LOCUS       NM_134164               3277 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus synaptotagmin XII (Syt12), mRNA.
ACCESSION   NM_134164
VERSION     NM_134164.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Kaeser-Woo,Y.J., Younts,T.J., Yang,X., Zhou,P., Wu,D.,
            Castillo,P.E. and Sudhof,T.C.
  TITLE     Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase
            is essential for hippocampal mossy fiber LTP
  JOURNAL   J Neurosci 33 (23), 9769-9780 (2013)
   PUBMED   23739973
  REMARK    GeneRIF: Synaptotagmin-12 is essential for cyclic AMP-dependent
            protein kinase presynaptic long term potentiation at mossy-fiber
            synapses.
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   Maximov,A., Shin,O.H., Liu,X. and Sudhof,T.C.
  TITLE     Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates
            spontaneous neurotransmitter release
  JOURNAL   J Cell Biol 176 (1), 113-124 (2007)
   PUBMED   17190793
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Fukuda,M.
  TITLE     Distinct developmental expression of synaptotagmin I and IX in the
            mouse brain
  JOURNAL   Neuroreport 17 (2), 179-182 (2006)
   PUBMED   16407767
REFERENCE   4  (bases 1 to 3277)
  AUTHORS   Fukuda,M., Kanno,E., Ogata,Y. and Mikoshiba,K.
  TITLE     Mechanism of the SDS-resistant synaptotagmin clustering mediated by
            the cysteine cluster at the interface between the transmembrane and
            spacer domains
  JOURNAL   J Biol Chem 276 (43), 40319-40325 (2001)
   PUBMED   11514560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124347.4.
            
            On Oct 19, 2007 this sequence version replaced NM_134164.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083139.1, AK046627.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC124347.4         53846-54054
            210-266             AC124347.4         63026-63082
            267-460             AC124347.4         70179-70372
            461-853             AC124347.4         74102-74494
            854-1069            AC124347.4         77009-77224
            1070-1190           AC124347.4         78592-78712
            1191-1324           AC124347.4         79927-80060
            1325-3277           AC124347.4         83129-85081
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.07 cM"
     gene            1..3277
                     /gene="Syt12"
                     /note="synaptotagmin XII"
                     /db_xref="GeneID:171180"
                     /db_xref="MGI:MGI:2159601"
     exon            1..209
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            210..266
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            267..460
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            461..853
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1069
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1190
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1324
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..3277
                     /gene="Syt12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1866..1871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt12"
                     /note="hexamer: AATAAA"
     polyA_site      1884
                     /gene="Syt12"
                     /note="major polyA site"
ORIGIN      
        1 gactgcggcg ctgctccatt cggccgccgg gccccgcgga gcccccatcg gtgaggcgag
       61 gctccagcag gagacgagcg ccccgctaca ctgcaggggt ggcgtagcag cgggcggccg
      121 agcgcctgtg agagccaact gcgggaggcc agcgtgggag cagagataga accaggagtc
      181 ggacccgcgt cccctccgcg gaaccccggt tcctgtcact gtgggggaca tcatggccgt
      241 ggacgtgaca gaatatcatc tgagcgtcat caagagcccc ccaggctggg aggtgggtgt
      301 ctatgctgcc ggggccctgg ctctgctggg aattgctgct gtgagtctat ggaagctctg
      361 gacatcgggg agcttcccca gcccctcccc gttccctaat tacgactaca ggtacctgca
      421 gcagaaatat ggagaggcct atgtggaggc taagctgaag cgggtccctc cttggaatga
      481 ccagcggacc actactcggg gaccacccag ccgcaaaggc agccttagta tagaagacac
      541 ctttgaaagc atcagtgagc tgggacccct ggagctgatg ggccgggaac tggacttagc
      601 cccctatggt actctccgaa agtcacagtc ggctgactct ctgaattcca tctcctctgt
      661 gagcaacacc tttgggcagg atttcaccct gggccaggtg gaggtgagca tggactatga
      721 tggagcctcc cacaccctcc acgtggcagt actacaaggc aaagacctcc tggagcgcga
      781 ggaggccacc ttcgagtcct gcttcatgcg tgtcagtctg ctgccagacg aacagatcgt
      841 gggcatctcc cggatccaga ggaatgccta ttccatcttc ttcgatgaga agttctctgt
      901 ccccctggat cccacagccc tggaggagaa gagccttaga ttttctgtgt ttggtatcga
      961 cgaggatgag cggaatgtga gcaccggcgt ggtggagctg aagctgtccg ttctggatct
     1021 cccgctgcag cccttcagtg gctggctata cttgcaggac cagaataagg ctgctgacgc
     1081 tgtgggagag atcctgctgt ccctcagtta cctgcccaca gctgagcggc tgactgtggt
     1141 tgtggtgaaa gccaagaatc tcatctggac caatgagaag agcacagcag accccttcgt
     1201 caaagtatac ctgctgcagg atgggaggaa aatgagcaag aagaagacgg ctgtgaagag
     1261 ggatgacccc aacccagtgt tcaacgaagc catgatcttc tcagtgccag ccattgtgct
     1321 acaggacctg tctctccggg tgacagtggc tgagagcagc agcgacggcc gtggggacaa
     1381 cgtgggccat gtcatcattg ggccaggggt cagtggcatg ggcaccacac attggaacca
     1441 gatgctggcc acactacgca ggcctgtgtc catgtggcat ccagtccggc gaaactaaca
     1501 gccagagcag gccaggttgg gcatcagagc ctcaggagcc tggcaccatc tcagttctat
     1561 ccagcgatgc cctctccata gccagctgga gctgtgaaca ccagggctgc cccacctcct
     1621 gggggatttc tcatcagcca tcttggatcc tctgtccaga ctgtcatgga agaatgggtg
     1681 tggctcttca tccggggacc cagggtaatt tccccactga ggtctacctg tagctggctg
     1741 gggacccacc agactgacct actgtattga agagccttag gaagtatgtc ccttggcctg
     1801 cagaaggatg tgggcttcag aacttgccaa ctccccttct gccattctcc tagaggacag
     1861 ctgttaataa atcttgaggg gatagttcct gtggtggcaa ggctaatatt aacaagacat
     1921 agcactcagg atgccaggaa cccaagatgc cctctctcat gctggcaccg agtaacaacc
     1981 cgggcagatg aacttgggaa ggagccctga ggggtggggt aacagcgagg ctctctcaga
     2041 cagggaagga gtttcacttt gagggtgaga gaaaaaatag catcccatct ttaccatggg
     2101 ggtcgtgggg atcatggtga gcagtcacac aatagaagag acacaaacta ccccatccca
     2161 aacacagact ctgcccacta cagtggacac aagaagaggc caggagacca ggcccaacag
     2221 aagccagtag gccgtatgaa ggctcccctg accatccact ctgagggaac cagaagtccc
     2281 cagtggccca ggtccagatc cttgtgtgga tccaaagcaa atcagcacag attccacaga
     2341 caccagtgtt ggctcgcgtc cctccaggcc aggcttctct agaaaggaag gtgtcaagcc
     2401 ggtctaatcc aaccctagga attgtaggtc aagttcccta aaactaagac tgctccttag
     2461 tcttgagcca gtaggaactc tggggaaatg gtgttcctaa gcaaagggct tggttgtaca
     2521 ccactaccag aatcgttctt tggtcagagt tattgagggg atcgcatcat acgtgaggtg
     2581 ctggctgtca cttgagaaag gcagttctcc tagagaaatg gtggcttttg gctccttctc
     2641 tctggaacct gaagattttt ttgttttttg atttttgggt tttttttttt tttttttccg
     2701 agacagggtt tctctgtgta gccctggctg tcctggaact cactttgtag accaggctgg
     2761 cctcaaactc agaaatctgc ctgcctctgc ctcccaagtg ctggaattaa aggtgtgtac
     2821 caccacggca gactcgaacc tgaagattta aaagggcagt gggcgtggga gtggtcagaa
     2881 gagggctttg gtccttggcc ctaatgaatc atggaggccc agatggaagc aggtctaata
     2941 atggtcaatg ataaggagaa gggcagatag aatagggaca caggtcaaca ggacaccagc
     3001 cacagctgga cccactgaag cttctcaccc tgtggccaat attcaagagg tgaaaacggg
     3061 ccagggatag tggtggctgg gccaggcctt gtcatctgga agcccccaga ctctttctaa
     3121 tccaatggct ttgcagggaa gaccacaccc cccaccctcc atccccttat tccttctttc
     3181 cttccttcta tactgcatga aacagtgtgc ccagatggct gtggtggcag ccagggatga
     3241 ttcttgaaac aaaataaaac tggggcagga aggaggc
//
