LOCUS       NM_018803               1845 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus synaptotagmin X (Syt10), mRNA.
ACCESSION   NM_018803 XM_001002914
VERSION     NM_018803.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Weingarten,D.J., Shrestha,A., Orlin,D.J., Le Moing,C.L.,
            Borchardt,L.A. and Jackman,S.L.
  TITLE     Synaptotagmins 3 and 7 mediate the majority of asynchronous release
            from synapses in the cerebellum and hippocampus
  JOURNAL   Cell Rep 43 (8), 114595 (2024)
   PUBMED   39116209
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Mortimer,T., Zinna,V.M., Atalay,M., Laudanna,C., Deryagin,O.,
            Posas,G., Smith,J.G., Garcia-Lara,E., Vaca-Dempere,M., Monteiro de
            Assis,L.V., Heyde,I., Koronowski,K.B., Petrus,P., Greco,C.M.,
            Forrow,S., Oster,H., Sassone-Corsi,P., Welz,P.S., Munoz-Canoves,P.
            and Benitah,S.A.
  TITLE     The epidermal circadian clock integrates and subverts brain signals
            to guarantee skin homeostasis
  JOURNAL   Cell Stem Cell 31 (6), 834-849 (2024)
   PUBMED   38701785
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Altaha,B., Heddes,M., Pilorz,V., Niu,Y., Gorbunova,E., Gigl,M.,
            Kleigrewe,K., Oster,H., Haller,D. and Kiessling,S.
  TITLE     Genetic and environmental circadian disruption induce weight gain
            through changes in the gut microbiome
  JOURNAL   Mol Metab 66, 101628 (2022)
   PUBMED   36334897
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Collins,B., Pierre-Ferrer,S., Muheim,C., Lukacsovich,D., Cai,Y.,
            Spinnler,A., Herrera,C.G., Wen,S., Winterer,J., Belle,M.D.C.,
            Piggins,H.D., Hastings,M., Loudon,A., Yan,J., Foldy,C.,
            Adamantidis,A. and Brown,S.A.
  TITLE     Circadian VIPergic Neurons of the Suprachiasmatic Nuclei Sculpt the
            Sleep-Wake Cycle
  JOURNAL   Neuron 108 (3), 486-499 (2020)
   PUBMED   32916091
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Husse,J., Zhou,X., Shostak,A., Oster,H. and Eichele,G.
  TITLE     Synaptotagmin10-Cre, a driver to disrupt clock genes in the SCN
  JOURNAL   J Biol Rhythms 26 (5), 379-389 (2011)
   PUBMED   21921292
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Cao,P., Maximov,A. and Sudhof,T.C.
  TITLE     Activity-dependent IGF-1 exocytosis is controlled by the
            Ca(2+)-sensor synaptotagmin-10
  JOURNAL   Cell 145 (2), 300-311 (2011)
   PUBMED   21496647
  REMARK    GeneRIF: Study shows that olfactory bulb neurons secrete IGF-1 by
            an activity-dependent pathway of exocytosis, and that Syt10
            functions as the Ca(2+)-sensor that triggers IGF-1 exocytosis in
            these neurons.
            GeneRIF: Syt10 knockout mice imply that Syt10 protein acts to
            trigger insulin-like growth factor 1 (IGF-1) secretion in the
            olfactory bulb
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Tucker,W.C., Edwardson,J.M., Bai,J., Kim,H.J., Martin,T.F. and
            Chapman,E.R.
  TITLE     Identification of synaptotagmin effectors via acute inhibition of
            secretion from cracked PC12 cells
  JOURNAL   J Cell Biol 162 (2), 199-209 (2003)
   PUBMED   12860971
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     A novel alternatively spliced variant of synaptotagmin VI lacking a
            transmembrane domain. Implications for distinct functions of the
            two isoforms
  JOURNAL   J Biol Chem 274 (44), 31428-31434 (1999)
   PUBMED   10531344
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093642.1, BC125634.1 and AC124133.13.
            
            On Dec 12, 2009 this sequence version replaced NM_018803.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB026807.1, BC125634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CJ093642.1         1-54
            55-1743             BC125634.1         1-1689
            1744-1845           AC124133.13        31616-31717
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.96 cM"
     gene            1..1845
                     /gene="Syt10"
                     /note="synaptotagmin X"
                     /db_xref="GeneID:54526"
                     /db_xref="MGI:MGI:1859546"
     exon            1..242
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1663
                     /gene="Syt10"
                     /note="sytX"
                     /codon_start=1
                     /product="synaptotagmin-10"
                     /protein_id="NP_061273.1"
                     /db_xref="CCDS:CCDS27756.1"
                     /db_xref="GeneID:54526"
                     /db_xref="MGI:MGI:1859546"
                     /translation="MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSG
                     QGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNLSVLPQSISS
                     APTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQR
                     QTTEPTSSSRHNSFRRHLPRQMNVSSVDFSVGTEPILQRGETRTSIGRIKPELYKQKS
                     VDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLL
                     PDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVI
                     LDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKA
                     MDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCI
                     AVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSF
                     DSQGSCSSPRPPSTP"
     exon            243..600
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1168
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1289
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1461
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1591
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1845
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgcccgtg ccaaccatgg ggccaactcg caactcttag ggctctgcct cagaccaagg
       61 gagatcaacg gagctgcgag cagaagccaa gatgagtttc cgcaaggagg acggtgtgag
      121 cagcctgtgc cagaaggcgc tgcacatcat caccgagctg tgcttcgcgg gtcaggtgga
      181 gtgggacaag tgttcgggca tctttccagc cgataggagc ggccagggag gaggtggcac
      241 agatatttca gtcagcctgt tagcggttgt tgtaagcttc tgtggcctgg ccttgctggt
      301 tgtctccctt tttgtcttct ggaagttgtg ctggccatgc tggaagagca agcttgtggc
      361 ccccaacctc agtgtccttc cacaaagcat ctcaagtgct ccaactgaag tttttgagac
      421 tgaagagaaa aaagaagtgg aagaaaatga aaagccagca cccaaagcca ttgagcctgc
      481 aataaaaatc agccacacat cccccgacat cccagcagaa gtgcagacag ctttaaagga
      541 gcacttgatt aaacatgctc gagtgcaaag gcaaacaacc gagcctacgt cttcatcccg
      601 ccacaactcc ttcaggagac acctaccaag gcaaatgaat gtctccagcg tcgactttag
      661 cgtgggcact gaacccatct tacaaagagg agaaacgaga acgagcatcg ggaggataaa
      721 accagaactc tacaagcaga aatcggttga ctccgagggc aacagaaaag acgacgtcaa
      781 gacctgtggg aaacttaact ttgcgctcca gtatgattat gaaaatgaac tcctagttgt
      841 taaaattatc aaagctttag atctcccagc taaagatttc acaggaactt ctgatcctta
      901 tgtgaagatc tatcttcttc cggataggaa gaagaaattt cagacccgcg tgcaccggaa
      961 gactttaaac cctctgtttg atgagctatt tcagtttccg gtggtttacg atcagctaag
     1021 caaccgcaaa ctacacttta gtatatatga ttttgacaga ttttccagac acgacatgat
     1081 tggggaagtg attcttgata atttatttga agtctctgat ctctccaggg aagccacagt
     1141 atggaaagat atccactgtg ctaccacaga aagcatagac ctgggggaaa tcatgttctc
     1201 cctttgctat ttgccaactg ctggccgtat gaccttgaca gtgatcaagt gcagaaatct
     1261 gaaggcaatg gacatcactg ggtcatcaga tccttatgtc aaagtgtctc tgatgtgtga
     1321 gggccgaaga cttaaaaaac ggaaaacaac tacaaagaaa aatactctca atcccgtgta
     1381 caacgaagcc attatcttcg atatccctcc agagaatgtg gaccaggtca gcctgtgcat
     1441 tgcagtcatg gattacgaca gggtggggca caatgaggtc ataggcgtgt gtcgaactgg
     1501 actagacgct gagggtcttg ggagagacca ttggaacgag atgctggcct atcaccgaaa
     1561 gccaatcaca cactggcacc ccttgctgga gttacctggc cgggccacca gctttgatag
     1621 tcaagggtcc tgttcttctc ccaggccacc gtccacacca taaaagcctc caaataagac
     1681 catatcacag aaagatctag aaccgtgtgc tcattgaatc agaaacctac acacagaaaa
     1741 cacacgcgcg cacagaacat ttgacttctt catttaaaat atacccatga taattaataa
     1801 cttgatgcat aatttctctt ggcttatttg gcttatttgt cttca
//
