LOCUS       NM_011522               1959 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptogyrin 3 (Syngr3), mRNA.
ACCESSION   NM_011522
VERSION     NM_011522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Shen,X.Y., Zhang,J., Huang,H.Z., Li,S.D., Zhou,L., Wu,S.P.,
            Tang,C., Huang,X., Liu,Z.Q., Guo,Z.Y., Li,X., Man,H.Y., Lu,Y.M.,
            Zhu,L.Q. and Liu,D.
  TITLE     The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear
            extinction in mice
  JOURNAL   J Clin Invest 134 (4), e172802 (2024)
   PUBMED   38175724
  REMARK    GeneRIF: The interaction of Synapsin 2a and Synaptogyrin-3
            regulates fear extinction in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Ho,P.W., Li,L., Liu,H.F., Choi,Z.Y., Chang,E.E.S., Pang,S.Y.,
            Malki,Y., Leung,C.T., Kung,M.H., Ramsden,D.B. and Ho,S.L.
  TITLE     In vivo overexpression of synaptogyrin-3 promotes striatal synaptic
            dopamine uptake in LRRK2R1441G mutant mouse model of Parkinson's
            disease
  JOURNAL   Brain Behav 13 (2), e2886 (2023)
   PUBMED   36624932
  REMARK    GeneRIF: In vivo overexpression of synaptogyrin-3 promotes striatal
            synaptic dopamine uptake in LRRK2[R1441G] mutant mouse model of
            Parkinson's disease.
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Largo-Barrientos,P., Apostolo,N., Creemers,E., Callaerts-Vegh,Z.,
            Swerts,J., Davies,C., McInnes,J., Wierda,K., De Strooper,B.,
            Spires-Jones,T., de Wit,J., Uytterhoeven,V. and Verstreken,P.
  TITLE     Lowering Synaptogyrin-3 expression rescues Tau-induced memory
            defects and synaptic loss in the presence of microglial activation
  JOURNAL   Neuron 109 (5), 767-777 (2021)
   PUBMED   33472038
  REMARK    GeneRIF: Lowering Synaptogyrin-3 expression rescues Tau-induced
            memory defects and synaptic loss in the presence of microglial
            activation.
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Egana,L.A., Cuevas,R.A., Baust,T.B., Parra,L.A., Leak,R.K.,
            Hochendoner,S., Pena,K., Quiroz,M., Hong,W.C., Dorostkar,M.M.,
            Janz,R., Sitte,H.H. and Torres,G.E.
  TITLE     Physical and functional interaction between the dopamine
            transporter and the synaptic vesicle protein synaptogyrin-3
  JOURNAL   J Neurosci 29 (14), 4592-4604 (2009)
   PUBMED   19357284
  REMARK    GeneRIF: A novel interaction between dopamine transporter (DAT) and
            synaptogyrin-3 suggests a physical and functional link between DAT
            and the vesicular dopamine system.
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Felkl,M. and Leube,R.E.
  TITLE     Interaction assays in yeast and cultured cells confirm known and
            identify novel partners of the synaptic vesicle protein
            synaptophysin
  JOURNAL   Neuroscience 156 (2), 344-352 (2008)
   PUBMED   18706977
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Ferguson,D.A., Chiang,J.T., Richardson,J.A. and Graff,J.
  TITLE     eXPRESSION: an in silico tool to predict patterns of gene
            expression
  JOURNAL   Gene Expr Patterns 5 (5), 619-628 (2005)
   PUBMED   15939374
REFERENCE   9  (bases 1 to 1959)
  AUTHORS   Belizaire,R., Komanduri,C., Wooten,K., Chen,M., Thaller,C. and
            Janz,R.
  TITLE     Characterization of synaptogyrin 3 as a new synaptic vesicle
            protein
  JOURNAL   J Comp Neurol 470 (3), 266-281 (2004)
   PUBMED   14755516
  REMARK    GeneRIF: Subcellular fractionation and immunoprecipitation of
            synaptic vesicles from mouse brain show that synaptogyrin 3 is
            associated with synaptic vesicles and can reside on the same
            synaptic vesicle with synaptogyrin 1.
REFERENCE   10 (bases 1 to 1959)
  AUTHORS   Sugita,S., Janz,R. and Sudhof,T.C.
  TITLE     Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells
  JOURNAL   J Biol Chem 274 (27), 18893-18901 (1999)
   PUBMED   10383386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK081164.1.
            
            On Apr 6, 2007 this sequence version replaced NM_011522.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081164.1, SRR1660815.123621.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1959              AK081164.1         2-1960
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.47 cM"
     gene            1..1959
                     /gene="Syngr3"
                     /note="synaptogyrin 3"
                     /db_xref="GeneID:20974"
                     /db_xref="MGI:MGI:1341881"
     exon            1..229
                     /gene="Syngr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..820
                     /gene="Syngr3"
                     /note="Sgyr III; synaptogryin III"
                     /codon_start=1
                     /product="synaptogyrin-3"
                     /protein_id="NP_035652.2"
                     /db_xref="CCDS:CCDS28491.1"
                     /db_xref="GeneID:20974"
                     /db_xref="MGI:MGI:1341881"
                     /translation="MEGASFGAGRAGAAFDPVSFARRPQTLLRVVSWVFSIAVFGPIV
                     NEGYVNSDSGPELRCVFNGNAGACRFGVVLGLGAFIACVAFLLLDVRFQQISSVRDRR
                     RAVLLDLGFSGVWSFLWFVGFCFLTNQWQRTTPGPGTAQAGDAARAAIAFSFFSILSW
                     VALTVKALQRFRLGTDMSLFATDQLGTGAAQAYPGYPVGSGVEGTETYQSPPFTETLD
                     TSSKGYQVPAY"
     exon            230..467
                     /gene="Syngr3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..610
                     /gene="Syngr3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..1959
                     /gene="Syngr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgacgcgc gctcccggga ggcggcggca gaggcagcat ccacagcatc agcagcctca
       61 gcttcatccc cgggcggtct ccggcgggga aggccggtgg gacaaacgga cagaaggcaa
      121 agtgcccgca atggagggag catcctttgg cgcgggccgt gcgggagctg cctttgatcc
      181 cgtgagcttt gcgcggcggc cccagaccct gttgcgggtc gtgtcctggg tgttttctat
      241 tgcggtgttc ggaccgattg tcaacgaggg ctacgtgaac tccgacagtg gtccagaact
      301 gcgctgcgtc ttcaacggaa atgcgggagc ctgccgcttc ggcgtcgtac taggtctagg
      361 ggccttcatc gcctgcgtgg ccttcttgct gctggacgtg cgctttcagc agatcagcag
      421 cgtccgagac cgtcgccggg ctgtgctact ggacctgggc ttctcagggg tctggtcctt
      481 cctgtggttc gtaggcttct gtttcctcac caatcagtgg caacgaacaa cgccagggcc
      541 aggcaccgcg caggctggag atgcggcgcg tgctgccatc gctttcagct tcttctccat
      601 cctcagctgg gtggcgctca ccgtgaaggc cctgcagcgg ttccgcctag gcaccgatat
      661 gtctctcttt gccacagatc agctaggtac tggggctgcc caggcctacc caggctaccc
      721 agtgggcagt ggtgtggagg gtacagaaac ataccagagc ccgcccttca ctgagaccct
      781 ggacaccagc tccaaagggt accaggtgcc tgcctattag taggtgttag gctccggcca
      841 gggctggaag gccacctcac caccgtaggc ctcaaggcct cctgagacct tttctgggtc
      901 ctaccgtgcc aaggacagag aaggtggcca ctatgggcct ctgggaccaa ggggagtagc
      961 ctccctggtg cctggactgt ccccacaaag ttccccccta gccagagatc tcagtcttaa
     1021 ggccctgaga agaaaactac ttcttggagt ggactggcct gggaggcatt ccttttatgg
     1081 gccagccaac cagggactca cctgtccact ctaggtcaga agtccagctg cctcccagct
     1141 cagggtgcaa gggctctggg gaccagggag agggagacta attgtaccct taggtgggga
     1201 ttatggccct tgttcccagt cccatgtccc tggctccaca tggtggtcca ccctgtccag
     1261 aggctccctc ccctcctctt acaggatccc tagagcagct cagccctgtc ggtgtcgtga
     1321 ttgtgattaa gtcttcaggt ctcatctcat agtgccccca taagccgccc ctctctgtgt
     1381 ggctcctgcc caggtgtttc tggccaggaa ggtatagaca actatgggcc tgggcacccg
     1441 cccttcagta agaccttccc tagggaacag acagctgggt acctgggtgc caggcaagac
     1501 aagactctta caaggagagg actaaaggtc tcatctgccc agggtgtcac tggagagtcg
     1561 ttcctgtaaa tggcttaacc ttggcttcct gaaccagtcc ctccctagtc tatcttctat
     1621 ccccttttaa ggcccagacc aggtgtgggt ccttgtgcat agcagactac tcatacattg
     1681 cttgaagctg gcttttcaca tcaagtcaaa accaaactcg ttgccatgtc tcattcttcc
     1741 agacaaaatg cctccctgtg gagttgcagt tgaatgacaa ccctgtacgt tgtagcatag
     1801 accaatcatg tggatattta agtgaacatg tttacaattt ttgtatatat ggatctattc
     1861 cttttcctct gaaagaacaa tccatgattg tgtattttca gtgtcccctg ttacaactgc
     1921 aacttcttta caataaagac tgtacgtgca ttgaccatc
//
