LOCUS       NM_019666               2782 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus synaptotagmin binding, cytoplasmic RNA interacting
            protein (Syncrip), transcript variant 1, mRNA.
ACCESSION   NM_019666
VERSION     NM_019666.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Wu,J., Yu,H., Dou,X., Yin,B., Hou,L., Xue,Y., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     Posttranscriptional Control of Neural Progenitors Temporal Dynamics
            During Neocortical Development by Syncrip
  JOURNAL   Adv Sci (Weinh) 12 (8), e2411732 (2025)
   PUBMED   39776340
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Herrejon Chavez,F., Luo,H., Cifani,P., Pine,A., Chu,E.L., Joshi,S.,
            Barin,E., Schurer,A., Chan,M., Chang,K., Han,G.Y.Q., Pierson,A.J.,
            Xiao,M., Yang,X., Kuehm,L.M., Hong,Y., Nguyen,D.T.T., Chiosis,G.,
            Kentsis,A., Leslie,C., Vu,L.P. and Kharas,M.G.
  TITLE     RNA binding protein SYNCRIP maintains proteostasis and self-renewal
            of hematopoietic stem and progenitor cells
  JOURNAL   Nat Commun 14 (1), 2290 (2023)
   PUBMED   37085479
  REMARK    GeneRIF: RNA binding protein SYNCRIP maintains proteostasis and
            self-renewal of hematopoietic stem and progenitor cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Riccioni,V., Trionfetti,F., Montaldo,C., Garbo,S., Marocco,F.,
            Battistelli,C., Marchetti,A., Strippoli,R., Amicone,L., Cicchini,C.
            and Tripodi,M.
  TITLE     SYNCRIP Modulates the Epithelial-Mesenchymal Transition in
            Hepatocytes and HCC Cells
  JOURNAL   Int J Mol Sci 23 (2), 913 (2022)
   PUBMED   35055098
  REMARK    GeneRIF: SYNCRIP Modulates the Epithelial-Mesenchymal Transition in
            Hepatocytes and HCC Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Kim,S.W., Hong,I.K., Kim,M., Song,Y.S. and Kim,K.T.
  TITLE     hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in
            Response to Transient Oxygen-Glucose Deprivation in Hippocampal
            Neurons
  JOURNAL   Cells 10 (12), 3567 (2021)
   PUBMED   34944075
  REMARK    GeneRIF: hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin
            in Response to Transient Oxygen-Glucose Deprivation in Hippocampal
            Neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2782)
  AUTHORS   Rossoll,W., Kroning,A.K., Ohndorf,U.M., Steegborn,C., Jablonka,S.
            and Sendtner,M.
  TITLE     Specific interaction of Smn, the spinal muscular atrophy
            determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role
            for Smn in RNA processing in motor axons?
  JOURNAL   Hum Mol Genet 11 (1), 93-105 (2002)
   PUBMED   11773003
REFERENCE   7  (bases 1 to 2782)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   8  (bases 1 to 2782)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   9  (bases 1 to 2782)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2782)
  AUTHORS   Harris,C.E., Boden,R.A. and Astell,C.R.
  TITLE     A novel heterogeneous nuclear ribonucleoprotein-like protein
            interacts with NS1 of the minute virus of mice
  JOURNAL   J Virol 73 (1), 72-80 (1999)
   PUBMED   9847309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV562339.1, BU505018.1, CN529994.1, AK162448.1 and BQ559204.1.
            
            On Sep 7, 2006 this sequence version replaced NM_019666.1.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055863.1, SRR1660817.58459.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               CV562339.1         163-297
            136-744             BU505018.1         1-609
            745-1356            CN529994.1         79-690
            1357-2452           AK162448.1         239-1334
            2453-2782           BQ559204.1         1-330               c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     gene            1..2782
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /note="synaptotagmin binding, cytoplasmic RNA interacting
                     protein"
                     /db_xref="GeneID:56403"
                     /db_xref="MGI:MGI:1891690"
     exon            1..342
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            343..502
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..2226
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein Q; hnRNP-Q;
                     glycine- and tyrosine-rich RNA-binding protein; RRM RNA
                     binding protein GRY-RBP; NS1-associated protein 1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein Q
                     isoform 1"
                     /protein_id="NP_062640.2"
                     /db_xref="CCDS:CCDS57686.1"
                     /db_xref="GeneID:56403"
                     /db_xref="MGI:MGI:1891690"
                     /translation="MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLD
                     EIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTY
                     RQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSV
                     GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQE
                     AVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILY
                     HQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVM
                     AKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMN
                     GKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG
                     RGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAP
                     SRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRK
                     ADGYNQPDTKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK"
     exon            503..621
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            622..729
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            730..843
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1020
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1156
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1362
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1512
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1634
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2782
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /note="hexamer: AATAAA"
     polyA_site      2770
                     /gene="Syncrip"
                     /gene_synonym="2610109K23Rik; 4632417O19Rik; GRY-RBP;
                     hnRNP Q; Nsap1; Nsap1l; pp68"
                     /note="major polyA site"
ORIGIN      
        1 gaaggaagga cgaaggctga gaggacaggg cggctagcgg ccggcggagg tggcgagggg
       61 agaaggagga gctgtcggag ggcaggggct gagctgaggg agtgagggag agaagcggac
      121 gcgccaggga ggggagggaa ggggggtcac gcgggggcgc gcgcgcaccg ggagcgcgct
      181 cggaggcgag tggaactgga tcgggtttgc tgccagcggc gtgagcttcg gccgccattt
      241 tacaacagct ccactcgcgc cggacacagg gagcagcgag cacgcgttcc ccgccagccg
      301 acccggtcgg acaggattcc tcggccccag ccccgcgggg agatctctgg aaacatggct
      361 acagaacatg ttaatggaaa tggtactgaa gagcccatgg atactacttc agcagttatc
      421 cattcagaaa attttcagac attgcttgat gctggtttac cacagaaagt tgctgaaaaa
      481 ctagatgaaa tttacgttgc agggctagtt gcacatagtg atttagatga aagagctatc
      541 gaagctttaa aagagttcaa tgaagacggc gcattggcag tgcttcaaca gtttaaagac
      601 agtgatctct ctcatgttca gaacaaaagt gcctttttat gtggagtcat gaagacttac
      661 aggcagagag aaaaacaggg gaccaaagta gcagactcta gtaaaggacc agatgaggca
      721 aagattaagg cacttttgga aagaacaggc tacacacttg atgtgactac aggtcagagg
      781 aagtatggag gaccacctcc agattccgtt tattcaggtc agcagccttc tgttggcact
      841 gagatatttg tggggaagat ccccagagat ctgtttgagg atgagcttgt tccattattt
      901 gagaaagctg gacctatatg ggatcttcgt ttaatgatgg atccgctcac tggtctcaac
      961 agaggttatg cgtttgtcac tttttgtaca aaagaagcag cacaagaggc tgttaaactg
     1021 tataataatc atgaaattcg ttccgggaag cacattggtg tctgcatctc agttgccaac
     1081 aataggcttt ttgtgggctc gattcctaag agtaaaacca aggagcagat tcttgaggaa
     1141 tttagcaaag tgacagaggg tctcacagat gtcattttat accaccaacc tgatgacaag
     1201 aaaaaaaaca gaggcttttg ctttcttgaa tatgaagatc acaaaacagc tgcccaggca
     1261 agacgtaggc taatgagtgg taaagtcaaa gtctggggaa atgttggaac tgttgagtgg
     1321 gctgatccta ttgaagatcc tgatcctgaa gttatggcaa aggtaaaagt gctgtttgta
     1381 cgcaaccttg ccaacacggt aacagaagaa attttagaaa agtcatttag tcagtttggg
     1441 aaactggaac gagtaaagaa gctaaaagat tatgctttca ttcattttga tgagagagat
     1501 ggtgctgtca aggctatgga agaaatgaat ggtaaagact tggagggaga aaatattgaa
     1561 attgtttttg ctaagccacc agatcagaag aggaaagaaa gaaaagctca gaggcaagca
     1621 gcaaagaatc aaatgtatga tgattactac tattatggtc cacctcatat gcctccccca
     1681 acaagaggtc gagggcgtgg aggtagaggt ggctatggat atcctccaga ttattatgga
     1741 tacgaagatt attatgatta ttatggttat gattaccata actatcgtgg tggatatgaa
     1801 gatccatact atggttatga agattttcaa gttggagcta gaggaagggg tggtagagga
     1861 gcaaggggtg ctgctccatc cagaggtcgt ggggctgctc ctccccgtgg tagagccggt
     1921 tattcacaga gaggaggccc tggatcagca agaggcgttc gcggtgcgag aggaggtgcc
     1981 caacaacaaa gaggccgcgg ggtacgtggt gcaaggggtg gccgcggtgg aaatgtagga
     2041 ggaaagcgca aagctgatgg gtacaaccag ccagatacca agcggcgcca gaccaataat
     2101 cagaactggg gctcccaacc cattgctcag caaccgctcc aaggtggtga tcattctggt
     2161 aactatggtt acaaatctga aaaccaggag ttttatcagg atacttttgg gcaacagtgg
     2221 aagtagaaac aggagggcgt ctgtaaaatt agagactgat agattgatca gaaattgccc
     2281 ctaaacctga aagggtgcca ctgtaatttg agacatctgg caagattttc cctttatgta
     2341 tatattttaa caatccgctt ggacatgaac aaagccaaac ttctaactgc ttctggcgaa
     2401 ctgattttat ttttactttt aatttttttt ccaataaatg cattatcaga cgatatgaaa
     2461 ggtagttaat gagtttgcat tcctgcttga gaatttggct catttggctg caatatatac
     2521 catgtttctg gatagtattt agacttggtg tcttgaaaag gtagttgatt aaaaactgag
     2581 tatgtcttta atatcttgta tcagaacaac tatttgtatg ttaccaactt aaattgctaa
     2641 aataaggtaa attggtacac aactgctaat tttaatttag aactctgacc taattgggtt
     2701 ttcaaaacca tttggctact tgtattcttt atgctgttgt taatttcaat aaaaaaaatt
     2761 cacacctaaa tgtatacgta ct
//
