LOCUS       NP_997546               1259 aa            linear   ROD 30-APR-2024
DEFINITION  synemin isoform M [Mus musculus].
ACCESSION   NP_997546
VERSION     NP_997546.2
DBSOURCE    REFSEQ: accession NM_207663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1259)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1259)
  AUTHORS   Garcia-Pelagio,K.P. and Bloch,R.J.
  TITLE     Biomechanical Properties of the Sarcolemma and Costameres of
            Skeletal Muscle Lacking Desmin
  JOURNAL   Front Physiol 12, 706806 (2021)
   PUBMED   34489727
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1259)
  AUTHORS   Sward,K., Krawczyk,K.K., Moren,B., Zhu,B., Matic,L., Holmberg,J.,
            Hedin,U., Uvelius,B., Stenkula,K. and Rippe,C.
  TITLE     Identification of the intermediate filament protein synemin/SYNM as
            a target of myocardin family coactivators
  JOURNAL   Am J Physiol Cell Physiol 317 (6), C1128-C1142 (2019)
   PUBMED   31461342
  REMARK    GeneRIF: Synemin is a target of myocardin family coactivators.
REFERENCE   4  (residues 1 to 1259)
  AUTHORS   Ikegami,K., Saigoh,K., Fujioka,A., Nagano,M., Kitajima,K., Sato,C.,
            Masubuchi,S., Kusunoki,S. and Shigeyoshi,Y.
  TITLE     Effect of expression alteration in flanking genes on phenotypes of
            St8sia2-deficient mice
  JOURNAL   Sci Rep 9 (1), 13634 (2019)
   PUBMED   31541165
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1259)
  AUTHORS   Garcia-Pelagio,K.P., Chen,L., Joca,H.C., Ward,C., Jonathan
            Lederer,W. and Bloch,R.J.
  TITLE     Absence of synemin in mice causes structural and functional
            abnormalities in heart
  JOURNAL   J Mol Cell Cardiol 114, 354-363 (2018)
   PUBMED   29247678
  REMARK    GeneRIF: synemin plays an important regulatory role in the heart
            and that the consequences of its absence are profound.
REFERENCE   6  (residues 1 to 1259)
  AUTHORS   Mizuno,Y., Guyon,J.R., Okamoto,K. and Kunkel,L.M.
  TITLE     Synemin expression in brain
  JOURNAL   Muscle Nerve 36 (4), 497-504 (2007)
   PUBMED   17654553
  REMARK    GeneRIF: Alpha- and beta-synemin transcripts and their encoded
            proteins colocalize in neurons, especially in the midbrain and
            pons.
REFERENCE   7  (residues 1 to 1259)
  AUTHORS   Jing,R., Wilhelmsson,U., Goodwill,W., Li,L., Pan,Y., Pekny,M. and
            Skalli,O.
  TITLE     Synemin is expressed in reactive astrocytes in neurotrauma and
            interacts differentially with vimentin and GFAP intermediate
            filament networks
  JOURNAL   J Cell Sci 120 (Pt 7), 1267-1277 (2007)
   PUBMED   17356066
  REMARK    GeneRIF: Dmn is expressed in reactive astrocytes in neurotrauma and
            interacts differentially with Vim and Gfap.
REFERENCE   8  (residues 1 to 1259)
  AUTHORS   Izmiryan,A., Cheraud,Y., Khanamiryan,L., Leterrier,J.F.,
            Federici,T., Peltekian,E., Moura-Neto,V., Paulin,D., Li,Z. and
            Xue,Z.G.
  TITLE     Different expression of synemin isoforms in glia and neurons during
            nervous system development
  JOURNAL   Glia 54 (3), 204-213 (2006)
   PUBMED   16817202
  REMARK    GeneRIF: synemin gene encodes proteins belonging to the
            intermediate filament which confer resistance to mechanical stress
            and modulate cell shape.
REFERENCE   9  (residues 1 to 1259)
  AUTHORS   Xue,Z.G., Cheraud,Y., Brocheriou,V., Izmiryan,A., Titeux,M.,
            Paulin,D. and Li,Z.
  TITLE     The mouse synemin gene encodes three intermediate filament proteins
            generated by alternative exon usage and different open reading
            frames
  JOURNAL   Exp Cell Res 298 (2), 431-444 (2004)
   PUBMED   15265691
REFERENCE   10 (residues 1 to 1259)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143019.1 and AC158296.6.
            
            On Jul 25, 2007 this sequence version replaced NP_997546.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, that results in a
            shorter protein (isoform M), compared to isoform H.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143019.1, AJ579701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 37.12 cM"
     Protein         1..1259
                     /product="synemin isoform M"
                     /calculated_mol_wt=140738
     Region          1..10
                     /region_name="Head. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          10..318
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          11..320
                     /region_name="Interaction with DMD and UTRN.
                     /evidence=ECO:0000250|UniProtKB:O15061"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          11..49
                     /region_name="Coil 1A. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          50..58
                     /region_name="Linker 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          59..163
                     /region_name="Coil 1B. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          164..186
                     /region_name="Linker 12. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          187..300
                     /region_name="Coil 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          371..421
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          549..574
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          591..637
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            653
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O15061; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15061; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            778
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            780
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          1033..1061
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            1044
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15061; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            1049
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Region          1075..1099
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            1077
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     Site            1087
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q70IV5.2)"
     CDS             1..1259
                     /gene="Synm"
                     /gene_synonym="4930412K21Rik; Dmn; E130104F11; Syn;
                     Synemin"
                     /coded_by="NM_207663.3:115..3894"
                     /note="isoform M is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS39983.1"
                     /db_xref="GeneID:233335"
                     /db_xref="MGI:MGI:2661187"
ORIGIN      
        1 mlswrlqtgs ekaelqelna rlydyvcrvr elerenllle eelrsrlsre drwaedqaly
       61 aeearslrqq ldelnwstal aegerdalrr ellelqregv eagtarsrld aelgaqrrel
      121 eealgaraal eallgrlete rrdldaaher qvrdlraraa sltmhfrara tspaappprl
      181 rdvhdsyall vaeswresvq lyedevrele qalrrgqesr lqaedearlc aqeadalrnq
      241 aleleqlrar ledellrmre eygmqaeerq rvidsledek ealtlamadr lrdyqellqv
      301 ktglslevat yrallegesn peiliwteni envpqeprnt syrytnsvlq rkneknlfpr
      361 rktpwaavnh ssasysnwpg hldsqtttav gsaarrgllt srhsssatts gqqkplekti
      421 ssranlrpvt pthgflrntd aqmktlphrs kvegtgdtha rratesvitr esyrghqghv
      481 aagavsstps nertvilgkk leaqatkeqe rdrsgvirik peekmfdske kaseernlrw
      541 eeltkldrda rkresrhlrd earekealke rsvkerevpi slevsrgsra evstihlqsp
      601 grkdvshsgg reaetketrf rldtqdtass lqsdstteti aesivttilk qftqspgaee
      661 eatsfpdtkv tyvdrkefpg dgktkteivv eskltdvvdv sdeagldyll skdvkevglk
      721 gkstetmige minlglkgre grakvvnvei veepmsyigg gkidfstpfq veevddvsps
      781 pkgfveeedg egethmafsm rphqtkqpqg tiphveevte agdsegeqsy fvstpdeypg
      841 ghdreddgsv ygqihieees tiryswqdei aqgtwrrkmr gdvggekpvk vlevpalslg
      901 gaigsahlke easgelraep tviekeikip hefhtsikgv fsseprhqlv evigqleetl
      961 permkeelsa ltrqsqgesg svsvdvkkvq saaggsvtlm aevnlsqtvd adqldleqls
     1021 rdeageiera vesvvresla krsspvprsp dredgeevpa ggilfkrwat relyspsger
     1081 ddagqvspss dqrvtqgpvs atvevtsptg fvqshvledv sqsvrhvklg ptemwrteqv
     1141 tfggptaqvv emdlsdtrai rswtrdtgse veahgvshrg gwriahsrde rvastgsgas
     1201 pgdahqapge kgteqagfdk tvqlqrmvdq rsvasdekkv allyldneee eeeegegwf
//
