LOCUS       NM_008596               3247 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus synaptophysin like 2 (Sypl2), mRNA.
ACCESSION   NM_008596
VERSION     NM_008596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Correll,R.N., Lynch,J.M., Schips,T.G., Prasad,V., York,A.J.,
            Sargent,M.A., Brochet,D.X.P., Ma,J. and Molkentin,J.D.
  TITLE     Mitsugumin 29 regulates t-tubule architecture in the failing heart
  JOURNAL   Sci Rep 7 (1), 5328 (2017)
   PUBMED   28706255
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Woo,J.S., Hwang,J.H., Huang,M., Ahn,M.K., Cho,C.H., Ma,J. and
            Lee,E.H.
  TITLE     Interaction between mitsugumin 29 and TRPC3 participates in
            regulating Ca(2+) transients in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 464 (1), 133-139 (2015)
   PUBMED   26141232
  REMARK    GeneRIF: Ca(2+) transients in skeletal muscle are regulated via
            interaction between Mg29 and TRPC3.
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Reynolds,J.O., Chiang,D.Y., Wang,W., Beavers,D.L., Dixit,S.S.,
            Skapura,D.G., Landstrom,A.P., Song,L.S., Ackerman,M.J. and
            Wehrens,X.H.
  TITLE     Junctophilin-2 is necessary for T-tubule maturation during mouse
            heart development
  JOURNAL   Cardiovasc Res 100 (1), 44-53 (2013)
   PUBMED   23715556
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Seth,M., Li,T., Graham,V., Burch,J., Finch,E., Stiber,J.A. and
            Rosenberg,P.B.
  TITLE     Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by
            stromal interaction molecule 1 and sarcolipin during muscle
            differentiation
  JOURNAL   Dev Dyn 241 (4), 639-647 (2012)
   PUBMED   22411552
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Kurebayashi,N., Takeshima,H., Nishi,M., Murayama,T., Suzuki,E. and
            Ogawa,Y.
  TITLE     Changes in Ca2+ handling in adult MG29-deficient skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 310 (4), 1266-1272 (2003)
   PUBMED   14559251
  REMARK    GeneRIF: MG29 is not involved in the store-operated Ca2+ entry
            activation at variance with the previous conclusion with immature
            muscles
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Pan,Z., Yang,D., Nagaraj,R.Y., Nosek,T.A., Nishi,M., Takeshima,H.,
            Cheng,H. and Ma,J.
  TITLE     Dysfunction of store-operated calcium channel in muscle cells
            lacking mg29
  JOURNAL   Nat Cell Biol 4 (5), 379-383 (2002)
   PUBMED   11988740
  REMARK    GeneRIF: Data show that slow cumulative calcium entry through
            store-operated calcium channel (SOC) is crucial for long-term
            calcium homeostasis, such that reduced SOC activity exaggerates
            muscle fatigue under conditions of intensive exercise.
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Nagaraj,R.Y., Nosek,C.M., Brotto,M.A., Nishi,M., Takeshima,H.,
            Nosek,T.M. and Ma,J.
  TITLE     Increased susceptibility to fatigue of slow- and fast-twitch
            muscles from mice lacking the MG29 gene
  JOURNAL   Physiol Genomics 4 (1), 43-49 (2000)
   PUBMED   11074012
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   Nishi,M., Komazaki,S., Kurebayashi,N., Ogawa,Y., Noda,T., Iino,M.
            and Takeshima,H.
  TITLE     Abnormal features in skeletal muscle from mice lacking mitsugumin29
  JOURNAL   J Cell Biol 147 (7), 1473-1480 (1999)
   PUBMED   10613905
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Shimuta,M., Komazaki,S., Nishi,M., Iino,M., Nakagawara,K. and
            Takeshima,H.
  TITLE     Structure and expression of mitsugumin29 gene
  JOURNAL   FEBS Lett 431 (2), 263-267 (1998)
   PUBMED   9708916
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB010140.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010140.1, AK082471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.87 cM"
     gene            1..3247
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /note="synaptophysin like 2"
                     /db_xref="GeneID:17306"
                     /db_xref="MGI:MGI:1328311"
     exon            1..236
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..977
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /note="mitsugumin 29"
                     /codon_start=1
                     /product="synaptophysin-like protein 2"
                     /protein_id="NP_032622.1"
                     /db_xref="CCDS:CCDS57253.1"
                     /db_xref="GeneID:17306"
                     /db_xref="MGI:MGI:1328311"
                     /translation="MSSTESPGRTSDKSPRQQVDRLLLGLRWQRLEEPLGFIKVLQWL
                     FAIFAFGSCGSYSGETGALVLCNNEAKDVSSIIVLFGYPFRLYQVQYEMPLCDQDSTS
                     KTMNLMGDFSAPAEFFVTLGIFSFFYTMAALVIYLRFHKLYTENKRFPLVDFCVTVSF
                     TFFWLVAAAAWGKGLTDVKGATRPSSLTAAMSVCHGEEAVCSAGATPSMGLANLSVLF
                     GFINFFLWAGNCWFVFKETPWHGQGQDQGQGPSQESAAEQGAVEKQ"
     exon            237..311
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /inference="alignment:Splign:2.1.0"
     exon            312..436
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /inference="alignment:Splign:2.1.0"
     exon            437..638
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /inference="alignment:Splign:2.1.0"
     exon            639..830
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /inference="alignment:Splign:2.1.0"
     exon            831..3247
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
                     /note="hexamer: AGTAAA"
     polyA_site      2383
                     /gene="Sypl2"
                     /gene_synonym="Mg29"
ORIGIN      
        1 gcggggcagc gcggcggaca gagcctccga gagcgcgagc agcagcgccc ccacgaccca
       61 gcccgccagc ctggagcccg gcctgcccac ggcctcgagc ccgccgcccc cagcgccccc
      121 gcgccccacg cagcctcccg gccagggagt cgaacccttg cactgcgccc cgacgcgcca
      181 gcatgtcctc gacggagagc cccggccgca cctcggacaa gtctccgcgc cagcaggtgg
      241 accgcctgct cctggggctg cgctggcagc gcctggagga gccgctgggc ttcatcaaag
      301 ttctccagtg gctctttgct attttcgcct tcgggtcctg cggctcttac agcggggaga
      361 cgggagcctt ggttctctgc aacaacgaag ccaaggacgt gagctccatc attgttttgt
      421 tcggctatcc cttcaggttg taccaggtcc agtatgagat gcctctctgt gatcaggact
      481 ccacctccaa aaccatgaac ctcatgggag acttctctgc ccccgccgag ttctttgtga
      541 cccttggcat cttttccttc ttctacacaa tggctgccct ggtcatctac ctgcgcttcc
      601 acaaactcta cacagagaac aaacgcttcc cgttggtgga tttctgtgtg actgtctctt
      661 tcaccttctt ttggctggtt gctgccgctg cctggggcaa gggcttgact gacgtcaaag
      721 gggccacccg gccatccagc ctgactgcag ccatgtctgt gtgccatgga gaggaggcag
      781 tgtgcagcgc cggggccaca ccctctatgg ggctggctaa cctctctgtg ctctttggct
      841 ttatcaactt cttcctgtgg gctggaaact gttggtttgt gttcaaagag accccgtggc
      901 acggacaagg ccaggaccag ggccagggcc ccagccagga gagtgcagcg gagcaggggg
      961 cagtggagaa gcagtaagca gccttcatct gcctactccc caactggacg gcaccttgtc
     1021 agctcctcca gcttctacag gacctcctcc tcttcctctt cctcctgctc ctcctctccc
     1081 tcctcctcca actcccttcc cccatcattc tggactttga gatttgagag aatggatggg
     1141 tgggcatcag ctgttggtaa cctgggcaga cctccactgg cttcctatcc ctcatcctgc
     1201 tggggcagca aacggcagga tctcagtgct tcttgtctgc tgcctggact gaagcatctt
     1261 acttggggaa gctgactggc aaccttgccc tgagttctgt gtggagggcc caccagtgat
     1321 tttgtggcat ccctcaataa ctggcatcta atctgtatcc tatctctagc cctcccagag
     1381 cccagtgtgc tcccaccatg tgtgaagcag ggagacccat tatcctatca gaggtccctc
     1441 taagggtcca catgagaccc ggacccaatg ggagcagaga gagttgcaag tacattgcag
     1501 caccaaggaa gaaagtgagg aaagttgctg gcagaataag ttttctgttc cctcagccct
     1561 tcctttccct cagctggaac actttcggta gcaccctata caccacttac tcatgaaacc
     1621 ccttactccc ttctccttct cggccttggt tttgtgggct ttgggagggc ctgaaggacc
     1681 atcgtgacat gagatgccca ggagtcccgg gacaaggata catgggccca cctgtccctt
     1741 accgtctgtt cattttctca agccagcacc ttttctagtt ctttcaaacc tttctgtccc
     1801 atctttacaa agagggttat ctgtccttgt ctctcgcctc catgcagtag ccaggcccca
     1861 tccttcccca gtcctgggca gcccgatgct attggtgctt cttcatttcg ggacccagat
     1921 ccatatttgt ctttggtgtg tctcctctcc ctgattcctc ctgtcatccc tctttgggcc
     1981 cgaaggccag agggtaccaa ctgggcaaat gccatctgcc ttttacccag atcaaaaccc
     2041 cttgatctac cctggcagta gggttgctta gggaaagatg ataaagaagg aagaaaccag
     2101 ccgtttccca atttagtggc aattgtccca cttagcaccc caaagatgaa tgtaccttgt
     2161 gccaacctgt cctcatgaca tgatcgaccc tctccaaccc ccttgccttc ctcaatgcta
     2221 cccacatcaa gatgtatttc ttgggggccc agggctcaga atccttaact ttgggctgtt
     2281 catttcttct ttgggttaca attcccccac ccttcagagg aagtaggata tttacacact
     2341 ttcagatgct cccgagccat tcagtaaaat aatttggaat ttttgttttc tgcttaagat
     2401 tttagggaaa agatttaagg aggggaaaat ttgatgaggg tgagaatgat cctaaatctg
     2461 aaactctcta tcctaagttg tccccatggt tacttaagga caagggagac agttttgcct
     2521 ccagctccag aggtacaaag aacaaaagag tgaccatttt tcttcaaaca agtccctgtg
     2581 gggatctggg agcagcttcg actcaaactg tgtttggatt ctgcgtctat atttataatt
     2641 tatttgaact gtgacggata aagtgttctc atttggggcc caagttagca actggcccat
     2701 caactacttt agagtaggag ttatccactc ccaccgagca ttcgtactcc agggctcgct
     2761 ctagggttga aaaggctctt cctggcaaga gtctggctat ggccaagaga gtcttgattt
     2821 aggctatggt ctttccatgg ccgccggaag aggaaagacc agttcacctc attacctcca
     2881 gggggctggg cagcagtaag tgccaagggc agctctgtcc tcatgagact cgtgtcctct
     2941 ccaaccaggg ctggcaccac cactttgcct agtcaggcct gaagcgggag aggtgtctgg
     3001 tttctctagc tattgcagga ggccaacaag cagggaactt gccctttgcc ctggtagact
     3061 ttaccatgtg gagacgccta tccaggacct ttcttagaca tgagtcccct tcaacatcct
     3121 gaccatgggc ctcctatttc tgggattgca gatcgaggat gtggggagaa tgttgcatgt
     3181 tgttctgtgg tgcttgttac tacacatttg aataaacagt gctgcgaaca tttgccaaga
     3241 agaagcc
//
