LOCUS       NM_207663               6960 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synemin, intermediate filament protein (Synm),
            transcript variant 2, mRNA.
ACCESSION   NM_207663
VERSION     NM_207663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6960)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6960)
  AUTHORS   Garcia-Pelagio,K.P. and Bloch,R.J.
  TITLE     Biomechanical Properties of the Sarcolemma and Costameres of
            Skeletal Muscle Lacking Desmin
  JOURNAL   Front Physiol 12, 706806 (2021)
   PUBMED   34489727
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6960)
  AUTHORS   Sward,K., Krawczyk,K.K., Moren,B., Zhu,B., Matic,L., Holmberg,J.,
            Hedin,U., Uvelius,B., Stenkula,K. and Rippe,C.
  TITLE     Identification of the intermediate filament protein synemin/SYNM as
            a target of myocardin family coactivators
  JOURNAL   Am J Physiol Cell Physiol 317 (6), C1128-C1142 (2019)
   PUBMED   31461342
  REMARK    GeneRIF: Synemin is a target of myocardin family coactivators.
REFERENCE   4  (bases 1 to 6960)
  AUTHORS   Ikegami,K., Saigoh,K., Fujioka,A., Nagano,M., Kitajima,K., Sato,C.,
            Masubuchi,S., Kusunoki,S. and Shigeyoshi,Y.
  TITLE     Effect of expression alteration in flanking genes on phenotypes of
            St8sia2-deficient mice
  JOURNAL   Sci Rep 9 (1), 13634 (2019)
   PUBMED   31541165
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6960)
  AUTHORS   Garcia-Pelagio,K.P., Chen,L., Joca,H.C., Ward,C., Jonathan
            Lederer,W. and Bloch,R.J.
  TITLE     Absence of synemin in mice causes structural and functional
            abnormalities in heart
  JOURNAL   J Mol Cell Cardiol 114, 354-363 (2018)
   PUBMED   29247678
  REMARK    GeneRIF: synemin plays an important regulatory role in the heart
            and that the consequences of its absence are profound.
REFERENCE   6  (bases 1 to 6960)
  AUTHORS   Mizuno,Y., Guyon,J.R., Okamoto,K. and Kunkel,L.M.
  TITLE     Synemin expression in brain
  JOURNAL   Muscle Nerve 36 (4), 497-504 (2007)
   PUBMED   17654553
  REMARK    GeneRIF: Alpha- and beta-synemin transcripts and their encoded
            proteins colocalize in neurons, especially in the midbrain and
            pons.
REFERENCE   7  (bases 1 to 6960)
  AUTHORS   Jing,R., Wilhelmsson,U., Goodwill,W., Li,L., Pan,Y., Pekny,M. and
            Skalli,O.
  TITLE     Synemin is expressed in reactive astrocytes in neurotrauma and
            interacts differentially with vimentin and GFAP intermediate
            filament networks
  JOURNAL   J Cell Sci 120 (Pt 7), 1267-1277 (2007)
   PUBMED   17356066
  REMARK    GeneRIF: Dmn is expressed in reactive astrocytes in neurotrauma and
            interacts differentially with Vim and Gfap.
REFERENCE   8  (bases 1 to 6960)
  AUTHORS   Izmiryan,A., Cheraud,Y., Khanamiryan,L., Leterrier,J.F.,
            Federici,T., Peltekian,E., Moura-Neto,V., Paulin,D., Li,Z. and
            Xue,Z.G.
  TITLE     Different expression of synemin isoforms in glia and neurons during
            nervous system development
  JOURNAL   Glia 54 (3), 204-213 (2006)
   PUBMED   16817202
  REMARK    GeneRIF: synemin gene encodes proteins belonging to the
            intermediate filament which confer resistance to mechanical stress
            and modulate cell shape.
REFERENCE   9  (bases 1 to 6960)
  AUTHORS   Xue,Z.G., Cheraud,Y., Brocheriou,V., Izmiryan,A., Titeux,M.,
            Paulin,D. and Li,Z.
  TITLE     The mouse synemin gene encodes three intermediate filament proteins
            generated by alternative exon usage and different open reading
            frames
  JOURNAL   Exp Cell Res 298 (2), 431-444 (2004)
   PUBMED   15265691
REFERENCE   10 (bases 1 to 6960)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143019.1 and AC158296.6.
            
            On Jul 25, 2007 this sequence version replaced NM_207663.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, that results in a
            shorter protein (isoform M), compared to isoform H.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143019.1, AJ579701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4302              AK143019.1         2-4303
            4303-6960           AC158296.6         82297-84954         c
FEATURES             Location/Qualifiers
     source          1..6960
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 37.12 cM"
     gene            1..6960
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /note="synemin, intermediate filament protein"
                     /db_xref="GeneID:233335"
                     /db_xref="MGI:MGI:2661187"
     exon            1..924
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..3894
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /note="isoform M is encoded by transcript variant 2"
                     /codon_start=1
                     /product="synemin isoform M"
                     /protein_id="NP_997546.2"
                     /db_xref="CCDS:CCDS39983.1"
                     /db_xref="GeneID:233335"
                     /db_xref="MGI:MGI:2661187"
                     /translation="MLSWRLQTGSEKAELQELNARLYDYVCRVRELERENLLLEEELR
                     SRLSREDRWAEDQALYAEEARSLRQQLDELNWSTALAEGERDALRRELLELQREGVEA
                     GTARSRLDAELGAQRRELEEALGARAALEALLGRLETERRDLDAAHERQVRDLRARAA
                     SLTMHFRARATSPAAPPPRLRDVHDSYALLVAESWRESVQLYEDEVRELEQALRRGQE
                     SRLQAEDEARLCAQEADALRNQALELEQLRARLEDELLRMREEYGMQAEERQRVIDSL
                     EDEKEALTLAMADRLRDYQELLQVKTGLSLEVATYRALLEGESNPEILIWTENIENVP
                     QEPRNTSYRYTNSVLQRKNEKNLFPRRKTPWAAVNHSSASYSNWPGHLDSQTTTAVGS
                     AARRGLLTSRHSSSATTSGQQKPLEKTISSRANLRPVTPTHGFLRNTDAQMKTLPHRS
                     KVEGTGDTHARRATESVITRESYRGHQGHVAAGAVSSTPSNERTVILGKKLEAQATKE
                     QERDRSGVIRIKPEEKMFDSKEKASEERNLRWEELTKLDRDARKRESRHLRDEAREKE
                     ALKERSVKEREVPISLEVSRGSRAEVSTIHLQSPGRKDVSHSGGREAETKETRFRLDT
                     QDTASSLQSDSTTETIAESIVTTILKQFTQSPGAEEEATSFPDTKVTYVDRKEFPGDG
                     KTKTEIVVESKLTDVVDVSDEAGLDYLLSKDVKEVGLKGKSTETMIGEMINLGLKGRE
                     GRAKVVNVEIVEEPMSYIGGGKIDFSTPFQVEEVDDVSPSPKGFVEEEDGEGETHMAF
                     SMRPHQTKQPQGTIPHVEEVTEAGDSEGEQSYFVSTPDEYPGGHDREDDGSVYGQIHI
                     EEESTIRYSWQDEIAQGTWRRKMRGDVGGEKPVKVLEVPALSLGGAIGSAHLKEEASG
                     ELRAEPTVIEKEIKIPHEFHTSIKGVFSSEPRHQLVEVIGQLEETLPERMKEELSALT
                     RQSQGESGSVSVDVKKVQSAAGGSVTLMAEVNLSQTVDADQLDLEQLSRDEAGEIERA
                     VESVVRESLAKRSSPVPRSPDREDGEEVPAGGILFKRWATRELYSPSGERDDAGQVSP
                     SSDQRVTQGPVSATVEVTSPTGFVQSHVLEDVSQSVRHVKLGPTEMWRTEQVTFGGPT
                     AQVVEMDLSDTRAIRSWTRDTGSEVEAHGVSHRGGWRIAHSRDERVASTGSGASPGDA
                     HQAPGEKGTEQAGFDKTVQLQRMVDQRSVASDEKKVALLYLDNEEEEEEEGEGWF"
     exon            925..1049
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1120
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..3567
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..6960
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6419..6424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /note="hexamer: AATAAA"
     polyA_site      6448
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /note="major polyA site"
     polyA_site      6483
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
     regulatory      6936..6941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /note="hexamer: AATAAA"
     polyA_site      6957
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /note="major polyA site"
ORIGIN      
        1 agtccaaggg cctccgaggc agcggcgcgg cgggcgcggc gcggcggggc ggaggggaca
       61 agatcagggc aggaggcaag cggctaatcg aaagggtccg gcacacccag caagatgctg
      121 tcctggcggc tgcagacggg ctctgaaaag gcggagctgc aggagctcaa cgcccggctt
      181 tacgactacg tgtgccgggt gcgagagctg gagcgcgaga acctgctact ggaggaggag
      241 ttgcgcagcc ggctgagccg ggaggaccgc tgggctgagg atcaggcact ctacgccgag
      301 gaggcgcgca gcctacgaca gcagctagat gaactgaact ggtccacagc cctggccgag
      361 ggcgagcgcg acgcgctgcg gagggaactg ctggagctgc agcgggaggg tgtggaagcc
      421 ggcactgccc gcagccgcct ggatgccgag ctgggagcgc aacggcggga gctagaggag
      481 gctctgggcg cgcgcgccgc cctcgaggcg ctgctgggcc ggctggaaac tgagcgccgc
      541 gacttggacg ctgcccacga acgccaagtg cgagatctac gagcccgcgc tgccagcctc
      601 accatgcact tccgagcccg cgccaccagc cccgccgcgc ccccgccgcg cctgcgggac
      661 gtgcacgaca gctacgccct gctggtggcc gagtcgtgga gggagagcgt gcagctgtac
      721 gaggacgagg tgcgcgagct ggagcaggcg ctgcgccgcg gccaagagag ccggctccag
      781 gcggaggacg aggcgcggct gtgcgcgcag gaggcagacg cgctgcggaa ccaggcgctg
      841 gagttggagc agctgcgcgc gaggctggag gatgagctgc tgcggatgcg cgaggagtac
      901 gggatgcagg cggaggagcg gcagagagtg attgacagcc tggaggatga gaaggaagcc
      961 cttaccttgg ccatggctga ccggctgcgg gattaccagg agctcctgca ggtgaagact
     1021 ggactcagct tggaggtagc cacctacagg gccttgttgg aaggagaaag caatccggag
     1081 atattgatct ggactgagaa cattgaaaac gtgccacaag agcccagaaa cacatcctat
     1141 cgctacacca actcagtatt gcagaggaaa aatgagaaaa atctctttcc aaggcgaaaa
     1201 acaccttggg cagctgtaaa tcacagctcg gcctcgtatt ctaactggcc agggcacctt
     1261 gactcacaga caaccacagc tgtaggaagt gctgccagaa ggggtctcct gacctcccgc
     1321 cattcttcct cagctacaac ctcagggcag caaaagcccc tggagaaaac catcagcagc
     1381 cgagccaatt taagaccggt cacgccaacc cacggctttc taagaaacac tgatgctcaa
     1441 atgaaaacac tcccccatag atccaaagtc gaaggcacgg gggacaccca cgcacggcgg
     1501 gctacagagt ctgttattac cagagagtca tacagaggtc accagggcca tgtggcagca
     1561 ggtgccgtga gcagcactcc gtcaaatgag aggactgtca ttctgggaaa gaaattagaa
     1621 gcgcaagcca ctaaagaaca agaaagggac agatcagggg tcatcagaat aaagccagaa
     1681 gagaaaatgt ttgattctaa agagaaggct tcagaggaaa gaaacttgag gtgggaagag
     1741 ctaaccaagt tagatagaga tgccagaaag agagaaagcc ggcatttgag ggatgaggcc
     1801 agagagaagg aagcactgaa ggagagaagt gtaaaagaaa gagaggtgcc catcagtcta
     1861 gaagtatccc ggggcagcag agcagaggtg tccaccatac acttgcagtc acctggaagg
     1921 aaggacgtta gccacagtgg gggaagagag gcagagacca aagagacaag gttccggctg
     1981 gatacccagg acactgccag ctctctgcaa agtgactcaa cgacagaaac catagccgaa
     2041 agcattgtca ccaccatcct taagcagttt acccagtctc caggtgccga ggaggaggcc
     2101 acttctttcc cggacacaaa ggtcacttat gtggacagga aagagtttcc tggtgatggg
     2161 aaaaccaaga cagaaatcgt tgtggagtcg aagctgacag atgttgttga tgtttctgat
     2221 gaagcaggcc tggactacct tctaagcaag gatgtcaagg aagtaggact gaaggggaag
     2281 tcaacggaga cgatgatcgg agagatgatc aacctgggtc tgaaaggcag ggaggggaga
     2341 gctaaagtcg taaatgtgga gattgtggaa gagcccatga gctacatagg tggtgggaaa
     2401 atagactttt ctaccccctt tcaggtagaa gaagtcgacg acgtgtctcc cagccccaag
     2461 ggctttgtgg aggaagagga tggtgaagga gagacccaca tggcattctc aatgcgtcca
     2521 catcagacca aacagcccca ggggaccatc cctcacgtgg aagaagtgac ggaggcgggc
     2581 gactcagagg gggagcagag ctattttgtg tctaccccag atgagtaccc cggggggcat
     2641 gacagagaag atgatggctc agtgtatggg cagattcata tcgaggaaga gtctaccatc
     2701 cggtactcat ggcaagacga aattgcgcag gggacctgga gaaggaaaat gagaggtgac
     2761 gtggggggag agaagcctgt gaaggtcctg gaggtcccag cactttccct gggtggtgct
     2821 attggttctg ctcacttgaa ggaagaagcc agtggtgaac tccgtgctga acccacagtc
     2881 attgagaaag agatcaaaat accgcatgaa ttccacacct ccatcaaggg tgtcttctcc
     2941 agtgagcccc ggcaccagct ggtggaggtc atcgggcagc tggaggaaac attgcccgag
     3001 cgcatgaagg aggagctgtc tgccctgacc agacagagtc aaggagagtc agggagcgtt
     3061 tctgtggacg taaagaaagt ccagagcgct gctggtggtt ctgtgacttt gatggctgag
     3121 gtcaacctct cacagactgt agatgctgat cagttggacc tggagcagtt gagcagagat
     3181 gaagctgggg aaatagagag ggctgtggag tctgtggtca gagagagctt ggccaagcgc
     3241 tccagcccag tgcctagaag cccagacagg gaagatggag aggaggtgcc tgctggtggc
     3301 attctcttca agcgctgggc caccagggag ctgtatagcc catctggtga gagggatgat
     3361 gctggccagg tctctcccag ctcagatcag cgtgttaccc agggcccagt gtcagctact
     3421 gtggaagtga ccagcccaac gggttttgta cagtctcatg tgctggagga tgtgagccag
     3481 tctgtaaggc atgttaaact aggtcccact gaaatgtgga ggacagaaca ggtgaccttc
     3541 ggaggaccca ccgcacaggt ggtggagatg gatctgagcg acacgagagc gatccgcagc
     3601 tggacccgag acacagggtc ggaagtggaa gctcacggcg tgtctcaccg tggtggctgg
     3661 agaattgcac acagtaggga tgagcgagtg gccagcactg gctctggggc ctcccctggg
     3721 gatgcacacc aggcccctgg agagaaaggc acggagcagg ctggatttga caagacggta
     3781 cagttgcaga gaatggtaga ccaaaggtcg gtggcctcag atgagaagaa agtggctctt
     3841 ctttatctag acaatgaaga ggaggaggag gaggagggcg aagggtggtt ttgatgaatg
     3901 caactatctt gtcctgaatg gctctctgga aacatcaatg tacaaagcct tcaaaatacc
     3961 gacatgcaag cccttcacta agtggagggg gagggggagg ctggttatca atacctttat
     4021 ttagagaagc ctaggctgaa atggtttgct ttagaatgta tttaaaggtt ggagatttta
     4081 catttgaggt ggaactttca cagacttctt ttcatctttt cagtctcaaa aagttccttt
     4141 ctccaaactt ttctctccac gcgtggggac agtttatacg agttttgcac caggtcacag
     4201 gcgtggctta tatctatctg ttctactgtt tatctatagg caagacactt ttaacattaa
     4261 ccagattaaa ataatatatt taagggtagg ttgtgtttgc atgtgctaat atcaaacagt
     4321 aagctaacac tggaaaggaa aataggtgcg tttttctctt tcctacatct taaaaacaaa
     4381 aaaagaaatt atagaaagta agcaagacta tgtttggaaa aacaatctag tcagtgattt
     4441 ctttaagaaa aagttactta tcagagattt aaaattattt ttcaaatgga atgaattgct
     4501 tctatgtaca gaagtttaga agaaaaaaaa aaagagggct tagagttatt tatggaaagg
     4561 cagctgtggc ctgttgttgg tacttcagat tcatgtatct gtcctgattg ttcagatttg
     4621 ctgtccctgg ccacaggctt gagcaaccaa gaatgacgat tgctcgcagc agcctttcaa
     4681 gtctttacaa ggctgtgagg tagcagatac cttcctgtac tgacctaagc tggagtactt
     4741 acctcctgct agagcagggc ttcttcaacc tgtgggtctc gacccttgca aggcattgcc
     4801 tatgaacatt ggcaaccact gatatttacg attcataaca gtggcaaaat cacagttatg
     4861 aagtggcaat ggcgtgattt tatggttggg ggtcagcaca acttgagaaa ctatattaaa
     4921 gggccgcagc ctttggaggg ttaaggaccg atgctctaga agaacagcca gtgcttctaa
     4981 ctactgaacc atttctctac cccatacaga cctccttcgt aggattttct gagctcctag
     5041 aattacggac aaaaatgcaa cagccgtata caaaccccac aaacgctttc tgcactttga
     5101 atagaaatcg tggtggcagg ggtatctaag tcaaacagag gtagtactta ggggaaggaa
     5161 ccaggtgcct cccgtgcacc ccagcatcta ggcccccagg gcaggctgac agatggcaaa
     5221 ggccccaccc gtgtgggcca cagattatgg acctggagct gtgcaccact gaatttaaga
     5281 aggatgagtg tgctcatttg ggattgttcc tttacacatg gacattgttt ttaaagctcc
     5341 catctcttaa gacttggcat cacataaaaa gaaaaagagc ctctatagtg cagcagtctg
     5401 tgagcgcaga atggtagctt tcttgagtcc gagctgtgct tttgaaccca ggccacaaac
     5461 ctgcctgtgg ggcactgagg atcctagagg atgccatctt caggtagggg aggagccttc
     5521 ttccctgacc cgtgtgtgtt tcacggggca tatctcccct ctggttccag caggtgggca
     5581 aaggagagta cgatgttttt cattgccaag tataagagaa acacagaacg gcttaagatg
     5641 atcttttcaa acgccttgca cggggtacag gaaggaagcg gatttgaatg gaaagccttt
     5701 gttaccctca tgccaactga gctcagggtt gtcagcctga gccaggagtt actacggctg
     5761 tggctcgtca tctcttatac tgtcagagat gtgcggactt atttttttcc ataagcagaa
     5821 aacccgagtg atttgtaaga atgtggccaa ggtggtacag ccttggtacc ataatgcaag
     5881 acacagtgac aatgtcgagt ttattatgag tctaagtggg cttagctgga tgtcattgtc
     5941 ctagttcatg aacttgtcca tgggcgctgg tgtgagcagg ttataaatac cgtggcactt
     6001 ctactttgaa aaataaatgt cttagaatga aatactaatt ttcatttcta agttggaatc
     6061 cccatcgagg caatgttatg gttatgtttg aagaacctac caggaaggag gagtcctcag
     6121 ctgtcactgg ttactatgtc tccaccatta cacccttgac attgtagcag atcaccgcca
     6181 aagctccctg aggttttaga aatcagtcac tctggagtca aatcaacact gtgggagggc
     6241 agggagggcc ccagtctctc ccagtttgtt attgttgaga ctacaggaga ctgaatgttt
     6301 cttagcttcc cactggttgt tttgatcgtt tgctttacag tgtttattta gaattatcta
     6361 agaagcctat tttgctaacc tgttccctac aaagagaact gtcacaagaa tgtgtagaaa
     6421 taaagatctg aggggggaaa aaaaacaact gtattgttct taaagagaat gttttctggc
     6481 tgacttccat gtggttcctt cgatgctgat gttccattcc tgagtttctt tccatgtttt
     6541 gatggtagcc atgggttact ggatgggtca taaatgttcc ttagttcctc ctgagatcag
     6601 aacttttccc tataggttca aactaggaag catgcactaa ctagcttata tccaagtgga
     6661 tagtttggtg gtaactgcca tcccagcccg gaagactgtt gtcagcagga tgagacagcc
     6721 atccattctg cccaggatgg aggagggagc caaggtacag ttattcctgc tgaacccagc
     6781 attgtctggg gctggagctg gtcaagtagt tactcgaagc acagtttgta aggctattca
     6841 tggccatttc tcagtatctt aagatataga tatatgcttg aaacaaggag tgggtgactg
     6901 ttcgtctgtc tataatctgg ccttttagca acaaaaataa aaacatgagt agttgtattt
//
