LOCUS       NM_009307               7202 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus synaptotagmin II (Syt2), transcript variant 1, mRNA.
ACCESSION   NM_009307
VERSION     NM_009307.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7202)
  AUTHORS   Lai Y, Fois G, Flores JR, Tuvim MJ, Zhou Q, Yang K, Leitz J, Peters
            J, Zhang Y, Pfuetzner RA, Esquivies L, Jones P, Frick M, Dickey BF
            and Brunger AT.
  TITLE     Inhibition of calcium-triggered secretion by hydrocarbon-stapled
            peptides
  JOURNAL   Nature 603 (7903), 949-956 (2022)
   PUBMED   35322233
REFERENCE   2  (bases 1 to 7202)
  AUTHORS   Liu Y, Sugiura Y, Sudhof TC and Lin W.
  TITLE     Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not
            Spontaneous Neurotransmitter Release at Neuromuscular Synapses
  JOURNAL   J Neurosci 39 (31), 6049-6066 (2019)
   PUBMED   31160536
REFERENCE   3  (bases 1 to 7202)
  AUTHORS   Park J, Park SJ and Kim S.
  TITLE     Inositol polyphosphate multikinase deficiency leads to aberrant
            induction of synaptotagmin-2 in the forebrain
  JOURNAL   Mol Brain 12 (1), 58 (2019)
   PUBMED   31221192
  REMARK    GeneRIF: These results suggest a physiological role for IPMK in
            regulating expression of Syt2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7202)
  AUTHORS   Liu Y, Sugiura Y, Chen F, Lee KF, Ye Q and Lin W.
  TITLE     Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse
            loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1)
  JOURNAL   PLoS Genet 15 (3), e1007857 (2019)
   PUBMED   30870432
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7202)
  AUTHORS   Wamsley B, Jaglin XH, Favuzzi E, Quattrocolo G, Nigro MJ, Yusuf N,
            Khodadadi-Jamayran A, Rudy B and Fishell G.
  TITLE     Rbfox1 Mediates Cell-type-Specific Splicing in Cortical
            Interneurons
  JOURNAL   Neuron 100 (4), 846-859 (2018)
   PUBMED   30318414
REFERENCE   6  (bases 1 to 7202)
  AUTHORS   Jones JM, Popma SJ, Mizuta M, Seino S and Meisler MH.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
REFERENCE   7  (bases 1 to 7202)
  AUTHORS   Fukuda M, Aruga J, Niinobe M, Aimoto S and Mikoshiba K.
  TITLE     Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of
            IP4BP/synaptotagmin II
  JOURNAL   J Biol Chem 269 (46), 29206-29211 (1994)
   PUBMED   7961887
REFERENCE   8  (bases 1 to 7202)
  AUTHORS   Hilbush BS and Morgan JI.
  TITLE     A third synaptotagmin gene, Syt3, in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 91 (17), 8195-8199 (1994)
   PUBMED   8058779
REFERENCE   9  (bases 1 to 7202)
  AUTHORS   Morita T, Kubota H, Murata K, Nozaki M, Delarbre C, Willison K,
            Satta Y, Sakaizumi M, Takahata N, Gachelin G et al.
  TITLE     Evolution of the mouse t haplotype: recent and worldwide
            introgression to Mus musculus
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6851-6855 (1992)
   PUBMED   1495973
REFERENCE   10 (bases 1 to 7202)
  AUTHORS   Willison K.
  TITLE     The mouse Brachyury gene and mesoderm formation
  JOURNAL   Trends Genet 6 (4), 104-105 (1990)
   PUBMED   2132728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ129987.1, AK036357.1,
            AC131591.13 and AI848167.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_009307.5.
            
            On Sep 26, 2017 this sequence version replaced NM_009307.3.
            
            Summary: This gene encodes a member of the synaptotagmin protein
            family. Synaptotagmin proteins are involved in membrane trafficking
            and are characterized by an N-terminal transmembrane region as well
            as tandem calcium binding domains. The encoded protein is able to
            bind inositol polyphosphate and is thought to be involved in
            synaptic function and neurotransmitter release. [provided by
            RefSeq, Sep 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036357.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381,
                                           SAMN01164136 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                CJ129987.1         54-122
            70-3455             AK036357.1         2-3387
            3456-6748           AC131591.13        84944-88236         c
            6749-7202           AI848167.1         1-454               c
FEATURES             Location/Qualifiers
     source          1..7202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.24 cM"
     gene            1..7202
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /note="synaptotagmin II"
                     /db_xref="GeneID:20980"
                     /db_xref="MGI:MGI:99666"
     exon            1..224
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            225..433
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            434..637
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1719
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /note="IP4-binding protein; inositol polyphosphate-binding
                     protein"
                     /codon_start=1
                     /product="synaptotagmin-2"
                     /protein_id="NP_033333.2"
                     /db_xref="CCDS:CCDS15312.1"
                     /db_xref="GeneID:20980"
                     /db_xref="MGI:MGI:99666"
                     /translation="MRNIFKRNQEPNVAPATTTATMPLAPVAPADNSTESTGPGESQE
                     DMFAKLKEKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKG
                     KGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLT
                     VGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQ
                     ELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGD
                     ICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKK
                     TLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWS
                     DMLANPRRPIAQWHSLKPEEEVDALLGKNK"
     exon            638..804
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            805..924
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1092
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1260
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1378
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1512
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..7187
                     /gene="Syt2"
                     /gene_synonym="IP4BP; mKIAA4194; sytII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgatcagc ccctccctcc gcccgggcgc agactgctaa gctcagcaag tcttgcggca
       61 aaggcacttc ggagaggagt tggacccggg gcggagtggg gactccgcgc ccccagggaa
      121 cggccaccgc cgctggaccg cagtcagcgc cgcatccctg cagccggtcg ctgcctcccg
      181 tcggggacag cggatctctc ctgccgcgtc ggggtcgccc tcgggttcca gcagaagacg
      241 tggtccagac tggagctggg tcccacttca aaagatctgg attagctggg gcagtggtgg
      301 cacatgggat taatctcagc aattgggaga cagatctctt gtgagtttga agactgcctg
      361 gtttacagag caagttccag gacatctagg gttacacagt gagtcctgtt ttgaaataaa
      421 aaatggatta aagctatccc ctctgccacc atgagaaaca tcttcaagag gaaccaggag
      481 ccaaatgtgg ctccggccac caccactgcc acaatgcccc ttgcacccgt cgcacctgcc
      541 gacaactcta cagagagcac gggtcctggg gagagccaag aagacatgtt cgccaagctg
      601 aaggagaaat tcttcaatga gatcaacaag atccccttgc ccccctgggc tctgatcgcc
      661 atggctgtgg ttgctggcct cctgctgctc acctgttgct tctgcatctg taagaagtgc
      721 tgctgcaaga agaagaagaa caagaaggag aagggcaaag gcatgaagaa cgccatgaac
      781 atgaaggaca tgaaaggggg ccaggatgac gatgatgcag agacaggcct gactgaagga
      841 gaaggtgaag gcgaggagga gaaagagcca gagaacctgg gcaaattgca gttttctctg
      901 gactatgatt tccaggccaa ccagctcacc gtgggtgtcc tgcaggctgc ggaactccca
      961 gccctggaca tgggtggcac atcagaccct tatgtcaaag tcttcctcct cccagacaag
     1021 aagaagaaat atgagactaa ggtgcatcgg aagacgctga acccagcctt caatgagaca
     1081 ttcactttca aggtgccata ccaggagtta ggaggcaaga ccctggtgat ggcaatctat
     1141 gactttgacc gcttctctaa gcatgacatc atcggggagg tgaaggtacc catgaacaca
     1201 gtggaccttg gccagcccat cgaggaatgg agagacctac aaggcggaga gaaggaagag
     1261 ccagagaagt tgggtgacat ctgtacctcc ttgcgctacg tgcccacagc tgggaagctc
     1321 accgtctgta tcctggaggc caagaacctg aagaagatgg atgtaggggg cctttcagac
     1381 ccctatgtga agatccacct gatgcagaac ggtaagagac tcaagaagaa gaagacgaca
     1441 gtgaagaaga agaccctgaa cccctacttc aacgagtcct tcagcttcga gatccccttt
     1501 gagcagatcc agaaagtcca ggtggtcgtc accgtgctag actacgacaa actgggcaag
     1561 aatgaagcca tcggaaagat ctttgtaggc agcaacgcca caggcaccga gttgcggcac
     1621 tggtccgaca tgctggccaa ccctcggagg cccattgccc agtggcactc tcttaagcct
     1681 gaggaagaag tggatgctct tctgggcaag aacaagtagg ctccagcggc cggggccacg
     1741 cccctaagga gccacgcccc cgaggcgcca cgccccctga ggacactgac gagatccaga
     1801 gctatcaata cctcagttac gcgaccttag aggtttcttc atttgtttgc ggtgtgtcct
     1861 gtttttcctt cctttttctc tttttaaaga ccaacttcct tttggtggct gtgtgaagag
     1921 agtcccctaa gaggtgaaag aaaagcctgg ctctgttatt gaccccggag cggcccttgt
     1981 tgcatgccct ttcacggttt cccccttacc ccaagtgggg ccctctactg tcagacagtt
     2041 gaagcactaa ctgcttttcc tgggttttgg accaacaaca tggcaagcac attctgtttc
     2101 ttgactgtga aggcaacata gtggccagca ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2161 gtgtgtgtgt gtgtgtacac ctgtatgtgc ccatccatcc ccatctgcct gttttgaaca
     2221 tctctcttca ttttctggaa tgagtcatgg acagtgaagc catgtgagag gagaatgtct
     2281 tcagagactc caagggaaag caagcccact gcctaagcgg tcagatgcca gaagagagct
     2341 tgcggatggc catttggaag gcggcgagat gtgatactgg atgggttcag aactgggacc
     2401 aaagcccttg atgccatcat agacaccctc ttgtcagtca tggctttccc ccctggagtg
     2461 gggttttggg gacattcgtg gaaatcaact attcaccaga tttgccagac tctaccaggg
     2521 actgccagcc ctgggatgtc actcctgttg acaacatcaa actttgaaga aacagaagtc
     2581 ccattactca gaaagcctag aattaagctc ctggatcttt gcctcgtccc tcgtccctgc
     2641 agagtacaag cagcgcggtc atttgcattc acgcaccatc ttgcttttgc ctctgtttcc
     2701 ctttttgtgt aagtggaaaa ataccatctg aagacaagtg ctttgcacag agccagagac
     2761 ctgttaaggg gatgcttggg ttttagttcc cttgaggtcc aggtaaggag gaggtgtcaa
     2821 gaaggggagc ttgggtggac agtgacaaac tggagagtgc agagctcctc gcaactccca
     2881 ttcctgaccc tctggaccct ttgaccctca gtgatggtag ctggagtggc cccggccaaa
     2941 ctgtggagag gccccacgct tccgttcctt agagacagtt ttcttggaat gccaggaaac
     3001 acggggcatt catttcaaat gggcggtgga gaaaatgtgc taaggtttgc atcctgtgtt
     3061 tagtttgtgt ttccttccct gtcccctact tgtccctagc attgattaaa aagccatata
     3121 tatgttagtc aggcttgcac taagtaccct tcccaacctg cagcctgggc agggggctta
     3181 ggctccctgt agccagaggc tgctcctttc ccttggtctt ggatttgttc ttgaatctct
     3241 caggcccttg ttttcttatc acagaaaaga tacagctttt ctgaagccgg caggggtggt
     3301 ggacacgctc ttcaacagca aatgtgtcag gacatctgct ctgccccacc tgggcccttc
     3361 cgtttcttgt aggactcaga gatggatggt gttgtagagt ttgagaaccc agcatggaga
     3421 agctgcagtg gcttcatttt aattttagtg aaaatgcata tgtgggtttg ctttgctttt
     3481 ttgtttttgt ttttttgttt tggtttaagt agggagtgag gtatcacttc taccagaaac
     3541 agaactgtga agtaggtttg acctgcctct cttttagaga ccctttttgc tattggccct
     3601 tggtacctgg gaaattgtgt atttcataca ctatctgtat gtgtgtttat gctaaacact
     3661 gaggaaggag gactctggta ggattatggg ctgtagtcct tgggaccaga gttctggtca
     3721 tggtagaaca ttgttgggca tcgggtacac tcagagttca ggtggttaga gagtgtcagg
     3781 gtcctggtat ggacatctga ggtcaccgga ttcttttctg tgcaatcttg gtgctttccc
     3841 ggtccctccc cactctggct cttctcaccc acattccatg aagcctgttc acagaccctc
     3901 tccccaacaa cctcaccctt cttcctgtgt tctcccgacc tttctcaatc acctttaaac
     3961 tcctgggttc ttccctacaa accgcactca gcccttccgt agtccatagt cctactgcgc
     4021 tgcggataga gggaagggag gaacggtgga tgcctctgtg gtttgactgt ccctgggctt
     4081 agacacaggc cagagctcat tccttgtggg cagtctgcca gggcttttga ctgatcacta
     4141 gtttggagcc agcatggatg ctgggagagg ttctcctcag gcttaaggct ggtcctggac
     4201 gagccaccca agcagatggc acctgtccag gtccaggggc caggcaggaa catgttgagg
     4261 cttaattgtt tctatactgg gggagggggg agggctgata tgatccaaac cccagcactg
     4321 cattccaaac cttcactgcc acctgggggg cggggtataa tttctgggga tgtcaggatc
     4381 ctggggtatc aagactatgc agagacagtc aatgtttctg gctggtaatg gattctggat
     4441 acttctgtgg atgcaagttt ttaatcccaa agagaggaaa gtatttatta gagggtttat
     4501 ttgttttgtt tttttgtttt tttgttttta aagagagctt aagaccatga gtacccacac
     4561 tccactcagg atctgggggc tcatgtcctc tctgaatgat cctcccagag tggagcaacc
     4621 tctgcagtgc tggggccctt gtggggactt agaaacaaag gctaaggcct ggggacgagg
     4681 gatctcccag cccagcaggt gcttggaaca agcaagggga ggcctagcca gagacctccg
     4741 tctttcttcc caggaagcca acacatcatt ttgtttttgt agaagtggtt tgtggtgatc
     4801 ttgctggccc acaattcagt gggggaagag gggggctttt taccacaggc ctcttcgtaa
     4861 aggtagcttt tataaacatg tctccatgct ggactcaagg gtgagcgatg ctagaaaaaa
     4921 aaaattcctc gttcatttaa tgtcatgtca gttcatgaga atcccaggtt ctcgatcctg
     4981 tagggagagt ctgtgtttga gggcaaacat agcagcagtc ttcctgaagg tgggaagaga
     5041 tggaacgtcc ccatcccctg ctcactggtg cctgctctgt ctctctgtct ccctctcact
     5101 gcaggctgct tggggtcttt tcccagagcc agtgggtagc aacaggtggc ccatagcccc
     5161 ataatggctg ccagatttgg caactataaa ttcaaaatac ttggttaaac ttgaatttca
     5221 gataagcaaa taattttgaa gtttaaggac gtcctatgca gtatttggga catactgtac
     5281 tgtaaacagt gattcattgt tcaatgtgaa atttaagttt aattggccaa tcctgtatca
     5341 tgtctggcaa cgtaccctct ggctccttcg tctctctttt cttcagtccc aggggccaga
     5401 ggctggttac cacagttttg atttagcctg ttttctgaac tgcaatattg agaaggggac
     5461 actgtgactt gaagatatat gaatatactt tatttttgaa gtaacaacaa aacaggaacc
     5521 ttctgaagcc attgagcctc atcggacccc cgcctcattt agttatatat tataaaagaa
     5581 gatgctattc tataaacata caagcagaat cttgtttaat caagatgcat gtctacaatt
     5641 ctgtatatag ccgcatggca aagctgagag cccccttgat ctcccaacct gttttacaga
     5701 actgcctgct cctggatttt atgttgtgtg aagtctttgt cctcacctcc cctacaggga
     5761 atgtccacag tgggagataa tgttctggcc ccagtgccag ccctgcccag ggaagatgct
     5821 gaaggaccct ggccccgaag gcaggcctgc tgcatgtcta cagggctaac ccttggggca
     5881 cagtgcactg tctagcctgg cgtctggtgt cctgttgctt ctgtgttcca tgtgtgtgac
     5941 gtgattcctt tcttccctct gtcttgaata aactgaaaaa gccataaagg ggcctcctac
     6001 aggagggtgc cctcgactcc ttccaggagc ccctctgtcc ctctaactgg ctccccacag
     6061 aacacttgtg aagggctcac ctgtccgcca ccctctcacg ctcccttagc cctgtgtcat
     6121 gaggacactt ggtgattcag ggcttctggt ggggtctcag gctggctttt gtggcctgag
     6181 tctgatggtg ggtcttccag gcagggcagt agttgtgact ctgtggcttg gataacctct
     6241 taagaggccc agaggcaacc agggttttca gaagcagtca gcagcccagt ctatagccag
     6301 gttctcagtg gcagtcttgg atgagcacag ccagccctgc ctatgtttcc ctgagcccac
     6361 agaaacagtg gaggggtggc ccatggggaa aacttggaac tgcagtggtg aaactctcca
     6421 cccattctct cctttgtctg gcagtgccac agaacagggt gccctgagag caaggtggga
     6481 ggtgtggtgg tgaaaagggg ccactcacaa ctgaggaaca ctaggctctg cccctcacct
     6541 cagctcccag ggcagcctga gcagtatggc aagtaatgag tatatgggta gacagggctg
     6601 gggcagcttg ggcacccaca gaacgccccc tcccccccca agaagccagt cgtatgttac
     6661 taatacaggg gacctcagaa agaattgggc aagtgtattg ggcaaggcca gggcaacaag
     6721 gtggggctgg ctggagatct ccagtctcca cagaaactga aattgggaac tgtagcagca
     6781 gaacggagtc tggcaaggtg gcgggagcag tgcgtgggcc tcagtttcac ccccagcttt
     6841 cctcagcagc caggagttca gggaaaggac ctgcaagcct gaccattctg ccctaactcc
     6901 tgctcaccta aggatttgat ttgctttctg aaaaccttgg gcccagaaac tttcaaaact
     6961 ggggcagaag ctgagcaagc tgtgtccccc ctggaataca ctggccccgc caggagccct
     7021 ccctgtcttc ctaagaagga cgtgtgtagc cctccccgtt cccactctgc ttggcaatgc
     7081 tctctccatt cccttatgtg gactctgttg ttcttgtctg atctcttgtc aaattgttat
     7141 tttgtaatga gctgcgtctc cttattaaag aaaagagctg aaagcaaaaa aaaaaaaaaa
     7201 aa
//
