LOCUS       NP_109650                426 aa            linear   ROD 18-FEB-2025
DEFINITION  synaptotagmin-13 [Mus musculus].
ACCESSION   NP_109650
VERSION     NP_109650.1
DBSOURCE    REFSEQ: accession NM_030725.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Bakhti,M., Bastidas-Ponce,A., Tritschler,S., Czarnecki,O.,
            Tarquis-Medina,M., Nedvedova,E., Jaki,J., Willmann,S.J.,
            Scheibner,K., Cota,P., Salinno,C., Boldt,K., Horn,N., Ueffing,M.,
            Burtscher,I., Theis,F.J., Coskun,U. and Lickert,H.
  TITLE     Synaptotagmin-13 orchestrates pancreatic endocrine cell egression
            and islet morphogenesis
  JOURNAL   Nat Commun 13 (1), 4540 (2022)
   PUBMED   35927244
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Tarquis-Medina,M., Scheibner,K., Gonzalez-Garcia,I.,
            Bastidas-Ponce,A., Sterr,M., Jaki,J., Schirge,S.,
            Garcia-Caceres,C., Lickert,H. and Bakhti,M.
  TITLE     Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and
            Pancreas
  JOURNAL   Int J Mol Sci 22 (22), 12526 (2021)
   PUBMED   34830411
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Nizzardo,M., Taiana,M., Rizzo,F., Aguila Benitez,J., Nijssen,J.,
            Allodi,I., Melzi,V., Bresolin,N., Comi,G.P., Hedlund,E. and
            Corti,S.
  TITLE     Synaptotagmin 13 is neuroprotective across motor neuron diseases
  JOURNAL   Acta Neuropathol 139 (5), 837-853 (2020)
   PUBMED   32065260
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Krawchuk,D. and Kania,A.
  TITLE     Identification of genes controlled by LMX1B in the developing mouse
            limb bud
  JOURNAL   Dev Dyn 237 (4), 1183-1192 (2008)
   PUBMED   18351676
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Mu,X., Beremand,P.D., Zhao,S., Pershad,R., Sun,H., Scarpa,A.,
            Liang,S., Thomas,T.L. and Klein,W.H.
  TITLE     Discrete gene sets depend on POU domain transcription factor
            Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic
            retina
  JOURNAL   Development 131 (6), 1197-1210 (2004)
   PUBMED   14973295
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Characterization of KIAA1427 protein as an atypical synaptotagmin
            (Syt XIII)
  JOURNAL   Biochem J 354 (Pt 2), 249-257 (2001)
   PUBMED   11171101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844903.11 and AL713913.10.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082425.1, AK083803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.37 cM"
     Protein         1..426
                     /product="synaptotagmin-13"
                     /note="sytXIII"
                     /calculated_mol_wt=46739
     Site            7..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQT6.1)"
     Region          160..277
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          288..425
                     /region_name="C2B_Synaptotagmin-13"
                     /note="C2 domain second repeat present in Synaptotagmin
                     13; cd08407"
                     /db_xref="CDD:176052"
     CDS             1..426
                     /gene="Syt13"
                     /gene_synonym="5730409J20Rik; mKIAA1427"
                     /coded_by="NM_030725.5:87..1367"
                     /db_xref="CCDS:CCDS16451.1"
                     /db_xref="GeneID:80976"
                     /db_xref="MGI:MGI:1933945"
ORIGIN      
        1 mvlsvpvial gatlgtatsi lalcgvtclc rhmhpkkgll prdrepdpek arpgvlqaaq
       61 qfnikkstep vqprpllkfp diygprpavt apevinyady tletteesaa paspqaqsds
      121 rlkrqvteel sirpqngvve dvcvmetwnp ekaaswnqap klhfrldydq kkaelfvtsl
      181 eavtsdhegg cdcyiqgsva vktgsveaqt alkkrqlhtt weeglalplg eeelptatlt
      241 ltlrtcdrfs rhsvigelrl gldgasvplg aaqwgelktt akepsagage vllsisylpa
      301 anrllvvlik aknlhsnqsk ellgkdvsvk vtlkhqaqkl kkkqtkrakh kinpvwnemi
      361 mfelpddllr assvelevlg qgeegpscel ghcslglhas gsershweem lknprrqiam
      421 whqlhl
//
