgg agatcctggg gtagcctgtt
     3601 gttcccacct caggatctcc tcaccttgag ctagcagccc tggggtacta tggaataagc
     3661 tactgactca aagatagctt tgtgggggca ttcaggcgaa gaagactacc cacgtggtaa
     3721 acagatggct ttgtgtgtgg agagctttac ctagccagta cagctgtggc cagaagctgg
     3781 ctatcaatct gaattccctc agctcatttg caactctgcc tctgttctct tgtgttctgt
     3841 ttggtctccc tttagtttcc tagtaaatat tccttttgaa aaata
//
