LOCUS       NM_001364282            3465 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus synaptotagmin XVI (Syt16), transcript variant 2, mRNA.
ACCESSION   NM_001364282 XM_006515840
VERSION     NM_001364282.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3465)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3465)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3465)
  AUTHORS   Fukuda,M.
  TITLE     Molecular cloning, expression, and characterization of a novel
            class of synaptotagmin (Syt XIV) conserved from Drosophila to
            humans
  JOURNAL   J Biochem 133 (5), 641-649 (2003)
   PUBMED   12801916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161591.2 and AC158365.2.
            
            On Jun 13, 2018 this sequence version replaced XM_006515840.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032606.1, ERR3363660.156754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC161591.2         137340-137426       c
            88-267              AC161591.2         5652-5831           c
            268-1088            AC158365.2         38674-39494
            1089-1301           AC158365.2         99200-99412
            1302-1555           AC158365.2         105833-106086
            1556-1996           AC158365.2         111427-111867
            1997-2186           AC158365.2         114799-114988
            2187-3465           AC158365.2         143256-144534
FEATURES             Location/Qualifiers
     source          1..3465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.02 cM"
     gene            1..3465
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /note="synaptotagmin XVI"
                     /db_xref="GeneID:238266"
                     /db_xref="MGI:MGI:2673872"
     exon            1..87
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            88..267
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            268..1088
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..2500
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synaptotagmin-16; synaptotagmin 14-like protein;
                     synaptotagmin XIV-related protein"
                     /codon_start=1
                     /product="synaptotagmin-16 isoform 2"
                     /protein_id="NP_001351211.1"
                     /db_xref="CCDS:CCDS88352.1"
                     /db_xref="GeneID:238266"
                     /db_xref="MGI:MGI:2673872"
                     /translation="MVLTMASQDVQNFFQPLSSWLSRVYEALQQAGDALSASLVLLSK
                     HDSALSDKPEQDLDAAQIQQTYLEDEEQDHDGSPEEASSLFLEEDHFSLSNSDLQDSV
                     QTASPTLGQQAEDSSSVIPPWPSKIPGAPKPQPVLSSIAEEDHHSERQRCGRQHGSGT
                     LEKVNGRKQVNSFGDDEEPSTSSESDEDVTKQFKISVSRSQSFRSGVSEKGKTTELEQ
                     KIKCKRLLCTHQEDSAEGSACEDLDRTSQLSYSEILSYEDRPISILPQSPFESRNVRH
                     HGPCRPEMGMVRSLGRPCADGVLETETAFVSRGFEDSYATHSSSLWSPEEQDGTSLQV
                     PHRLLEPISKCGDLDVIFEYRAVTQKLTVTIVRAQGLPDKDRSGVNSWQVHIVLLPSK
                     KQRGKTNIQRGPNPVFKEKVTFTKLEPRDVASCAVRFRLYAARKMTRERMMGEKLFCL
                     SHLHPEGEMKVTLVLEPRSNLSSGESPLSPSVVSHSDSASSTQSLSHGGVPELLVGLS
                     YNATTGRLSVEMIKGSHFRNLAANRAPDTYGKLFLLNCVGQEMSRCKTSIRRGQPNPV
                     YKETFVFQVALFQLSDVTLMISIYSRRTMKRKEMIGWVALGQNSSGEEEQEHWEEMKE
                     SKGQQTCRWHTLLES"
     exon            1089..1301
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1555
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1996
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2186
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..3465
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3434..3439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /note="hexamer: AATAAA"
     polyA_site      3465
                     /gene="Syt16"
                     /gene_synonym="Strep14; Syt14l; syt14r"
                     /note="major polyA site"
ORIGIN      
        1 gagaacgcgc gcggccgggc gcggcgtggg taccccagcc gcgggcggcc gccctgcaac
       61 cccccgacgc gaccatggcg actgacatca ctcctgaagc cattggcttc ctgtctgcaa
      121 ttggggtctt tgttgtcctt ctggctgtcc ttctcctctt catcaacaag aagctatgct
      181 ctgaaaacct aagagggcat ccatacccgg agcaacgagg gaagagaaag cactcgagag
      241 acaagactgg aggccacaca ggaactgctg agaagtgttg agagtgaaat ggtcccagcc
      301 attaagagac caccctgtca aacacgcttg ctctgttccc tgcaaagacc tactccatag
      361 accttggtgc aagagccagc atgcagcctg gttttactta ctgccaacgg tgcttacgta
      421 ctgcacatgt tttctttatg tatatattaa taaagttttg cctgttataa aaaagagacc
      481 tccagttaga tttctcatcg tgcttgttct atatttcaca taagttcaga gttcaggagg
      541 aacggaacaa gtggactctg cagacacgag gtatttgatc atggtgttga ccatggcatc
      601 tcaggatgtc cagaacttct tccagccttt gtcttcctgg ctttcccgag tttatgaagc
      661 tctccagcaa gccggggatg cattatctgc ttcactggtc cttcttagca aacacgattc
      721 ggcattgagt gataagccag agcaggactt agatgctgcc cagattcagc aaacctactt
      781 ggaagatgaa gaacaggacc acgatggcag tccagaggag gcaagctccc tgtttcttga
      841 agaggaccat ttctcactct ctaatagtga tctgcaggac tccgtccaaa cggcaagccc
      901 cacgcttggt cagcaagccg aagactcaag ctctgtaata cccccgtggc ccagtaagat
      961 cccaggggcc ccgaagcccc agcctgtgct ttcttcgatc gccgaggaag accatcactc
     1021 tgagaggcag agatgtggcc gtcagcatgg ctctggcact ttagaaaagg ttaatggaag
     1081 aaagcaagtt aacagctttg gggatgatga agagccatcc acatcttctg agagtgatga
     1141 agatgtgact aagcaattca agatctcagt gtcccgatcc cagagttttc gttcaggagt
     1201 atctgagaag ggaaagacaa cagagttgga gcagaaaata aaatgcaaac gtttgctgtg
     1261 tacccaccag gaagacagcg ctgaagggtc tgcttgtgaa gatttggatc gaaccagcca
     1321 acttagttat tctgagattc tgtcttatga agaccgcccc atttccattc tcccacaatc
     1381 ccccttcgag agcaggaacg tcaggcacca tggcccttgc cgtccggaga tgggcatggt
     1441 ccgaagcctc ggtcgtcctt gtgcagatgg cgtcctggag acggagacag cttttgtgag
     1501 tcggggcttt gaagattcct atgccaccca cagttcctct ctgtggagtc cagaggagca
     1561 ggatggcacc agtctgcagg taccacacag gcttttggag cctatctcaa aatgcggtga
     1621 cctcgatgtc atctttgaat atagagctgt aacccagaag ctcactgtga ccattgtgag
     1681 agcacagggt ctcccagata aggaccgaag tggtgtcaac tcttggcaag ttcacatagt
     1741 gctgctgccc agcaagaaac agaggggtaa gacgaacata cagagagggc ccaaccctgt
     1801 cttcaaggaa aaggtcacct tcaccaagct ggagcccaga gatgtggctt cctgtgctgt
     1861 ccgcttccgc ctgtatgctg cccgtaagat gacccgggag agaatgatgg gggagaagct
     1921 gttctgtctc agccacttgc acccagaagg ggaaatgaaa gtgactctgg ttctggagcc
     1981 aagaagtaat ctgagcagtg gagagtctcc gctcagccca tctgtggtgt ctcacagtga
     2041 cagtgcttca tccacgcagt cactgtctca tggaggggtg ccagagctgc tggtgggact
     2101 gtcctacaat gccacaacag ggcgattatc tgtggaaatg atcaaaggca gccatttccg
     2161 caacctcgct gctaaccgag ctcctgacac atatggaaaa ctcttcctcc tcaactgtgt
     2221 gggtcaagag atgtcccgct gcaagacgtc cattcgtcgt ggccaaccca atcctgtcta
     2281 taaagagacc tttgtcttcc aggtggccct cttccagctc tcggacgtca ccttgatgat
     2341 ttccatttac agcaggcgca ctatgaagcg taaagagatg atcggctggg tcgctctggg
     2401 ccagaacagc agtggggagg aggagcagga acactgggag gaaatgaagg aaagcaaggg
     2461 ccagcagacc tgccggtggc atacgctgtt ggaatcctag atttaccaac agcattcctg
     2521 ttatgtcagc cttgattatc tgacatgagt cagatcattg ggggcagaag agctttcaaa
     2581 cggagaacta aacttaggtc attctgtggc ttgggacagt ttcaaaggtt tgatttgagt
     2641 ttaaatgttg tcatgaaagg aagcctacat acgcagtatg ggcaatggta tctggttgag
     2701 accagtggtt atgtcacaat ctgtgctaat gggtggttgt gttttggttc gcactatgtg
     2761 gtgcagcttc ttcctgctgt ctctctttgc tgggagaata gcctgagatt tcaaaggagc
     2821 tataaacgtt actgttttcc atcactgagg tgtatgaatc agactcttct cagtgttcaa
     2881 aattccaaaa cagaaatgaa tcagatgctg agtgctaagg aagggtgtaa ccaatccgca
     2941 atcctctgcc accccattct ctttatgaat aataaaaaaa agagccctgt ttactttaaa
     3001 aggtaatcgt tataaacttg tggtgtaaaa taaatttgta ttcatgaaaa gtctctttct
     3061 atctcaatta gatatcacgg tttctaaaag aattgggtta gacgaatcat atggaagctg
     3121 taaaacagtt aaaaactgac tgttatctga cctgtctctt tttgaatatt taagatttcc
     3181 aaaaaatcac agattttgtg ctttcttacc gaatcggcac ccaaagaaga agaggaaaac
     3241 ctagaagata atttaagtct tggctttctc gatgtttctg aatttgtcat tcatttggat
     3301 tatacctttt ctatagataa ttgtactaac tctcacatgt attttttgta tgtatttctg
     3361 catgccaacc acattcatct ttatgctatg taccttgcca gtagaacata gaaagatgcc
     3421 tacaatggat ctcaataaat actaatttga ttgacttaaa gggaa
//
