LOCUS       NM_009306               4756 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synaptotagmin I (Syt1), transcript variant 2, mRNA.
ACCESSION   NM_009306
VERSION     NM_009306.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4756)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4756)
  AUTHORS   Han,Y. and Yu,L.
  TITLE     Calcium ions promote migrasome formation via Synaptotagmin-1
  JOURNAL   J Cell Biol 223 (8) (2024)
   PUBMED   38647453
  REMARK    GeneRIF: Calcium ions promote migrasome formation via
            Synaptotagmin-1.
REFERENCE   3  (bases 1 to 4756)
  AUTHORS   Wang,L., Yang,Z., Satoshi,F., Prasanna,X., Yan,Z., Vihinen,H.,
            Chen,Y., Zhao,Y., He,X., Bu,Q., Li,H., Zhao,Y., Jiang,L., Qin,F.,
            Dai,Y., Zhang,N., Qin,M., Kuang,W., Zhao,Y., Jokitalo,E.,
            Vattulainen,I., Kajander,T., Zhao,H. and Cen,X.
  TITLE     Membrane remodeling by FAM92A1 during brain development regulates
            neuronal morphology, synaptic function, and cognition
  JOURNAL   Nat Commun 15 (1), 6209 (2024)
   PUBMED   39043703
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4756)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4756)
  AUTHORS   Ma,Y., Gao,K., Sun,X., Wang,J., Yang,Y., Wu,J., Chai,A., Yao,L.,
            Liu,N., Yu,H., Su,Y., Lu,T., Wang,L., Yue,W., Zhang,X., Xu,L.,
            Zhang,D. and Li,J.
  TITLE     STON2 variations are involved in synaptic dysfunction and
            schizophrenia-like behaviors by regulating Syt1 trafficking
  JOURNAL   Sci Bull (Beijing) 69 (10), 1458-1471 (2024)
   PUBMED   38402028
  REMARK    GeneRIF: STON2 variations are involved in synaptic dysfunction and
            schizophrenia-like behaviors by regulating Syt1 trafficking.
REFERENCE   6  (bases 1 to 4756)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 4756)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   8  (bases 1 to 4756)
  AUTHORS   Kohrman,D.C., Plummer,N.W., Schuster,T., Jones,J.M., Jang,W.,
            Burgess,D.L., Galt,J., Spear,B.T. and Meisler,M.H.
  TITLE     Insertional mutation of the motor endplate disease (med) locus on
            mouse chromosome 15
  JOURNAL   Genomics 26 (2), 171-177 (1995)
   PUBMED   7601440
REFERENCE   9  (bases 1 to 4756)
  AUTHORS   Jones,J.M., Popma,S.J., Mizuta,M., Seino,S. and Meisler,M.H.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
REFERENCE   10 (bases 1 to 4756)
  AUTHORS   Geppert,M., Goda,Y., Hammer,R.E., Li,C., Rosahl,T.W., Stevens,C.F.
            and Sudhof,T.C.
  TITLE     Synaptotagmin I: a major Ca2+ sensor for transmitter release at a
            central synapse
  JOURNAL   Cell 79 (4), 717-727 (1994)
   PUBMED   7954835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY268027.1, BY238701.1, BC042519.1, CD774438.1 and AI842617.1.
            
            On Nov 10, 2011 this sequence version replaced NM_009306.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048187.1, AK133578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BY268027.1         1-67
            68-356              BY238701.1         2-290
            357-4141            BC042519.1         1-3785
            4142-4738           CD774438.1         19-615              c
            4739-4756           AI842617.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 56.52 cM"
     gene            1..4756
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="synaptotagmin I"
                     /db_xref="GeneID:20979"
                     /db_xref="MGI:MGI:99667"
     exon            1..400
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            401..501
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            502..567
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            568..747
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     CDS             585..1850
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="isoform 1 is encoded by transcript variant 2;
                     synaptotagmin-1; p65"
                     /codon_start=1
                     /product="synaptotagmin-1 isoform 1"
                     /protein_id="NP_033332.1"
                     /db_xref="CCDS:CCDS24163.1"
                     /db_xref="GeneID:20979"
                     /db_xref="MGI:MGI:99667"
                     /translation="MVSASRPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQ
                     KFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAIN
                     MKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLV
                     GIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSE
                     LGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDI
                     CFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNT
                     LNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSD
                     MLANPRRPIAQWHTLQVEEEVDAMLAVKK"
     exon            748..932
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1055
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1223
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1391
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1509
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1643
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..4740
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4715..4720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="hexamer: AATAAA"
     polyA_site      4738
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="major polyA site"
ORIGIN      
        1 tcctcactgg agggattcct ggagaagctg cagtgtgggg atgctctgac cgagttcagc
       61 ccccagtgtc tttcctcctc ctcctcctgc agcgacagca tccgcagtta gcagtgggca
      121 acttgaggct gtaaccgggg caagccccca gggtcctgct cacccaacag ggggctcagg
      181 tccccgaagg ggtgtgtgca gggcgggggc ggccagctgg gaccagctgg tggccctaga
      241 aaacctcacc cacacccaca cccacacacc ccttttgtgt tgcaggctgc ccctctgaga
      301 gcggaggcag cgagagagta ctcgtgtgcc tcgcaccggt ccgcggtgag agcagcgggg
      361 accaagactc gcaccatctc ccggtcggtc ctcgctccag gaaaagaaga ctttggcgcg
      421 ctcgaacaac caacatccgc agtctgatca gaagacattg cccttgccgt cccgagagct
      481 ccagcagaac atctcgttaa gattgaagaa aggagattcc aaaaggaaca aaaaaaccca
      541 aatactccag actaccccag cagaacattc cgcttgaacc aaaaatggtg agtgccagtc
      601 gtcctgaggc cctggctgcc cctgtcacca ctgttgcgac ccttgtccca cacaacgcca
      661 ctgagccagc cagtcctggg gaagggaagg aagatgcctt ttccaagctg aagcagaagt
      721 ttatgaatga actgcataaa atcccattgc caccgtgggc cttaattgcc atagccatag
      781 ttgcggtcct tctagtcgtg acctgctgct tctgtgtctg taagaaatgt ttgttcaaaa
      841 agaaaaacaa gaagaaggga aaggaaaagg gagggaagaa cgccattaac atgaaagacg
      901 tgaaagactt agggaagacc atgaaggatc aggcccttaa ggatgacgat gctgaaactg
      961 gactgactga tggagaagaa aaggaggagc ccaaggaaga ggagaaactg ggaaagcttc
     1021 aatattcact ggactatgac ttccagaata accagctgct ggtgggaatc atccaggctg
     1081 ctgaactgcc cgccctggac atgggaggca catctgatcc atacgtcaaa gtcttcctgc
     1141 tgcccgacaa aaagaagaag tttgagacaa aagtccaccg gaaaaccctc aatccagtct
     1201 tcaatgaaca gtttactttc aaggtgccat actcggaatt aggtggcaag acactggtga
     1261 tggctgtgta tgattttgac cgcttctcca agcacgacat cattggagag ttcaaagttc
     1321 ctatgaacac cgtggatttt ggccacgtca ccgaggagtg gcgcgatctc cagagtgctg
     1381 agaaagaaga gcaagagaaa ctgggtgaca tctgcttctc cctccgctac gtccctactg
     1441 ccggcaagct gactgttgtc attctggaag ccaagaacct gaagaagatg gatgtgggtg
     1501 gcttatctga tccctatgta aagattcacc tgatgcagaa cggcaagaga ctgaagaaga
     1561 aaaagacaac gattaagaag aacacactta acccctacta caatgagtcc ttcagctttg
     1621 aagttccgtt cgagcaaatc cagaaagtgc aagtggtggt aactgttttg gactatgaca
     1681 agattggcaa gaacgacgcc atcggcaaag tctttgtggg ctacaacagc accggcgcag
     1741 agctgcgaca ctggtcagac atgctggcca acccccggcg acccatcgcc cagtggcaca
     1801 ctctgcaggt agaggaggag gttgatgcca tgctggctgt caagaagtaa aggggaaaag
     1861 aagcctttct gcgtctgccc acatagtgct ctttagccag tatctgtaaa tacctcagta
     1921 atatgggtcc tttcagtttc cagccatgca ttcctgatac aatccagtgg tacttcagat
     1981 cctgttttaa tttgcacaaa tttaagtgta gaaagcccct atgcccttca tcataccact
     2041 gccctccaaa tctactcttc ttttaagcaa tatgatgtgt agatagagca tgactgaaat
     2101 gtattgtatc acaccgttgt atataccagt atgctaaaga tttatttcta gtttgtgtat
     2161 ttgtatgttg taagcgtttc ctaatctgtg tatatctaga tgtttttaat aagatgttct
     2221 attttaaact atgtaaattg actgagatat aggagaactg ataatatatt atatggtaaa
     2281 tatagtatcg tctgcattcc agcaaaaata tcaatttgaa aggcactagt acagttaaac
     2341 caacatctta aaggacaact taaacctgaa ctttctattg aatcctttga gtaccaagat
     2401 ttgctcacat gacatctttg atgggtgaac ccaattttgt agaattcttt cacaggcaaa
     2461 tagcatgttc tgagcagcat ccatgctgac ctcaaggaag caaagccaca aaccagaata
     2521 gcatctgtct gtctgtctct gcaaagctaa aaaatcatgg cttcactctt ccagtcaagg
     2581 aagcaacgaa cacgaaggag ccagtgagtt cctacgactg catctagcat agcataaccg
     2641 tggtgttctc tgtgtgtgcg tgtgcaagtg tgaaagtgta tgcacgagtc ttatgtgtgg
     2701 tgcatgcctt tgttcggggt tggggtggga gaggagaagc tgagagaagt cagcgtttct
     2761 gaaatgttgc ctgactactt aaacagaaac taatagctct ccagtatcac atttatataa
     2821 cacgtgcaac ctgggaattc tggtccagat ttcaccccaa tattgattcc aaaaggtatg
     2881 cacgtgagac tttgtaacaa aatattttat tatataaaac cagattagaa ggaatgcaga
     2941 atatttttaa cacagcaatc tgtgcttatt ccacaacatt actttgtggt aaacagacag
     3001 tattgtaatc ccatgaaaag atgaaatata acaattagcc atagttctga atgcacttcg
     3061 attaagccaa aacagacagc tagtgatctt tttatatgct ctttttactt aagttttaat
     3121 ttgtccttta aacaaaggtg aaaaaaaaaa ccaagaacaa gttctagcaa actgaagcaa
     3181 cctcttatgt acactagatg cttgacttag gaggagtttt taaatgttct caatgttatt
     3241 ctgtagtaaa tggcactatt atgaagccac tagtcattcc atatgagtct taaggactgc
     3301 tctgtgtaac actgtgactg ccctgtgtgc ttagacacgt agtttcctca gtggctagca
     3361 cccaacttac tccgtagtga tattgtaaca atactgccat tccctcgtac tgcactgccc
     3421 aatgtgtgtg tagcacaaac agttctcatt cttaaggacc aattcagaac tgaacagcta
     3481 tgcataggac agaaagatac atagactggg ggggtgggga gaacacacag catcttgtca
     3541 acactgtgca ctagtccaca tttgtctcgc tgaggtagac agccacttca ggaaggtgag
     3601 cctgctacct aacactgctt ctagactctt cgcccacttg atagtgcggc ctgttttcac
     3661 ctccaggtca cagaaaacag caacatcctg acgggagagg accatcttca catctaccaa
     3721 aataaaatgg aggcatggaa agtgtggcct cctgtttgat ctataggatt tagctccatg
     3781 ctttggacaa aagtcaagag aatcccagaa agggctcttg gtagacttta aacatggggt
     3841 tggccgttcc tcctgcacac acaacacaat ctccaaaccc tggttcttcc ctcattggag
     3901 aagaggcaaa gcctttgctc ctcacctcca tcccagcaaa ctcttcagaa ttagaacaga
     3961 tgcagaggac aaggagaaaa tcctttcctg tggacgaaca gcacattttc aacattaaaa
     4021 ccacagatga taggaaaggc acactcatag gtgagattaa acaggagact caaatgaggg
     4081 gctttcctac ttaagggacc aagtcctacc aaagagaagg agttgacttt aaaaaaaaaa
     4141 ataccttaga taccagacac cgacatttcg gttcaccacc tcccgactta agttgtacac
     4201 ggtggagcaa catttccaag gaagcagctt ccagctgccc aagcagacat tccttcctgc
     4261 atcacaacac tactagcaca ttctcttgca acactgccaa cgtgggattg tcaccataga
     4321 cttagttggt actatatcat ctcccatgag ccggtgactg gacctgcttc ctgacctgcc
     4381 atccatcctc agatgagcca cctgtaccct tctgacagtg cagtgtgaag tcttagaagc
     4441 tgatgcccta gaaagatcct agttgccttt gttgcatata tttactgcct gcttgagtgt
     4501 ttctctgtgt gggttctctc tgtgtctcgt agaaatgttg gggtgttttc ttctgccata
     4561 agggctcgtg gcccgcgagc caactccttt agctgtattc ttccttcatt ttttgataag
     4621 tggtttaaat tctgtttcac tttgtgtagt gaaccccatg gtagttttct gatcgttgtt
     4681 aaaaaaaatg acttaacata ttacatggac actcaataaa aatgttttat ttcctgttga
     4741 aaaaaaaaaa aaaaaa
//
