LOCUS       NM_198710               4615 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synaptophysin like 1 (Sypl1), transcript variant 2,
            mRNA.
ACCESSION   NM_198710
VERSION     NM_198710.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4615)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4615)
  AUTHORS   Liu,J., Hermo,L., Ding,D., Wei,C., Mann,J.M., Yan,X., Melnick,A.F.,
            Wu,Y., Withrow,A., Cibelli,J., Hess,R.A. and Chen,C.
  TITLE     SYPL1 defines a vesicular pathway essential for sperm cytoplasmic
            droplet formation and male fertility
  JOURNAL   Nat Commun 14 (1), 5113 (2023)
   PUBMED   37607933
  REMARK    GeneRIF: SYPL1 defines a vesicular pathway essential for sperm
            cytoplasmic droplet formation and male fertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4615)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 4615)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4615)
  AUTHORS   Pogson,G.H.
  TITLE     Nucleotide polymorphism and natural selection at the pantophysin
            (Pan I) locus in the Atlantic cod, Gadus morhua (L.)
  JOURNAL   Genetics 157 (1), 317-330 (2001)
   PUBMED   11139512
REFERENCE   6  (bases 1 to 4615)
  AUTHORS   Windoffer,R., Borchert-Stuhltrager,M., Haass,N.K., Thomas,S.,
            Hergt,M., Bulitta,C.J. and Leube,R.E.
  TITLE     Tissue expression of the vesicle protein pantophysin
  JOURNAL   Cell Tissue Res 296 (3), 499-510 (1999)
   PUBMED   10370136
REFERENCE   7  (bases 1 to 4615)
  AUTHORS   Haass,N.K., Kartenbeck,M.A. and Leube,R.E.
  TITLE     Pantophysin is a ubiquitously expressed synaptophysin homologue and
            defines constitutive transport vesicles
  JOURNAL   J Cell Biol 134 (3), 731-746 (1996)
   PUBMED   8707851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB847647.1, AK049556.1 and AC155258.2.
            
            On Apr 18, 2009 this sequence version replaced NM_198710.2.
            
            Transcript Variant: This variant (2) lacks a segment of the 5' UTR
            and 5' coding region, compared to variant 1. These differences
            result in a unique 5' UTR and a protein (isoform 2) with a shorter
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167617.1, AK052556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BB847647.1         3-45
            44-1328             AK049556.1         1-1285
            1329-4615           AC155258.2         208087-211373
FEATURES             Location/Qualifiers
     source          1..4615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.87 cM"
     gene            1..4615
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /note="synaptophysin like 1"
                     /db_xref="GeneID:19027"
                     /db_xref="MGI:MGI:108081"
     exon            1..174
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..837
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synaptophysin-like protein 1; pantophysin; Pan I"
                     /codon_start=1
                     /product="synaptophysin-like protein 1 isoform 2"
                     /protein_id="NP_942003.1"
                     /db_xref="CCDS:CCDS25873.1"
                     /db_xref="GeneID:19027"
                     /db_xref="MGI:MGI:108081"
                     /translation="MSAFQINLNPLKEPLGFIKILEWFASIFAFATCGGFKGKTEIQV
                     NCPKVGVNKNQTVTATFGYPFRLNQASFHTPPNVSVCDVNWEKHVLIGDYSSSAQFYV
                     TFAVFVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTD
                     IKVATGHRIVEELEICNPESGVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYK
                     ETSLHSPSNTSASHSQGGGPPTSGM"
     exon            175..302
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /inference="alignment:Splign:2.1.0"
     exon            303..510
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /inference="alignment:Splign:2.1.0"
     exon            511..702
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /inference="alignment:Splign:2.1.0"
     exon            703..4615
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /note="hexamer: AATAAA"
     polyA_site      2025
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /note="major polyA site"
     regulatory      4124..4129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /note="hexamer: AATAAA"
     polyA_site      4151
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
     regulatory      4419..4424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
                     /note="hexamer: TATAAA"
     polyA_site      4440
                     /gene="Sypl1"
                     /gene_synonym="D12Ertd446e; PanI; Pphn; Sypl"
ORIGIN      
        1 gccccgccgg ctccgcctcc cgctctcgcc gcggagtcgc tccggtctcg ccgctcccct
       61 cctccgcccc gcgtcctgac tctcttccct cctttccctc agaggatgtc cgccttccag
      121 atcaacctca acccgctcaa ggagccgctc ggcttcatca agatcctcga gtggtttgcc
      181 tccatctttg cttttgccac ctgtggtggg tttaagggca aaacagaaat tcaagtgaac
      241 tgtcctaaag ttggtgtcaa taagaaccag actgtgacag ctacttttgg ttatccattc
      301 aggttgaatc aggcatcatt tcatacacct ccaaatgtca gtgtgtgtga cgtgaactgg
      361 gaaaagcatg ttctcatagg tgattactcc tcttctgcac agttctacgt tacgtttgca
      421 gtctttgtgt tcctgtactg cattgctgcc cttctgctct atgttggtta cacgaacctc
      481 taccgggata gtcgcaaact gcccatgatc gactttattg ttactcttgt tgctactttt
      541 ttgtggttgg tgagttcctc agcctgggct aaagctctta cagatattaa agtagctact
      601 ggacacagaa ttgtggagga acttgaaatt tgtaatccag aatcaggagt gtcatgttac
      661 tttgtctctg tgactagtat gggctccctg aatgtatccg tgatctttgg ctttctgaat
      721 atgatacttt ggggaggaaa tgcttggttt gtgtacaagg agaccagctt acacagtccg
      781 tcaaatacgt cagcttccca cagccaaggc ggtggcccac ccacttctgg aatgtaacta
      841 aggggagaaa tacactgtat gaaatgtgtg ctctagcatg ccttgttgcc aacaccttga
      901 aaagcattat tgtttctaat aaaaagtaat ggctttttca gtaaattggt gggtttaaaa
      961 atttgctgct tttctacata aaatgtgcct tttctagaaa tttaagatgt aaatgtattt
     1021 ttacatgaaa gtttgaaaat tcgggagcct gttatgagat gatgttactt ttaactgaac
     1081 aataatttaa ctaagttgct tctaaagtgt ttacacctta aactttaaca taaaccttca
     1141 ttcagaaaac agttatgtcg tatcataata taggaagaat gtgtttggaa aatacactac
     1201 tgttagtttg tatacattag atctttcagg cttggcttgt ttaaagaaaa ccttgattgc
     1261 ataaatcata tttagaaaaa aattagtgca attttatatt tgaatattgt tcatgttaaa
     1321 atttttttga attgcaaaga ctgggtatat attttgtttc tgttttttct aaatgatctg
     1381 ctgtacttat taggtgtact aaaattgtct tagaagcgag ggtttgaaaa ttgtacaaat
     1441 gtgtagaggt aactttgcac ttgtgctgca tgggtatatc cattatttct ggtggtttct
     1501 taggcttgca aagagcacgg ttcccaagac gggtttatac acgtaggcgt tctccatcag
     1561 gcttgtttac tatcttttgt tcataccaag agaaaaaaat ctactttttt tttccagacc
     1621 ctgtttagag ggttactaaa aattaaggtt gccttttacg tttgaaatgt ttaacattta
     1681 gtcaatgatg tttcttctcc tgagtttaac attgatattg tgaaaataaa tgcagttcag
     1741 atttatttct taagattcat tcttcacaaa agggtgatta aggaattatg ctcataaagg
     1801 aacctaagca agctgtattg tgtgtgtgct gtgtgtacac acatttgtgt gtgctcagaa
     1861 tacatgcttt ctgctcctga ctttttgttg tacaggattc agattcctag tcctacaaga
     1921 tgatgtttgt gtgtaaggca cacctttttt gttgctttat tcatgacaaa gtgtcagttt
     1981 gagaatgtat gtttaataag caaacaataa agaagtgaaa ataaagaatg ccccgttgtt
     2041 atattacaat gaactcttca tcctaaaggt ataagcattg caaaatggaa cctcttttca
     2101 aagcaggaga tagaattaca atagtaattt taagtgccaa tagaacagac taaaatggtt
     2161 cagacatttc attcttgttt gaaaaatatt tataactatt agattgtctt cctggtaaat
     2221 attttataat tggtcactca aatagggaag attactgact gagggcatac aacttccagg
     2281 cctgtttcca tagttcagtt ggaagactgc ttgtctagct agccccgtcc atccttctgc
     2341 actactgcat acataagcca acgatggcag cccaagcctc aaatctcagc actccatagt
     2401 ttaagatcat ccttgcctgc ttggggagtt caaggctagc ctgggctata tcaatcagtg
     2461 aggagtactc ttttcctgct ctctctctct ctctctctct ctctctctct ctttacatat
     2521 accatctttt cctccctcct ccttcctcct cttccttttt cctcttcacc tccccatcct
     2581 gaagcgaaac tgctgggatt agaacctgtc cttggccagc tcccaagctg gctaacaagg
     2641 tgaagcctgt atttgtatct gaaaacatgg aaataaagaa tattgacctt ggactggaga
     2701 gatggctcag gggttaggag cactgactgc tcctccagag gacccacatg acatttaata
     2761 accagctata actcctagga ggatctaatg ttctcttctg gcttctacag gtattacata
     2821 cattcacaga cagtatgcat gcaggtaaaa cattcacata aacttaaact gacttcaaaa
     2881 aaaatatgaa aagcaaatgg gtctagaggt tttgaaatgt cttcagcaca ggttctccat
     2941 aaatgttagt tgtgtctaag acagcctgga gtccaagggg ctaggggaca caggctgaga
     3001 agcggaaaaa gctttaagca tctaagtttt tcctttggta gtgtttacaa tttggtttcc
     3061 cttaatcaat cctaagtgtt tgggtgtatt tgtttttctg ttggtgcaga tattggcaag
     3121 gctaatgaaa ttaaaaaaaa aaaaagtagt ccattgaaat gagagtaaac tcagaaaggg
     3181 ctcctgctag cctcccctcc ccgctgtttt ttagggaaca ttgtagaggc aatttctagg
     3241 acagaagtga taagctttaa cttcccagaa gacaagctgc agagagacag ctaacagact
     3301 cgttactaat tgtttttaaa aaacattcac ctagataaag atctttaaat gtgtaaaagg
     3361 taggggtaga attacatggt attttgtgtt tgggcataat tataattttt atgtaatatt
     3421 tccagaaaca ggtgcctgta aaatcatacc gaagaacttt atatgtacca gatttttaaa
     3481 agaaataaaa tattgctaga agaacttgtt cctcatggag atagaattgg tacagatagc
     3541 tcagaatgaa tattctcctc agtacttgat gctgccgggc cactcgtcac tgctctgagt
     3601 ttgaagcgtc atgtttgttt taaagcctgt ttgtggttgc tgttgaggct gacctccctt
     3661 tagtttagtt acagctcctc tgcttctcct gccttccctt ctcaaaccct tagctgagtt
     3721 ttcttctgtg agactttctc tgtggatgta cacagttccc tacatcacct tggtagtaac
     3781 cccttggcgt ttccatggct gcagtgttcg ccccatctgt ggcttgtatt ttcactggat
     3841 tttgtcatat aaatttgtaa tttcttcatt tcaatggtat gtaactacct tcctggtggg
     3901 tttagtttct gcaatggttt tggctgtggt gaagtcacat attcctgtat acattttaga
     3961 atcctcttat caagctccta aagacccttt gtgaggtttc agttgtgaag aattgcattg
     4021 aatttgtaca tcagttaatt tgtgaagaat tgtcaaattt ataatgccac agttttgtat
     4081 ttataaacat ggtatatttc tgcattttta ttttatgctt tccaataaag ttttataatt
     4141 ttctacataa agatttaaga ttatacttag cctcaagaat tttcatgctg tttacacaat
     4201 tacattagat tatattttga attgagttgt aattgtttat tgctgttata tataaacaac
     4261 atgtataggt ttttacctac tgataattat agaagttggc agtttttcaa accttgaatt
     4321 tttaatatgt aaattatcct ggtatttaat gtttatcatc tacagatgtt gatagtttta
     4381 tcatgtttgg aaattacaca ttctaaatat tctctaatta taaagtgatc ttcaagaaaa
     4441 cctgttttaa aagtagaaaa agtacattta cctgacatac tgactgataa ctgcttcagt
     4501 acatcacttg taatgacaga tttgcactgt tgtatattgg tagttgtagt aacgtaaact
     4561 ggtcagatcg attggttctt tatagagttg aattaaaccg atcacagtga gaatg
//
