LOCUS       NM_001417324            2524 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus synaptotagmin III (Syt3), transcript variant 4, mRNA.
ACCESSION   NM_001417324
VERSION     NM_001417324.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Weingarten,D.J., Shrestha,A., Orlin,D.J., Le Moing,C.L.,
            Borchardt,L.A. and Jackman,S.L.
  TITLE     Synaptotagmins 3 and 7 mediate the majority of asynchronous release
            from synapses in the cerebellum and hippocampus
  JOURNAL   Cell Rep 43 (8), 114595 (2024)
   PUBMED   39116209
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Lu,H., Chen,S., Nie,Q., Xue,Q., Fan,H., Wang,Y., Fan,S., Zhu,J.,
            Shen,H., Li,H., Fang,Q., Ni,J. and Chen,G.
  TITLE     Synaptotagmin-3 interactions with GluA2 mediate brain damage and
            impair functional recovery in stroke
  JOURNAL   Cell Rep 42 (3), 112233 (2023)
   PUBMED   36892998
  REMARK    GeneRIF: Synaptotagmin-3 interactions with GluA2 mediate brain
            damage and impair functional recovery in stroke.
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Weingarten,D.J., Shrestha,A., Juda-Nelson,K., Kissiwaa,S.A.,
            Spruston,E. and Jackman,S.L.
  TITLE     Fast resupply of synaptic vesicles requires synaptotagmin-3
  JOURNAL   Nature 611 (7935), 320-325 (2022)
   PUBMED   36261524
  REMARK    GeneRIF: Fast resupply of synaptic vesicles requires
            synaptotagmin-3.
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Awasthi,A., Ramachandran,B., Ahmed,S., Benito,E., Shinoda,Y.,
            Nitzan,N., Heukamp,A., Rannio,S., Martens,H., Barth,J., Burk,K.,
            Wang,Y.T., Fischer,A. and Dean,C.
  TITLE     Synaptotagmin-3 drives AMPA receptor endocytosis, depression of
            synapse strength, and forgetting
  JOURNAL   Science 363 (6422) (2019)
   PUBMED   30545844
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Tremblay,M.G. and Moss,T.
  TITLE     Loss of all 3 Extended Synaptotagmins does not affect normal mouse
            development, viability or fertility
  JOURNAL   Cell Cycle 15 (17), 2360-2366 (2016)
   PUBMED   27399837
  REMARK    GeneRIF: the combined inactivation of all 3 E-Syt genes has no
            effect on mouse viability or fertility.
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Fukuda,M., Kojima,T., Aruga,J., Niinobe,M. and Mikoshiba,K.
  TITLE     Functional diversity of C2 domains of synaptotagmin family.
            Mutational analysis of inositol high polyphosphate binding domain
  JOURNAL   J Biol Chem 270 (44), 26523-26527 (1995)
   PUBMED   7592870
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Jones,J.M., Popma,S.J., Mizuta,M., Seino,S. and Meisler,M.H.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Hilbush,B.S. and Morgan,J.I.
  TITLE     A third synaptotagmin gene, Syt3, in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 91 (17), 8195-8199 (1994)
   PUBMED   8058779
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Morita,T., Kubota,H., Murata,K., Nozaki,M., Delarbre,C.,
            Willison,K., Satta,Y., Sakaizumi,M., Takahata,N., Gachelin,G. et
            al.
  TITLE     Evolution of the mouse t haplotype: recent and worldwide
            introgression to Mus musculus
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6851-6855 (1992)
   PUBMED   1495973
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Willison,K.
  TITLE     The mouse Brachyury gene and mesoderm formation
  JOURNAL   Trends Genet 6 (4), 104-105 (1990)
   PUBMED   2132728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152939.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D45858.1, SRR7345562.1053634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC152939.2         143026-143246
            222-414             AC152939.2         144226-144418
            415-943             AC152939.2         148793-149321
            944-1316            AC152939.2         150696-151068
            1317-1535           AC152939.2         151646-151864
            1536-1656           AC152939.2         153707-153827
            1657-1828           AC152939.2         153936-154107
            1829-1961           AC152939.2         154200-154332
            1962-2029           AC152939.2         157383-157450
            2030-2524           AC152939.2         157833-158327
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     gene            1..2524
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /note="synaptotagmin III"
                     /db_xref="GeneID:20981"
                     /db_xref="MGI:MGI:99665"
     exon            1..221
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            222..414
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2027
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /codon_start=1
                     /product="synaptotagmin-3"
                     /protein_id="NP_001404253.1"
                     /db_xref="GeneID:20981"
                     /db_xref="MGI:MGI:99665"
                     /translation="MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNELRIRGY
                     PRGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLA
                     PGVGLAGLVGGGGHHLGASLGGHPLLGGPHHHGHTAHHPPFAELLEPGGLGGSEPPEP
                     SYLDMDSYPEAAVASVVAAGVKPSQTSPELPSEGGTGSGLLLLPPSGGGLPSAQSHQQ
                     VTSLAPTTRYPALPRPLTQQTLTTQADPSTEERPPALPLPLPGGEEKAKLIGQIKPEL
                     YQGTGPGGRRGGGSGEAGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDP
                     YVKIYLLPDRKKKFQTKVHRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRH
                     DLIGQVVLDNLLELAEQPPDRPLWRDILEGGSEKADLGELNFSLCYLPTAGRLTVTII
                     KASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESV
                     ENVGLSIAVVDYDCIGHNEVIGVCRVGPEAADPHGREHWAEMLANPRKPVEHWHQLVE
                     EKTLSSFTKGGKGLSEKENSE"
     exon            415..943
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1316
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1535
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1656
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1828
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1961
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2029
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2524
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="Syt3"
                     /gene_synonym="sytIII"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcgcgc agctacttcg agtcgggcaa gatgcaaagc ttgggctgat tttttccctc
       61 ccgatttggg tccctagatc agtcaccagc cccccttctt gccacctggc aagcgtggag
      121 accggtccgc agcggctagg ctcgtccacc ctgcaatccc catgggctac cgccccccgc
      181 cgcctcggct gccacccagg acaaggcagg ggtaagcaca gctctgccca ccccactctt
      241 aagtatagga tcacgtggcc actatgtctg gggactatga agatgacctc tgtcggcggg
      301 cgctcatcct ggtctcagac ctctgtgcac gggtccgaga tgctgatacc aatgataggt
      361 gtcaagagtt caacgaactg cggatcagag gatatccccg gggtccggat gcagatattt
      421 ccgtgagcct gctgtcagtc atcgtgacat tctgtggcat cgtcctcttg ggtgtctccc
      481 tcttcgtgtc ctggaagttg tgctgggtgc cctggaggga caaaggaggc tcagcagtgg
      541 gtggtggccc cctgcgcaaa gacttagccc ctggggttgg gctggcaggc ctggtaggag
      601 gtggtgggca ccacctagga gccagcctcg gtggtcatcc cctgctgggt ggcccacacc
      661 atcatgggca cacagcccac catccaccat ttgcggagct gctggaacca ggtggtcttg
      721 ggggctctga gccgccagaa ccttcctacc tggacatgga ctcatatcca gaggctgctg
      781 tggcctctgt ggtagctgct ggagtcaaac caagccagac atcccctgag ctgccttctg
      841 agggtggaac aggttctggg ctgctcctgc tgcctcccag tggtgggggc ttacccagtg
      901 cccagtctca tcagcaggtc acaagtctag cacccaccac aaggtaccca gccctgcctc
      961 ggcccctcac ccagcagacc ctgaccaccc aagcagaccc aagcactgag gagcgaccgc
     1021 ctgcactgcc cttacctctg ccgggtggag aggaaaaagc caagctcatc ggtcagatca
     1081 aaccagagct gtaccagggc actggacccg gtggtcggcg aggcgggggc tcaggggaag
     1141 caggggcacc ctgtggccgc atcagttttg ccctccggta cctctatggt tctgaccagc
     1201 tcgtggtgcg gatcctacag gccctggatc tcccagcaaa ggactccaat gggttctcag
     1261 acccctacgt caagatctac ctgttgcctg atcgcaaaaa gaagttccag accaaggtgc
     1321 acaggaagac gttgaacccc atcttcaacg agacgtttca gttctcggtg cccctggccg
     1381 agctggcaca gcgcaagctg cacttcagcg tctatgactt cgaccgcttc tcgcggcatg
     1441 atctcattgg ccaggtggtt ttggacaacc tgctggagct ggctgaacag ccccctgacc
     1501 gcccgctctg gagggacatc ctggagggtg gctcggaaaa ggcagatctc ggagagctca
     1561 acttctctct ctgctacctc cccacggctg ggcgcctcac cgtgaccatc atcaaagcct
     1621 ctaacctcaa agcaatggac ctcactggtt tctcagaccc ctatgtgaag gcctctctga
     1681 tcagcgaggg gcggcgtctg aagaaacgga agacctccat taagaagaac acactgaacc
     1741 ccacgtacaa cgaggccctg gtgttcgacg tggctcccga gagcgtggag aacgtgggtc
     1801 tcagcatcgc agtggtagac tatgactgca tcggccacaa tgaagtgatc ggggtgtgcc
     1861 gcgtgggtcc agaggctgcc gacccacacg gcagagaaca ctgggcagag atgctggcta
     1921 acccgcgcaa gcctgtggaa cactggcacc agctagtgga ggagaagact ctgagcagct
     1981 tcacaaaggg tggcaaagga ttgtcagaga aagagaattc agagtgaggg tctggtcaag
     2041 gcctggggtt ggaccaggca ccctcaggac ccatcccttc ctgcccggac tgtgaactca
     2101 tctcctcgaa gccataatgt ccgagcggct ggtgcggggc tgcctggacc tacccctcct
     2161 tctcctggag gtgtgaggct aggaggcagc aggcccagct ccctgtttca gggtgggagg
     2221 tcctcggcct ccattgtctc tcttcttatc cccagagttc cccctagagg caaggggcca
     2281 tgcatgtctg gggacccctg cccccagccc tctgtctgtc tatctgtctg tctctttgct
     2341 gttgtccaag tcttgctgtt ctggcctgtg tcctcactgt gaatgtcgac agaccaatcc
     2401 ttgatgtccc ctgaacagac acaccctcca gtgtccaccc cttctgtccc tccatctgcg
     2461 tctggccaat cccccctctg ccgctgctat catcaccaga aataaacaca ctctgtgagt
     2521 ctca
//
