LOCUS       NM_001013751            2918 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus syncytin a (Syna), mRNA.
ACCESSION   NM_001013751
VERSION     NM_001013751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2918)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 2918)
  AUTHORS   Wang,Y.N., Chen,X.L., Yang,J., Gong,X.X., Zhang,H.F., Zhang,Y.M.,
            Zeng,D.F., Chen,P.S. and Chen,H.B.
  TITLE     Reduced syncytin-1 regulates trophoblast invasion and apoptosis in
            preeclampsia
  JOURNAL   Placenta 155, 32-41 (2024)
   PUBMED   39121585
  REMARK    GeneRIF: Reduced syncytin-1 regulates trophoblast invasion and
            apoptosis in preeclampsia.
REFERENCE   3  (bases 1 to 2918)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   4  (bases 1 to 2918)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2918)
  AUTHORS   Astrof,S., Arriagada,C., Saijoh,Y., Francou,A., Kelly,R.G. and
            Moon,A.
  TITLE     Aberrant differentiation of second heart field mesoderm prefigures
            cellular defects in the outflow tract in response to loss of FGF8
  JOURNAL   Dev Biol 499, 10-21 (2023)
   PUBMED   37060937
REFERENCE   6  (bases 1 to 2918)
  AUTHORS   Schubert,S.W., Lamoureux,N., Kilian,K., Klein-Hitpass,L. and
            Hashemolhosseini,S.
  TITLE     Identification of integrin-alpha4, Rb1, and syncytin a as murine
            placental target genes of the transcription factor GCMa/Gcm1
  JOURNAL   J Biol Chem 283 (9), 5460-5465 (2008)
   PUBMED   18167345
REFERENCE   7  (bases 1 to 2918)
  AUTHORS   Mangeney,M., Renard,M., Schlecht-Louf,G., Bouallaga,I.,
            Heidmann,O., Letzelter,C., Richaud,A., Ducos,B. and Heidmann,T.
  TITLE     Placental syncytins: Genetic disjunction between the fusogenic and
            immunosuppressive activity of retroviral envelope proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (51), 20534-20539 (2007)
   PUBMED   18077339
  REMARK    GeneRIF: findings show that in both humans and mice, one of the two
            syncytins (human syncytin-2 and mouse syncytin-B) is
            immunosuppressive and, rather unexpectedly, the other (human
            syncytin-1 and mouse syncytin-A) is not
REFERENCE   8  (bases 1 to 2918)
  AUTHORS   Peng,X., Pan,J., Gong,R., Liu,Y., Kang,S., Feng,H., Qiu,G., Guo,D.,
            Tien,P. and Xiao,G.
  TITLE     Functional characterization of syncytin-A, a newly murine
            endogenous virus envelope protein. Implication for its fusion
            mechanism
  JOURNAL   J Biol Chem 282 (1), 381-389 (2007)
   PUBMED   17105734
  REMARK    GeneRIF: syncytin-A is a candidate regulator of fusion from
            retroviral origin
REFERENCE   9  (bases 1 to 2918)
  AUTHORS   Gong,R., Huang,L., Shi,J., Luo,K., Qiu,G., Feng,H., Tien,P. and
            Xiao,G.
  TITLE     Syncytin-A mediates the formation of syncytiotrophoblast involved
            in mouse placental development
  JOURNAL   Cell Physiol Biochem 20 (5), 517-526 (2007)
   PUBMED   17762178
  REMARK    GeneRIF: present evidence in support of the direct role for
            syncytin-A in mouse trophoblast stem cell fusion and
            differentiation involved in placental dev
REFERENCE   10 (bases 1 to 2918)
  AUTHORS   Dupressoir,A., Marceau,G., Vernochet,C., Benit,L.,
            Kanellopoulos,C., Sapin,V. and Heidmann,T.
  TITLE     Syncytin-A and syncytin-B, two fusogenic placenta-specific murine
            envelope genes of retroviral origin conserved in Muridae
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 725-730 (2005)
   PUBMED   15644441
  REMARK    GeneRIF: critical role of syncytin-A and -B in syncytiotrophoblast
            formation, a situation where two pairs of endogenous retroviruses,
            independently acquired by primate and rodent lineages, were
            selected for a convergent physiological role. (syncytin-A,
            syncytin-B)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC138919.1 and AC166938.5.
            
            On May 14, 2011 this sequence version replaced NM_001013751.1.
            
            Summary: Many different endogenous retrovirus families are
            expressed in normal placental tissue at high levels, suggesting
            that endogenous retroviruses are functionally important in
            reproduction. This gene is part of a mouse endogenous retrovirus
            provirus on chromosome 5 that has inactivating mutations in the gag
            and pol genes. This gene is the envelope glycoprotein gene which
            appears to have been selectively preserved. The gene's protein
            product plays a major role in placental development and trophoblast
            fusion. The protein has the characteristics of a typical retroviral
            envelope protein, including a cleavage site that separates the
            surface (SU) and transmembrane (TM) proteins which form a
            heterodimer. [provided by RefSeq, Apr 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC138919.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            endogenous retrovirus  :: PMID: 15644441
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2026              BC138919.1         1-2026
            2027-2918           AC166938.5         150798-151689
FEATURES             Location/Qualifiers
     source          1..2918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.67 cM"
     gene            1..2918
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
                     /note="syncytin a"
                     /db_xref="GeneID:214292"
                     /db_xref="MGI:MGI:2684898"
     exon            1..2918
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1932
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
                     /note="envelope glycoprotein syncytin-A"
                     /codon_start=1
                     /product="syncytin-A precursor"
                     /protein_id="NP_001013773.1"
                     /db_xref="CCDS:CCDS19721.1"
                     /db_xref="GeneID:214292"
                     /db_xref="MGI:MGI:2684898"
                     /translation="MVRPWVFCLLLFPCSSAYSDSWMPLVNLTQHLLQEANSSFSSNC
                     WVCLSIQTQRSLAMPAPLRTWTETPMKLRIMYSARTLSGPYPITDLERRLQNFQPLTP
                     HSSFVNPDQRAIAFLQITSVTGILPILSRITSVRYPDDHVYESAQRPIWGSLSTQTIL
                     TSQAPLCISRFFKNSNHATFVGKLPASLCNHTFQLSPSANHQSIDLSSSYAFAPLMAM
                     PGSKWRNPLRFSGPPSLNSGMPHYSCPIDDIHCHTYPTTPWRSCPSFPASTCYNLTLF
                     EPDNSSHPITLSVDTTYFKIKLQGHKDPYPLFQYQPLMGAALSGQYSIWEYEPTVKKN
                     GGITPNIFSHLVSLTYSFCLNSSGVFFLCGNSTYVCLPANWSGVCTLVFQYPDIELLP
                     NNQTISVPLFATVPSSVPASRRKRALPLLPLLAGLGIASALGLGIAGITTSTVYFQQL
                     SKALSDSLDEIATSIISLQDQIDSLAGVVLQNRRALDLIVAERGGTCLFLQEECCFYI
                     NQSGVVRHAARKLRERASELGTSSSSWIQWLGLGPWLPSWLTSLMAPILFILVLLVFR
                     PCLLNCLTHSVSRRMSSFIHTTTEGHVDKILLLRESQYKRLPQEPPEEDAV"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
                     /note="hexamer: ATTAAA"
     polyA_site      2381
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
                     /note="hexamer: AATAAA"
     polyA_site      2918
                     /gene="Syna"
                     /gene_synonym="Gm453; Gm52; syncytin-A"
                     /note="major polyA site"
ORIGIN      
        1 tgagcgaagc cttgcctttg gaactctcag gacagcatct ctgtgcctcc cactgccgtg
       61 ggccactcct gaagagccat ggttcgtcct tgggttttct gtctcctcct gttcccttgt
      121 tcctctgcct actcggacag ctggatgccc ctggtaaacc tcactcaaca cctcctccag
      181 gaggctaact cttccttctc ttccaactgc tgggtctgct tatccatcca aacccagcgc
      241 tctctagcca tgccagcccc actaaggact tggacagaga cacccatgaa acttcgaatc
      301 atgtactcag cccggaccct ctccggccca taccctatca ccgaccttga gaggcgcctc
      361 cagaatttcc aaccattgac tccccactcc tcttttgtca accctgacca gcgggccatt
      421 gctttccttc agatcaccag cgtgacaggc atacttccca tactttctcg gatcacctcg
      481 gtgagatacc ccgatgacca cgtctatgaa tctgcccagc gccccatatg gggctcactc
      541 tccacccaga cgatcctcac ctcccaggcc cctctctgca tatcccgctt cttcaagaat
      601 tcaaaccatg ccaccttcgt gggcaaactc cctgcctctc tttgcaatca cacctttcag
      661 ctctccccct ctgccaacca ccaatccata gatctgtcct ccagctatgc attcgcccca
      721 ttaatggcca tgccagggtc taaatggaga aaccccttac gcttttcagg acccccttcc
      781 ctgaactcag ggatgcctca ctactcctgc ccgatagatg acatccactg ccacacctac
      841 cccaccaccc cctggaggtc ctgtccttcc ttcccagcta gcacctgcta taatctcacc
      901 ctattcgagc cggacaattc gagccaccct attaccctgt ctgtggacac cacatacttc
      961 aagattaaac tccagggaca caaagacccc tatccactct ttcagtacca gcccctcatg
     1021 ggggcagccc tctctggaca atattcaatc tgggaatatg aacccactgt taagaaaaac
     1081 ggcggtatca ctccaaatat cttctcccac cttgtctcct taacatactc cttctgcctc
     1141 aactcctctg gtgttttctt cctctgtgga aactcaactt atgtctgtct cccggccaat
     1201 tggtccggcg tctgtaccct tgtcttccaa tacccggata ttgaactcct tcccaacaac
     1261 caaaccatat ctgtcccgct ttttgctaca gttccctcct ctgtccccgc ttctcgccgg
     1321 aagcgagccc ttcctctcct tcctctcctc gcgggcctgg gcattgcttc tgccctgggg
     1381 ttaggcatcg cgggtatcac cacctcaact gtgtatttcc aacagctttc caaggctctc
     1441 tcggacagcc tagatgaaat agccacctcc atcatcagcc tccaagacca aatagactcg
     1501 ctggcgggtg tcgttctcca aaaccgcaga gctctggacc tcattgtggc tgagaggggg
     1561 ggcacctgcc tcttcctcca ggaagagtgc tgcttctaca taaaccagtc cggggtagtc
     1621 cggcacgcgg caaggaaact tcgagaaagg gcctcggaac tcggcacaag ctcgagttct
     1681 tggatccagt ggctggggct aggaccctgg ctgccctctt ggttgacttc cctcatggct
     1741 cccattctct ttatcctggt actgctggtt ttcaggcctt gtcttcttaa ctgcctgact
     1801 cattctgtat cgcggcgaat gagttctttc attcacacca ccaccgaagg acacgtggac
     1861 aagatccttc tgcttcgaga gtcccagtac aagagacttc cccaagagcc cccggaggag
     1921 gatgccgtct agcagggagg agctcgtgaa ccataaccga cttccacctt gtctctatct
     1981 atggatctgt agaaaagaac acccatccgt gttagccaca gccttgccac ttgcaagaac
     2041 taatccattt tgcttaaacg gtggtagttt cccccaaacc acaataatcg ttctaggctg
     2101 gtttttctag atgcctgaca ccccttgccc cctgataatg gctgcccatt ggagatgttt
     2161 atgatattta tgatcaccta cacactccag tcgtggtgtg gttcatgact ctttgatcat
     2221 gtctgctttt gaccccaccc caccccaccc caccccaccc cacccccatc cctccaactt
     2281 cgcttcccag tctgttagcg gacagcgagc tttctggttt cccccggatc tggagtcctc
     2341 ccttcccaag gtttatctca gattaaacct gtcctgttga agaagctgct taagtccttg
     2401 tttgccccac ccctgccttg ggccttgcag ccaccaccct gggggcttct caaccaaagg
     2461 aatttgtctg gatgatgttg actccccagt tccagagaca aggagatgcc tcgaatgcag
     2521 ttcctttcct tctgctgcag ccaaatgagc aaaataagaa ttttctagaa agctaaattt
     2581 acttaattta caagcaactc tattattttg agagtgggct gtggtcttac ctcatgccac
     2641 atgaccttcc tattagggga gaatgtcccc cataggctcc aacagtggaa tcctgagtcg
     2701 cccccccccc ccacgtaggc gtggggtgtg gccatgatgg aggaggcgtg cctctggagg
     2761 tgagctttga gaacttagag gaagggtact ctgagtttac catctctgcc ttgcgcttgt
     2821 ggttctgctt ctgtttcgtc tgccatttgc tgcatgcttc cccgctgtta cagactcctc
     2881 tctccagcac cggaaaacaa ataaaccctc ccgctata
//
