LOCUS       NM_023485               2038 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus syncoilin (Sync), mRNA.
ACCESSION   NM_023485
VERSION     NM_023485.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Zhong,J., Tang,G., Zhu,J., Wu,W., Li,G., Lin,X., Liang,L., Chai,C.,
            Zeng,Y., Wang,F., Luo,L., Li,J., Chen,F., Huang,Z., Zhang,X.,
            Zhang,Y., Liu,H., Qiu,X., Tang,S. and Chen,D.
  TITLE     Single-cell brain atlas of Parkinson's disease mouse model
  JOURNAL   J Genet Genomics 48 (4), 277-288 (2021)
   PUBMED   34052184
  REMARK    GeneRIF: Single-cell brain atlas of Parkinson's disease mouse
            model.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Li,Z., Parlakian,A., Coletti,D., Alonso-Martin,S., Hourde,C.,
            Joanne,P., Gao-Li,J., Blanc,J., Ferry,A., Paulin,D., Xue,Z. and
            Agbulut,O.
  TITLE     Synemin acts as a regulator of signalling molecules during skeletal
            muscle hypertrophy
  JOURNAL   J Cell Sci 127 (Pt 21), 4589-4601 (2014)
   PUBMED   25179606
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Van Rossen,E., Liu,Z., Blijweert,D., Eysackers,N., Mannaerts,I.,
            Schroyen,B., El Taghdouini,A., Edwards,B., Davies,K.E., Sokal,E.,
            Najimi,M., Reynaert,H. and van Grunsven,L.A.
  TITLE     Syncoilin is an intermediate filament protein in activated hepatic
            stellate cells
  JOURNAL   Histochem Cell Biol 141 (1), 85-99 (2014)
   PUBMED   24043511
  REMARK    GeneRIF: in the liver, syncoilin is predominantly expressed by
            activated Hepatic stellate cells and displays very low-expression
            levels in other liver cell types, making it a good marker of
            activated Hepatic stellate cells.
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Anwar,S., Peters,O., Millership,S., Ninkina,N., Doig,N.,
            Connor-Robson,N., Threlfell,S., Kooner,G., Deacon,R.M.,
            Bannerman,D.M., Bolam,J.P., Chandra,S.S., Cragg,S.J.,
            Wade-Martins,R. and Buchman,V.L.
  TITLE     Functional alterations to the nigrostriatal system in mice lacking
            all three members of the synuclein family
  JOURNAL   J Neurosci 31 (20), 7264-7274 (2011)
   PUBMED   21593311
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Zhang,J., Bang,M.L., Gokhin,D.S., Lu,Y., Cui,L., Li,X., Gu,Y.,
            Dalton,N.D., Scimia,M.C., Peterson,K.L., Lieber,R.L. and Chen,J.
  TITLE     Syncoilin is required for generating maximum isometric stress in
            skeletal muscle but dispensable for muscle cytoarchitecture
  JOURNAL   Am J Physiol Cell Physiol 294 (5), C1175-C1182 (2008)
   PUBMED   18367591
  REMARK    GeneRIF: Syncoilin may play a supportive role for desmin in the
            efficient coupling of mechanical stress between the myofibril and
            muscle fiber exterior.
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   McCullagh,K.J., Edwards,B., Poon,E., Lovering,R.M., Paulin,D. and
            Davies,K.E.
  TITLE     Intermediate filament-like protein syncoilin in normal and
            myopathic striated muscle
  JOURNAL   Neuromuscul Disord 17 (11-12), 970-979 (2007)
   PUBMED   17629480
  REMARK    GeneRIF: The data show that absence of alpha-dystrobrevin or desmin
            leads to dynamic changes in syncoilin that may compensate for, or
            participate in, different muscle myopathies.
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   Poon,E., Howman,E.V., Newey,S.E. and Davies,K.E.
  TITLE     Association of syncoilin and desmin: linking intermediate filament
            proteins to the dystrophin-associated protein complex
  JOURNAL   J Biol Chem 277 (5), 3433-3439 (2002)
   PUBMED   11694502
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Borges,A.C., Marques,S. and Belo,J.A.
  TITLE     The BMP antagonists cerberus-like and noggin do not interact during
            mouse forebrain development
  JOURNAL   Int J Dev Biol 45 (2), 441-444 (2001)
   PUBMED   11330864
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Newey,S.E., Howman,E.V., Ponting,C.P., Benson,M.A., Nawrotzki,R.,
            Loh,N.Y., Davies,K.E. and Blake,D.J.
  TITLE     Syncoilin, a novel member of the intermediate filament superfamily
            that interacts with alpha-dystrobrevin in skeletal muscle
  JOURNAL   J Biol Chem 276 (9), 6645-6655 (2001)
   PUBMED   11053421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY728583.1, AJ251641.1 and AK081983.1.
            
            On May 6, 2004 this sequence version replaced NM_023485.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081983.1, AJ251641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY728583.1         1-75
            76-1865             AJ251641.1         12-1801
            1866-2038           AK081983.1         1871-2043
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..2038
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /note="syncoilin"
                     /db_xref="GeneID:68828"
                     /db_xref="MGI:MGI:1916078"
     exon            1..168
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1531
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /note="syncoilin-1; syncoilin intermediate filament 1"
                     /codon_start=1
                     /product="syncoilin"
                     /protein_id="NP_075974.3"
                     /db_xref="CCDS:CCDS18687.1"
                     /db_xref="GeneID:68828"
                     /db_xref="MGI:MGI:1916078"
                     /translation="MASPEPLRGGDGARASREPHTEASFPLQESESPKEAKTFNPEAT
                     LSLEGTVNLEDILYLGASGDFEESFYEEEYEKPALTLFIDESRQPDEALGLEEPVRPE
                     EMLSVEESVTPDEVQISEQPVEPAKSPTACEGEMVATEGSLPAQPIPNTEEDPLSVED
                     LERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAE
                     LERDGLREEIRTVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEE
                     LTQLRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQFENLMAESRQGLEEEYEP
                     QLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKR
                     DEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLE
                     QADAPTSQAGGVEAQSPGTV"
     exon            169..1318
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1443
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1520
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2038
                     /gene="Sync"
                     /gene_synonym="1110057H03Rik; SNIP4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccgccgg gatctggtgt ccgctgcagc tggcagtgcg gcgggcgccg gcaccggcac
       61 aatcgccgac ggcgttggct attaataaca ctccgggcga gcccggggtc gcgcagccat
      121 ggccagcccg gaacccctgc gcggcgggga cggcgcccgg gcctcgaggg aaccacacac
      181 cgaggcgagt tttcctcttc aggagtcaga atccccgaag gaggccaaga cctttaaccc
      241 agaggccact ctgtctttgg aggggactgt gaacctagag gacattctct atctgggggc
      301 atcgggggac tttgaagaga gtttttatga ggaagaatat gagaagccag cactgacact
      361 gtttatcgac gaatcgaggc agccagacga ggcgctgggc ctagaagagc ccgtgcgccc
      421 agaggagatg ctgtctgtgg aggaatccgt gacgccagat gaggtgcaaa tttcagagca
      481 gcctgtggag ccagctaaga gcccaactgc ttgtgaggga gaaatggtgg ccacggaggg
      541 aagcctgcct gctcaaccga ttcccaacac cgaggaggat cccctcagcg tggaggacct
      601 ggagcggctg gaagctcgtt tccagcagtg tgtacaagcc gtgtcccagc tggaagagga
      661 gagggaccag ctaatccacg agctcgtgct actccgggag ccagccctgc aggaggtgca
      721 gcaagtccac caggacatcc tggctgccta caagctccac gcacaggcag agctggagag
      781 ggacgggctc agggaggaga tccggacggt gaagcagaag ctgttcaagg tgaccaagga
      841 atgcgtggct taccaatacc agctggagtg ccgtcagcag gatgtggctc agtttgccga
      901 ctgcagggaa gcgctgacca ctcgggcagc ccagctctcg gaagaactga cccagctccg
      961 agatgcctgt cagaagcaga aggagcagtt acagcaacaa ctagaagcac ccccgaccca
     1021 gagcgatggg cactttctcc aggagagccg acggctgtcg acacagtttg aaaatctcat
     1081 ggccgagagc cgccagggcc tggaggagga gtatgagcct cagctgctcc ggctcctgga
     1141 aaggaaagag gccgggacca aagctctaca ggacacccag gcggagatcc aggagatgag
     1201 ggaggctctg cgacccctgg aagcagaggc ccggcagctc caacttcaga acaggaacct
     1261 ggaggaccag atcacgctcg tgaggcaaaa acgcgatgaa gaggttcaac agtacaggga
     1321 gcagctggag gagatggagg agagacagag gcagttgcgc agtggggtgc aagttcagca
     1381 acagaagaac aaggagatgg agcggctgag gatgagcctt gctgaagagc tttccacata
     1441 taaggctatg ctacccaaga gtctggaaca ggctgatgca cccacttctc aggcaggtgg
     1501 agtcgaggca caatccccag ggactgttta gaaatatatg gtcggacctg tagcccagaa
     1561 acaagaaaac atttattaaa ggatcactag gatggacttt cccccaacag ataagagtac
     1621 cagcactggc aagcaattca ccctgtaaaa gtacaaacac tggctgtttt gcctaaaaat
     1681 attttaggtt ggctggaagc agaatcccag tcaacttttt ttgtaggctg ctggtactga
     1741 tttcagtgta ctatggaagg gaaaaagagc cttttatctt ccagcagaac cctgagtgat
     1801 ggatgcatca ccataccctg aactatcgtg aagaatgtta tggagtgctt tgtgctgacc
     1861 caaaccaaga acgtctgagg gaaaatgttg gggtcaaagg gcagccaatt tctgctatat
     1921 ggatccacaa ctttgtgcta caggtattag attttaagac tctgctcaca aagccatctt
     1981 ccccttcaag tctacactcg tattttactc ttaaaatagt gtcaaattaa aaaacacc
//
