LOCUS       NM_009305               2482 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus synaptophysin (Syp), mRNA.
ACCESSION   NM_009305
VERSION     NM_009305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2482)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 2482)
  AUTHORS   Zhang,Y., Karagiannis,D., Liu,H., Lin,M., Fang,Y., Jiang,M.,
            Chen,X., Suresh,S., Huang,H., She,J., Shi,F., Liu,J., Luo,D.,
            Angel,J.C., Lin,G., Yang,P., El-Rifai,W., Zaika,A., Oro,A.E.,
            Liu,K., Rustgi,A.K., Wang,T.C., Lu,C. and Que,J.
  TITLE     Epigenetic regulation of p63 blocks squamous-to-neuroendocrine
            transdifferentiation in esophageal development and malignancy
  JOURNAL   Sci Adv 10 (41), eadq0479 (2024)
   PUBMED   39383220
REFERENCE   3  (bases 1 to 2482)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2482)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2482)
  AUTHORS   Wang,C., Jiang,W., Leitz,J., Yang,K., Esquivies,L., Wang,X.,
            Shen,X., Held,R.G., Adams,D.J., Basta,T., Hampton,L., Jian,R.,
            Jiang,L., Stowell,M.H.B., Baumeister,W., Guo,Q. and Brunger,A.T.
  TITLE     Structure and topography of the synaptic V-ATPase-synaptophysin
            complex
  JOURNAL   Nature 631 (8022), 899-904 (2024)
   PUBMED   38838737
  REMARK    GeneRIF: Structure and topography of the synaptic
            V-ATPase-synaptophysin complex.
REFERENCE   6  (bases 1 to 2482)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 2482)
  AUTHORS   Newman,L.S., McKeever,M.O., Okano,H.J. and Darnell,R.B.
  TITLE     Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific
            vesicle coat protein
  JOURNAL   Cell 82 (5), 773-783 (1995)
   PUBMED   7671305
REFERENCE   8  (bases 1 to 2482)
  AUTHORS   Blair,H.J., Ho,M., Monaco,A.P., Fisher,S., Craig,I.W. and Boyd,Y.
  TITLE     High-resolution comparative mapping of the proximal region of the
            mouse X chromosome
  JOURNAL   Genomics 28 (2), 305-310 (1995)
   PUBMED   8530041
REFERENCE   9  (bases 1 to 2482)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   10 (bases 1 to 2482)
  AUTHORS   Ozcelik,T., Lafreniere,R.G., Archer,B.T. 3rd, Johnston,P.A.,
            Willard,H.F., Francke,U. and Sudhof,T.C.
  TITLE     Synaptophysin: structure of the human gene and assignment to the X
            chromosome in man and mouse
  JOURNAL   Am J Hum Genet 47 (3), 551-561 (1990)
   PUBMED   1975480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY239748.1, AK043756.1, BC052354.1 and AI325251.1.
            
            On Jan 30, 2008 this sequence version replaced NM_009305.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090259.1, BC014823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               BY239748.1         1-104
            105-1203            AK043756.1         2-1100
            1204-2226           BC052354.1         1098-2120
            2227-2482           AI325251.1         7-262               c
FEATURES             Location/Qualifiers
     source          1..2482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.44 cM"
     gene            1..2482
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /note="synaptophysin"
                     /db_xref="GeneID:20977"
                     /db_xref="MGI:MGI:98467"
     exon            1..149
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1058
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /note="BM89 antigen; major synaptic vesicle protein p38;
                     Syp I"
                     /codon_start=1
                     /product="synaptophysin"
                     /protein_id="NP_033331.2"
                     /db_xref="CCDS:CCDS29967.2"
                     /db_xref="GeneID:20977"
                     /db_xref="MGI:MGI:98467"
                     /translation="MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATC
                     GSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYS
                     SSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSA
                     WAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVG
                     NLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQ
                     PDYGQPASGGGGGYGPQGDYGQQGYGQQGAPTSFSNQM"
     exon            150..215
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     exon            216..340
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     exon            341..539
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     exon            540..731
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1062
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..2482
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /note="hexamer: AATAAA"
     polyA_site      2479
                     /gene="Syp"
                     /gene_synonym="A230093K24Rik; p38; Syn"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcaaggg gcgtggctgc cgccgactgg gctgttccga cgatcgcgca ccgcccccgc
       61 cgctccccgc gcccgccctt gctaccaggc accttccgcc ccccgcattg ctgatgctgc
      121 tgctggcaga catggacgtg gtgaatcagc tggtggctgg gggtcagttc cgggtggtca
      181 aggagcccct tggcttcgtg aaggtgctgc agtgggtctt tgccatcttc gcctttgcta
      241 cgtgcggcag ctacaccgga gagcttcggc tgagcgtgga gtgtgccaac aagacggaga
      301 gtgccctcaa catcgaagtc gaatttgagt acccattcag gctgcaccaa gtgtactttg
      361 atgcaccctc ctgcgttaaa gggggcacta ccaagatctt cctagttggt gactactcct
      421 cctcggctga attctttgtc accgtggctg tgtttgcctt cctctactcc atgggggccc
      481 tggccaccta catcttcctg cagaacaagt accgagagaa caacaaaggg ccaatgatgg
      541 acttcctggc cacagcagtg ttcgctttca tgtggctagt tagctcatcc gcctgggcca
      601 aaggcctgtc cgatgtgaag atggccactg acccagagaa cattatcaag gagatgccta
      661 tgtgccgcca gacaggaaac acatgcaagg aactgaggga ccctgtgact tcaggactca
      721 acacctcggt ggtgtttggc ttcctgaacc tggtgctctg ggttggcaac ctatggttcg
      781 tgttcaagga gacaggctgg gccgccccat tcatgcgcgc acctccaggc gccccagaaa
      841 agcaaccagc tcctggcgat gcctacggcg atgcgggcta tgggcagggc cccggaggct
      901 atgggcccca ggactcctac gggcctcagg gtggttatca acccgattac gggcagccag
      961 ccagcggcgg tggcggtggc tacgggcctc agggcgacta tgggcagcaa ggctacggcc
     1021 aacagggtgc gcccacctcc ttctccaatc agatgtaatc tggtcagtga agcccacgaa
     1081 gaccccacgg gtgggcaaga gctcaagaga aggcctgccc cccttcccat ccccatatcc
     1141 taggtctcca cccctcaacc caggagaccc tgtctttgct gtttatatat atatatatta
     1201 tatataaata tctatttatc tgtctgagcc ctaccttcac ccactcctcc atgcactagg
     1261 ggcccagtcc tgaatgggct cctccctacc cctgaccttg cactcctcag cccctatcgg
     1321 ttccccagcc ctgtcccgtg atgtaagggg gctctagaaa ggggacagga agggggccag
     1381 accttggctg catggagtgg gtcgatgtga ctttttcccc cttccttctc tccctctgcc
     1441 cctcctaact ctagccttgg ttcctccagc atcgcctgaa cttaagaagc tctcaaatgg
     1501 aaattcaacc ccaagagtag aggggtggag gtggcttgga tgaaatgggt ggagaggaga
     1561 tggcctctgt agagagagga ccagtcagcc aaaagttgaa ttccacacat actggatgtg
     1621 gagcctaaaa gggaagtggt gtcctacacc attctggaat ggggctaaaa gggactgggg
     1681 agaggggtac taggaggggt gtggcttaaa cacatggtgg gttccggagt gggcaggttt
     1741 gggttggatc cagcatctct agaaggggtg tgtcttggaa cattcaggag tttgagcttg
     1801 attccaaaga gcttgagcaa ggctagaagt gggattcggg aatgatctaa gcttgagaga
     1861 aggttctggt caggattgca gacaggcagg tgaagaggac gagggatgtg tggtgctctc
     1921 agaagaggaa gcccattctg taatggggca gaaaagaaaa tacggtttca gttgagtgga
     1981 gtttgagcag tgggtgtagg aggccatggt tgggagctgt gaggtgagtt ttgctaaaag
     2041 taggaaggag tactcctgat tccaccccac gccccagaac ggacataacc tgggaagagc
     2101 caagtattgt ggtttggagg gtgagcgaaa tgtcccttac tgactccctc agaagagggc
     2161 tagataatca gaagacagaa tctacaggtc tgtggggctg gcctaccttc tccacccttt
     2221 ctctgccctc tccctccaca ctcccgtctg tcccggagca ctgggaggct ggctctggag
     2281 ccccaatcct ggaccctctg ctgtgtctgt gacgttggta gtgcctgtga tcgtgtgttg
     2341 ccattttgtc tgactgtggc ccctcccttt tccctccaga ccccctactt tcctgtgccc
     2401 ttcggtattg tttgaagacc cccctcccca aggaagagca aatatgagaa ccccccccaa
     2461 taaactcctc aactatctag tc
//
