LOCUS       NM_173420               3001 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus syncytin b (Synb), mRNA.
ACCESSION   NM_173420
VERSION     NM_173420.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Mousseau,G., Preault,N., Souquere,S., Bireau,C., Cassonnet,P.,
            Bacquin,A., Beck,L., Pierron,G., Jacob,Y., Dupressoir,A. and
            Heidmann,T.
  TITLE     Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor
            for the endogenous retroviral envelope syncytin-B involved in mouse
            placenta formation
  JOURNAL   J Virol 98 (10), e0091524 (2024)
   PUBMED   39287391
  REMARK    GeneRIF: Sodium-dependent phosphate transporter PiT1/SLC20A1 as the
            receptor for the endogenous retroviral envelope syncytin-B involved
            in mouse placenta formation.
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Astrof,S., Arriagada,C., Saijoh,Y., Francou,A., Kelly,R.G. and
            Moon,A.
  TITLE     Aberrant differentiation of second heart field mesoderm prefigures
            cellular defects in the outflow tract in response to loss of FGF8
  JOURNAL   Dev Biol 499, 10-21 (2023)
   PUBMED   37060937
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Chen,X., Liu,Z. and Xu,J.
  TITLE     The cooperative function of nuclear receptor coactivator 1 (NCOA1)
            and NCOA3 in placental development and embryo survival
  JOURNAL   Mol Endocrinol 24 (10), 1917-1934 (2010)
   PUBMED   20685850
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Dupressoir,A., Vernochet,C., Bawa,O., Harper,F., Pierron,G.,
            Opolon,P. and Heidmann,T.
  TITLE     Syncytin-A knockout mice demonstrate the critical role in
            placentation of a fusogenic, endogenous retrovirus-derived,
            envelope gene
  JOURNAL   Proc Natl Acad Sci U S A 106 (29), 12127-12132 (2009)
   PUBMED   19564597
REFERENCE   8  (bases 1 to 3001)
  AUTHORS   Simmons,D.G., Natale,D.R., Begay,V., Hughes,M., Leutz,A. and
            Cross,J.C.
  TITLE     Early patterning of the chorion leads to the trilaminar trophoblast
            cell structure in the placental labyrinth
  JOURNAL   Development 135 (12), 2083-2091 (2008)
   PUBMED   18448564
  REMARK    GeneRIF: Synb is co-expressed with Cebpa and Gcm1 in basal cells in
            contact with the allantois.
REFERENCE   9  (bases 1 to 3001)
  AUTHORS   Mangeney,M., Renard,M., Schlecht-Louf,G., Bouallaga,I.,
            Heidmann,O., Letzelter,C., Richaud,A., Ducos,B. and Heidmann,T.
  TITLE     Placental syncytins: Genetic disjunction between the fusogenic and
            immunosuppressive activity of retroviral envelope proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (51), 20534-20539 (2007)
   PUBMED   18077339
  REMARK    GeneRIF: findings show that in both humans and mice, one of the two
            syncytins (human syncytin-2 and mouse syncytin-B) is
            immunosuppressive and, rather unexpectedly, the other (human
            syncytin-1 and mouse syncytin-A) is not
REFERENCE   10 (bases 1 to 3001)
  AUTHORS   Dupressoir,A., Marceau,G., Vernochet,C., Benit,L.,
            Kanellopoulos,C., Sapin,V. and Heidmann,T.
  TITLE     Syncytin-A and syncytin-B, two fusogenic placenta-specific murine
            envelope genes of retroviral origin conserved in Muridae
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 725-730 (2005)
   PUBMED   15644441
  REMARK    GeneRIF: critical role of syncytin-A and -B in syncytiotrophoblast
            formation, a situation where two pairs of endogenous retroviruses,
            independently acquired by primate and rodent lineages, were
            selected for a convergent physiological role. (syncytin-A,
            syncytin-B)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK086309.1 and AC134575.3.
            
            On Dec 10, 2009 this sequence version replaced NM_173420.2.
            
            Summary: Many different endogenous retrovirus families are
            expressed in normal placental tissue at high levels, suggesting
            that endogenous retroviruses are functionally important in
            reproduction. This gene is part of an endogenous retrovirus
            provirus that has inactivating mutations in the gag and pol genes.
            This gene is the envelope glycoprotein gene which appears to have
            been selectively preserved. The gene's protein product plays a
            major role in placental development and trophoblast fusion. The
            protein has the characteristics of a typical retroviral envelope
            protein, including a cleavage site that separates the surface (SU)
            and transmembrane (TM) proteins which form a heterodimer. [provided
            by RefSeq, Apr 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086309.1, BB662839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            endogenous retrovirus  :: PMID: 15644441
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2986              AK086309.1         2-2987
            2987-3001           AC134575.3         82662-82676
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.04 cM"
     gene            1..3001
                     /gene="Synb"
                     /gene_synonym="D930020E02Rik; syncytin-B"
                     /note="syncytin b"
                     /db_xref="GeneID:239167"
                     /db_xref="MGI:MGI:3045308"
     exon            1..244
                     /gene="Synb"
                     /gene_synonym="D930020E02Rik; syncytin-B"
                     /inference="alignment:Splign:2.1.0"
     exon            245..441
                     /gene="Synb"
                     /gene_synonym="D930020E02Rik; syncytin-B"
                     /inference="alignment:Splign:2.1.0"
     exon            442..3001
                     /gene="Synb"
                     /gene_synonym="D930020E02Rik; syncytin-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..2452
                     /gene="Synb"
                     /gene_synonym="D930020E02Rik; syncytin-B"
                     /note="placenta-specific/fusogenic; envelope glycoprotein
                     syncytin-B"
                     /codon_start=1
                     /product="syncytin-B precursor"
                     /protein_id="NP_775596.1"
                     /db_xref="CCDS:CCDS27239.1"
                     /db_xref="GeneID:239167"
                     /db_xref="MGI:MGI:3045308"
                     /translation="MTGFWVLCFVLFPSSLSYPESWMPLVNLTHHILRDTNSSLFSNC
                     WVCLSTQTQRSLAVPAPLSIWTDTPMKLHLTYSVRPFSGSFSISDIERRLRLFRPLTA
                     SYSFHNPDRRAIAFLQLVSSTGIFRIITRITSVIYPHKDRFFESAQRPLWGPLFTETV
                     LRSQAPLCISRFFKVSAYATFVGNLSASLCNYTMHISPSTSHENLDLSTTHTFKQAMK
                     RPDAKWKNPLRFSGPPSLIFSKPAYYPCPTDIKHCHTSPATPWMHCPQAPFGTCYNLT
                     LFEPDNSTHPVTMSVNPTHFKVKLQGHRDPYPLSHYQPLTGAALSGQYSVWENEITVQ
                     ENWDITSNIFSHLLSFSYAFCLNSSGVFFLCGTSTYICLPANWSGVCTLVFQYPDIEL
                     LPNNQTVPVPLFASVLSSDSVLRPKRSPHLFPFLAGLGISSALGTGIAGLATSTLYFQ
                     QLSKVLSETLEEIAASITTLQNQIDSLAGVVLQNRRALDLITAEKGGTCLFLQEECCF
                     YVNQSGIVRDAARKLQERASELGQHSDSWGQWPDLGRWLPWLTPFLGPLLFLFFLLTF
                     GSCLLNCLTRFVSQRLGSFVQDTAKRHVDSILQNFQYKKLPQDSPDEDTIPT"
ORIGIN      
        1 ttgctcttct ctggcactcg aattagcatg aaaatgaagg ctaacagcta cctcagttcc
       61 aaattcctaa ttctggtgcc acaatttggt aagagagaga ggctctccgc acttcccaga
      121 gcactgctgt cattcatgac aaagaccttc aagctgcctg gctgtctctg gctgcagcaa
      181 tcctctactg cacaggccag atagccaaag gcaactctcc gcagctgaca ccctcattaa
      241 acaggttctc tccaggaaag cccgttgatc tcagcctcct aaggctcaag cacagctggt
      301 tcgtcaccac cttctcactg gcacttcatt cccatttctg gatgcacgga ctgcttcaca
      361 tcttaccacc ttctgccttc atttggctca caaacacctt cctaaactca tcctgagtct
      421 tccggaaagg gacctgccca ggtctgacct ctcacctcat aacctgagag cctacagcca
      481 ccctgtcttt accagccacc tttgaacacc ccaactgagc aagtttcagg actcaaggat
      541 ccactcgacc aacgtctcgg caccccgcac tactgctggc cattcccaaa gcaccatgac
      601 aggcttttgg gtcctctgtt tcgtcctttt cccctcctcc ttatcctatc cggaaagctg
      661 gatgcccctt gtaaacctca ctcaccacat cctacgtgat accaactctt ccctgttttc
      721 caactgttgg gtctgcttgt ctacccaaac ccagcggtcc ttagcagtcc cagcccctct
      781 gtccatttgg acagatacac ccatgaagct tcatcttacc tactcagtca ggcccttctc
      841 tggctccttt tccattagcg acattgaaag acgcctccgt ctcttccgcc cactgactgc
      901 ctcctattct ttccacaatc ctgacagaag ggcgattgct tttcttcaac tcgtcagctc
      961 aacaggcata tttcggatca tcacccggat aacctctgtg atatatcccc ataaggaccg
     1021 tttcttcgaa tctgcccaac gccctctctg gggaccactc tttactgaga ccgtgctcag
     1081 gtcgcaggcc ccactctgca tatctcgctt tttcaaggtc tcagcatatg ccacttttgt
     1141 aggcaacctc tctgcctctc tctgcaacta caccatgcat atttcacctt ctaccagtca
     1201 tgaaaaccta gatctttcca ccacccatac gttcaaacag gcaatgaaaa gaccggatgc
     1261 caaatggaaa aacccgctcc gtttttccgg gcccccctcc ctcatcttct cgaagccggc
     1321 ttactatccc tgcccaacag acatcaaaca ctgccatacc tctccggcca ctccctggat
     1381 gcactgtcct caggctccct tcggcacctg ctataacctc actttatttg aaccagacaa
     1441 ctcaacccac cctgttacca tgtcagtgaa ccctacccac ttcaaggtca aactccaggg
     1501 gcacagagac ccctatccgc tctcccatta ccagcccctc acgggagctg ccctgtctgg
     1561 acaatattca gtctgggaga acgagatcac tgtccaagaa aactgggaca tcacctccaa
     1621 cattttctca catcttctca gcttctcgta cgccttctgc ctcaactctt caggcgtttt
     1681 cttcctctgc ggaacatcga cttacatctg cctcccagcc aattggtccg gtgtctgtac
     1741 cctggtcttc caatacccgg atattgaact tctccccaat aaccaaacgg tgcctgttcc
     1801 cctttttgct tcagttcttt cctcagactc agttcttcgc ccaaagaggt cccctcacct
     1861 ctttcccttc cttgcaggcc tgggtatctc ttctgccctt ggtacgggga tagctggctt
     1921 ggccacctcg actctctatt tccaacagct ttctaaggtt ctttccgaaa ccttggaaga
     1981 aatagctgcc tctatcacta ccctccagaa ccaaatagac tcgctcgcag gtgttgttct
     2041 acaaaaccgc cgagctctgg acctcatcac tgctgagaaa gggggcacct gtctcttcct
     2101 ccaggaagag tgctgcttct acgtaaacca gtctggaata gtccgggacg cggcaaggaa
     2161 actccaagaa cgagcatctg aactcggcca gcattctgac tcttggggac agtggcctga
     2221 ccttggacgt tggttgccct ggctgactcc ctttctggga cctcttctct tcctcttctt
     2281 cctactgaca tttgggtctt gtcttctgaa ctgcctaacc cgttttgtgt cccagagact
     2341 tggctccttt gttcaagaca ctgccaaaag gcatgtggac agcatcctcc aaaatttcca
     2401 atataaaaaa ctgccccaag actccccaga tgaggacacc attcctacat aacagggaaa
     2461 agttgagaga gcaccaagta taccctccct tctacccagt taatagaatc caagtcggga
     2521 gacttagtta tggcctcatg tttgtatcag ggttaattcc agaaactata gtaatttggc
     2581 atccagaaaa tttcttcttt ttctagatct gagctccttc tgctccttct agatcttctc
     2641 cttatcagta gcccccatct cagacatggc ctctggagtt gtttcacctg acattcttta
     2701 atccatcact caccttgctg cttagctact cttagcaatg gccaaagaag gaatgttttc
     2761 agtgccctgc ctgtaggtgg agagtgggct ctcttataca gagatctctg ctcccaggcc
     2821 tgtgctgcca gggagtggct tgttcctccg ttgtctttct tgctttctga cctcatacga
     2881 agaacattga ggtgtcaggg agcttccaga agctggaagg gggccagcaa ggattctcta
     2941 tgacagcttt gagagagaga gagagagagg gagagagaga gagagagatt atttttttta
     3001 a
//
