LOCUS       NM_001163032            2657 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus synaptoporin (Synpr), transcript variant 2, mRNA.
ACCESSION   NM_001163032
VERSION     NM_001163032.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   van de Haar,L.L., Riga,D., Boer,J.E., Garritsen,O., Adolfs,Y.,
            Sieburgh,T.E., van Dijk,R.E., Watanabe,K., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Posthuma,D., Meye,F.J., Basak,O. and
            Pasterkamp,R.J.
  TITLE     Molecular signatures and cellular diversity during mouse habenula
            development
  JOURNAL   Cell Rep 40 (1), 111029 (2022)
   PUBMED   35793630
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Suh,J., Romano,D.M., Nitschke,L., Herrick,S.P., DiMarzio,B.A.,
            Dzhala,V., Bae,J.S., Oram,M.K., Zheng,Y., Hooli,B., Mullin,K.,
            Gennarino,V.A., Wasco,W., Schmahmann,J.D., Albers,M.W., Zoghbi,H.Y.
            and Tanzi,R.E.
  TITLE     Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating
            Cerebral BACE1 Transcription
  JOURNAL   Cell 178 (5), 1159-1175 (2019)
   PUBMED   31442405
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Raja,M.K., Preobraschenski,J., Del Olmo-Cabrera,S.,
            Martinez-Turrillas,R., Jahn,R., Perez-Otano,I. and Wesseling,J.F.
  TITLE     Elevated synaptic vesicle release probability in
            synaptophysin/gyrin family quadruple knockouts
  JOURNAL   Elife 8, e40744 (2019)
   PUBMED   31090538
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Chung,J., Franklin,J.F. and Lee,H.J.
  TITLE     Central expression of synaptophysin and synaptoporin in nociceptive
            afferent subtypes in the dorsal horn
  JOURNAL   Sci Rep 9 (1), 4273 (2019)
   PUBMED   30862809
  REMARK    GeneRIF: Central expression of synaptophysin and synaptoporin in
            nociceptive afferent subtypes in the dorsal horn.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Machado,C.B., Kanning,K.C., Kreis,P., Stevenson,D., Crossley,M.,
            Nowak,M., Iacovino,M., Kyba,M., Chambers,D., Blanc,E. and
            Lieberam,I.
  TITLE     Reconstruction of phrenic neuron identity in embryonic stem
            cell-derived motor neurons
  JOURNAL   Development 141 (4), 784-794 (2014)
   PUBMED   24496616
  REMARK    Erratum:[Development. 2014 Mar 15;141(6):1416]
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Kotani,T., Murata,Y., Ohnishi,H., Mori,M., Kusakari,S., Saito,Y.,
            Okazawa,H., Bixby,J.L. and Matozaki,T.
  TITLE     Expression of PTPRO in the interneurons of adult mouse olfactory
            bulb
  JOURNAL   J Comp Neurol 518 (2), 119-136 (2010)
   PUBMED   19924828
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Medrihan,L., Rohlmann,A., Fairless,R., Andrae,J., Doring,M.,
            Missler,M., Zhang,W. and Kilimann,M.W.
  TITLE     Neurobeachin, a protein implicated in membrane protein traffic and
            autism, is required for the formation and functioning of central
            synapses
  JOURNAL   J Physiol 587 (Pt 21), 5095-5106 (2009)
   PUBMED   19723784
REFERENCE   10 (bases 1 to 2657)
  AUTHORS   Singec,I., Knoth,R., Ditter,M., Hagemeyer,C.E., Rosenbrock,H.,
            Frotscher,M. and Volk,B.
  TITLE     Synaptic vesicle protein synaptoporin is differently expressed by
            subpopulations of mouse hippocampal neurons
  JOURNAL   J Comp Neurol 452 (2), 139-153 (2002)
   PUBMED   12271488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD354682.1, AK032442.1, AK049661.1 and AC132330.5.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032442.1, AK049661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                CD354682.1         1-99
            100-2542            AK032442.1         2-2444
            2543-2647           AK049661.1         2389-2493
            2648-2657           AC132330.5         142164-142173
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 6.86 cM"
     gene            1..2657
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /note="synaptoporin"
                     /db_xref="GeneID:72003"
                     /db_xref="MGI:MGI:1919253"
     exon            1..395
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..1169
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; synaptorin"
                     /codon_start=1
                     /product="synaptoporin isoform 2 precursor"
                     /protein_id="NP_001156504.1"
                     /db_xref="CCDS:CCDS49402.1"
                     /db_xref="GeneID:72003"
                     /db_xref="MGI:MGI:1919253"
                     /translation="MCMVIFAPLFAMFAFATCGGYSGGLRLSVDCVNKTESNLSIDIA
                     FAYPFRLQQVTFEVPTCEGKEQQKLALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIF
                     FQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQ
                     PSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQRYLSDPMEKH
                     SSSYNQGRYNQESYGSSGGYSQQANLGPTSDEFGQQPSGPTSFNNQI"
     exon            396..520
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /inference="alignment:Splign:2.1.0"
     exon            521..719
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /inference="alignment:Splign:2.1.0"
     exon            720..911
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /inference="alignment:Splign:2.1.0"
     exon            912..2657
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /note="hexamer: AATAAA"
     polyA_site      2574
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /note="major polyA site"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
                     /note="hexamer: AATAAA"
     polyA_site      2649
                     /gene="Synpr"
                     /gene_synonym="1500003F20Rik; SPO"
ORIGIN      
        1 gcttgtgcaa agcagcctgc acttgcagtt gtgagcagag agccaagtgt gggagtgcac
       61 aacggaggta acgtcctccc cacaaagcag ccagcacaca gcaagggagt atcaggttcc
      121 tgtagtcagc tgtgggctgt cactgtctac taatatgact gtcttcccat ctctctgcaa
      181 gaaggcagaa gctgctatct gattggtata gcatctgact ttccctctgc attgatttct
      241 tgtccttttc ctttgcttca taaagagagg gacaagagct ggtgctgtgg acagagaagc
      301 ttcattttta gtatgagaca acctctttat tttttcagga gagggaagtt ggattatcaa
      361 ttcttttgta aatgtgtatg gtgatatttg ctccgctttt tgcaatgttt gcatttgcaa
      421 catgtggtgg ctattcagga ggcctgcggc tgagtgtgga ctgtgtcaat aagacagaaa
      481 gtaacctcag cattgacata gcgtttgcgt acccattcag gctgcaacag gtgacctttg
      541 aagtgcccac ctgtgaggga aaggaacagc agaagctggc attggttgga gactcctcat
      601 cctcagcaga attctttgtc accgtggctg tgttcgcctt tctctactcc ctggctgcca
      661 cggtcgtgta cattttcttc cagaacaagt accgcgaaaa caaccggggc ccactcattg
      721 actttatcgt cactgtagtc ttttcattct tgtggctggt gggttcctct gcttgggcaa
      781 aaggactgtc tgatgtcaaa gtggcaacag atcccaaaga agtcctgttg ctgatgtcag
      841 cttgcaagca gccttccaac aagtgcatgg ctgtccacag ccctgtcatg tccagcttaa
      901 acacatctgt ggtcttcggg tttttgaatt ttatcctctg ggctggaaac atttggtttg
      961 ttttcaagga gactggctgg cattcctctg gacagagata cctttcagac cccatggaga
     1021 agcactccag cagctacaat caaggacgct acaaccaaga gagttatggg tcaagtggtg
     1081 ggtacagcca gcaggcgaat ctggggccaa cttccgatga gtttggccaa cagcctagtg
     1141 gtcccacttc ctttaacaat cagatataac ggagtatcac ccaaattctt ctggtgatag
     1201 catcaccacc ctccatttca gtagcagaag aatttttaag agtttcaatc aattattaat
     1261 gtagagaatg ttgaatgtaa atcagagatc tgtagtcctc attaagacac aaaggcctgg
     1321 gtggtgataa atggtactta gagatgagat gtcataagga gataaattat tcatcacaga
     1381 tgggtaatta gaaagtatct tgttatatac acagacactt ttatggtcgt tttgtattgt
     1441 ggtaaaaata gtagaagcat ttgtagctta aagtctctag tatgtaatgt gcatagatta
     1501 ccttaaatag tatacagttt tcgtatgtgt tttgatgcaa caaatatttt actgatttct
     1561 agatgactat ttgatgaatc acatcatgca tgcattacta ttttttagtt taggcctttt
     1621 agaactgtaa ctctgttttg ataattattc tctattgttt tcacttgata aaacaatgtt
     1681 tatatgattt catgcatgaa taagtatttt ctcacagaat gtttggctgt atttctggag
     1741 acatttcagt ttgcatcatg agtttgttaa gcaagtattt aaagacatgt atgcatgtct
     1801 ttctagactt tgcaagtttg tcactctgac tttacccaag ttctgaatgc attagagcta
     1861 aagtctggga gctttcccta tttgtcaata gtgttctgta aggtgactgc tcaacacttc
     1921 tctgatttat ttaagtaaat atttacattc ttgtaacttt ctatgcagtt tcgtgtatct
     1981 tatcttacga gccatgactg ataacgtcca atgaccctgt gcttgtagag tggcgttttc
     2041 tttgcatcca gagaggcaga tttagacacc atagtttaag tagtattaag aaatgagcta
     2101 tgctgtttta tgtgaccaaa tgaacgtttg tttagttttg tttatttttg aagctaatat
     2161 gttgttcatt ctaattttag aaatctcatg ttatagctta acagaattac taatttcgat
     2221 ttgcttatac atagattaat aatggcttct ctatgtcact ctattcccaa agagggttct
     2281 catgaaactc tccacagaac atattcatta ttaagaagaa accaatcttc gtttcttcat
     2341 tttaactcaa ttgaaataag aatgcccaac aggaagggca agctaaacat ctgtgcttct
     2401 agataaagtt gtaactgatg tgcaaattgt atgtgtgatc tgtgatgttg aaagcagttt
     2461 agcacaaaat aggctgtctt aaatactatc tgtaactagt ttcttaaatc ctattgttta
     2521 ttaaatcctg tactgtgata tctatttgac ctcaataaag ttattgcata caaactgact
     2581 gaacaatgaa gaatcataac tatagggccc tgttggcttt aatcatgaga gaataaaggt
     2641 taaatgcaat tcttcta
//
