LOCUS       NM_001085521            2073 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus synapse differentiation inducing 1 (Syndig1),
            transcript variant 4, mRNA.
ACCESSION   NM_001085521 XM_485077 XM_925688
VERSION     NM_001085521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2073)
  AUTHORS   Jiang,L., Zhang,H., He,Y., Liu,H., Li,S., Chen,R., Han,S., Zhou,Y.,
            Zhang,J., Wan,X., Xu,R., Wang,S., Gu,H., Wei,Q., Qin,F., Zhao,Y.,
            Chen,Y., Li,H., Wang,L., Wang,X., Wang,Y., Dai,Y., Li,M., Chen,Y.,
            Zhang,H., Hu,Y., Bu,Q., Zhao,Y. and Cen,X.
  TITLE     Synapse differentiation-induced gene 1 regulates stress-induced
            depression through interaction with the AMPA receptor GluA2 subunit
            of nucleus accumbens in male mice
  JOURNAL   Neuropharmacology 213, 109076 (2022)
   PUBMED   35500677
  REMARK    GeneRIF: Synapse differentiation-induced gene 1 regulates
            stress-induced depression through interaction with the AMPA
            receptor GluA2 subunit of nucleus accumbens in male mice.
REFERENCE   2  (bases 1 to 2073)
  AUTHORS   Matt,L., Kirk,L.M., Chenaux,G., Speca,D.J., Puhger,K.R.,
            Pride,M.C., Qneibi,M., Haham,T., Plambeck,K.E., Stern-Bach,Y.,
            Silverman,J.L., Crawley,J.N., Hell,J.W. and Diaz,E.
  TITLE     SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and
            Plasticity Underlying Cognitive Function
  JOURNAL   Cell Rep 22 (9), 2246-2253 (2018)
   PUBMED   29490264
REFERENCE   3  (bases 1 to 2073)
  AUTHORS   Kim,S.K., Avila,J.J. and Massett,M.P.
  TITLE     Strain survey and genetic analysis of vasoreactivity in mouse aorta
  JOURNAL   Physiol Genomics 48 (11), 861-873 (2016)
   PUBMED   27764765
REFERENCE   4  (bases 1 to 2073)
  AUTHORS   Chenaux,G., Matt,L., Hill,T.C., Kaur,I., Liu,X.B., Kirk,L.M.,
            Speca,D.J., McMahon,S.A., Zito,K., Hell,J.W. and Diaz,E.
  TITLE     Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not
            Formation In Vivo
  JOURNAL   eNeuro 3 (5) (2016)
   PUBMED   27800545
  REMARK    GeneRIF: Mice with reduced SynDIG1 exhibit deficits in the
            structure and function of excitatory synapses. Mature synapses are
            still present, albeit at a significantly reduced number, suggesting
            that synapses can reach maturity without SynDIG1. However, the
            overall reduction in the number of mature synapses by multiple
            criteria suggests that SynDIG1 is important for normal development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2073)
  AUTHORS   Kaur,I., Yarov-Yarovoy,V., Kirk,L.M., Plambeck,K.E., Barragan,E.V.,
            Ontiveros,E.S. and Diaz,E.
  TITLE     Activity-Dependent Palmitoylation Controls SynDIG1 Stability,
            Localization, and Function
  JOURNAL   J Neurosci 36 (29), 7562-7568 (2016)
   PUBMED   27445135
  REMARK    GeneRIF: This study provides mechanistic insight into SynDIG1
            structure and function to demonstrate that its stability and
            subcellular localization are regulated by activity-dependent
            palmitoylation
REFERENCE   6  (bases 1 to 2073)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   7  (bases 1 to 2073)
  AUTHORS   Kalashnikova,E., Lorca,R.A., Kaur,I., Barisone,G.A., Li,B.,
            Ishimaru,T., Trimmer,J.S., Mohapatra,D.P. and Diaz,E.
  TITLE     SynDIG1: an activity-regulated, AMPA- receptor-interacting
            transmembrane protein that regulates excitatory synapse development
  JOURNAL   Neuron 65 (1), 80-93 (2010)
   PUBMED   20152115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB653505.1, CJ061528.1, BC147352.1, BY638665.1 and BQ176304.1.
            
            On Apr 8, 2010 this sequence version replaced NM_001085521.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.88296.1,
                                           SRR1660815.166327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BB653505.1         1-11
            12-199              CJ061528.1         1-188
            200-1723            BC147352.1         1-1524
            1724-2049           BY638665.1         80-405
            2050-2073           BQ176304.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.8 cM"
     gene            1..2073
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /note="synapse differentiation inducing 1"
                     /db_xref="GeneID:433485"
                     /db_xref="MGI:MGI:3702158"
     exon            1..143
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     exon            144..701
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..998
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /note="isoform 1 is encoded by transcript variant 4;
                     synapse differentiation-inducing gene protein 1; dispanin
                     subfamily C member 2; transmembrane protein 90B"
                     /codon_start=1
                     /product="synapse differentiation-inducing gene protein 1
                     isoform 1"
                     /protein_id="NP_001078990.1"
                     /db_xref="CCDS:CCDS38262.1"
                     /db_xref="GeneID:433485"
                     /db_xref="MGI:MGI:3702158"
                     /translation="MDGIIEQKSVLVHSKISDAGKRNGLINTRNFMAESRDGLVSVYP
                     APQYQSHRLVASAAPGSLEGGRSEPVQQLLDPNTLQQSVESHYRPNIILYSDGVLRSW
                     GDGVATDCCETTFIEDRSPTKDSLEYPDGKFIDLSGDDIKIHTLSYDVEEEEELQELE
                     SDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHETNKAVAKGDFHQ
                     ASTSSRRALFLAVLSITIGTGIYVGVAVALIAYLSKNNHL"
     exon            702..839
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     exon            840..2055
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /note="hexamer: AATAAG"
     polyA_site      1953
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /note="major polyA site"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
                     /note="hexamer: AACAAA"
     polyA_site      2003
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; Gm14134; H2C20orf39; Tmem90b"
ORIGIN      
        1 gcgcagggga gggcagaggc ggagagccac gagcccagaa gcagaggcgg gctccgcacc
       61 gccccgcgcc cctcacgctt cccggctctc gagacgcgcg ggcggccgcc tgggcgcacc
      121 agccgggtca ccttgtcccg gagggaaatg ggtcctatgg ggcttgtgtg acctgtgaat
      181 acagcctgct agcctgactc cgagcaggga gggagtctac catggatggc atcattgagc
      241 agaagagtgt tctggtacac agtaagatca gtgatgctgg caaaaggaat ggcttaatta
      301 acaccagaaa cttcatggct gagagcaggg atggtctggt gtctgtttac ccagcacctc
      361 agtaccagag ccacaggcta gtggccagtg cggcaccagg cagcctggaa ggaggcagaa
      421 gtgagcctgt gcagcagttg ctggacccaa acactctgca gcagtccgtc gagtcccact
      481 atcgtcccaa tatcatcctc tactcagatg gtgtacttcg atcctggggg gatggtgtag
      541 ccactgactg ctgtgagacc accttcattg aggaccggtc acccaccaaa gacagcctgg
      601 agtaccccga tgggaaattc atcgacctct caggggatga catcaaaatc cataccctgt
      661 cctatgacgt ggaggaagaa gaggagttac aggagctgga gagtgactac tccagcgaca
      721 cagaaagtga ggacaacttc ctcatgatgc ccccacggga tcacctggga ctcagcgtct
      781 tctccatgct ctgctgcttc tggcctttgg gcattgcagc cttctacttg tcccatgaga
      841 caaacaaagc tgtggccaaa ggagacttcc atcaggccag caccagctct cggagggccc
      901 tgttcctggc agtcctgtcc attactattg gaactggcat ctatgtgggt gtggctgttg
      961 ccctcattgc ctacctctcc aaaaacaacc acctgtgagc ttcccaaatg ctggcatgaa
     1021 ggagggggag tcaagccagc tgtacgaggg cagagaagag acacctgtgt gttactgtac
     1081 agtacaagtg attgccaaac aactccatga tgccctggaa tcttctactc ctggagttct
     1141 ttcattttta tccttcaact tcatcttcag cactgtgcag agcaccaggc agccagcgtt
     1201 gccgattctt ccacatggaa gttccaaaga ttccatccca gtggctgacc ctgaatgaat
     1261 tctattggat ggatgacaac ccagctctgc agcctgccag tgcctggacc aacaccccat
     1321 tagcaatata caaacagtta aaatatgttt attttttatg gaatatggtg caataggcag
     1381 aatgcaagag acatgtcacc actagcttgt ggcccgctta aatcctctat gtgtacccca
     1441 tctttgtggc ttccttgtca gaaacaagtg gggctgagaa gggaaagaaa gcacctgctg
     1501 ggagatcttc tgtctctgtc cacagatgga tcctgcctga gaatgcagaa ttagaggagc
     1561 ataacgcctg acctggccct gctcagtccc agcacgctgc cccagcttgg agcatcaggc
     1621 ttcttgcaga tacccagcaa tacacatttg tggggcctca ctaatcttaa aggagaagaa
     1681 gccacagctc ctcgtaaaaa caaacccagt gttttccccc aggagcctgg gggaaaggag
     1741 ctgtgaagac acaccagatg tttaactcct ggacactcat cctggccatg aacaccactg
     1801 atgttggaga tcctggaaat gagatgggcc ttactctgtc cactaaatga atggctattt
     1861 tcttgtcatt tttaaagtgc aactcttgct tcatgctgct tcagttgcca gatgaatgct
     1921 gagaaataag taatcacaga tgttttaata ccatgtcact gctgttttac gagtgttcat
     1981 tatttaacaa aaattatctt ttagcttgtt tgcttacgac ttttctttct gatgaatggt
     2041 gatgtttgga ctctgaaaaa aaaaaaaaaa aaa
//
