LOCUS       NM_207708               4188 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus synaptogyrin 1 (Syngr1), transcript variant 1a, mRNA.
ACCESSION   NM_207708
VERSION     NM_207708.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4188)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4188)
  AUTHORS   Haggman Henrikson,J., Pombo Antunes,A.R., Wieloch,T. and Ruscher,K.
  TITLE     Enhanced functional recovery by levodopa is associated with
            decreased levels of synaptogyrin following stroke in aged mice
  JOURNAL   Brain Res Bull 155, 61-66 (2020)
   PUBMED   31805305
  REMARK    GeneRIF: Enhanced functional recovery by levodopa is associated
            with decreased levels of synaptogyrin following stroke in aged
            mice.
REFERENCE   3  (bases 1 to 4188)
  AUTHORS   Raja,M.K., Preobraschenski,J., Del Olmo-Cabrera,S.,
            Martinez-Turrillas,R., Jahn,R., Perez-Otano,I. and Wesseling,J.F.
  TITLE     Elevated synaptic vesicle release probability in
            synaptophysin/gyrin family quadruple knockouts
  JOURNAL   Elife 8, e40744 (2019)
   PUBMED   31090538
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4188)
  AUTHORS   Yu,C., Ji,S.Y., Dang,Y.J., Sha,Q.Q., Yuan,Y.F., Zhou,J.J.,
            Yan,L.Y., Qiao,J., Tang,F. and Fan,H.Y.
  TITLE     Oocyte-expressed yes-associated protein is a key activator of the
            early zygotic genome in mouse
  JOURNAL   Cell Res 26 (3), 275-287 (2016)
   PUBMED   26902285
REFERENCE   5  (bases 1 to 4188)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 4188)
  AUTHORS   Lin,S.S., Bassik,M.C., Suh,H., Nishino,M., Arroyo,J.D., Hahn,W.C.,
            Korsmeyer,S.J. and Roberts,T.M.
  TITLE     PP2A regulates BCL-2 phosphorylation and proteasome-mediated
            degradation at the endoplasmic reticulum
  JOURNAL   J Biol Chem 281 (32), 23003-23012 (2006)
   PUBMED   16717086
REFERENCE   7  (bases 1 to 4188)
  AUTHORS   Belizaire,R., Komanduri,C., Wooten,K., Chen,M., Thaller,C. and
            Janz,R.
  TITLE     Characterization of synaptogyrin 3 as a new synaptic vesicle
            protein
  JOURNAL   J Comp Neurol 470 (3), 266-281 (2004)
   PUBMED   14755516
REFERENCE   8  (bases 1 to 4188)
  AUTHORS   Belfort,G.M. and Kandror,K.V.
  TITLE     Cellugyrin and synaptogyrin facilitate targeting of synaptophysin
            to a ubiquitous synaptic vesicle-sized compartment in PC12 cells
  JOURNAL   J Biol Chem 278 (48), 47971-47978 (2003)
   PUBMED   12928441
  REMARK    GeneRIF: Cellugyrin and synaptogyrin have roles in facilitating
            targeting of synaptophysin to a ubiquitous synaptic vesicle-sized
            compartment
REFERENCE   9  (bases 1 to 4188)
  AUTHORS   Janz,R., Sudhof,T.C., Hammer,R.E., Unni,V., Siegelbaum,S.A. and
            Bolshakov,V.Y.
  TITLE     Essential roles in synaptic plasticity for synaptogyrin I and
            synaptophysin I
  JOURNAL   Neuron 24 (3), 687-700 (1999)
   PUBMED   10595519
REFERENCE   10 (bases 1 to 4188)
  AUTHORS   Kedra,D., Pan,H.Q., Seroussi,E., Fransson,I., Guilbaud,C.,
            Collins,J.E., Dunham,I., Blennow,E., Roe,B.A., Piehl,F. and
            Dumanski,J.P.
  TITLE     Characterization of the human synaptogyrin gene family
  JOURNAL   Hum Genet 103 (2), 131-141 (1998)
   PUBMED   9760194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161199.4.
            
            On Sep 1, 2022 this sequence version replaced NM_207708.1.
            
            Transcript Variant: This variant (1a) encodes the longest protein
            (isoform 1a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048172.1, AK044007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC161199.4         121196-121352
            158-395             AC161199.4         140304-140541
            396-541             AC161199.4         141459-141604
            542-4188            AC161199.4         145715-149361
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..4188
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /note="synaptogyrin 1"
                     /db_xref="GeneID:20972"
                     /db_xref="MGI:MGI:1328323"
     exon            1..157
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..763
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /note="isoform 1a is encoded by transcript variant 1a"
                     /codon_start=1
                     /product="synaptogyrin-1 isoform 1a"
                     /protein_id="NP_997591.1"
                     /db_xref="CCDS:CCDS27657.1"
                     /db_xref="GeneID:20972"
                     /db_xref="MGI:MGI:1328323"
                     /translation="MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWVFSIVVFGSIV
                     NEGYLNNPEEEEEFCIYNRNPNACSYGVTVGVLAFLTCLLYLALDVYFPQISSVKDRK
                     KAVLSDIGVSAFWAFFWFVGFCFLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFT
                     WAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPSAGSDPAGMGGTYQHP
                     ANAFDAEPQGYQSQGY"
     exon            158..395
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            396..541
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            542..4188
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /note="hexamer: AATAAA"
     polyA_site      4188
                     /gene="Syngr1"
                     /gene_synonym="p29; Syngr1b"
                     /note="major polyA site"
ORIGIN      
        1 gcacgcgcac gggtcggcgg cgcgcgccga gcggggggcg ccgcgcggtg cagccacgat
       61 ggaagggggt gcgtacggag cgggcaaagc cgggggcgcc ttcgacccct acaccctggt
      121 gaggcagcca cacaccatcc tgcgcgtcgt gtcttgggtc ttctccatcg tggtcttcgg
      181 ctctatcgtg aacgagggct acctcaacaa cccagaggag gaggaggagt tctgcatcta
      241 caaccgcaac cccaatgcct gcagctacgg tgtgactgtg ggtgtgttgg ccttcctcac
      301 ctgcctgctc tacctggcgc tcgatgtgta cttcccgcag atcagcagtg tcaaggaccg
      361 caagaaggcc gtgctctctg acatcggtgt ctcggccttc tgggccttct tctggttcgt
      421 gggtttctgc ttcctggcca accagtggca agtctccaag cccaaggaca accctctgaa
      481 cgaagggacg gacgcagccc gggctgccat cgccttctcc ttcttctcca ttttcacgtg
      541 ggcgggccag gctgtgctag ccttccagag gtaccagatt ggcgccgact cggccctctt
      601 ctcccaggac tacatggacc ccagccagga ctccagcatg ccttatgcac cctacgtgga
      661 gcccagcgct gggtcggacc ctgctggcat gggtggcacc taccagcatc cagccaacgc
      721 ctttgatgct gagcctcagg gctaccagtc gcagggctac tgagcccccc tcccccacat
      781 ggcggcgacg gtgaccgcct accctgcccc tgcccttcca tcctagctcc cctcccaagc
      841 accctgctcc ctcccaggtg actctgccta gcacatgctc agcctccaag tgactccact
      901 gaagcccagt gcagctgggg tggggagtgt caataaatgt gagcaagtgt gtgtccagca
      961 ggggtgggga gtggtggggt gtgtccacat gtgtgtgtcc agctggggtg gggagtggtg
     1021 gggtgtgtcc acatatgtgt gcaagtgtgt gtccagcagg ggtctacagg tggggcccag
     1081 gggttacagt cattcattgt gtccttgaca ctgagtacct actgaatgcc aggctttgtt
     1141 tagctggaga gtaagagaga gagggaaagg ggaagggggg ctgaggaggc cctgttccaa
     1201 atacaggaaa ggtgggacag atagatactg ggaagtttgc ctgcaagggg ctcagccaca
     1261 tggtgagtgt ggtcagtcac aggatgtggg ctgtcattcc cagaatcctt gatagacatc
     1321 agtcctcctg ggatggccag ggttatctcc attttatggt tgaggaaacc gaggtctgaa
     1381 gggtcaagac actttgttca aggtcattga atcaggctgt tgatgaggcc acattaagat
     1441 gggccagata gagctcctgc cagccttctt tacttcctct gctgctctgc cactcagcgt
     1501 tactcgttac tcgagtttga tgaaggggtt gggggtgggg gcagggcagc gcttcaagac
     1561 gtgagtccag tgagaccccc gtgatcagcc tcaaagcgag ggccttccct gcctcagctg
     1621 ctttctttcc tcatgcaagt cccttcctcc gtcttggtct tctcctagtg ggctccctca
     1681 acctactctt gtccctttgt gttgctccgt gctctacatg gcctgcaggg aactcctttg
     1741 gggtatgcca gccacccttt gcagtttccc aaaggagtgg tggccatccc tggctcttgg
     1801 agggctcact gagccctttg ctcatggctg agtagacagg aggccaggag gtagtggaca
     1861 ctgacccaag gtcccagtga gtaaatggta gagatgacct tgcttcctaa atgtattggc
     1921 tccacccacc cagcaagtgg tcccgccccc tgtgtcacct aggacactgt cctctctctg
     1981 cttgtttggg tcagcaaagg ttccaggctg gagcagtggg gagagctttc aactacaggg
     2041 tcaagatgag tgccacagcc acaggtcaca tgaccccaaa tgacgcaggc gtgagatgtt
     2101 gagaaacttc cagccacggg aaagtgaata gcggcttgcc ggttgccaca aagacagaag
     2161 ggaaagtggg cggggcctaa gaggacaaca aggaggcatt ttcatacctg gtgcttccct
     2221 ccctgtgaca gaggggacgc agagggaggt tgtctgtgct gtcctcctgt gtgtgcccag
     2281 tacacagtag ctggttactg ggaagcgggt ccgtgccctt taacaattga gtgtccccac
     2341 cacctcaccc catgccctac tgggctctgc cgggcagact tgctcttctg gtacccgtgt
     2401 tagtgtgatg tcaccaaggg tgactgtggt ccctgtcctg taggagcctc tgaagaacat
     2461 acaggcacag ggtccattac ggtgggaaac gttgcgtgag cacgggcctg aggaagagtc
     2521 agggagggga caagggtgtc agaggcctag aagcagcccc gcagctcctc ttgagcagaa
     2581 ggggaaacca ggaagggaaa caaacccttc cgagtcctcg ggaagtttcc agaaccagga
     2641 gcacagagag ttacagttgg atccagactg ggggggtctc caagtttgct aggaggtcac
     2701 agtgttggga gagagcccca ggcggctgag tgacagctgg ctgttgctga cttccatttt
     2761 tcacacctgg gaaagggctc tgtgtacagc cctatgcccc cgaccaggtg gctcaagtag
     2821 ggacggcttg gggatggtgg acagtgacca gaggagagac tggctatggg aatgttgcag
     2881 tgccacccta agtcacaaaa agtctttgct actcacagcc ccaagccttc cctgcctgtg
     2941 ggtactaaac acccaaggac tgcccatctg tttctccctg gacagcaacg gacggcaggg
     3001 gatgtcaggc agagggcagg gtgctggtta aactctgccc agctttgggc atctctcata
     3061 gactcttcct agtgctcaag ctggagacat ttatgggacc aggaggcggg tcttgagcat
     3121 ctccccttgt cccatgcatg ccaccatcat ggtagtgata tcagatggtg ggtgagtggt
     3181 ccgagcagga tttgagtaag atccaggctt ctgactcagt agtttaggag ggatcacacc
     3241 cccacagaca taacatagcc cgtggaggac ccaaggccag cagcaccctg gatttccttt
     3301 ccctctccac ggaccctgct ttcctcccac attctctttg gagagggtcc cccacagcca
     3361 tgccctatgg aactggggtt cccttttccc tgtcaagcac aaaagaaggt ctgggggaac
     3421 atgggttcca tgcgagttta gagctgcaga gatcctttga gagaatccta tttcatccac
     3481 ggtcatgcac agagtgagag attgggagcc ccatcttctg ccttctgaga tgacatgtcc
     3541 tgcgcagtcc acaggccatc ttgtctgggc ggcaccccgt ccacctggga tgtagcaatc
     3601 aaggggctta tttccagggg actgacacca gtctctactc catctgtccg taatgattct
     3661 tgattttcaa agacttgggg tcccaggctt ttcccatgta agcaagagct cccacttgtc
     3721 accccgggac acctctaacc tttgacccat aagtcctttg atccctgaag gttatgagca
     3781 ggagtcccca gagtttatgg aggatgaact gggctagctg tctcccagtg ctacccctga
     3841 cctgataact tctgccccct ggtgcccaca gctcttgtct gggtgccctg gtccctcccg
     3901 cagcgttact gcctgtgtat agtataaata tatatatttt ctatatataa gatgtataat
     3961 ataaggctcc acaatatatc tgtgagtgtg tgtgcgtgtg cgtgtgtgcg gtgaagggcg
     4021 gcccccaact tgggccctgc tctagcccct cccccacctg gttaagcctc tccagtggac
     4081 ccagtggctc tgaggcaacc tcctctgtga catccatcca tctgtggtga ccaagtgaag
     4141 gtggtgactt ctggtgacat agtaataaag tgaagagtca actcacca
//
