LOCUS       NM_021482                966 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus synaptogyrin 4 (Syngr4), transcript variant 1, mRNA.
ACCESSION   NM_021482 XM_914835
VERSION     NM_021482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Marques,R.F., Engler,J.B., Kuchler,K., Jones,R.A., Lingner,T.,
            Salinas,G., Gillingwater,T.H., Friese,M.A. and Duncan,K.E.
  TITLE     Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1
            in mutant TDP-43 amyotrophic lateral sclerosis models
  JOURNAL   Hum Mol Genet 29 (16), 2647-2661 (2020)
   PUBMED   32686835
  REMARK    GeneRIF: Motor neuron translatome reveals deregulation of SYNGR4
            and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
REFERENCE   2  (bases 1 to 966)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048469.1, AK006050.1 and BX635824.1.
            
            On Jan 4, 2007 this sequence version replaced NM_021482.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048469.1, AK006050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               BC048469.1         1-656
            657-963             AK006050.1         612-918
            964-966             BX635824.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.58 cM"
     gene            1..966
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /note="synaptogyrin 4"
                     /db_xref="GeneID:58867"
                     /db_xref="MGI:MGI:1928903"
     exon            1..104
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            105..305
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..914
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptogyrin 4 protein"
                     /codon_start=1
                     /product="synaptogyrin-4 isoform 1"
                     /protein_id="NP_067457.2"
                     /db_xref="CCDS:CCDS39962.1"
                     /db_xref="GeneID:58867"
                     /db_xref="MGI:MGI:1928903"
                     /translation="MHLPESLHDLADNETVRFLRRPKSISRIFGGVFSLVIFSSLLTD
                     GYQNRTESPQLRCVLNSNHMACSFAVGAGFLSFLSCLVFLAIDAYERRLVGTRFKIAF
                     QLLDFILAVLWAGVWFVAFCFLASQWQHSKSKHFLLGNSSAKAAIAFSFFSVPVWILQ
                     AYLAFQDLRDEAPVPYKRSLEEGSVVLNTLSPSSTSPSNPPITGPNSLSYTSSALSPY
                     MTTPKAPRLAMMPDS"
     exon            306..543
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..683
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..964
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      931..936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      964
                     /gene="Syngr4"
                     /gene_synonym="1700016O14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaaaaaga ggaaccaaaa agaggctaga ggtggctccc gggaccagga gaggaagcca
       61 ggcaggcaga agaggaacgc aggtcctcgg ccctcggaga agagtagctg agccttgagg
      121 tgggtctgag gcacacagga agtggtgccc agaaagcagc acccaacacc cctgccccta
      181 cctcccggga cacccaaaga agagcagcca ctatgcacct ccctgaaagc ctccacgacc
      241 tggcagacaa tgagactgtg cgctttctga ggagaccaaa gagcatctca aggatcttcg
      301 gaggggtctt ttccctggtc atcttttcct ctctactaac tgatggttac cagaacagaa
      361 cagagtctcc tcagctccgc tgtgtcctca acagcaacca catggcctgt agctttgcag
      421 taggagctgg cttcctgtcc tttctcagct gcttggtctt ccttgccata gatgcctatg
      481 agaggcgcct cgtgggcacc cgctttaaga tagccttcca gctcttggac ttcattctgg
      541 ctgtcctctg ggcaggtgtc tggtttgtgg ctttctgctt cctagccagc cagtggcagc
      601 attcgaagtc caagcacttc ctcttgggga acagcagcgc caaggcagcc attgcctttt
      661 ctttcttctc cgtccctgtc tggatactcc aggcctacct agccttccag gacctccgag
      721 acgaggctcc agtcccctac aagcgctccc tggaggaggg tagtgtggtg ctgaacaccc
      781 tctctccatc atccaccagc ccctccaacc ctcccatcac aggccccaac agtctgagtt
      841 acaccagctc agccctgtcc ccctacatga cgactccaaa ggccccacgc ctggctatga
      901 tgccagacag ctaaacagcc tgtatacata agtaaatagc cccctctgag gggtttatga
      961 accaaa
//
