LOCUS       NM_080451               7116 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synaptopodin 2 (Synpo2), transcript variant 1, mRNA.
ACCESSION   NM_080451 XM_619958 XM_915986
VERSION     NM_080451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7116)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7116)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   3  (bases 1 to 7116)
  AUTHORS   Lohanadan,K., Molt,S., Dierck,F., van der Ven,P.F.M., Frey,N.,
            Hohfeld,J. and Furst,D.O.
  TITLE     Isoform-specific functions of synaptopodin-2 variants in
            cytoskeleton stabilization and autophagy regulation in muscle under
            mechanical stress
  JOURNAL   Exp Cell Res 408 (2), 112865 (2021)
   PUBMED   34637763
  REMARK    GeneRIF: Isoform-specific functions of synaptopodin-2 variants in
            cytoskeleton stabilization and autophagy regulation in muscle under
            mechanical stress.
REFERENCE   4  (bases 1 to 7116)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 7116)
  AUTHORS   Turczynska,K.M., Sward,K., Hien,T.T., Wohlfahrt,J., Mattisson,I.Y.,
            Ekman,M., Nilsson,J., Sjogren,J., Murugesan,V.,
            Hultgardh-Nilsson,A., Cidad,P., Hellstrand,P., Perez-Garcia,M.T.
            and Albinsson,S.
  TITLE     Regulation of smooth muscle dystrophin and synaptopodin 2
            expression by actin polymerization and vascular injury
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (6), 1489-1497 (2015)
   PUBMED   25857312
REFERENCE   6  (bases 1 to 7116)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7116)
  AUTHORS   Faul,C., Dhume,A., Schecter,A.D. and Mundel,P.
  TITLE     Protein kinase A, Ca2+/calmodulin-dependent kinase II, and
            calcineurin regulate the intracellular trafficking of myopodin
            between the Z-disc and the nucleus of cardiac myocytes
  JOURNAL   Mol Cell Biol 27 (23), 8215-8227 (2007)
   PUBMED   17923693
  REMARK    GeneRIF: The identification of myopodin as a direct target of PKA,
            CaMKII, and calcineurin defines a novel intracellular signaling
            pathway whereby changes in Z-disc dynamics may translate into
            compartmentalized signal transduction in the heart.
REFERENCE   8  (bases 1 to 7116)
  AUTHORS   Faul,C., Huttelmaier,S., Oh,J., Hachet,V., Singer,R.H. and
            Mundel,P.
  TITLE     Promotion of importin alpha-mediated nuclear import by the
            phosphorylation-dependent binding of cargo protein to 14-3-3
  JOURNAL   J Cell Biol 169 (3), 415-424 (2005)
   PUBMED   15883195
REFERENCE   9  (bases 1 to 7116)
  AUTHORS   Weins,A., Schwarz,K., Faul,C., Barisoni,L., Linke,W.A. and
            Mundel,P.
  TITLE     Differentiation- and stress-dependent nuclear cytoplasmic
            redistribution of myopodin, a novel actin-bundling protein
  JOURNAL   J Cell Biol 155 (3), 393-404 (2001)
   PUBMED   11673475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121315.14 and AC121540.14.
            
            On or before Apr 19, 2009 this sequence version replaced
            XM_915986.2, XM_619958.3, NM_080451.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158045.1, SRR9219381.269916.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC121315.14        45775-46021
            248-399             AC121540.14        42917-43068
            400-1181            AC121540.14        46450-47231
            1182-3376           AC121540.14        49561-51755
            3377-7116           AC121540.14        83929-87668
FEATURES             Location/Qualifiers
     source          1..7116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.8 cM"
     gene            1..7116
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /note="synaptopodin 2"
                     /db_xref="GeneID:118449"
                     /db_xref="MGI:MGI:2153070"
     exon            1..247
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3916
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myopodin; mypodin"
                     /codon_start=1
                     /product="synaptopodin-2 isoform 1"
                     /protein_id="NP_536699.2"
                     /db_xref="CCDS:CCDS51063.1"
                     /db_xref="GeneID:118449"
                     /db_xref="MGI:MGI:2153070"
                     /translation="MGTGDFICISMTGGAPWGFRLQGGKEEQQPLQVAKIRSQSKASG
                     SGLREGDEVVSINGNPCADLTYPEVIKLMEGITDSLHLLVKRPSSGTSETLDSESETT
                     NHQHLTHEGPMESTTLQIQQATETQSEDFFLAPVQTKVPLTEDQSNAWGYAECPKEEQ
                     APPMLGSQEGHLVEEVILRQKAEAGQPGHVVELQLSLSKERHQCTSGPIVTLQGNDKS
                     TSPDPDWSSQLERTVHINSIPAPEKADTSLTSSTSSGRELRVIQGRDPGGAGLPQVEV
                     ILDCSDRLKAEECRLQTGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEHGEDQRSGKD
                     QSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRR
                     RARKYTLVSYGTGELEREEEEEEDQEAGDKDEISEVAFLGTSESEVDEELLSDVDDNT
                     QVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTG
                     GMAGGGPDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLASVPQQNGFSGVS
                     ETAGAQRMFPMNRTAKPFLGSMNQPAAPFSPTRSVTSPISDFPAPPPYSAVSPPPEAF
                     SRGVSSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEAKRR
                     GTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGGDSGPEEDYLSLGAEACNFMQSSA
                     KQKTPPPVAPKPAVKSPSSSQPVAPVSPVWSPGVAPAQRPAFSTSNPPNPPQVTAVSS
                     IKIAQPAAPPARPASALNLAGPFKGPQAVVVSHNYTPKPSAPTPLVNAAPAGAGGPSN
                     ELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPP
                     PVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNASLFTF
                     QPPDSKDGLPQKSTVKVSSAPAMKQALPPRQANVGSPTNAQASSVYSVPAYTSQPNFF
                     AAEATSPVSASPVPVSVPTSPKQESTSTSYFVAPRPKFSAKKSGVTVQENGRSLSLPG
                     RSAPPIISASPWLYQSACNYSSKPTFELEKANKRPTPWEAAARSPLGLVDDAFRPRNI
                     QESIVAHVVSAARRKVSPGSQEDWKERLSFVPQTQKTNMSFSERQEYPAPSPVNSHVS
                     SHSLYSSQLPYVCYRQESRNDLKTMSMETRSEYCLPLGGYDYNPHPRGWRQQP"
     exon            248..399
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1181
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..3376
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..7116
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7094..7099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /note="hexamer: AATAAA"
     polyA_site      7116
                     /gene="Synpo2"
                     /gene_synonym="1110069I04Rik; 2310068J10Rik;
                     9530006G20Rik; Myo"
                     /note="major polyA site"
ORIGIN      
        1 actttccccg cagccggcag cggggcagcc ttgcgtcctg caccctctgc accaccagcc
       61 cagcttaaga cgcgtcctct cctgcaccgc ggcttcccct ggctttctca agctcttgat
      121 gctgcccaac tgaaaggaga agatgggcac cggagatttc atctgcattt ccatgactgg
      181 aggggcgccc tgggggttca gactgcaagg aggcaaggag gagcagcagc ctttgcaagt
      241 tgcaaagatt cgaagccaga gcaaggcgtc gggctccggg ctgcgtgagg gggatgaagt
      301 ggtgtccatc aatggcaacc cctgtgcaga ccttacttac cctgaagtca tcaagcttat
      361 ggaaggcata acggactctc tgcacttgct tgttaaaaga ccctctagtg gaacaagtga
      421 gactttggat tctgaatcag aaactacaaa ccatcaacat cttacacatg aggggcccat
      481 ggaaagtacc accctgcaga ttcagcaagc caccgagacc cagagcgaag acttctttct
      541 tgctccagtc cagactaaag ttcccctaac tgaggaccaa agcaatgcct ggggttatgc
      601 agaatgtcca aaagaagaac aagctccccc gatgcttggc tcccaggaag gacacttggt
      661 agaagaggtc atcttaaggc aaaaggcaga agcaggccag ccaggccatg tggttgagct
      721 acagctgtcc ctctcaaagg aaagacatca atgcaccagt ggccctatag tgactctcca
      781 gggaaatgac aaatccacgt ctccagaccc agactggagc tcacaactcg agaggactgt
      841 ccacataaat tcgatccctg ctcctgagaa agcagacact tctctgacgt ccagcacctc
      901 cagtggccga gagttgagag tgatccaggg aagagaccca ggaggcgcag ggctgcccca
      961 ggtggaagtg attctagatt gctctgacag gctgaaggct gaagagtgca ggctgcagac
     1021 aggaaggggg tgtgtggctt ctcccgtgga aggagggcgg tcagaagcac ctccttctct
     1081 ggtctccttt gcggtctcgt cagaaggcac cgagcacgga gaagatcaac gctcgggaaa
     1141 ggatcagagc agaccacaca agcaccgtgc acgccatgct cggctcagga ggagtgaaag
     1201 tctatctgaa aagcaagtga aagaagcaaa gtctaagtgc aaaagcatcg ccctcctcct
     1261 aacggatgct cccaacccaa actccaaggg ggtgttgatg tttaagaagc ggaggcggag
     1321 ggcccggaag tacaccctag tcagttacgg tactggcgag cttgagcgag aggaggagga
     1381 ggaggaggac caggaagcag gtgacaagga cgagataagt gaggttgcat ttcttggaac
     1441 cagtgagtcg gaagtggatg aagagttgct gtctgacgtt gacgacaaca cccaagttgt
     1501 gaactttgat tgggattctg gactggtgga cattgaaaag agactcaacc gaggggacaa
     1561 gatggaaatg ttgccagaca ccacaggcaa gggagcgctc atgtttgcca agaggagaga
     1621 gaggatggaa cagttcacag cccaaaatga agaggagaag acgggtggga tggcaggtgg
     1681 aggaccggat gccctgcaga cggatggtct gagaaccatg acttcttatc agcgaaaaga
     1741 agaatcggta agaatgcaga gctctgtgag cgaaagttcc ttccagatgg gacgcagtct
     1801 tgccagtgtg ccacaacaga atggcttcag tggagtgtca gagacagcag gggcccagag
     1861 gatgttccct atgaatagaa ccgccaaacc cttcctggga tctatgaacc agccagcagc
     1921 accattctcc ccaacgcgga gtgtgacaag tcccatctct gacttcccgg ctccgccacc
     1981 atactctgcg gtctcacctc caccggaagc cttctctagg ggggtatcaa gcccagtggc
     2041 tggcccagca cagccccctc catggcccca gcctgctccg tggtcacaac cagccttcta
     2101 tgattcatct gaacaaatag cttcccgcga tgagagaatc gcagtgccgg ccaaaagaac
     2161 gggaatactg caggaagcca aaagacgagg cacaacaaaa cccatgttta ctttcaaaga
     2221 aaccaaagta agccccaacc ccgaactcct gtcacttctt caaaatgcag aaggcaagcg
     2281 aggcactgga ggggactctg ggcccgaaga agactacctc agtttaggcg cagaggcttg
     2341 taacttcatg cagagttctg ccaaacaaaa gaccccacct cctgtcgctc caaagcctgc
     2401 agtcaagtcc ccctcttcct cccaaccggt agccccagtt tctccagtct ggtctccagg
     2461 agtggctcca gcccagcgtc ctgccttctc cacatcaaat ccaccgaacc caccacaggt
     2521 cactgctgtg tcctccatca aaatagctca gcctgccgcc cctcctgccc ggcccgcgag
     2581 tgcgctgaac ctggctggtc ctttcaaagg tccccaagca gtagtggtca gtcataacta
     2641 cacgcccaag ccatcagcac ccacaccatt agtaaatgct gctcctgctg gtgcaggggg
     2701 accatccaat gagcttcctg gaatgagtgg gaaaggagcc caactcttcg ctaaaaggca
     2761 gtctaggatg gagaagtatg tggtagattc cgacacagtg caggcccaca cagttcgggc
     2821 ccagtctccc actccatccc tgcccgccag ttggaagtac tcctccaacg tccgagcacc
     2881 cccgcccgtg gcctacaatc ctatccattc cccctcttac ccactggctg ctatcaagtc
     2941 tcaaccaccg ggtgcccagg cttccaaaac gagcaagaaa aagggcaaga aacctcttaa
     3001 cactttggat gtcatgaagc accaaccgta tcagctcaac gcgtctttgt ttacctttca
     3061 accccctgat tcaaaggatg gcctccctca gaagtcaaca gtcaaggtca gttcagcccc
     3121 ggccatgaag caagccctcc ctccccggca ggcgaatgtt gggtctccca caaatgcgca
     3181 ggcttcttct gtgtactcgg taccagctta tacctctcag cccaacttct ttgccgcgga
     3241 ggccacttca cccgtcagcg catccccggt gcctgtgagt gtccccacct ctccaaagca
     3301 agaatcgacc tccacatcct attttgtggc tccaaggccg aagttctcag ccaagaaaag
     3361 tggggtcaca gttcaggaga acgggcgctc cctttctctc cctggaagat cggccccgcc
     3421 catcatttct gcatctccct ggctgtacca gtctgcttgc aattactcca gcaaaccaac
     3481 cttcgagctg gagaaagcta acaagagacc gacaccttgg gaagcagcag ccaggtcccc
     3541 tctcggtcta gtggatgacg ccttcagacc taggaacatc caggaatcca tcgtggcaca
     3601 tgtagtctcc gcagctcgga ggaaggtgtc tccagggtcc caagaggact ggaaagagag
     3661 actgtccttt gtccctcaaa ctcagaagac caacatgagc ttttcggaaa ggcaagagta
     3721 tcctgccccg tccccagtca acagccatgt gtctagccac tccttatata gttcccagtt
     3781 gccatatgtg tgttataggc aggagtccag aaatgatttg aaaacgatgt ccatggagac
     3841 taggtctgaa tattgtcttc cattgggtgg ttatgactat aacccacacc caagggggtg
     3901 gagacaacaa ccgtgaaagc ttgtgtgaca gttgtgtgga ttttgttgtt agagaggttc
     3961 tttattttta aaaatagact taaacccacg tttagtcctc tgtggctctc acagatcatt
     4021 tctctgagtg tacatgtgtg taaacacaca agtgtggatc acttccttat ctgccaatgc
     4081 ctaaggaact gctaggtaga caagagtcag agtgggcagg gcgtggtggc acacacccgt
     4141 aatctcagtg catatgagac aagtcaagaa accaggaatt caagaagatt actttcttgc
     4201 attgatattc tggcacttat ataaaaattc aaaatatgaa tttcatttgt aaggagtccc
     4261 atgcaactca actttgtctt cgtgtaaaga gagagaatcc aaacattttc ttctgcctta
     4321 gctcaaaaaa gaattattag actaggatgt agtgattacc aatacttcta atagtgagga
     4381 atataaaatt ctttgtatag atataacatg catttgccat ttaccttgtt caaatccacc
     4441 tgtcagccca ttgcctgtcc cggtgcctct agattttcct ctggctggtt cccatccttt
     4501 ctataaggac aaattcctaa ggcaagccca acaagaagta ataatcatac agaaaagaat
     4561 ttccttgatg ttatttcaaa catttctcta acacatttta ggtgtagttc agatgaatta
     4621 gaaggctgaa atggaaatgt tctattcttc ttcttttgtt tgtttgtgac agtcctttgc
     4681 tgtgtagccc tgactggtgt ggtactcctt ttgtagctca ggctatcctt aaactcatgg
     4741 ttccaccctg cctcaaccta cgcagtgcta gggtttcagg tgggcaccac tgtgcctgga
     4801 caggatggga atgtttttag acagggatat gtcagggtga gggtacgata caagccatat
     4861 ggacttagaa gaaaactgca atgtatggaa agcacacatc taggcattag atttatttcc
     4921 aatctattta aagccagcag cctgagacgg gaagacgtga gctgaagtgt tctcattcgt
     4981 cagatgagaa ggctggattg tctaattgct taggttcttt acaattctgc tatctcaaga
     5041 tcttctcgtt gaatgacctt tgatgcattg tttgtggtgg ctcatcacat agatatcaga
     5101 ttacctttag gagtggacga ggtcattaat gccaagaaat gcgtcactaa aggtcccaaa
     5161 aggaatttct aagtggctgg ttttgtgtaa gtggagtgaa gattgatgta aagataaaac
     5221 tattcatgga tttagggaag tagtagatgg atgtgcctgt cattgtgcaa ctgatgtgcc
     5281 tgatggctta tagaaacaaa cagaagtata cacacaaggg ctgcttctgg gctgttcaga
     5341 tgaagttagg cggctaactc gcctctccat taaccaaccc agccttataa gcatgaccac
     5401 gaacagatca acaccagctc cttaccaaca tacctcaaag cgttaaatac aagggaattc
     5461 aaagtagttc atatcatcat caagtttatt cagtcttttt taatttaaaa attcttcttg
     5521 gcttttcaaa catgataatt ttgctttatt ttcctttcat cttagcatta tgatggtagc
     5581 gcccacagaa taaaaatgga ttatgaggat gcagacagtc tgttacttta gaagttacaa
     5641 aaaagaaaat tgaagaattc tcagtaagtg gcaagagtgg ccacatgcta atttgttcaa
     5701 tcatgcagca aagagataga taactacttc ccaaaatatg attgctagcc ttatgcctgc
     5761 atcactctga gggatgaaga aaaaaggttg ctgaaaattc catgccagcc tgaactacaa
     5821 gttttataaa aactagagca aaagctttca ctgttaattt atctaaatca atatagtatt
     5881 aattccctta aagtataaaa tataattatt ggcatccatg agggtttttt taatgtatag
     5941 aatcttaaaa gaataatgtt aggccactgg agtcttaaga agtgtgcaca tatgatcctt
     6001 actggcttca attttgtcat caaatttatc actaggtgtt taagtcattc tggattaggc
     6061 tggttttaga agtggaggat taaaggaaaa gatgttactt aatgggtcca cattctctcc
     6121 tgctactttc ttttgtaagt actaggcttt attgccacca gttgactcac agcacactct
     6181 ttgctaaaac tcatttgatt caaggagcag atgtcttaga tattattata aaatgcactt
     6241 atcttttgct tgcaccacac caaaaattag cattgatatt gagctatctg aatgtattct
     6301 atacaacaga aaggctgcac attttcttca caagaacatg aatatcttta gcacacagtg
     6361 atgcttcaac acagtcaaat tgtgtagatg cctttgaata caatactacc actgcagact
     6421 agaaagtgat acagttccat gactgacagt cagccacccc aagatctggc ttttatggtg
     6481 ggtcattatg ttaccgtttt aagaagaata aaacaagttg gtctcatttt ccaagcaata
     6541 gcccttgcac agaagagttg tggctttaaa agctacacca catttgctac agatatattc
     6601 caatcatcag aagctacata gtgtcttact aaaggttgag cacagagaca ctaatcgggc
     6661 attgcctccc atccaagttt aaacattgta tcattgcata ggtgtgaaac cttagtagat
     6721 aattttaact tgaactctga gtgtggtggc tacacagatt ctagtccctt tgtttttgag
     6781 gctgtctcat gtttggcagc atcatgcacc ttgaagagca tgcacttagt ggggcttaat
     6841 cacagatatg catgtgtatt aatgacttaa aactttggag aaaaaaatgt atcaatttgg
     6901 gacagttata atggggggaa attgcagaaa tgtttgtttc ttaagaaaag gattttcaca
     6961 cttggattct attcaaagta gaagtaactg ctacacaggg catactttcc tattaggttg
     7021 ttatttctat ttctctctgt cctcaaaggc tgtatgtgaa agatttggac tgaaaaatcc
     7081 aaatgatatt agtaataaat gtaacttgaa aaccaa
//
