LOCUS       NM_001373944            5469 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus synaptotagmin VII (Syt7), transcript variant 4, mRNA.
ACCESSION   NM_001373944 XM_006527208
VERSION     NM_001373944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5469)
  AUTHORS   Weingarten,D.J., Shrestha,A., Orlin,D.J., Le Moing,C.L.,
            Borchardt,L.A. and Jackman,S.L.
  TITLE     Synaptotagmins 3 and 7 mediate the majority of asynchronous release
            from synapses in the cerebellum and hippocampus
  JOURNAL   Cell Rep 43 (8), 114595 (2024)
   PUBMED   39116209
REFERENCE   2  (bases 1 to 5469)
  AUTHORS   Zhu,C., Xu,J., Lin,J., Liu,J. and Yu,E.
  TITLE     Double-strand-break repair protein rad21 homolog/Synaptotagmin-7
            alleviates Alzheimer's disease in mice by promoting M2 polarization
            of microglia
  JOURNAL   Brain Res Bull 214, 110994 (2024)
   PUBMED   38830486
  REMARK    GeneRIF: Double-strand-break repair protein rad21
            homolog/Synaptotagmin-7 alleviates Alzheimer's disease in mice by
            promoting M2 polarization of microglia.
REFERENCE   3  (bases 1 to 5469)
  AUTHORS   Tsotsokou,G., Miliou,A., Trompoukis,G., Leontiadis,L.J. and
            Papatheodoropoulos,C.
  TITLE     Region-Related Differences in Short-Term Synaptic Plasticity and
            Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model
            of Fragile X Syndrome
  JOURNAL   Int J Mol Sci 25 (13), 6975 (2024)
   PUBMED   39000085
  REMARK    GeneRIF: Region-Related Differences in Short-Term Synaptic
            Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus
            of a Rat Model of Fragile X Syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5469)
  AUTHORS   Wu,Z., Kusick,G.F., Berns,M.M.M., Raychaudhuri,S., Itoh,K.,
            Walter,A.M., Chapman,E.R. and Watanabe,S.
  TITLE     Synaptotagmin 7 docks synaptic vesicles to support facilitation and
            Doc2alpha-triggered asynchronous release
  JOURNAL   Elife 12, 90632 (2024)
   PUBMED   38536730
  REMARK    GeneRIF: Synaptotagmin 7 docks synaptic vesicles to support
            facilitation and Doc2alpha-triggered asynchronous release.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5469)
  AUTHORS   Lebowitz,J.J., Kissiwaa,S.A., Engeln,K.A., Bowman,A.M.,
            Williams,J.T. and Jackman,S.L.
  TITLE     Synaptotagmin-7 Counteracts Short-Term Depression during Phasic
            Dopamine Release
  JOURNAL   eNeuro 11 (3) (2024)
   PUBMED   38365841
  REMARK    GeneRIF: Synaptotagmin-7 Counteracts Short-Term Depression during
            Phasic Dopamine Release.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5469)
  AUTHORS   Tucker,W.C., Edwardson,J.M., Bai,J., Kim,H.J., Martin,T.F. and
            Chapman,E.R.
  TITLE     Identification of synaptotagmin effectors via acute inhibition of
            secretion from cracked PC12 cells
  JOURNAL   J Cell Biol 162 (2), 199-209 (2003)
   PUBMED   12860971
REFERENCE   7  (bases 1 to 5469)
  AUTHORS   Fukuda,M., Ogata,Y., Saegusa,C., Kanno,E. and Mikoshiba,K.
  TITLE     Alternative splicing isoforms of synaptotagmin VII in the mouse,
            rat and human
  JOURNAL   Biochem J 365 (Pt 1), 173-180 (2002)
   PUBMED   12071850
  REMARK    GeneRIF: identified the conserved alternative splicing events in
            the spacer domain of Syt VII; also shown that Syt VIIa-GFP is
            mainly localized in the perinuclear region and tips of neurites
            (dense-core vesicles), and not in the plasma membrane
REFERENCE   8  (bases 1 to 5469)
  AUTHORS   Hutt,D.M., Cardullo,R.A., Baltz,J.M. and Ngsee,J.K.
  TITLE     Synaptotagmin VIII is localized to the mouse sperm head and may
            function in acrosomal exocytosis
  JOURNAL   Biol Reprod 66 (1), 50-56 (2002)
   PUBMED   11751263
REFERENCE   9  (bases 1 to 5469)
  AUTHORS   Sugita,S., Han,W., Butz,S., Liu,X., Fernandez-Chacon,R., Lao,Y. and
            Sudhof,T.C.
  TITLE     Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis
  JOURNAL   Neuron 30 (2), 459-473 (2001)
   PUBMED   11395007
REFERENCE   10 (bases 1 to 5469)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124169.3.
            
            On Oct 13, 2019 this sequence version replaced XM_006527208.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.27654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AC124169.3         114949-115439       c
            492-595             AC124169.3         91019-91122         c
            596-675             AC124169.3         86420-86499         c
            676-807             AC124169.3         82574-82705         c
            808-1176            AC124169.3         77795-78163         c
            1177-1299           AC124169.3         74002-74124         c
            1300-1435           AC124169.3         68777-68912         c
            1436-1706           AC124169.3         65040-65310         c
            1707-1876           AC124169.3         61465-61634         c
            1877-1991           AC124169.3         60971-61085         c
            1992-2191           AC124169.3         60278-60477         c
            2192-5469           AC124169.3         52845-56122         c
FEATURES             Location/Qualifiers
     source          1..5469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.58 cM"
     gene            1..5469
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /note="synaptotagmin VII"
                     /db_xref="GeneID:54525"
                     /db_xref="MGI:MGI:1859545"
     exon            1..491
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..2296
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /note="isoform 4 is encoded by transcript variant 4;
                     synaptotagmin-7; sytVII"
                     /codon_start=1
                     /product="synaptotagmin-7 isoform 4"
                     /protein_id="NP_001360873.1"
                     /db_xref="CCDS:CCDS89341.1"
                     /db_xref="GeneID:54525"
                     /db_xref="MGI:MGI:1859545"
                     /translation="MYRDPEAASPGAPTRDVLLVSAIITVSLSVTIVLCGLCHWCQRK
                     LGKRYKNSLETVGTPDSGRGRGEKKAINDLDRDFWNNNESTVQQKWSSYPPKEFILNI
                     SPYAPYGDPRLSLNFEDSTLSTATTLESIPSSAGEPKCQRPRTLMRQQSLQQPLSQNQ
                     QGRQPSQPTTSQSLGQLQAHAASAPGSNPRAYGRGQARQGTSAGSKYRAAGGRSRSNP
                     GSWDHVVGQIRNRGLDMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQNPGTQQNQNAQ
                     GDKRLPAGGKAVNTAPVPGQTPHDESDRRTETRSSVSDLVNSLTSEMLMLSPGSEEDE
                     AHEGCSRENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKK
                     HKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRVLYLQVLDYDRFSRNDPIGEVSIPL
                     NKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGG
                     TSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDIPTEKLRETTIIITVMDK
                     DKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQLKA"
     exon            492..595
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            596..675
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..807
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1176
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1299
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1435
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1706
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1876
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1991
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2191
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..5469
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5448..5453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5469
                     /gene="Syt7"
                     /gene_synonym="B230112P13Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtggccgtg gcgctccacg gcgggcgggc ggcgccggcg gtgccccggg cgcgcacaca
       61 ctctctcgct ctctctctca cacacacata cacacacaca tacacacaca ctcactcact
      121 cacacacgca cgcacacaca tacatacaca catacacaca cacacacaca tcgcctcgta
      181 cacactcaca cacgctccgg cgcgcacacg cggcgcgcag gccagaggga ggaggctccg
      241 cgcggctcgg cggcggcggc agcgtgctcc gcgggcggcc cggagggctg gcgggcggcc
      301 cccgctcccc ggctccgcgg ctcggtgcag cccgcgcggc ccccgccctc ggacccgccc
      361 ccgggggtcg cccggcccca tgccctgcag cggcggcaga gaagcgcgcg gccgcaggcg
      421 gctctgagga gcccggaggg agccggcgac gaaggggacc atgtaccggg acccggaggc
      481 ggccagccca ggggcaccta cccgcgatgt cctgctggtc tctgcaatca tcaccgtcag
      541 ccttagcgtc actatcgtcc tctgcggcct gtgccactgg tgtcagcgca aactgggcaa
      601 acgctacaag aattccttgg agacggtggg cacgccagac tcggggcgtg ggcgcggtga
      661 gaagaaagcc atcaacgacc tagacagaga cttttggaat aacaatgaaa gcacagtgca
      721 gcagaaatgg agttcctatc ctcccaagga gtttattcta aacatttcac cctacgcccc
      781 ttatggcgac cctcgactgt ccctcaattt cgaggactcc accctgtcca cggccactac
      841 ccttgagtct atccccagct ccgcgggaga gccgaaatgc cagcgacccc gcacactgat
      901 gcggcagcag agcctgcagc agccgctgag ccagaaccag cagggccggc agcccagtca
      961 gcccaccacc agccagagcc tgggccagct gcaggcccac gcggcctcgg caccgggctc
     1021 caacccccgg gcctatggtc ggggtcaggc tcggcagggc acctcggccg gctccaagta
     1081 ccgggcagct gggggccgca gccgctccaa cccaggcagc tgggaccacg tggtggggca
     1141 gattcgaaac cgaggcttgg acatgaaatc cttcctggaa ggccggatgg tggtgctatc
     1201 cctggtatta gggctttcgg aacaggatga ctttgccaat atccctgacc tgcaaaaccc
     1261 aggaacccag cagaaccaga acgctcaggg ggacaagagg ttgcctgcag gagggaaggc
     1321 tgtgaataca gccccagtgc ccggccagac gccacacgat gagtctgacc gcagaacgga
     1381 gacccgttcc tctgtctcgg acctcgtcaa ctcccttacc agcgagatgc tcatgctctc
     1441 cccgggttct gaggaggatg aggcccacga gggctgcagc cgagagaacc tgggccgaat
     1501 ccagttcagt gttggctaca acttccaaga gtccacactc accgtgaagg tcatgaaggc
     1561 ccaagagctg ccagccaagg acttcagcgg tactagtgac ccctttgtca agatctacct
     1621 gctacccgac aagaagcaca aactggagac caaggtgaag cggaagaatc taaacccgca
     1681 ctggaatgag acctttctat ttgaagggtt tccctacgag aaagtggtgc agagggtcct
     1741 ctacctccag gtcctggatt atgaccgttt cagccgcaat gaccccattg gggaggtgtc
     1801 catccctctg aacaaggtgg acctgaccca gatgcagacc ttctggaagg atctgaagcc
     1861 atgcagcgat gggagtggga gccgagggga gctgctcttg tccctctgct acaacccctc
     1921 tgccaactcc atcatcgtga acatcatcaa agctcgaaac ctcaaagcca tggacatcgg
     1981 gggcacatca gacccctatg tgaaggtgtg gctgatgtat aaagacaagc gggtagagaa
     2041 aaagaagacc gtgacaaaga agaggaacct gaaccccatc ttcaatgagt ctttcgcctt
     2101 cgacataccc acggagaagc tgagggagac cacgatcatc atcactgtca tggacaaaga
     2161 caagctcagc cgcaacgacg tcatcggcaa gatctacctg tcctggaaga gcggaccagg
     2221 tgaagtgaaa cactggaagg acatgatcgc tcgtccccgg cagcctgtgg cccagtggca
     2281 ccagctgaaa gcctgagtgg ggccaaggga ggctccaagg gccaaggcct ggctccccat
     2341 catgccccta ccactttatg cacaatgccc agcccggcac ccctgccatg gtgaggggag
     2401 accccgaggg ctcagccagg gaggggtacc agaactctac tgggccccat ttctaggaag
     2461 taccagcccc accccatgag tccagctcag gggtgggggc ttgggagcca ttccctgctt
     2521 tgcctctttc tttcctgatt tgctgatact aaagacgtgg gggagagctc aagagccaga
     2581 tgggcagatc cctccagagg cccgccaggt gggcatagcc cccgttttct ttaaggcagt
     2641 gcctggagtg gagagaagcc accccttccc tagatcccct ttttggggcc cagaagagga
     2701 aggccgaggc gtttggccac ggcctggtca tcaggcccat ccccagcttc aggtgccggc
     2761 tgggccctgg acactgagga tagtatatag cctgtgctcc agagtcctgg agatgtggcc
     2821 ctgtgtattt gtgttgtgtc tactgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc
     2881 ccacatgcgt gtacacatgt gcacctggaa gctcatgcgc acgtgtggga aagggggagc
     2941 tcactcccta tcgccctggg accagcagtg ctgattggct atggaaaata gcagagtttc
     3001 gtgaggatga agtagggctg ggtcaggtag aggtcaaggc cacagggaag gtaggagagg
     3061 aagggtatgg acggctgaga agaagtgggg accagggcaa atggctgttt cagctgcctc
     3121 ctggcaccca ctttgcctgt ctctgtagcc cccaccccca caattcccca gtagcaactc
     3181 tctactgcaa tgtcgtccct tgggcctggg ctcacacttt gtaggcacct actcaccgtg
     3241 tgcatggcct tccaacaggg caccactccc atccttctca ggcattccta acccctcgcc
     3301 cagggacccc cacctttcca aatctcattt tgcagtcaaa ttggcatctg ctccacactc
     3361 tggcttggat atagcccccg atccccaccc cttgccccga cacctccacc ttttctttgc
     3421 ataatctgat caacccctgg ccttctccag gctgtcttga cacatacccc acccccaccc
     3481 ctacccccac cccagagtag cagctctttc tgcccctccc acccaccacg caagcagagg
     3541 aagcggggag cattccagga gtctgaagtt gccataccca aagaagctgt cgtcccttct
     3601 ccccgcctct gctgagacta gaactggctt ccctttggaa atagcagact ccagaatgat
     3661 ccctcttaag tcctgtcgtc cctctgtgct gtattgaaaa gacccagctg gtgaaagagc
     3721 ctcaaaacca attcagagac ttgagcccaa cataccctaa ttctaccacc aggtggcacc
     3781 agaacaccac atctatggta gcagttgggg accataaata cagttctacc ctgactggca
     3841 ccttgacacc ccaaggatgg aaggggctct ggactgcatc tgcttatcta gagcacagtg
     3901 ggaacacagt tatgtgggca cagtttcctt cagtgggctt ccccttaagc tcacccttct
     3961 gctctaggtg ggagatctcc ttttgtccat agcaaaatgt ccttaaatca gatttcacac
     4021 cctgtcccca gggacctgga ggaatccctt atgtagtagg tgaatcattc gtagagtgaa
     4081 taattccatt gtaaaacaaa tagttaccca tattacttgt aaatctaaat gtttgtatac
     4141 tacagctttt gctttaaata ggaccatccc caactccctt gcccagctgg gtgtaacccc
     4201 aggaaaggga ccctcccaac tccctgcaga ggctgtgtgg gaacagaaga gggtaatgta
     4261 gaaagtctgg aaactcgaga gaaatcgctg ccatccttcc ttccatctgc ctcagtctcc
     4321 tgagtgcttc caccaaggca tccgaggggc ccgagcaacc tgcaccagca ggtgtaaagt
     4381 tggcagcggg tttatgcaga gcgtgctcct gcacctctta gccagtcagc tcagcatccc
     4441 cccacatagc tgttctcccc tcagactact aggaatagta gtgacccagc ctgggtggag
     4501 gggtgggggg gccagccaga ccttgcaaac agtgggtgga gaacagagtg ggtttgcaca
     4561 gggtgcagct ggatgacaca gaggctgggc ataagatgtt agggcaactg ggggaacatg
     4621 gaaatggggg ggagggactt gagggtgagg agggcaccag agctctgcca ccactgtcct
     4681 aggatcttgg gcaagtcacc cacactccct gggcctcagt ttctccatct gtaaaatgat
     4741 ggtaataata cttcacctac ctcatggggg aggttgtgag gccaccatca cctgacctag
     4801 ggggtcaagg caggagggct ctgaaggtgc tacccagagc aaagttgtca gtgaggcctg
     4861 aaagcaaggc ccacctgcca gtccacccta ccccacagag cctctaggga ccgccagagc
     4921 caatctgtct cttcactgtg tccccacccc ctttatgagc gtcatctgac atcttgtggg
     4981 caccctagac ttagttgtta cattgtttag gtagcttttc ttgtgatcat cttctctgtg
     5041 taactgctat acaaattcca cctgccccag cacacccctc cacctgccct ccagcaccag
     5101 aggccaggga agggacaaag gaaaacagcc acaaaagaaa aaaaaaaaaa aaaaaagcca
     5161 aggggactcc cagctcagct ggggccccca ggggtgggaa ctggtggcgc tgtttgtatt
     5221 gtgtttgagt ccttgagcgc aagtgtttta taaaaaataa aacaaaaatc cactatcaca
     5281 aaaaaagaaa aaaaatacag caaagagaac tgaagacaaa agggaaaaag aaccatacaa
     5341 tttttttcca ccatatgcac cctctaagcc agcaaaattt tcctctttgc aaaatcatat
     5401 ttttgtggga atgggccctg ctttttgtgg caaggcctgt tctgattaat aaaggatcgt
     5461 gaaaaagta
//
