LOCUS       NM_001403645            2958 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus synaptotagmin XVII (Syt17), transcript variant 6,
            mRNA.
ACCESSION   NM_001403645 XM_006507204
VERSION     NM_001403645.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Fujioka,A., Nagano,M., Ikegami,K., Masumoto,K.H., Yoshikawa,T.,
            Koinuma,S., Nakahama,K.I. and Shigeyoshi,Y.
  TITLE     Circadian expression and specific localization of synaptotagmin17
            in the suprachiasmatic nucleus, the master circadian oscillator in
            mammals
  JOURNAL   Brain Res 1798, 148129 (2023)
   PUBMED   36332665
  REMARK    GeneRIF: Circadian expression and specific localization of
            synaptotagmin17 in the suprachiasmatic nucleus, the master
            circadian oscillator in mammals.
REFERENCE   3  (bases 1 to 2958)
  AUTHORS   Ruhl,D.A., Bomba-Warczak,E., Watson,E.T., Bradberry,M.M.,
            Peterson,T.A., Basu,T., Frelka,A., Evans,C.S., Briguglio,J.S.,
            Basta,T., Stowell,M.H.B., Savas,J.N., Roopra,A., Pearce,R.A.,
            Piper,R.C. and Chapman,E.R.
  TITLE     Synaptotagmin 17 controls neurite outgrowth and synaptic physiology
            via distinct cellular pathways
  JOURNAL   Nat Commun 10 (1), 3532 (2019)
   PUBMED   31387992
  REMARK    GeneRIF: Study localized syt-17 in primary hippocampal neurons to
            two compartments: the Golgi complex in the soma and Rab5-positive
            early endosomes in neurites and concluded that syt-17 is a
            multifunctional regulator of intracellular protein trafficking in
            excitatory hippocampal neurons, modulating both neural development
            and synaptic physiology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2958)
  AUTHORS   Huang,X., Dubuc,A.M., Hashizume,R., Berg,J., He,Y., Wang,J.,
            Chiang,C., Cooper,M.K., Northcott,P.A., Taylor,M.D., Barnes,M.J.,
            Tihan,T., Chen,J., Hackett,C.S., Weiss,W.A., James,C.D.,
            Rowitch,D.H., Shuman,M.A., Jan,Y.N. and Jan,L.Y.
  TITLE     Voltage-gated potassium channel EAG2 controls mitotic entry and
            tumor growth in medulloblastoma via regulating cell volume dynamics
  JOURNAL   Genes Dev 26 (16), 1780-1796 (2012)
   PUBMED   22855790
REFERENCE   5  (bases 1 to 2958)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     The N-terminal cysteine cluster is essential for membrane targeting
            of B/K protein
  JOURNAL   Biochem J 360 (Pt 2), 441-448 (2001)
   PUBMED   11716773
  REMARK    GeneRIF: The N-terminal domain of B/K protein contains a novel
            cysteine-based motif that allows B/K protein to localize in the
            trans-Golgi network.
REFERENCE   6  (bases 1 to 2958)
  AUTHORS   Burbelo,P.D., Kozak,C.A., Finegold,A.A., Hall,A. and Pirone,D.M.
  TITLE     Cloning, central nervous system expression and chromosomal mapping
            of the mouse PAK-1 and PAK-3 genes
  JOURNAL   Gene 232 (2), 209-215 (1999)
   PUBMED   10352232
REFERENCE   7  (bases 1 to 2958)
  AUTHORS   Gautam,M., Noakes,P.G., Moscoso,L., Rupp,F., Scheller,R.H.,
            Merlie,J.P. and Sanes,J.R.
  TITLE     Defective neuromuscular synaptogenesis in agrin-deficient mutant
            mice
  JOURNAL   Cell 85 (4), 525-535 (1996)
   PUBMED   8653788
REFERENCE   8  (bases 1 to 2958)
  AUTHORS   Kwon,O.J., Adamson,M.C., Chin,H. and Kozak,C.A.
  TITLE     Genetic mapping of five mouse genes encoding synaptotagmins
  JOURNAL   Mamm Genome 6 (12), 880-881 (1995)
   PUBMED   8747928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122912.2 and AC125126.4.
            
            On Apr 1, 2022 this sequence version replaced XM_006507204.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.498620.1,
                                           SRR7974084.12163.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC122912.2         131204-131612       c
            410-427             AC122912.2         126509-126526       c
            428-576             AC122912.2         125738-125886       c
            577-725             AC122912.2         120213-120361       c
            726-1345            AC122912.2         117223-117842       c
            1346-1466           AC125126.4         160486-160606       c
            1467-1622           AC125126.4         158587-158742       c
            1623-2958           AC125126.4         131279-132614       c
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.44 cM"
     gene            1..2958
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /note="synaptotagmin XVII"
                     /db_xref="GeneID:110058"
                     /db_xref="MGI:MGI:104966"
     exon            1..409
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1819
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /note="isoform 3 is encoded by transcript variant 6; brain
                     and kidney protein; synaptotagmin-17; B/K protein"
                     /codon_start=1
                     /product="synaptotagmin-17 isoform 3"
                     /protein_id="NP_001390574.1"
                     /db_xref="GeneID:110058"
                     /db_xref="MGI:MGI:104966"
                     /translation="MAYIQLEPLNEGLLSRISDVLLCGWTCQHCCQRCYESSCCQSSE
                     DEVEILGPFPAQTPPWLMASRSNDKDGDSVHTASDVPLTPRTNSPDGRRSSSDTSKST
                     YSLTRRISSLDSRRPSSPLIDIKPVEFGVLSAKKESIQPSVLRRTYTPDDYFRKFEPR
                     LYSLDSNLDDVDSLTDEEIMSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHD
                     GSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLL
                     TVVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKALIPSSQNEVELGELLLSLNYLPS
                     AGRLNVDIIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESF
                     SFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSESNHWRRMLNTHRTA
                     VEQWHSLRSRAECDRVSPASLEVT"
     exon            410..427
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            428..576
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            577..725
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1345
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1466
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1622
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..2958
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2934..2939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /note="hexamer: AATAAA"
     polyA_site      2958
                     /gene="Syt17"
                     /gene_synonym="Bk; sytXVII"
                     /note="major polyA site"
ORIGIN      
        1 gcactccggc cctggcgtcg cccgccccgc ctgcgccggg gtcgccgcag tccccgcggc
       61 tctcccgggg ctccctggcc aggcgctcca gcttttttgc aaccagggag caccccaagg
      121 tgtggatgtg ggtgccggcc caccagaaac cgaagcggag gacctcgggc atccaggttc
      181 tgcgctccag ggaggcggcc ccgcagggct gggcaaggac ggggcggtcg gcagaggggc
      241 gggcgccgct catcagccac gccagtcacg tctggggcca cccggccgcc cactgatatc
      301 ttgccggctg gctgtgccac ctcgccgaat cggcgagggc aaaggggctg tggcgacgcc
      361 atgcccgggc cggagtgagt gagcgcgggc gaagatggcg tacatccagt tggaaccact
      421 gaacgagggc ttgctttcta gaatctctga cgtgctgctg tgcggctgga cttgccaaca
      481 ctgctgtcag aggtgctatg agtccagctg ctgccagtcc agtgaagatg aagtggagat
      541 cttggggcct ttccctgccc agactcctcc atggctgatg gccagccgga gcaatgacaa
      601 ggatggagac tccgtgcata cagccagcga tgttcctttg accccaagga ccaactcccc
      661 tgatgggaga cgctcgtcct cagacacatc caagtccacg tacagcctga ctcggagaat
      721 ctccagtctg gattcccggc gccccagctc cccactcatc gacatcaaac ccgttgagtt
      781 cggcgttctc agtgccaaga aggagtccat ccagccgtct gtgctgcgcc ggacctacac
      841 gcccgatgac tacttccgga agtttgagcc ccgactttac tccctcgact ccaatcttga
      901 tgacgtagac tctctgactg acgaggagat catgtccaag taccagctgg gcatgctgca
      961 cttcagcaca cagtatgacc tgctacacaa ccacctcacc gtgagggtga tcgaggcccg
     1021 ggacctgcca cctccaatct cccatgatgg ctcgcgccag gacatggccc actccaaccc
     1081 ctacgtcaag atctgcctcc tgcctgacca gaagaactcc aagcagacgg gagtcaaacg
     1141 caagacccag aagcctgtgt ttgaggaacg ctacaccttc gagatcccct tcctagaagc
     1201 ccagaggagg accctgctgc tcactgtggt ggattttgac aaattctccc gccactgtgt
     1261 gattgggaaa gtagcggtgc ctttgtgcga ggtggacttg gtgaagggtg gccactggtg
     1321 gaaggccctg atccccagtt ctcagaatga agtggagctc ggggagctgc tgctttctct
     1381 aaattatctc ccaagtgctg gcagactgaa cgtggacatc attcgagcca agcaactcct
     1441 gcagaccgat gtgagccagg gttcagaccc atttgtgaaa atccagctgg tacacggact
     1501 caagcttgtg aaaactaaga agacatcatt cttacgaggc acaattgatc ctttttacaa
     1561 tgaatccttc agcttcaaag ttccccagga agaactggaa aacgccagcc tagtattcac
     1621 agtgttcggc cacaacatga aaagcagcaa tgacttcatc gggaggatcg tcatcggcca
     1681 gtattcctcc ggcccctcag aatccaacca ctggcggcgg atgctcaaca ctcaccgcac
     1741 tgctgtggaa caatggcata gcctgaggtc ccgggctgag tgtgaccgcg tgtctcctgc
     1801 ctccctggag gtgacctgat caccataagg aaggcaacct tcatttgtta aaaaaagaag
     1861 ggaaaaaaat gtgtcacata aatattcaac ccacatctag gtatactttc acacatgtgc
     1921 acgtgcatac acaacgccct ctcagtactg agagcgagct gacagttgat catgaaatag
     1981 ccaccctcat tgagggaagc ttgtgaagtt tccagaaact ccattcatgc ataaatcaca
     2041 agctgggtag gctctgctgt gggacttatt agcagtgcct actcttatcc acacccaatg
     2101 tcccaagatg tactttcaac cctcaggcca gagaaaggag gccttcctaa gaagagcctg
     2161 actcagttta ccaagagttc agctgatatg tggggggagg gggtgcttgg ttcccctcct
     2221 taaaaccaca tcttccagga aacttctgaa caggccgctg tttcctgggg tctccacaca
     2281 tgatcccttt ctccagcggt gtaagtatct ttattttctc cttagcaaat atggtaaata
     2341 gcttagactc tttggagaga ccgaagggtg gcaaaagaca gtaagcccgt gtcaggaacc
     2401 caggctcacc tgctttgtcc ttgtgtttgc ttatttctgg gactccctgt gggggtgtgt
     2461 gcatatgtta ttgtgagtgt gctctaacgg gtgagtacat gtgtacccac tcatcccaat
     2521 agacagcaaa gtggtggcca gggcctccat ccacgaagct cccttacctc tgcctcttat
     2581 ccaatgcaag cttaccccat gtcctctcat gcaccagaga ccccacctga ggtagtaata
     2641 gttcacatgt gcccataaat agggttatga tagagcaaag gtaacatgtc tgactgaatc
     2701 gtggtggtta tgacccatca ggggtctggc atgggaatga aaatggtgcc acatccctcc
     2761 accatgacct ctcccctcca gtgatccttc tgtgtttgtg tgtgcaccac agtcatgtct
     2821 catgtgctaa gtaaggcttt agtgtagtta gaatagatct tccctcatgg gacgcttctg
     2881 tacctttctc cacagtgtgt tgtcctctgt gatggggagt tatctgttgt tgaaataaaa
     2941 gattatttat ttgtgaca
//
