LOCUS       NM_001358506            4647 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synaptotagmin I (Syt1), transcript variant 8, mRNA.
ACCESSION   NM_001358506 XM_017313868
VERSION     NM_001358506.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4647)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4647)
  AUTHORS   Han,Y. and Yu,L.
  TITLE     Calcium ions promote migrasome formation via Synaptotagmin-1
  JOURNAL   J Cell Biol 223 (8) (2024)
   PUBMED   38647453
  REMARK    GeneRIF: Calcium ions promote migrasome formation via
            Synaptotagmin-1.
REFERENCE   3  (bases 1 to 4647)
  AUTHORS   Wang,L., Yang,Z., Satoshi,F., Prasanna,X., Yan,Z., Vihinen,H.,
            Chen,Y., Zhao,Y., He,X., Bu,Q., Li,H., Zhao,Y., Jiang,L., Qin,F.,
            Dai,Y., Zhang,N., Qin,M., Kuang,W., Zhao,Y., Jokitalo,E.,
            Vattulainen,I., Kajander,T., Zhao,H. and Cen,X.
  TITLE     Membrane remodeling by FAM92A1 during brain development regulates
            neuronal morphology, synaptic function, and cognition
  JOURNAL   Nat Commun 15 (1), 6209 (2024)
   PUBMED   39043703
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4647)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4647)
  AUTHORS   Ma,Y., Gao,K., Sun,X., Wang,J., Yang,Y., Wu,J., Chai,A., Yao,L.,
            Liu,N., Yu,H., Su,Y., Lu,T., Wang,L., Yue,W., Zhang,X., Xu,L.,
            Zhang,D. and Li,J.
  TITLE     STON2 variations are involved in synaptic dysfunction and
            schizophrenia-like behaviors by regulating Syt1 trafficking
  JOURNAL   Sci Bull (Beijing) 69 (10), 1458-1471 (2024)
   PUBMED   38402028
  REMARK    GeneRIF: STON2 variations are involved in synaptic dysfunction and
            schizophrenia-like behaviors by regulating Syt1 trafficking.
REFERENCE   6  (bases 1 to 4647)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 4647)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   8  (bases 1 to 4647)
  AUTHORS   Kohrman,D.C., Plummer,N.W., Schuster,T., Jones,J.M., Jang,W.,
            Burgess,D.L., Galt,J., Spear,B.T. and Meisler,M.H.
  TITLE     Insertional mutation of the motor endplate disease (med) locus on
            mouse chromosome 15
  JOURNAL   Genomics 26 (2), 171-177 (1995)
   PUBMED   7601440
REFERENCE   9  (bases 1 to 4647)
  AUTHORS   Jones,J.M., Popma,S.J., Mizuta,M., Seino,S. and Meisler,M.H.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
REFERENCE   10 (bases 1 to 4647)
  AUTHORS   Geppert,M., Goda,Y., Hammer,R.E., Li,C., Rosahl,T.W., Stevens,C.F.
            and Sudhof,T.C.
  TITLE     Synaptotagmin I: a major Ca2+ sensor for transmitter release at a
            central synapse
  JOURNAL   Cell 79 (4), 717-727 (1994)
   PUBMED   7954835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY259903.1, BB624461.1, AK018163.1, AK133578.1, BC042519.1,
            CD774438.1 and AI842617.1.
            
            On Dec 1, 2017 this sequence version replaced XM_017313868.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.260651.1,
                                           SRR1660819.194422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               BY259903.1         2-221
            221-336             BB624461.1         370-485
            337-508             BY259903.1         258-429
            509-647             AK018163.1         533-671
            648-832             AK133578.1         739-923
            833-1443            AK018163.1         858-1468
            1444-4032           BC042519.1         1197-3785
            4033-4629           CD774438.1         19-615              c
            4630-4647           AI842617.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 56.52 cM"
     gene            1..4647
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="synaptotagmin I"
                     /db_xref="GeneID:20979"
                     /db_xref="MGI:MGI:99667"
     exon            1..220
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            221..300
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            301..401
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            402..467
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            468..647
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..1741
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="isoform 2 is encoded by transcript variant 8;
                     synaptotagmin-1; p65"
                     /codon_start=1
                     /product="synaptotagmin-1 isoform 2"
                     /protein_id="NP_001345435.1"
                     /db_xref="GeneID:20979"
                     /db_xref="MGI:MGI:99667"
                     /translation="MVSASRPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQ
                     KFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAIN
                     MKDVKDLGKTMKDQDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGII
                     QAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGG
                     KTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFS
                     LRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNP
                     YYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLA
                     NPRRPIAQWHTLQVEEEVDAMLAVKK"
     exon            648..832
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            833..946
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1114
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1282
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1400
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1534
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..4631
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4606..4611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="hexamer: AATAAA"
     polyA_site      4629
                     /gene="Syt1"
                     /gene_synonym="G630098F17Rik; SytI"
                     /note="major polyA site"
ORIGIN      
        1 gggaaatatc cagttctatg taacaggagg gcaatgcaac cgggttctgc aggagcaaag
       61 cgaaagcagg agatgctggt tccaagataa atctttctga tgtatcagga gagacgccaa
      121 gtcgtaggtt ttttttttct aaatgcccat ttgagataag aagagggggt cttccctttt
      181 taagtctctc tcaactccca caccagcctg ggtaccgcag tttccctctg aatcctacac
      241 ttcatatgta gacaccttac tcaactggca tttgttagtc aagtctcctc tgcatccaag
      301 gaaaagaaga ctttggcgcg ctcgaacaac caacatccgc agtctgatca gaagacattg
      361 cccttgccgt cccgagagct ccagcagaac atctcgttaa gattgaagaa aggagattcc
      421 aaaaggaaca aaaaaaccca aatactccag actaccccag cagaacattc cgcttgaacc
      481 aaaaatggtg agtgccagtc gtcctgaggc cctggctgcc cctgtcacca ctgttgcgac
      541 ccttgtccca cacaacgcca ctgagccagc cagtcctggg gaagggaagg aagatgcctt
      601 ttccaagctg aagcagaagt ttatgaatga actgcataaa atcccattgc caccgtgggc
      661 cttaattgcc atagccatag ttgcggtcct tctagtcgtg acctgctgct tctgtgtctg
      721 taagaaatgt ttgttcaaaa agaaaaacaa gaagaaggga aaggaaaagg gagggaagaa
      781 cgccattaac atgaaagacg tgaaagactt agggaagacc atgaaggatc aggatgacga
      841 tgctgaaact ggactgactg atggagaaga aaaggaggag cccaaggaag aggagaaact
      901 gggaaagctt caatattcac tggactatga cttccagaat aaccagctgc tggtgggaat
      961 catccaggct gctgaactgc ccgccctgga catgggaggc acatctgatc catacgtcaa
     1021 agtcttcctg ctgcccgaca aaaagaagaa gtttgagaca aaagtccacc ggaaaaccct
     1081 caatccagtc ttcaatgaac agtttacttt caaggtgcca tactcggaat taggtggcaa
     1141 gacactggtg atggctgtgt atgattttga ccgcttctcc aagcacgaca tcattggaga
     1201 gttcaaagtt cctatgaaca ccgtggattt tggccacgtc accgaggagt ggcgcgatct
     1261 ccagagtgct gagaaagaag agcaagagaa actgggtgac atctgcttct ccctccgcta
     1321 cgtccctact gccggcaagc tgactgttgt cattctggaa gccaagaacc tgaagaagat
     1381 ggatgtgggt ggcttatctg atccctatgt aaagattcac ctgatgcaga acggcaagag
     1441 actgaagaag aaaaagacaa cgattaagaa gaacacactt aacccctact acaatgagtc
     1501 cttcagcttt gaagttccgt tcgagcaaat ccagaaagtg caagtggtgg taactgtttt
     1561 ggactatgac aagattggca agaacgacgc catcggcaaa gtctttgtgg gctacaacag
     1621 caccggcgca gagctgcgac actggtcaga catgctggcc aacccccggc gacccatcgc
     1681 ccagtggcac actctgcagg tagaggagga ggttgatgcc atgctggctg tcaagaagta
     1741 aaggggaaaa gaagcctttc tgcgtctgcc cacatagtgc tctttagcca gtatctgtaa
     1801 atacctcagt aatatgggtc ctttcagttt ccagccatgc attcctgata caatccagtg
     1861 gtacttcaga tcctgtttta atttgcacaa atttaagtgt agaaagcccc tatgcccttc
     1921 atcataccac tgccctccaa atctactctt cttttaagca atatgatgtg tagatagagc
     1981 atgactgaaa tgtattgtat cacaccgttg tatataccag tatgctaaag atttatttct
     2041 agtttgtgta tttgtatgtt gtaagcgttt cctaatctgt gtatatctag atgtttttaa
     2101 taagatgttc tattttaaac tatgtaaatt gactgagata taggagaact gataatatat
     2161 tatatggtaa atatagtatc gtctgcattc cagcaaaaat atcaatttga aaggcactag
     2221 tacagttaaa ccaacatctt aaaggacaac ttaaacctga actttctatt gaatcctttg
     2281 agtaccaaga tttgctcaca tgacatcttt gatgggtgaa cccaattttg tagaattctt
     2341 tcacaggcaa atagcatgtt ctgagcagca tccatgctga cctcaaggaa gcaaagccac
     2401 aaaccagaat agcatctgtc tgtctgtctc tgcaaagcta aaaaatcatg gcttcactct
     2461 tccagtcaag gaagcaacga acacgaagga gccagtgagt tcctacgact gcatctagca
     2521 tagcataacc gtggtgttct ctgtgtgtgc gtgtgcaagt gtgaaagtgt atgcacgagt
     2581 cttatgtgtg gtgcatgcct ttgttcgggg ttggggtggg agaggagaag ctgagagaag
     2641 tcagcgtttc tgaaatgttg cctgactact taaacagaaa ctaatagctc tccagtatca
     2701 catttatata acacgtgcaa cctgggaatt ctggtccaga tttcacccca atattgattc
     2761 caaaaggtat gcacgtgaga ctttgtaaca aaatatttta ttatataaaa ccagattaga
     2821 aggaatgcag aatattttta acacagcaat ctgtgcttat tccacaacat tactttgtgg
     2881 taaacagaca gtattgtaat cccatgaaaa gatgaaatat aacaattagc catagttctg
     2941 aatgcacttc gattaagcca aaacagacag ctagtgatct ttttatatgc tctttttact
     3001 taagttttaa tttgtccttt aaacaaaggt gaaaaaaaaa accaagaaca agttctagca
     3061 aactgaagca acctcttatg tacactagat gcttgactta ggaggagttt ttaaatgttc
     3121 tcaatgttat tctgtagtaa atggcactat tatgaagcca ctagtcattc catatgagtc
     3181 ttaaggactg ctctgtgtaa cactgtgact gccctgtgtg cttagacacg tagtttcctc
     3241 agtggctagc acccaactta ctccgtagtg atattgtaac aatactgcca ttccctcgta
     3301 ctgcactgcc caatgtgtgt gtagcacaaa cagttctcat tcttaaggac caattcagaa
     3361 ctgaacagct atgcatagga cagaaagata catagactgg gggggtgggg agaacacaca
     3421 gcatcttgtc aacactgtgc actagtccac atttgtctcg ctgaggtaga cagccacttc
     3481 aggaaggtga gcctgctacc taacactgct tctagactct tcgcccactt gatagtgcgg
     3541 cctgttttca cctccaggtc acagaaaaca gcaacatcct gacgggagag gaccatcttc
     3601 acatctacca aaataaaatg gaggcatgga aagtgtggcc tcctgtttga tctataggat
     3661 ttagctccat gctttggaca aaagtcaaga gaatcccaga aagggctctt ggtagacttt
     3721 aaacatgggg ttggccgttc ctcctgcaca cacaacacaa tctccaaacc ctggttcttc
     3781 cctcattgga gaagaggcaa agcctttgct cctcacctcc atcccagcaa actcttcaga
     3841 attagaacag atgcagagga caaggagaaa atcctttcct gtggacgaac agcacatttt
     3901 caacattaaa accacagatg ataggaaagg cacactcata ggtgagatta aacaggagac
     3961 tcaaatgagg ggctttccta cttaagggac caagtcctac caaagagaag gagttgactt
     4021 taaaaaaaaa aataccttag ataccagaca ccgacatttc ggttcaccac ctcccgactt
     4081 aagttgtaca cggtggagca acatttccaa ggaagcagct tccagctgcc caagcagaca
     4141 ttccttcctg catcacaaca ctactagcac attctcttgc aacactgcca acgtgggatt
     4201 gtcaccatag acttagttgg tactatatca tctcccatga gccggtgact ggacctgctt
     4261 cctgacctgc catccatcct cagatgagcc acctgtaccc ttctgacagt gcagtgtgaa
     4321 gtcttagaag ctgatgccct agaaagatcc tagttgcctt tgttgcatat atttactgcc
     4381 tgcttgagtg tttctctgtg tgggttctct ctgtgtctcg tagaaatgtt ggggtgtttt
     4441 cttctgccat aagggctcgt ggcccgcgag ccaactcctt tagctgtatt cttccttcat
     4501 tttttgataa gtggtttaaa ttctgtttca ctttgtgtag tgaaccccat ggtagttttc
     4561 tgatcgttgt taaaaaaaat gacttaacat attacatgga cactcaataa aaatgtttta
     4621 tttcctgttg aaaaaaaaaa aaaaaaa
//
