LOCUS       NM_018800               4473 bp    mRNA    linear   ROD 31-JAN-2024
DEFINITION  Mus musculus synaptotagmin VI (Syt6), transcript variant 1, mRNA.
ACCESSION   NM_018800 XR_375545
VERSION     NM_018800.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4473)
  AUTHORS   Chatterjee,S., Nandakumar,P., Auer,D.R., Gabriel,S.B. and
            Chakravarti,A.
  TITLE     Gene- and tissue-level interactions in normal gastrointestinal
            development and Hirschsprung disease
  JOURNAL   Proc Natl Acad Sci U S A 116 (52), 26697-26708 (2019)
   PUBMED   31818953
REFERENCE   2  (bases 1 to 4473)
  AUTHORS   Larsen,R., Proue,A., Scott,E.P., Christiansen,M. and Nakagawa,Y.
  TITLE     The Thalamus Regulates Retinoic Acid Signaling and Development of
            Parvalbumin Interneurons in Postnatal Mouse Prefrontal Cortex
  JOURNAL   eNeuro 6 (1) (2019)
   PUBMED   30868103
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4473)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4473)
  AUTHORS   Awasthi,A., Ramachandran,B., Ahmed,S., Benito,E., Shinoda,Y.,
            Nitzan,N., Heukamp,A., Rannio,S., Martens,H., Barth,J., Burk,K.,
            Wang,Y.T., Fischer,A. and Dean,C.
  TITLE     Synaptotagmin-3 drives AMPA receptor endocytosis, depression of
            synapse strength, and forgetting
  JOURNAL   Science 363 (6422) (2019)
   PUBMED   30545844
REFERENCE   5  (bases 1 to 4473)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 4473)
  AUTHORS   Hutt,D.M., Baltz,J.M. and Ngsee,J.K.
  TITLE     Synaptotagmin VI and VIII and syntaxin 2 are essential for the
            mouse sperm acrosome reaction
  JOURNAL   J Biol Chem 280 (21), 20197-20203 (2005)
   PUBMED   15774481
REFERENCE   7  (bases 1 to 4473)
  AUTHORS   Tucker,W.C., Edwardson,J.M., Bai,J., Kim,H.J., Martin,T.F. and
            Chapman,E.R.
  TITLE     Identification of synaptotagmin effectors via acute inhibition of
            secretion from cracked PC12 cells
  JOURNAL   J Cell Biol 162 (2), 199-209 (2003)
   PUBMED   12860971
REFERENCE   8  (bases 1 to 4473)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     A novel alternatively spliced variant of synaptotagmin VI lacking a
            transmembrane domain. Implications for distinct functions of the
            two isoforms
  JOURNAL   J Biol Chem 274 (44), 31428-31434 (1999)
   PUBMED   10531344
REFERENCE   9  (bases 1 to 4473)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
REFERENCE   10 (bases 1 to 4473)
  AUTHORS   Fukuda,M., Kojima,T. and Mikoshiba,K.
  TITLE     Phospholipid composition dependence of Ca2+-dependent phospholipid
            binding to the C2A domain of synaptotagmin IV
  JOURNAL   J Biol Chem 271 (14), 8430-8434 (1996)
   PUBMED   8626542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123057.4 and BC050760.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_018800.6.
            
            On or before Oct 27, 2017 this sequence version replaced
            XR_375545.2, NM_018800.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.185793.1,
                                           SRR9219379.41593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC123057.4         110082-110377       c
            297-645             AC123057.4         99932-100280        c
            646-1207            AC123057.4         97828-98389         c
            1208-1328           AC123057.4         64716-64836         c
            1329-1500           AC123057.4         59954-60125         c
            1501-1651           AC123057.4         58490-58640         c
            1652-1719           AC123057.4         54653-54720         c
            1720-4451           AC123057.4         50444-53175         c
            4452-4473           BC050760.1         4264-4285
FEATURES             Location/Qualifiers
     source          1..4473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.45 cM"
     gene            1..4473
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /note="synaptotagmin VI"
                     /db_xref="GeneID:54524"
                     /db_xref="MGI:MGI:1859544"
     exon            1..296
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1669
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptotagmin-6"
                     /codon_start=1
                     /product="synaptotagmin-6 isoform 1"
                     /protein_id="NP_061270.2"
                     /db_xref="CCDS:CCDS38575.1"
                     /db_xref="GeneID:54524"
                     /db_xref="MGI:MGI:1859544"
                     /translation="MSGVWGAGGPRCQAALAVLASLCRARPPPLGLDVETCRSFELQS
                     PEQSPSAADSGTSVSLLAVVVIVCGVALVAVFLFLFWKLCWMPWRKKEASSPSSANPA
                     SETLQSPSSRGNMADKLKDPSALGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTKLQ
                     RQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAAEQPTSIGRIKPELYKQKSV
                     DGDDAKSEAAKSCGKINFSLRYDYESETLIVRILKAFDLPAKDFCGSSDPYVKIYLLP
                     DRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVIL
                     DNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAM
                     DITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPIYNEAIIFDIPPENMDQVSLLIS
                     VMDYDRVGHNEIIGVCRVGINAEGLGRDHWNEMLAYPRKPIAHWHSLVEVKKSFKEGT
                     PRL"
     exon            297..645
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            646..1207
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1328
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1500
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1651
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1719
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..4452
                     /gene="Syt6"
                     /gene_synonym="3110037A08Rik; sytVI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtgatta aaagcagagc ggagcctcag ggggccgctg cggggagggt cttcttgggg
       61 ccttcttacc ccgccccagt ccggccgcgg ctggagttcg agccactact ccgctggcct
      121 gagtgtccgg ggcatgagcg gggtttgggg ggccggaggg cctcggtgcc aggcggcgct
      181 cgcggtcctg gcttctctgt gccgggcccg gccgccccct ctcgggctgg acgttgagac
      241 ttgtcggagc ttcgagctgc agtccccgga gcagagtcca agcgcggcag actcaggcac
      301 ctctgtcagc ctcctcgccg tggtagttat tgtgtgtggc gtggccctgg tggcagtttt
      361 tctctttctc ttttggaagc tgtgctggat gccctggagg aagaaagagg cctccagccc
      421 ttcttctgct aaccctgctt cagagactct ccagagcccc agctccagag gcaacatggc
      481 ggataagctg aaggacccca gtgccctggg cttcctggag gcagctgtga agatcagcca
      541 cacttcccca gacatcccag ccgaggtgca gatgtcggtc aaagagcaca tcatgcgcca
      601 cacaaagctg cagcgacaga ccacagagcc agcatcctcc accaggcaca catccttcaa
      661 gcgccacctg ccacgacaga tgcatgtctc cagcgtggac tatggcaatg agctgccgcc
      721 ggctgccgcc gagcagccca ccagtattgg ccgtatcaag cctgagcttt acaagcagaa
      781 gtcagtggat ggggatgatg ccaagtcgga ggccgccaag agctgtggga agatcaactt
      841 cagcctccgc tatgactatg aaagcgagac gctgattgtg cgcatcctga aggcctttga
      901 cctccctgcc aaggactttt gcggaagttc tgacccttat gttaagatct acctcctgcc
      961 tgaccgcaag tgcaagctgc agacccgggt gcaccgcaag accctgaacc ccacctttga
     1021 tgagaacttc cacttccccg tgccctacga ggagctggct gaccgcaagc tgcatctcag
     1081 tgtctttgac tttgaccgct tctcccgcca tgacatgatt ggggaggtca tcctggacaa
     1141 tctctttgag gcctctgacc tgtcccggga gacctccatc tggaaggaca tccagtacgc
     1201 tactagtgaa agtgtggact tgggagagat catgttctcc ctctgctacc tgcccacagc
     1261 aggcaggctc accctcacag tgatcaagtg tcgaaatctc aaagcaatgg acatcacagg
     1321 ctactcagat ccctacgtca aagtatccct actgtgtgat ggacggaggc tgaaaaagaa
     1381 gaaaacgacc ataaaaaaga acaccctaaa ccccatctac aacgaggcca tcatctttga
     1441 catcccccca gaaaacatgg accaagtgag cctgctcatc tccgttatgg actatgatag
     1501 agttggccac aacgagatca taggagtctg tagagtgggg atcaatgctg aaggccttgg
     1561 cagggaccac tggaatgaga tgttggcgta cccacgaaag cccattgcgc actggcactc
     1621 cttggtggag gtaaagaaat ccttcaaaga ggggacccct cggttgtgat ttcattcacg
     1681 tggatgctgc aagcggagac acagccactg gagttaggat ggcagggccg agctgccagc
     1741 ttcgacagtg agagctcatg cccgtctccg aaaccacctc cgacgccatg agctgcacag
     1801 cggagccgat gggactcagc aatgttattt ccacacttgt tccagtctct aaacacagtg
     1861 ttcgtgcagt cacagtgatg gccgcagcag cagccactgc ctgccagccc gtggtcttaa
     1921 ctgctcttgt gcagggcaag gcccagacac ttgtcctgtg tgatcagatc tgtcttagtc
     1981 ttttctgtct cccaaggtga cgctttttgt ggtttttcac tttgtttggg tctgctgtcg
     2041 agaaagaaat aaaaacacaa taattagaga tacaaaatga agaatggaga gcccagaagc
     2101 tggttctggg aaatacaatg taagatagca gtctttgggg ggaaagcaga ctgaatctct
     2161 gaaattttgt gcctccatca aatgttgacc cctggagatg caccagaaag atggagccat
     2221 ggctgtattt tcagtgccct ccaagaacgg accctatcaa cttaggagcc tctccaaggc
     2281 aaattattct tcatggaagc tcttcactgc tgtgacacaa gacaagatgt ggtcttcttg
     2341 tcccgtgttg aaatcatgag gcctctgata tgtttgtgac tctgaaggag tacccctgtt
     2401 cccctctttg ttggctttcc ccaactggaa acattttgac tccacgtggg aacttagtcg
     2461 ctttccttag gaatgatcct gctgaaagta accacgccat atgtttccca acactccaca
     2521 gttaatgatc acatttgttt gacaacggga tcttaattct caaaaataac cttcattgta
     2581 aagaaaggag gtacatatgt tccagaagga ttcctgtgtt atacatagct ttataattcc
     2641 atgacgtagt aagcagctgt ttaaaatgcc taaacagagc aaagaaaaat ctaggtaaca
     2701 cgttcttttc tgaatgggtc attttgaaat ccgaaccaca tttttgagtc tgcctgtcta
     2761 tgaagagcct tctcttagtt gaaacccagt tagccagaga ctagctcagc cccacggact
     2821 ctgggacaat aactcacctt aaactttagt tctataaatt aataagtatt ctgtgttgtt
     2881 tgttttagtc gtagtgagaa gatctttgct tgtttgtttg tttttccatt agatctctat
     2941 cttaggccaa attcagttta gaaaacaaaa atgaatgact gtatttataa tagcacatct
     3001 ctacagtgtg accagtgagt ggcctttcca ccacaccctg taagcacatg aaagtgagtt
     3061 tccactccaa ctcgtggcta ctgtaggact tgcatgaagc aagtcagctt ggaaaattcc
     3121 ttctttcaac aacagaaggt caagaacaca aaagctatct gcatacctcg tgtcttactc
     3181 tttacatatg ccccatgcta taggagtagc tacttaataa agtcaccacc attttaagtc
     3241 aagccaccaa gtttctctgc tgccctaact tacataagtg tctgctagtc agaagaatga
     3301 ctggattgga catgagccaa caggatattg tggcaagaga agcgatccac ttttctagta
     3361 aatgtagatt aatttagatt ccactgagta tgagccttgt gctagcgact ggtgggtaaa
     3421 gatgattttt ctcttcaaat atcttacaat tgataagtct ttataaccag gcagtgccct
     3481 gtttggacgt tcacttgaga gagagaaaaa tcacaaggtc gtgacaagag tctcagcaag
     3541 caagtaactt cattgtgttt cttgactcta gatgggcccc actaaggtga ctgtcacagc
     3601 acatagcagt gtaactagga aaggaccaat tgagttttct gggtcagaag gagtccagac
     3661 attagtgagt atgtcatctt cccagaagtg ggctccaaaa gcatgcccag ctgccacccc
     3721 gaaaccctta ggcaggtggg atgttccatt ctaagatttc agatagaagg gtgtggtctg
     3781 cctaaattat gggatagcag ctgcctgtct gagacagctt ctatatccca gctactcttt
     3841 tccataagtg aacattttct ggaaatgttt ctgaaaacag cacctggttc tggccacacc
     3901 cctctcacca cccaagtcaa ctgctttagc accaccagcc tcggtggaca ttaggcatgg
     3961 aaacccactc cagaaaggct cctagctcct gggttccctc ccccaagtcc ccaccaaagg
     4021 tggccagacc agtcctcttc actctgaagc atgaatggta taaataggct tcaccattta
     4081 ttaaccagga ctcttccctc acagaggaga cataatgaca ataaatgcag aagaaactga
     4141 aattcaaaat tgactcttct gttggcttcc cctggtacag gaaaccctta tgggtggcaa
     4201 gctttgctga agttatgaaa accagggcca tttgcacaca gaggtttgct aaagccacca
     4261 agttctcctc tcctttattt agaagtgttt cttggctgag agatgcttcc ccccccccct
     4321 tgcacttacc caggatgtta attaattgta tcatcatttt aaaaaattat gttgttaatt
     4381 actgctttgt gtcttcccac ccctgtcaca gcctggagtt tctattcaat taaatctctg
     4441 tctcttgccc ataaaaaaaa aaaaaaaaaa aaa
//
