LOCUS       NP_705805                388 aa            linear   ROD 14-JUN-2024
DEFINITION  nesprin-4 isoform 1 [Mus musculus].
ACCESSION   NP_705805
VERSION     NP_705805.1
DBSOURCE    REFSEQ: accession NM_153577.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 388)
  AUTHORS   Taiber,S., Gozlan,O., Cohen,R., Andrade,L.R., Gregory,E.F.,
            Starr,D.A., Moran,Y., Hipp,R., Kelley,M.W., Manor,U., Sprinzak,D.
            and Avraham,K.B.
  TITLE     A Nesprin-4/kinesin-1 cargo model for nuclear positioning in
            cochlear outer hair cells
  JOURNAL   Front Cell Dev Biol 10, 974168 (2022)
   PUBMED   36211453
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 388)
  AUTHORS   Taiber,S., Cohen,R., Yizhar-Barnea,O., Sprinzak,D., Holt,J.R. and
            Avraham,K.B.
  TITLE     Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4
            deafness
  JOURNAL   EMBO Mol Med 13 (2), e13259 (2021)
   PUBMED   33350593
REFERENCE   3  (residues 1 to 388)
  AUTHORS   Feng,Q. and Kornmann,B.
  TITLE     Mechanical forces on cellular organelles
  JOURNAL   J Cell Sci 131 (21) (2018)
   PUBMED   30373893
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 388)
  AUTHORS   Horn,H.F., Brownstein,Z., Lenz,D.R., Shivatzki,S., Dror,A.A.,
            Dagan-Rosenfeld,O., Friedman,L.M., Roux,K.J., Kozlov,S.,
            Jeang,K.T., Frydman,M., Burke,B., Stewart,C.L. and Avraham,K.B.
  TITLE     The LINC complex is essential for hearing
  JOURNAL   J Clin Invest 123 (2), 740-750 (2013)
   PUBMED   23348741
REFERENCE   5  (residues 1 to 388)
  AUTHORS   Morimoto,A., Shibuya,H., Zhu,X., Kim,J., Ishiguro,K., Han,M. and
            Watanabe,Y.
  TITLE     A conserved KASH domain protein associates with telomeres, SUN1,
            and dynactin during mammalian meiosis
  JOURNAL   J Cell Biol 198 (2), 165-172 (2012)
   PUBMED   22826121
REFERENCE   6  (residues 1 to 388)
  AUTHORS   Roux,K.J., Crisp,M.L., Liu,Q., Kim,D., Kozlov,S., Stewart,C.L. and
            Burke,B.
  TITLE     Nesprin 4 is an outer nuclear membrane protein that can induce
            kinesin-mediated cell polarization
  JOURNAL   Proc Natl Acad Sci U S A 106 (7), 2194-2199 (2009)
   PUBMED   19164528
  REMARK    GeneRIF: Nesprin 4 is an outer nuclear membrane protein that can
            induce kinesin-mediated cell polarization.
REFERENCE   7  (residues 1 to 388)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149067.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004761.1, SRR7345562.1873268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.39 cM"
     Protein         1..388
                     /product="nesprin-4 isoform 1"
                     /note="nesprin-4; nuclear envelope spectrin repeat protein
                     4; KASH domain-containing protein 4"
                     /calculated_mol_wt=41893
     Region          60..92
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CII8.1)"
     Region          116..197
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Site            340..360
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CII8.1)"
     Region          <365..388
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..388
                     /gene="Syne4"
                     /gene_synonym="0610012K07Rik; KASH4; Nesp4"
                     /coded_by="NM_153577.3:117..1283"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21086.1"
                     /db_xref="GeneID:233066"
                     /db_xref="MGI:MGI:2141950"
ORIGIN      
        1 malvpplgre fppepvncpl aapreldvvg gticpapeee tsrpeqvqas lglpehcmge
       61 lkstesatsp srlplasshe hqdggkpceh sdsglevlea eqdslhlcll rlnfrlqdle
      121 rglgswtlah nrivqmqalq aelrgaaerv dallafgegl aerseprawa sleqvlralg
      181 thrdtifqrl wqlqaqlisy slvlekanll dqdlevegds dgpaaggvwg pwapstfptp
      241 aelewdpagd vgglgpsgqk isripgapce lcgyrgpqss gqgledllsl glghrkhlaa
      301 hhrrrlrkpq drkrqvspsl pdamlevdrg vpapaskrpl tlfflllfll lvgatlllpl
      361 sgvsccshar lartpylvls yvnglppi
//
