LOCUS       NM_001310431            4449 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus synaptopodin 2-like (Synpo2l), transcript variant 1,
            mRNA.
ACCESSION   NM_001310431 XM_006519486
VERSION     NM_001310431.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4449)
  AUTHORS   Yamada,H., Osaka,H., Tatsumi,N., Araki,M., Abe,T., Kaihara,K.,
            Takahashi,K., Takashima,E., Uchihashi,T., Naruse,K. and Takei,K.
  TITLE     Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin
            Contributes to Actin Bundle Formation in Cardiomyocytes
  JOURNAL   Cells 13 (16), 1373 (2024)
   PUBMED   39195263
  REMARK    GeneRIF: Direct Binding of Synaptopodin 2-Like Protein to
            Alpha-Actinin Contributes to Actin Bundle Formation in
            Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4449)
  AUTHORS   van Eldik,W., den Adel,B., Monshouwer-Kloots,J., Salvatori,D.,
            Maas,S., van der Made,I., Creemers,E.E., Frank,D., Frey,N.,
            Boontje,N., van der Velden,J., Steendijk,P., Mummery,C., Passier,R.
            and Beqqali,A.
  TITLE     Z-disc protein CHAPb induces cardiomyopathy and contractile
            dysfunction in the postnatal heart
  JOURNAL   PLoS One 12 (12), e0189139 (2017)
   PUBMED   29206857
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4449)
  AUTHORS   van Eldik,W., Beqqali,A., Monshouwer-Kloots,J., Mummery,C. and
            Passier,R.
  TITLE     Cytoskeletal heart-enriched actin-associated protein (CHAP) is
            expressed in striated and smooth muscle cells in chick and mouse
            during embryonic and adult stages
  JOURNAL   Int J Dev Biol 55 (6), 649-655 (2011)
   PUBMED   21948713
  REMARK    GeneRIF: analysis of CHAP expression in mouse during embryonic and
            adult stages; CHAP is expressed in the developing heart and
            somites, as well as muscle precursors of the limb buds in mouse and
            chick embryos
REFERENCE   4  (bases 1 to 4449)
  AUTHORS   Beqqali,A., Monshouwer-Kloots,J., Monteiro,R., Welling,M.,
            Bakkers,J., Ehler,E., Verkleij,A., Mummery,C. and Passier,R.
  TITLE     CHAP is a newly identified Z-disc protein essential for heart and
            skeletal muscle function
  JOURNAL   J Cell Sci 123 (Pt 7), 1141-1150 (2010)
   PUBMED   20215401
  REMARK    GeneRIF: essential for heart and skeletal muscle function
            GeneRIF: Cloning and characterization of CHAP, both a sarcomeric
            and nuclear protein which is essential for striated muscle
            development and function. Two isoforms are described: ChapA is
            predominantly expressed in adult muscle and ChapB in
            embryonic/fetal muscle.
REFERENCE   5  (bases 1 to 4449)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   6  (bases 1 to 4449)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY766488.1, BC137972.1 and AK084541.1.
            
            On Jul 14, 2015 this sequence version replaced XM_006519486.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BY766488.1         1-86
            87-3506             BC137972.1         1-3420
            3507-4449           AK084541.1         2737-3679
FEATURES             Location/Qualifiers
     source          1..4449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..4449
                     /gene="Synpo2l"
                     /gene_synonym="1110054M18Rik; Chap"
                     /note="synaptopodin 2-like"
                     /db_xref="GeneID:68760"
                     /db_xref="MGI:MGI:1916010"
     exon            1..264
                     /gene="Synpo2l"
                     /gene_synonym="1110054M18Rik; Chap"
                     /inference="alignment:Splign:2.1.0"
     exon            265..416
                     /gene="Synpo2l"
                     /gene_synonym="1110054M18Rik; Chap"
                     /inference="alignment:Splign:2.1.0"
     exon            417..931
                     /gene="Synpo2l"
                     /gene_synonym="1110054M18Rik; Chap"
                     /inference="alignment:Splign:2.1.0"
     exon            932..4449
                     /gene="Synpo2l"
                     /gene_synonym="1110054M18Rik; Chap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggccaagt tgcctgcctg tggtggtggg gggttgggag taggcctggg ttggcaggag
       61 caggacagcc ggacaggcag gctggacggg gtaccagcac ctcaacttct ctctcaggga
      121 cactgtccaa actccggggg ccacaggcta agctgtgcga tgggtgctga ggaggaggtg
      181 caggtcacat tagcaggggg agcaccctgg ggcttccgac ttcagggggg gaccgaacag
      241 aggaaacctt tacaggtatc taagatccga agacggagcc aggctggcag agcaggactc
      301 cgggagaggg accagctctt agcgatcaac ggggtttctt gcaccaactt ctcccatgcc
      361 agtgccatga ccctcatcga cgcctcaggg cgtcaacttg tccttactgt gaggagggta
      421 acagatgaag ggtctgtgag atccccatcc cccggagagc tacaggtgct atcaccctta
      481 tctccactga gtcctgagcc cccaggtgct cctgtttccc aggctcttca gcccacaagc
      541 cttcgttcac cccctgacag cgaagcttac tatggagaga cagatagtga tgttgatggc
      601 cctgccacac aagagaagcc acgccgaacc cgccgcagag gtcctgcaag gccttccctt
      661 ccaggagccc cacctgatga ggtgtacctg tctgacagcc ctgcagaacc agcacctgtt
      721 aaaactggct ctcccagcca gggcgacagc cgtgtaagct ccccatcttg ggaggaaggg
      781 gcagcccttc agcccccacc agcagaggca cttctgttac cccatggtcc actccggcct
      841 ggccctcatc tcatccctat ggtgggccct gtcccccacc cagtggcaga agatctcact
      901 accacctaca cccagaaggc caagcaagcc aaactgcaac gcgcagaaag cctccaggag
      961 aaaagcgtaa aggaggcaag aaccaaatgc cggaccattg catccctgct aacagcagcc
     1021 cccaaccctc actccaaggg ggtgcttatg tttaagaagc ggcggcagag agccaagaag
     1081 tacaccctag tgagttttgg ggccgcagct gggacaggaa cagaggagga ggacggcatc
     1141 cccccaacga gtgagtcgga gctggacgag gagaccttct cagacgcccg cagccttact
     1201 aatcaatccg actgggacag cccctatcta gacatggagc tggctagggc tggcttaggc
     1261 acagcagaga gtcagaactc tggactggga gggcagctaa gtgaggtctc tgggcgaggg
     1321 gtccagctct ttgaacagca gcgccagcgg gtagcctcca gctcccagga gctggctcag
     1381 gtgggcccag cagctatgct taatgggcag agtctgcagt ccccacctcg agcacagagt
     1441 gctcccccag aggcagctgt gctcccactc agccctttgt cggtccctgc agtcagccct
     1501 acccccttct tcccggatgg tggagccccc atccctgcac caagtatctt taacaggtca
     1561 gcgaggcctt ttaccccagg tttacaaggg caaaggtcag gtaccacctc agtgattttc
     1621 cggcccttgg cccctaagaa ggtgaatgaa ggcttgggga gcactagccc cgccccgtcc
     1681 cccttcgcag cccctccaca ggggcccacc cctctgccca gcttcaccac agtggttccc
     1741 agccacacgc cggtctctgg ggcttctagc agcacccaac gctcctctgg tcctgtgacc
     1801 gctaccagtt ccttgtacat cccagcccca agccggcctg ttacaccagg aggcgcccca
     1861 gaaccgccca ctcctcctag cgctgctgcc atgacctcca ccgcttccat cttcttgtcc
     1921 actccactaa gaaactctgc gcgcccggag gcgccgggcc ccgcggtccc cgagcctgcc
     1981 agcgttcggg agcagcgcat ctctgtgccg gctgcccgca ccggcatcct gcaggaggct
     2041 aggcgccggg gcacccgcaa gcagatgttc cggcctggga aggaagagac gaagaactcg
     2101 cccaacccgg agctgctgtc actagtgcag aacctggatg aaaaacctcg ggcgggcggt
     2161 gcggaatctg gtccggagga ggacgcttta agcctcgggg ctgaagcctg taacttcatg
     2221 cagccactag ggggcaggag ttacaagacc ttgcctcaag tatcaccgaa aaccccgcct
     2281 ccaatggctc ccaaaactcc accccctaca acgcctaaga ctccacctcc cgtggctcct
     2341 aaacctgggt cgcgagggct ccttgatggg ctagtgaatg gatcgacccc gatggtggga
     2401 atccctgagc cgccaaggct gcaagggagg ggcggggagc tatttgccaa acggcagagc
     2461 cgtgccgata ggtacgtggt ggaagctaca tctggctcta gccttaatcc aggccttcgc
     2521 cctagaagtc cttctcccac accctcactg cccccatcct ggaaatactc acccaacatc
     2581 cgtgccccac ctcctattgc ttacaaccca cttctctcac ccttttttcc ccaagctgcc
     2641 cgaactctcc ccaataaggc tcaatcccag gggcctcggg tgacccctaa gcagggtatc
     2701 aaggccctgg atttcatgcg acatcagcca taccaactta aaacggccat gttttgtttt
     2761 gatgagggtt cttcaactcc tggccccact tcagggcctc ccaaaactgc ccgagttcag
     2821 gagatccgca gattttccac tcctgcaccc cagcccactg cagagccctt ggctcccact
     2881 gtgcttgtcc ccagagcggc taccaccttg gacgaaccca tttggagggc agagctggcc
     2941 tcaacccctg tccctaaccc agaccatcaa gagtctctca ggagctttgc tgccgctccc
     3001 agttcctgtg gtttccaagt agccaggccc cggttctcag ccaccagaac agggttgcag
     3061 gcccatgtct ggaggcctgg ggcagggcac cagtgagcag ggaataggtc ccaggaccaa
     3121 gtaatggaac ttagattccc agaagtttct tctgctttgt cctacctagg ctttctcccc
     3181 acatctgagg ccaattgccg attgccagag atagtgtttc cctcagcctc ctcagctctc
     3241 tgctggtgtt ttaaggccct tacctctctg ctttgcaatc ttctctatat ttccttgcct
     3301 ctctggcttc tccacccaga ggtctcagca ggtctctgtt ttccttttgc atttgtgttt
     3361 ctctctgtgg gcagcacttt agtgttaggt aaaaagcaca ctgtaaagtg accactgaga
     3421 tctcaggcaa aatggtcact cactgtaagg caagcttcta agaggctgaa ctgtgtccca
     3481 agcccctcca tcctcctcac tccgctttcc ctaggttagt tggcatacgc ctaggggtgt
     3541 gtgtgtgtgt gtgtatgtgt gtgtgtgtgt ctgtgtctgt gtgtgtgtgc gcgcgcgcat
     3601 gcgtgctttc acaaatatgt gtggttagga tctgctctag aaagacatca aatacacata
     3661 catgtgtgct tctcttgagg caaaggtaag agaggttttt tccccttcta ctgaaagggt
     3721 cagatagctt cagaaagacc tgtgggggtc aagagctact acagaaaaac tcctgagaga
     3781 ggagtgcctg tagcatgtag agatatgtgc acagcatctt gtgaaatcaa cgtgtctgac
     3841 aagactggga gacagggaca atttcatggg cctgagttat acaagctaga cccataataa
     3901 aactaagaat tctatttcct tggattacag gaagttagca accagggccc tgtgctgagc
     3961 acatcagaat ccagaaagta aaaaagaaat tttcttctga actgcttaat gagtgtaaga
     4021 cagaaaggat ggtgaagaga gccagagtgg atggcgggga gagcaaggca aaagccagga
     4081 acaaggctgg aatgagtgaa agtgaccaag gagagaggaa agttggctaa caagaaacta
     4141 tgtagccagg tggtggtggc tcacgccttt aattccagca cttgagaggc agaggcaggc
     4201 ggatttctga gttcaaggcc agaagggcaa ggatgggtct tttctaccct acccgtataa
     4261 gcccagtgct ttgcagattc aggccctcat gtctgatccc agaagggcaa ggactgtcct
     4321 tccgtgaaga ccaccaccag ccatgcttgc tgtttgacct ggaaaccaat cttttccttt
     4381 gcagtatttt gcagtattgg gtgtcataat tctttggttt gtgcacaaga ataaacgtat
     4441 gcccacacc
//
