LOCUS       NM_181546               7896 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptotagmin XIV (Syt14), transcript variant 2, mRNA.
ACCESSION   NM_181546
VERSION     NM_181546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7896)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7896)
  AUTHORS   Fukuda,M.
  TITLE     Molecular cloning, expression, and characterization of a novel
            class of synaptotagmin (Syt XIV) conserved from Drosophila to
            humans
  JOURNAL   J Biochem 133 (5), 641-649 (2003)
   PUBMED   12801916
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK045901.1, BC145602.1,
            AL365326.14, AK047918.1 and AW121643.1.
            
            On Aug 14, 2014 this sequence version replaced NM_181546.2.
            
            Summary: This gene encodes a member of the synaptotagmin family.
            The encoded protein may be involved in membrane trafficking.
            Disruption of a similar gene in human has been associated with
            autosomal recessive spinocerebellar ataxia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2014].
            
            Transcript Variant: This variant (2) lacks an exon in the 3' coding
            region compared to variant 1. The encoded isoform (2) is shorter
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB102947.1, SRR7345562.2494060.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AK045901.1         2-59
            59-1494             BC145602.1         1-1436
            1495-1905           BC145602.1         1494-1904
            1906-4363           AL365326.14        16170-18627
            4364-7656           AK047918.1         1-3293
            7657-7896           AW121643.1         1-240               c
FEATURES             Location/Qualifiers
     source          1..7896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.55 cM"
     gene            1..7896
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /note="synaptotagmin XIV"
                     /db_xref="GeneID:329324"
                     /db_xref="MGI:MGI:2444490"
     exon            1..153
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1808
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synaptotagmin-14"
                     /codon_start=1
                     /product="synaptotagmin-14 isoform 2"
                     /protein_id="NP_853524.1"
                     /db_xref="CCDS:CCDS48489.1"
                     /db_xref="GeneID:329324"
                     /db_xref="MGI:MGI:2444490"
                     /translation="MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIVLMLLLFL
                     YINKKFCFENVGGFPDLGSGYNTRTNSQDKMYNSYMDRDEPGSSSESEDEALGKYHEA
                     LSRTHNSRWPLVDSRQKSYAWETRQKYSPLSAEYDGYSTEASMEDGNCIQRMRRTPPL
                     DELQPPPYQDDSGSPHLSCTPSEIGDAKCEISHCSNSPRCSFNKCPSEGSTGHEAESY
                     HNKGYEDDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSERQK
                     LLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVE
                     SEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNPSGCDS
                     QVSLSEASCGDSTSSCQSLQHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRP
                     PNTYVKLTLLNSMGQEMSKCKTSTRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNR
                     RSMKRKEMIGWISLGLNSSGEEELRHWTAMKESKGQQVCRWHALLES"
     exon            154..201
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            202..366
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            367..582
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            583..854
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1304
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1494
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..7882
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7860..7865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /note="hexamer: AATAAA"
     polyA_site      7882
                     /gene="Syt14"
                     /gene_synonym="B230320I09Rik; sytXIV"
                     /note="major polyA site"
ORIGIN      
        1 gccccgcccc agctcctgga ggcccagctg cctggccccg gggcgttccc gcccctctgg
       61 cccgaggcct aagaagagca agctccagca cttacccccg ctctccctgc gtggttggtg
      121 cggtccatgg cgagcgcatc atggcgatcg aaggtggaga gagaacctgt ggagtacatg
      181 aacttatctg tattagaaaa gtctctccag aggcggttgg atttttgtca gcagttgggg
      241 tgtttattgt cttgatgctg ctcctttttc tctatattaa taagaagttc tgttttgaaa
      301 atgttggagg gtttccagat cttggttcag gatacaatac acggacgaat tcacaagata
      361 aaatgtataa ttcttacatg gacagagatg agcctggttc atcctctgaa agtgaagatg
      421 aagcactggg taaatatcac gaggccttat ccagaacaca caattccaga tggccattgg
      481 tagattctag acaaaagagc tatgcctggg aaacaaggca gaagtacagc cccctgtctg
      541 cagagtacga cgggtacagc actgaggcat ccatggagga cggaaactgc attcagagaa
      601 tgaggaggac acctccgctg gatgagctgc agccgccgcc ttaccaagac gacagcggtt
      661 ctcctcacct ctcatgcaca ccttccgaaa ttggggatgc caagtgtgag atttcccact
      721 gcagcaatag cccaaggtgt tctttcaaca agtgccccag tgaaggaagc acgggtcacg
      781 aggccgagag ctatcacaat aaaggatatg aagatgatgt acctagcgac agcacagcag
      841 tccttagccc tgaagacatg tcagctcaag gatcctcctc acagcttcct aaaccttttg
      901 atccagagcc agaagctaaa tatggcacat tggatgtgac tttcgactat gactctgaaa
      961 gacagaagct cctggtaacg gtgacagctg tcacagacat tccaacatat aacaggacag
     1021 gtggcaactc gtggcaggta caccttgttc ttctacctat aaaaaaacag agagccaaaa
     1081 ccagcatcca gagaggacca tgccctgtct tcacagaaac attcaaattt aaccacgttg
     1141 aatccgagat gattggaaac tatgcagtta ggtttagact atatggtgtc catcgcatga
     1201 agaaagaaaa gattgtgggg gaaaagattt tttatttaac aaagttgaat cttcaaggga
     1261 aaatgtcgtt accggtgata ctggaacctt catacaatcc ttctggctgt gactctcagg
     1321 tgagcttgtc tgaggcatcc tgtggtgaca gtacatcctc ctgtcagtct cttcaacatg
     1381 gctctgttcc agaaatcctc attgggctcc tttacaatgc caccactgga agactatcag
     1441 cagaagtgat caaaggcagc cacttcaaaa acctggcagc aaacagacca cccaatacat
     1501 atgttaagtt aacactgctg aattccatgg gccaagagat gtccaaatgc aagacatcca
     1561 cccgcagagg gcagccaaat ccggtgtaca aggaaacttt tgtttttcaa gtggccttgt
     1621 ttcagctttc tgacgtgact ctgatactgt ctgtgtataa caggcggagc atgaaaagga
     1681 aggagatgat aggctggatt tccttaggtc taaacagctc tggggaggag gagctcagac
     1741 actggactgc aatgaaggag tcgaagggac agcaagtgtg caggtggcac gcactgctgg
     1801 agtcctgagg aagtcggaag acggctgcaa gcccagcact gcctcagagg agccgttccc
     1861 tggagagtcc tcttcaacac cctaccacaa cgcttcacat cagcgaggga ccatccagtg
     1921 ctgcctgagg ggaaggaagc tttgcctctg gtagagcgag ctcacatgag aaaccaagaa
     1981 acttgtgtcc ttaatgctca gcagccctcc agaaattgaa ttgcatactc tttatttgaa
     2041 cttgattttc ttagtgaaag agctaggaat tccgtggaga ttgtggcttt aaaccagagt
     2101 ttccattgca gcactacata tcatcaccca catgctgtcc atgagacatc tctatggcca
     2161 gtccttgggt ggatctcagt gagcactcct gtctcaaggt gaaagctcac tcacactaat
     2221 gatactttca tttcagatat gctctctctg tgcctcagcc ttcatagtac taagccaagt
     2281 gcaaaattcc ctgaagagta gtttaaggtt ggtttgtttg acgtttgttt ctttacctcc
     2341 tttgtttttt ctgatccaaa gagaccatgt tcttatggtc ccttgcaaac ctttatgact
     2401 gtcctgcaga acttcataac tttacgttca agtcctttat gtaccatgtg tcccagagta
     2461 gaaaatggta agagcagagc tgtcatttgg aattgctttc agtggtcagt ctttacagct
     2521 gtgcaatgca gcagacacag tagatagctg ttgaaattgg aagacaactc tagttaaaag
     2581 gaatcttgat tatctgttcc aagaatctag tctccaacag gagtaaaaca ggtagcattc
     2641 aaaacagaat ctcctggagt ccttcctcac tcactcccat ttctctgtgg ctctcagttt
     2701 tattctactt aaaaccattc tgagatccct tatgctccag tgacttgtgc tgtgcctgtg
     2761 atgtcttcag catgatgtca ccctgtgcct tccatgcaag ttgaccttgc ttacactgct
     2821 gggaagccat agttgtgggt ttggccttca gcactcatag atatggagct ccttggcagt
     2881 cccatggcct tgcctactct gcaggaagcg aggccatgta ctgtgctggc ctccacactg
     2941 caagcgtttc cctgtcgtgt tttcatattt agaaactaca ggtcaactgg aaatagtgta
     3001 agctattttc tttttaattt tcttttttaa caaaatttta tgcatatact ctaatagagt
     3061 ccgttttgta tacatgaaaa tagtttcatt ttgctccttc tcatttctag ttaaactaga
     3121 caaaagcata ctatttacca attagtgaaa agctctatct cagttccaac cccagctgag
     3181 cgctttggac tgttactgtg aactagaact catcagtaca atctagcaga gtcgtgtagt
     3241 gcacggactt actaaaatgt ggcagtgctg agaggcctta aagagtccaa aagaccatga
     3301 actgctacag ttttagctta aaagaaggca actttatact ttcaagctca gcattttaaa
     3361 gaaaagaaaa tgcaagtaag atgcacagag ttagttttaa aatggaagtt tcagagccca
     3421 gcatagtggc tcatccctgt aatcctagca cttgggagtc tgaggcagga ggattgctgt
     3481 gatcttgagg ctagcctggg ctacatagtt ccaggccttt ctgggctaca gagtgataac
     3541 tgtaccacca aaatattatg ttgcaaagtt acattttaaa aaaaggaaaa gaaaaggcat
     3601 ccttctatcc ttccattagt gaacttctca gaattgcttt gttataaagt gagtttggtt
     3661 agaaatgaaa acatgaacaa gaagcaaaat agttggtttt ttttaagtgt tattgaagaa
     3721 cagagtgagg caaaatgtga acaggatata ggttacactg aaaattgggt acaggcattt
     3781 gatgctccaa tgagccttca ctggctttga aacaaccgcc cgcatggcta acagctgctg
     3841 tcttcctaat aaagtctctg gtctattttg caacaaagct caattggaca ttataagacc
     3901 aacctggtgc tttcactgtg ttgagagaaa aatctgttat ttgttaaacc tccttcctac
     3961 agagtggacc cagaactctg tatactccca aaaatcctca ggggtatctg gcatggtgta
     4021 agtatcactt catatatggc ctggaaattg attcagtctt ctttaacatt gggaaaagcc
     4081 cccctctatc ccatttgcca agtcctcaat gattataaat tatgtatgtg catataacta
     4141 cacacgtagc atgctgtgca catgtaaagg tgaggctgtc ctgcctttac acataactga
     4201 ccagaaaggc atttccactg atcatggatt gctgcttttc ttctctgtgt aacttctaaa
     4261 tgtgatacta ggtttgtagc caaatgctgc cattctgctg catataaagc aagtatacaa
     4321 cttattctct cctgggcttt aacacaaata cttctccaaa ttatctgggc cacagatgtt
     4381 gacttgggaa cttgaaaatg acagtctaca cccttattat tctgctaaag tcaaatgaaa
     4441 tgtccagatt caacaactaa ctggtatatg gttattcaag agcctcgttt cttaacttcc
     4501 ctgacgcggt ttgttgatca ctgtccagaa gtgcagtatt gtccaaactt tcagaagctt
     4561 ctgcagtctg gtgcctgaat actagtcacc ttctatttga aatacaattg catattatct
     4621 cactgcacat tgatgagttt tcagtagcac tgtgctcact gacaaaagaa gttattaggc
     4681 catgtttaaa gaaacagaaa atacttaagc tgcctggata cctatgctgt cgttgtaaag
     4741 ttgggccctg gcagggagtc tgatctgatc tgtgcaaaac ccagctctgt ctgctaaatc
     4801 actggtgctt ccacaaactg ggagtatagc tagggcttgg gaatgcgaat tcatcagtag
     4861 ggaagcggag acagtctagg atgttctcgg caaggaatac aaatggtatc acaactttat
     4921 gaggggacta agagataggt gagctgtttg aagtggtgta agcccagtgg tcaccaactt
     4981 ttttttttta attcttgttc aggtattaat aaaaataaca caaagttcat ttgcataaac
     5041 taccatttac ctccatagac tgaagaattc catggggggg aaaaaatcac attgctagtt
     5101 gttcttcaca ggttcttttt cttactttct ttataatcca agattcttct cttcatctgt
     5161 caattgcatg tggccatcgg tatcattgtt gccagccaat gatactaaaa caagatgagg
     5221 catgtggtaa agcaccttaa agccacaggc tgtgccctct acactgacag tactgatgat
     5281 ggttacagcc ataacttagt aaagagctaa cacaagaatg tactgtctta tttgactcac
     5341 aaaatatgaa gaggcaagta acatcatcag tgttttattc atgaggaagt tgctgcatgg
     5401 agaagctgag ctgaccccct aaggctgccc cctcttaaga aaacccagta gaactgggat
     5461 tgctccaaac ccactcatgc gcattgtatc ttaacccagt ttattacggg tgagaggaac
     5521 agcatcatat tgggcaattc ttgcccagct tatctgaatg gcagagagag gcccaagaga
     5581 acagagctgg gaaagagaga cgacagtgca gggggcttgc cttctcagga cacaaaccat
     5641 acttcggtat catagtttgt atttttattt aaggacttgg gatctgtttg ttgtgtctac
     5701 actgtacttc gattctgaag atatattaac tcacggtatt tccattgcct gtatacacct
     5761 ttctatgctg tgaaatgaca ggatgtctga taacctgtac ttgtgtcagg ggtcagagga
     5821 gagaatgttg ccttcctgag cacacttacc caagtttgtt tctatttctt tgttaaagtt
     5881 tgttaatatt agacaagatt cccacctacc ctctttccct tcactgttag tgattactat
     5941 gtcctagagt ctttatgagc cctttggctg atgagtaaag tctctatggt agaatcaaca
     6001 ctaccattgt gaaagtcttc tgtgaacctt gtctactgag taggtttctt tttctcctaa
     6061 tgtatgagga ccccagctgt gtgccatgtg ctgcggaaga ggctacaggt tggatgggca
     6121 gtcttccctc atcttgtatt ttgatgtact gagacagcat cgggtggtgt ctttcattgt
     6181 aatatatgag gtgtagagag aggcatgcgc agggcattgg ggttgagtag gaaagttaca
     6241 tggtgagttc tattagaaga caagaaaaga aatactgttt tgactcccat caaactcccc
     6301 tttattaaac acagacagtg gctcccaagt agtaatgtac ataagaattc tgtccaggtt
     6361 ctagccagag attctgtctc atttggtata gaggaaagtc tgagggtcta gatctgaatg
     6421 agttccctag gaaatcctag ctgggcagta ctgggaaata atacttttgt ttcttatctg
     6481 ctgttgctgg cagccgattc tgtgcccata gattaagtct tgatgtggtg gtaggaaggt
     6541 ttgtagtctc tggtatctat gaggaagcaa gcctctatca cattttctcc ttctgatctc
     6601 tctcaggttg cttaacacaa tttccaaaac tataaaaccg agattttata aagtcagagg
     6661 aaggcctttt taaaggtgag gatgacattt tggcagcttt gttgaataaa tactgaggat
     6721 attaatatgt cccataatgc accaacattt gtttgccggg ggaaatgagg acaattttga
     6781 caagtgtact gacactgtac tcaagtgttg tgagtgatta tttcaagcac agctagacat
     6841 gtgtggtgat acttccaaat aatttgagtt taccaagaga aaaactgtag tagtaacgta
     6901 ttttataatt taattttttg tgtttataca tagctatact acaataactt tagcgaaaac
     6961 aatatagcaa ttctgaggaa ctttcgagct gatatgaagg ggacagcctt tgcctgagct
     7021 ggcagtgctg gagatgtccc agcaacttgg ctagacttat acctgaattc tgaaataagc
     7081 aagtatattg gttctgtttc tcagtgctgg agctacgatc tgttagagtc tgataagtgt
     7141 tgtgacctag tctttttcta aaacccaaga ggttcatcac tactccgggg cattgcttct
     7201 caaaaataat gtacttttta taggaaaact caatcagtgg atctttttat tcggtatccc
     7261 tcctcttcct ccccagtccc tcctctcttc ctttctttga gtttttgagg caagaagctt
     7321 cctgaatagt ctagtttcta cggagctttc gtacttattt ttctaataat aggtgtagct
     7381 gagtgatgat gtttaactgc tctgtgagca gaattctcaa ccaacctgaa gaaacatgct
     7441 gcctatgggt gtttcctttg gtctcaactg tgtctgacct gtttgctagt gactttcacc
     7501 catgaatgga ctttgctcgt gtgcatagta tgtccatgta catagtatgt ccatgtggtc
     7561 atcagcagtg ctgtgttgtt atcacatatt tatatgcact tggtcaaaac agaagctgat
     7621 gagtgtgtga gccatcattt tgtagagtga acggctgaac cccctttgtg tcattggagt
     7681 cacgttgcgc gtctgttgcc tttaaactct cataccttct tttgtactct acaccgactg
     7741 tcgcggtgcc tttttccttt tgtataattg tattacatta aaaaattgct gacctgtgtg
     7801 taaaatgtta aaactacacc agtccaagga gattttaatg gcagtccagt tttccagaga
     7861 ataaattttt gtgtgcatta aaaaaaaaaa aaaaaa
//
