LOCUS       NM_018804               4585 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus synaptotagmin XI (Syt11), mRNA.
ACCESSION   NM_018804 XM_909839
VERSION     NM_018804.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4585)
  AUTHORS   Trovo,L., Kouvaros,S., Schwenk,J., Fernandez-Fernandez,D.,
            Fritzius,T., Rem,P.D., Fruh,S., Gassmann,M., Fakler,B.,
            Bischofberger,J. and Bettler,B.
  TITLE     Synaptotagmin-11 facilitates assembly of a presynaptic signaling
            complex in post-Golgi cargo vesicles
  JOURNAL   EMBO Rep 25 (6), 2610-2634 (2024)
   PUBMED   38698221
  REMARK    GeneRIF: Synaptotagmin-11 facilitates assembly of a presynaptic
            signaling complex in post-Golgi cargo vesicles.
REFERENCE   2  (bases 1 to 4585)
  AUTHORS   Zhang,F., Yang,D., Li,J., Du,C., Sun,X., Li,W., Liu,F., Yang,Y.,
            Li,Y., Fu,L., Li,R. and Zhang,C.X.
  TITLE     Synaptotagmin-11 regulates immune functions of microglia in vivo
  JOURNAL   J Neurochem 167 (5), 680-695 (2023)
   PUBMED   37924268
  REMARK    GeneRIF: Synaptotagmin-11 regulates immune functions of microglia
            in vivo.
REFERENCE   3  (bases 1 to 4585)
  AUTHORS   Wang,Y., Zhu,Y., Li,W., Yan,S., Li,C., Ma,K., Hu,M., Du,C., Fu,L.,
            Sun,J. and Zhang,C.X.
  TITLE     Synaptotagmin-11 Inhibits Synaptic Vesicle Endocytosis via
            Endophilin A1
  JOURNAL   J Neurosci 43 (36), 6230-6248 (2023)
   PUBMED   37474308
  REMARK    GeneRIF: Synaptotagmin-11 Inhibits Synaptic Vesicle Endocytosis via
            Endophilin A1.
REFERENCE   4  (bases 1 to 4585)
  AUTHORS   Ho,G.P.H., Wilkie,E.C., White,A.J. and Selkoe,D.J.
  TITLE     Palmitoylation of the Parkinson's disease-associated protein
            synaptotagmin-11 links its turnover to alpha-synuclein homeostasis
  JOURNAL   Sci Signal 16 (772), eadd7220 (2023)
   PUBMED   36787382
  REMARK    GeneRIF: Palmitoylation of the Parkinson's disease-associated
            protein synaptotagmin-11 links its turnover to alpha-synuclein
            homeostasis.
REFERENCE   5  (bases 1 to 4585)
  AUTHORS   Wang,Y., Yan,S., Zhang,F., Li,J., Li,R. and Zhang,C.X.
  TITLE     Parkin-dependent and -independent degradation of synaptotagmin-11
            in neurons and astrocytes
  JOURNAL   Neurosci Lett 739, 135402 (2020)
   PUBMED   32976921
  REMARK    GeneRIF: Parkin-dependent and -independent degradation of
            synaptotagmin-11 in neurons and astrocytes.
REFERENCE   6  (bases 1 to 4585)
  AUTHORS   Fukuda,M.
  TITLE     Molecular cloning, expression, and characterization of a novel
            class of synaptotagmin (Syt XIV) conserved from Drosophila to
            humans
  JOURNAL   J Biochem 133 (5), 641-649 (2003)
   PUBMED   12801916
REFERENCE   7  (bases 1 to 4585)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 4585)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Characterization of KIAA1427 protein as an atypical synaptotagmin
            (Syt XIII)
  JOURNAL   Biochem J 354 (Pt 2), 249-257 (2001)
   PUBMED   11171101
REFERENCE   9  (bases 1 to 4585)
  AUTHORS   Zhang,N., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Gridley,T.
  TITLE     Cloning, expression, and chromosomal localization of a mouse gene
            homologous to the germ cell migration regulator wunen and to type 2
            phosphatidic acid phosphatases
  JOURNAL   Genomics 63 (1), 142-144 (2000)
   PUBMED   10662554
REFERENCE   10 (bases 1 to 4585)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY295190.1, BC054526.1, CV561059.1, BU056967.1 and CD776044.1.
            
            On Feb 2, 2007 this sequence version replaced NM_018804.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054526.1, SRR1660811.234351.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY295190.1         2-60
            60-2747             BC054526.1         1-2688
            2748-3566           BC054526.1         2691-3509
            3567-4226           CV561059.1         60-719
            4227-4560           BU056967.1         195-528
            4561-4585           CD776044.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..4585
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.96 cM"
     gene            1..4585
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /note="synaptotagmin XI"
                     /db_xref="GeneID:229521"
                     /db_xref="MGI:MGI:1859547"
     exon            1..309
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            310..1133
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1257
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..4567
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4541..4546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4567
                     /gene="Syt11"
                     /gene_synonym="1500004A13Rik; 3632445O20Rik;
                     5430404N14Rik; 6530420C11Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcttct gccgagggcc gttcgggaag aggcggagcc tatctctcat caggaccagt
       61 ctgactgcac ctgcatcctt agctcagagc atccctggag catctaagag gaaagcgcag
      121 ctagcaacca gggatcgtac tgcaggggca atcggccatg caccttcccc tcccctgatc
      181 tggaggtcta cagccgcggc ctcggtactg accgagattc ccaaagttgt ctgacctctg
      241 caaaagtgtt tctatcaaca gcctctgatt acaacatggc tgagatcaca aatatacgcc
      301 ccagctttga tgtgtcaccg gtagcggctg gcctcatcgg ggcctccgtg ctggtggtgt
      361 gtgtttcagt gactgtcttt gtgtggacgt gctgccacca gcaggcagag aagaagcaca
      421 agaccccgcc atacaagttc attcatatgc tgaaaggcat tagcatctac ccagagaccc
      481 tcagcaacaa gaagaaaatc atcaaagttc ggagagacaa agatggccct cggagggaaa
      541 gtggacgagg gaacctgtta ataaacgcgg agtctggcct gctgagccac gacaaggatc
      601 ccagagggcc tagccctgca tcttgtatgg accagttacc catcaaaaga gactatgggg
      661 aagaactgag gagccccatg acaagcctga cccctggtga gagcaaagcc acctccccat
      721 cctcgccaga ggaagacgtg atgttaggct ctcttacctt ctccgtggac tacaactttc
      781 ccaagaaagc tctggtggtg acaatccaag aggctcacgg gctgccagtg atggatgacc
      841 agacccaggg ctccgatccc tacatcaaaa tgaccattct cccggacaag cggcatcgag
      901 tgaagacccg agtgcttcgc aagacgctgg acccggtgtt cgatgagacc ttcaccttct
      961 acggcatccc gtacagccag ctgcaggacc tggtgctgca tttcctggtg ctcagctttg
     1021 atcgattctc tcgggatgac gtcatcggag aggtcatggt gccattggct ggagtggacc
     1081 ccagcacagg caaggttcag ctgaccaggg acatcatcaa gaggaacatt cagaagtgca
     1141 ttagcagagg ggaactccag gtatctctgt cataccagcc cgtcgcacag agaatgacag
     1201 tggtggtcct caaagccaga cacttgccga agatggatat caccggtctc tcaggtaatc
     1261 cttatgtcaa ggtgaacgtc tactacggca gaaaacgcat tgccaagaag aaaacccatg
     1321 taaagaagtg cactttgaac cccgtcttca atgagtcgtt catctatgac atccccaccg
     1381 accttctgcc tgatatcagc atcgagttcc ttgtcattga cttcgatcgc actactaaga
     1441 atgaggtggt agggaggctg atcttggggg cacacagtgt cacaaccagt ggtgcggaac
     1501 actggagaga ggtctgcgag agtccccgca agcccatagc caagtggcac agtctgagcg
     1561 agtactaacc ctggggccag gtggggaggc acatggcggg gagaggtgac agagaagctg
     1621 actcaaaacc tcattttagt cgtagaagaa gatttcttac agaacaaacc acacgaagaa
     1681 cctcacactc cacacagctg cagattggtt cttagcgtga ggattgcttt cttctttgca
     1741 aggcactaga cgatcttttg tttttaaaaa tgagggggga agagaaggaa agaccccaag
     1801 tctatatata acaatgtaac cttatacttg catgtctaat acaaacaaga aattagccta
     1861 accaatatca agttgcagat tttaatccat gaaaattgtg ttttgtgccg aattgtattt
     1921 gctgatcccc tgaaattggc ctctctttat caggcttctc tgggttattc cagtccccca
     1981 tcactgcagg agaaaagtct gcccttgtaa agccccgcgt tcccgtcatc cagtcctttt
     2041 ttctgtcacc tctcacatct ctgctctttg gctgagttcc aaatcctgag gtctgtagta
     2101 agcaaagaaa agagttgggt ttccaggaaa aagagtaatt gagaatgggg tgtgtgctgt
     2161 aaaaggctaa caggcagcca gtgactagag atatccccgt gagcacagga gaggtggggc
     2221 tggacttagg actcactagc tgatttctct agttgctatg gagatatcac ctggggaggg
     2281 acctgtgagc acagcatatc ctgaatgcga cttgcaggtc aggggacaga ggaggaaata
     2341 agatgcccac gtggccctct gtggtaggct cttcatcggt ggtcagcagt gctaggtttg
     2401 aaaggttaca ctggctttta cttttccaga gctgcttctg aagctctggt gtctccacat
     2461 tatgtagctg ccaacacagg ttgctttctg tctcttaagg aaatgggccc cagaaaggac
     2521 tctttctccc tgagttttac agtaatggct cttaagaaag ccacgtgggc cgggcggtgg
     2581 tggcacacgc ctttaatccc agcactcggg aggcagaggc aggcggattt ctgagttcga
     2641 ggccagcctg gtctacaaag tgagttccag gacagccagg gctacacaga gaaaccctgt
     2701 ctcaaaaaac caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagaa gaaagccacg
     2761 tggggctgag tagtaagatc atgtgaatgc cttgagagcc ccactctcct cagcagaagc
     2821 gcacggctgg agaactggga gtctccccac acggtgaagg gtggaaacca aagtttcacc
     2881 atctctctgc cactgcacaa cacagtgcag agcttgcaca ctgtgctgca gttcagatcc
     2941 aggtctccac atggaggctt tgggaacgag gggtgagagt ggatgggcag tgccgacttt
     3001 gacagcctga agaggatctc agtcagatga gaaacagctt gatccagggc ctgaaagatt
     3061 agctgtaact gaagtgccca cgtccctaaa gaccgtcact ttctagcttg cttctgagaa
     3121 ggggtggacc agctgacttt ccatggagag ggttggtgac aatgcctttg gtggttcccc
     3181 tcgtgcttgt agatctgaat ccactctgcc cccctgcaac ctttcatttg ctttttgttt
     3241 ggttggtttt gcttttgctt ctgtttttgt ttgtttttgt tttctgccga ctcttggcaa
     3301 ggcagagcag tgctgtacag gcaggcagcc ccactgtgct cttgctactg atagctcttc
     3361 catcccatca tctgactcag tgtctcgcca tcagctggga tcacaccact agtccctgtc
     3421 ctttaaccca tggaatgtaa atattgtatc atacgtagaa gaaaatactt tttgttttct
     3481 aaaaaggcat tttgacatag tttaatgaaa acccggcagg agcattctaa gccccattag
     3541 ggaaaaaaaa aaaaaaaaaa aaaaaaggaa atggttcctc ttcgtcgcct taatgtgtaa
     3601 agatcagaag tcactgagca gctcctcgga gaagatgcga agtgacaggt ggagcctggc
     3661 ctctgtcccg ctgtgtgtgc ctctgttgct ccccctgaga agtctgggaa acagcgctcc
     3721 tcccttcccc atcccgctgc agctcaatcc cttgcatcct ctgggtctgc agagcagagg
     3781 gtgctggtgg aggagccagt acttctacag gctcggggct gcctcggtgt ctgtcggggt
     3841 gggcagtaca ggattcctcc ctcctacctc aggcctgatc catcatgccc tggacgcggt
     3901 accctagagc ttcttagctg actctggctg tcacatctgt tcttcacaga gctcgctgat
     3961 gtgggtagag gcagaatgcc tctccctgtc caatgaaaga caagagagtc gcttcctagc
     4021 ttttgcacaa ggctcttgtg gttaggaata ggttagggaa aggtcactcc tgatttccca
     4081 gcagccaatc tgtctatgga gatttcttga ctctttggga actctgagag ctattcacaa
     4141 tatcagaagt tccctcttga gttcttcctt cttttggttc tcagcacggc cacagtgtac
     4201 atgtttatgg acaatgctgt gctggagagc agacagaagg ctgtgtggga ccagggggcc
     4261 ctacttagga gggggatagg aagacaaaat tttaacactg gtcatagtga cattgccctc
     4321 accacgatcc ctctccaaag tggtcgtctt tctttacctt gtgtcttctc ttgtaaaaat
     4381 aaaactcaag aaaaaaaaaa tacaagtgtc aaactaaaaa gaaaaaaaaa tggaaaaagc
     4441 taacatgaac tgtgtgaaat tgcatactgc tgtgacgcta acctgcaata tgtaatgcta
     4501 tcttgtatgt ggaccttgtt aatgcgccac acacgtgcag aataaagact gattctgatt
     4561 aaataggaaa aaaaaaaaaa aaaaa
//
