LOCUS       NM_013722               8797 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synapsin III (Syn3), transcript variant 1, mRNA.
ACCESSION   NM_013722
VERSION     NM_013722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8797)
  AUTHORS   Bruentgens,F., Moreno Velasquez,L., Stumpf,A., Parthier,D.,
            Breustedt,J., Benfenati,F., Milovanovic,D., Schmitz,D. and
            Orlando,M.
  TITLE     The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal
            Mossy Fibers in Male Mice
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38866497
  REMARK    Erratum:[eNeuro. 2024 Sep 13;11(9):ENEURO.0360-24.2024. doi:
            10.1523/ENEURO.0360-24.2024.. PMID: 39271241]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8797)
  AUTHORS   Stavsky,A., Parra-Rivas,L.A., Tal,S., Riba,J., Madhivanan,K.,
            Roy,S. and Gitler,D.
  TITLE     Synapsin E-domain is essential for alpha-synuclein function
  JOURNAL   Elife 12, 89687 (2024)
   PUBMED   38713200
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8797)
  AUTHORS   Longfield,S.F., Gormal,R.S., Feller,M., Parutto,P., Reingruber,J.,
            Wallis,T.P., Joensuu,M., Augustine,G.J., Martinez-Marmol,R.,
            Holcman,D. and Meunier,F.A.
  TITLE     Synapsin 2a tetramerisation selectively controls the presynaptic
            nanoscale organisation of reserve synaptic vesicles
  JOURNAL   Nat Commun 15 (1), 2217 (2024)
   PUBMED   38472171
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8797)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8797)
  AUTHORS   Kim,H.Y., Lee,J., Kim,H.J., Lee,B.E., Jeong,J., Cho,E.J.,
            Jang,H.J., Shin,K.J., Kim,M.J., Chae,Y.C., Lee,S.E., Myung,K.,
            Baik,J.H., Suh,P.G. and Kim,J.I.
  TITLE     PLCgamma1 in dopamine neurons critically regulates striatal
            dopamine release via VMAT2 and synapsin III
  JOURNAL   Exp Mol Med 55 (11), 2357-2375 (2023)
   PUBMED   37907739
  REMARK    GeneRIF: PLCgamma1 in dopamine neurons critically regulates
            striatal dopamine release via VMAT2 and synapsin III.
REFERENCE   6  (bases 1 to 8797)
  AUTHORS   Heeroma,J.H., Plomp,J.J., Roubos,E.W. and Verhage,M.
  TITLE     Development of the mouse neuromuscular junction in the absence of
            regulated secretion
  JOURNAL   Neuroscience 120 (3), 733-744 (2003)
   PUBMED   12895513
REFERENCE   7  (bases 1 to 8797)
  AUTHORS   Feng,J., Chi,P., Blanpied,T.A., Xu,Y., Magarinos,A.M., Ferreira,A.,
            Takahashi,R.H., Kao,H.T., McEwen,B.S., Ryan,T.A., Augustine,G.J.
            and Greengard,P.
  TITLE     Regulation of neurotransmitter release by synapsin III
  JOURNAL   J Neurosci 22 (11), 4372-4380 (2002)
   PUBMED   12040043
REFERENCE   8  (bases 1 to 8797)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   9  (bases 1 to 8797)
  AUTHORS   Kao,H.T., Porton,B., Hilfiker,S., Stefani,G., Pieribone,V.A.,
            DeSalle,R. and Greengard,P.
  TITLE     Molecular evolution of the synapsin gene family
  JOURNAL   J Exp Zool 285 (4), 360-377 (1999)
   PUBMED   10578110
REFERENCE   10 (bases 1 to 8797)
  AUTHORS   Kao,H.T., Porton,B., Czernik,A.J., Feng,J., Yiu,G., Haring,M.,
            Benfenati,F. and Greengard,P.
  TITLE     A third member of the synapsin gene family
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4667-4672 (1998)
   PUBMED   9539796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043854.1, AK080557.1, BC107397.2, AC122919.3 and BC059894.1.
            
            On Sep 1, 2009 this sequence version replaced NM_013722.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080557.1, AF192754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK043854.1         2-41
            41-1014             AK080557.1         2-975
            1015-1518           AK080557.1         977-1480
            1519-1995           BC107397.2         1385-1861
            1996-7714           AC122919.3         42509-48227
            7715-8797           BC059894.1         1-1083
FEATURES             Location/Qualifiers
     source          1..8797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.95 cM"
     gene            1..8797
                     /gene="Syn3"
                     /note="synapsin III"
                     /db_xref="GeneID:27204"
                     /db_xref="MGI:MGI:1351334"
     exon            1..107
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            108..564
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1993
                     /gene="Syn3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synapsin-3; synapsin IIIa"
                     /codon_start=1
                     /product="synapsin-3 isoform 1"
                     /protein_id="NP_038750.2"
                     /db_xref="CCDS:CCDS24096.1"
                     /db_xref="GeneID:27204"
                     /db_xref="MGI:MGI:1351334"
                     /translation="MNFLRRRLSDSSFVANLPNGYMPDLQRPESSSSSPASPATERRH
                     PQPLAASFSSPGSSLFSSFSGAMKQTPQAPSGLMEPPTPVTPVVQRPRILLVIDDAHT
                     DWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKIVRSFKPDF
                     ILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLG
                     PEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMA
                     KTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLW
                     VDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKM
                     SQLLVPGATVPSPLRPWGPQTKPAKSPGQGQLGPLLGQPQPRPPPQGGPRQAQSPQPP
                     RSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSH
                     NRPPVQGRSTSQQGEEPQKSASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETI
                     RNLRKSFASLFSD"
     exon            565..622
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..714
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..871
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..961
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1024
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1167
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1242
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1345
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1480
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1568
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1860
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..8779
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8752..8757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syn3"
                     /note="hexamer: AATAAA"
     polyA_site      8779
                     /gene="Syn3"
                     /note="major polyA site"
ORIGIN      
        1 actgtgcagg gcagaggcag agcgcgcaag ctgcagcgct cccgcagatc ctgtaattgg
       61 cggcgccagt ccgaggtaca cacgggccac cgtagctggc actgtcgata aacagagtcc
      121 tgggaagtcc acttctcatg gtgcagaagc tctctctgac cccaagcctc cagctccccg
      181 taactggcaa cctgagcttc aaacctcatc gagttgattc tgtgtggaag gagaattccc
      241 atctattgca gccatgaact tcctccggag gcggctgtct gacagcagct ttgtggccaa
      301 cctgcccaat ggctacatgc cggacctgca gcgcccagag agctccagta gctctccagc
      361 atccccggcc acagagagga ggcaccccca gcccctggct gcctccttct catctccagg
      421 atccagcctg ttcagctcct tctccggtgc catgaaacag accccacagg ctccctcagg
      481 gctgatggaa ccacccactc ctgtcacacc cgtggttcag agacccagga tcttgttggt
      541 tatcgatgac gcccatacag actggtcaaa gtattttcat gggaagaaag tgaatggcga
      601 cattgagatc cgagtggaac aggctgagtt ctctgagctg aacctggctg cttatgttac
      661 cggaggctgc atggtggaca tgcaagttgt gagaaatggc accaaaattg tgcggtcctt
      721 caaacctgac ttcatcctgg tccgacagca tgcctacagc atggccctgg ctgaggacta
      781 ccggagcctg gtcatcggcc tccagtatgg agggcttcct gctgtcaact ctctctactc
      841 cgtatacaac ttctgcagca agccttgggt gttttctcag ctcattaaga tcttccattc
      901 cttgggtcct gagaaatttc cactagtgga gcaaacattt ttccccaacc acaagccaat
      961 gctcacagcc ccgaacttcc ccgtggtgat caagctggga catgcccatg ctggcatggg
     1021 aaagatcaaa gtagaaaacc agcacgacta ccaggacatc accagcgtgg tggccatggc
     1081 caaaacctat gccaccacgg aggcctttat tgactccaag tatgacatcc gcatacagaa
     1141 gattggatcc aactacaagg catacatgag aacctccatc tctggaaact ggaaggccaa
     1201 tacaggctct gctatgctgg agcaggtggc catgacagaa aggtacaggc tgtgggtgga
     1261 cagctgctca gaaatgttcg gcggcctaga catctgtgct gtcaaggctg tccacagcaa
     1321 ggacggcaga gattatatca tcgaggtcat ggacagttca atgcccctga ttggagaaca
     1381 cgtggaagaa gacaagcagc taatggctga ccttgtcgtt tccaagatga gccaactcct
     1441 ggtgccaggg gccacggtgc cctcacctct gagaccttgg ggtccacaga ctaaacctgc
     1501 aaaatctcca gggcaaggcc agctaggacc tctactagga cagccccagc caaggccacc
     1561 tccacaaggg ggccctcgtc aggctcagtc tcctcagcct cccagatcta ggagtccatc
     1621 ccaacagcga ctctcgccac aaggccagca gcctgtgagt ccccagtcag gctctccaca
     1681 gcagcaaagg tcaccggggt ctccacagct atcccgggca tccggtggca gttctccaaa
     1741 ccaggcctcc aagccaagtg ccagcctcag ttcacacaac cggcctccag tgcagggacg
     1801 cagcacctcc cagcagggtg aagagcctca aaaatcagca tcaccccacc cccacctcaa
     1861 caaatctcag tccctgacta acagcctcag cacatcagat acctcccatc gagggacccc
     1921 aagtgaagat gaggccaagg ctgagacaat ccgcaacctg aggaagtcct tcgccagtct
     1981 cttctctgac tagcccctat ccaggctgga agacaggcag gcaggcaaga agactcgatc
     2041 actggagcct ttctctggtt ccctccttct cagccttggt tcccaacgga aatatgcttc
     2101 ctaaagatgc aggaactgat gatctacagc cattcccccc tccttgacca tgacattcca
     2161 atgctgtctg actgaatggt agccttggga gcccctaggt tcctcaacac gggccctcta
     2221 gacagacaag gcatcactac atccaccata tgcctgctcc cctgtcgccg gtaccaagtg
     2281 agatgtctgt gtggcttgtt tttgcagtct tattagtatt ttgcttgcct ttgggcagag
     2341 gccctcttct aggccttgac tcaccttcat caaatgcata cattatagtc ggacctcagc
     2401 aacacaagag gcaatacttt ttaatggtgg ttttgcaaac agaaataggg aagcccagcc
     2461 tgggagccca ctactcacct gaagctaact aatgccatcc ctgctggggg taggctgaca
     2521 aaggccccca tcacagctgg ccctcatggt gaccttgatg tcaatagaaa gaagctagac
     2581 cctatgcaac aagtgggacc tttcagaaca ggacagagga aaacccacag agccaacagc
     2641 aggaatccag aggagagagc ttgtgttccc aggggagagg gacgcaggag gattgtgcct
     2701 gtctgacctc acacagaatc tgttcttttt catccttaag gctagatggg aacccagaga
     2761 aagtggatgg ctccctgtca caggatcaga agacacagtg atggctcagc atcctacctg
     2821 ctctgaaaga ggagttagta ggtcactcag tttatagtgg gagatccttt aaaaacaggg
     2881 tgtgtggttt ctttaggagc tactgaagcc ttttggaatt tcttccagaa aaagttccac
     2941 tccaaccttg ttgtcggcgt agccacgatg actacgatgg tttgctgcag agctaggcaa
     3001 agtggtcctg attccctttc cagtggtctt tcccctgcac cagatggcct cccaggacca
     3061 catcaccaag cacctggtgc taggaacatt gtaggtgcca gaagccgcct cctggtcccc
     3121 agacagaccc agaacatcag aacagagcca tgttcctctc tatacagccc ctgtggcctc
     3181 ccgaggcgtg ccctcgctgc actgtctgag gcaggggagt tattaactga agaagcgtct
     3241 ggttatgctt gagttctgca cattgcttgg tgatcatctg aggcctcctt gggtctccag
     3301 gagcatagag gccatcacta tgatttctgg ggactttgtt ttcttgaaac aatctcactc
     3361 agcaactcag gctggcatag aatatattat gtagcccaca caagtctcaa actcagcgat
     3421 tctcctgctt tatcagcctc ccaagtgctg agattacatt tatgaaccac cacgcccagc
     3481 aagcaatcca tcacttttgg gtcctcccag cccagacatg agtggcagaa acaaagggta
     3541 aagaccctgt cctgccttgg accacttaga cccctgcatt tctgcagaat gcaccttcca
     3601 gctggtttcc agcagggatc agctcagtat aaaaagtggt agctttgcca ctggctgcta
     3661 gagatccggt tagccctcaa ggtcatcctc tctctcctta cctcttccct ctccctcttg
     3721 atcaagtcag tgttgagagc aagcgtactg gagttatttc agaagccctc cttggcctcc
     3781 ctttccatat ccttggtttg gagtgataag ttgcagctgt gatgtaggat catgtaggtc
     3841 ccgtgactgc tgaggccatc atttggagct gcacatacag gacttaggcc caattgaaat
     3901 tgaccagaat caacagtaaa taggctgtgg tgttaaggtg tagaggccct cccagtacca
     3961 agaaagccca gcctgtttta ttgctaacct ccaggaattc agtgtgagga ggacagtccc
     4021 cgagcatggc cacacccagc ctgcccacat ctccctcatt ttactcaact gctcttctat
     4081 cgcaggatga ggctgcaaaa gcttccagaa tgcttttgga ggctaatggg gatgacccag
     4141 cacgtggtga gacacatggc acaactgcca gtgcaatctc ctagacacat ctgctccctg
     4201 gtaagggagg aagtctggag gccagcaccc cccaagccat actttaggta ggtcaaccaa
     4261 aggagaaaga agatcagtct gtgagtccac agaacactgc ttcttcctcc tgcccctccc
     4321 tccctcctct gcgcttagct cttgcacctt tctctagagc ctctgaagaa tgcgagggga
     4381 gacagaagga aggagtgtgg tgtgggaagt aagatttgaa gtatcaaaag agagtctgtg
     4441 aagtgagctc cacagaagag gatgtggatg ctaatgcctg ggtaatgacc tgaatgagca
     4501 cattaggacg taacagccta aagccccatt acctcatctc ggacggtaac tcttgctagt
     4561 tcctgatatt tgcttcagtg acagtctgct tccccaccag atcctgagaa gccaggcctt
     4621 gctcatgggg catgtgtgga ggaaaatcag aacaccagcg gcacagaagc tcctgacaat
     4681 gacagctgaa gttgctcctg aagcgtactc ccgtgcacac acacacacac acacacacac
     4741 acacacacac acacacacac actgacagac acagagataa aaacagagac aggcaggcca
     4801 gcaggcagac actgacagac aggcaggcag gcaggcagac agatggacgg acggacaggt
     4861 agacaggaga actttgcatt ctgaacaagg gtgagaggca cgctttgagt gacttaagaa
     4921 cacagggaac atcggtggca gccatcactc tacagcactc tcagccttgt ctaaatgata
     4981 gaacagctcc tgacacacag tggagtaaaa accaacagca ggaagtttct caaaatgtag
     5041 gccatggccc tggacataac tacttataaa ggcccagaaa actttgcttc agagcacagc
     5101 acattgaact tgtagttaga gagctcaaag cctgcagctg gatcagcccg ctgagactgg
     5161 gctgcattct gaagccgggt ggggagcaat atatgtcaat caccagcctt gctaaggacc
     5221 cgttcctttg acaggcagaa ccagtggctc cataaatgac catgtggcca aaatactctc
     5281 atagtctgcc ctttaaaata tctcagcaat cgatgacatc cctccaggat ctcaactaca
     5341 gtaacacaaa tgtctttcaa aatctaaacc aggccaggca tcctgatttt tataaccatg
     5401 caagtatgtc tacatccatg atgcaacact agactgtggc cagcactttt atctaatttc
     5461 caactggcct gggaatgaaa acagaagcca agactataga tacatgtccg tccagtggag
     5521 cccacatctc tctccaacgg actgttgttc ccatagcctg gtacatgtcg ctctgaaacc
     5581 tggtaaccct cagtaactgt gacatttaga ggtagaaaag ggcaaaagga acagggtagg
     5641 gccattgtaa atagaatctg aaaggtttta tttattgggt tctgctcttt tacaattttg
     5701 acccaaacaa tagcattttc cttccaagct gacctaatga agccgagaca caacaaagac
     5761 ctattcaatt tgtacacaat gaccaaggac ttccaaacac gaccccaaaa gacacctcaa
     5821 ggccgccaca gcacacttcc tccagacctg tcccatgatt agatgatgct gcttggactt
     5881 tggctggtgg cgaatcaact ttcaaggcac agaataccca caccatttct ctttccccaa
     5941 tgcttctggg ctgctgcgtc cactctagca tgcacttggt ctattcctca agtatcaggt
     6001 gtggcagttc ttcagtataa ctttaaagga aaatcaactg aaaactccat gcaagggaat
     6061 cgccactgcc tccaggaagt tctcatgtga ctatccagca ccagggggcg agctggctgg
     6121 gcacctgggg gctggcacag cagcaccagg agagcaggct ggctgggcac ctgggggctg
     6181 gcacagcagc accaggggat cgagctggct gggcacctgg gggctggcac aggagcttgg
     6241 agcagctgct cagtgcccgt taggtactca ggattctctt taggttactc tcctagaaaa
     6301 ttaggaaaat aatgacatgt atgtgacaga ttaagaatgg aaaatggatg gtttcttaag
     6361 ttgagaaact cacctggaat taaacagaaa tatgagtaaa aagagaaaat agaaaaaaac
     6421 aaacaaacaa caaaacaaaa ccactactag acccagaaaa ggaagcggac ttctacaaga
     6481 gagcctcaca gactctactg atcaaatgta gcgcggcttt gtaaacaagg ccccagggcc
     6541 ttgcgtgagg accagctccc aacagcaggc ccttctcttc tgctttgttc agcctcataa
     6601 aacagcttgg tggttcattt agtgtcttca gaagtggtga acgactgcag gttagtcgca
     6661 ggcactggtt aagccagcct tgcaagtatg gacaaggggt aacataacta tcaccaggac
     6721 cagtccattc ccttcaagag agcttgcaca tgtatctcta ggcttcttat cccagagcca
     6781 agtcagctga tagaattaac ctggtggcag atgctgtcct aaaccacagt agctgattaa
     6841 actgtttaat gtttagactt taataggagg aggcactttg ggcttgattg aagacaaatg
     6901 ggaaggctgg gtggcaagca agccaaactg gtctatttag gagcataaaa gacacagaac
     6961 ctcttttgtg ttcccacaaa gcatgagccc agattgataa acatgcacac ccaggcttca
     7021 tatgcagatc taactggtag atctagagaa gaaagcaaaa acacccagag gtggtcatca
     7081 agtcttgaga agttaaacac ttttcatacc caacacttca ttttactttg gaatatcaga
     7141 aaaataagag ttaacaactc acatgggatt tccaatagag aaaaaaagaa gtcatatcaa
     7201 atcaaatctt tagggtctcg atagatcggt cggtgtttgc agtacaagca caaggacctg
     7261 catttgattc tcaggagcca tgctgaaaag ccgggcaggg cagtgagcac ttagaacctc
     7321 aaccctggta acataaagag agatagagac ttgcctagca tactgcaata cccttatcca
     7381 tgcaagagtt tacaaaacac caccagcact agagcacagc agaggacctg tctagctctt
     7441 ctccaaggct caaataggca gataggaaga aaacagacct tggaacaact ctgaacagaa
     7501 gaaggagaag gactatccga ctctgccagg taagaattac agagatatgt atggcctcag
     7561 caactgagag gaactaggaa aaaagagcta cagaattcag gatttttaca cagggagcca
     7621 caagttggaa agggctcttc ccaagactga attattacca gccatgacaa atgggcattt
     7681 tccacttaca gtgctaaggg aaggagactc agatcctatt actaaaagtg actactggag
     7741 aacttagggg ccgagaaaga tgtgaggcta ctacaagtca atgcgccggg gctgcaccat
     7801 tctcaagcgc ttgccatggg cttctaggct gtcctgctcc cattacagtg catggagatg
     7861 acatcaacaa agccatgcag tgaacaagct actgccaagc caagatctca ctcagtatca
     7921 gcaatacgta aagctccaaa gcccaatgac aaggatgtgt gcgagacgtt caaagcttct
     7981 caatataaaa ttaactgcta gtcaagggga aagttttgag gactcttaat aaaaattttt
     8041 gagtggtacc taagtttagg tttagagcac tctgccaata atcttaaact ggagacttgc
     8101 aacatctgcc agttacgcct agtgagactg acaccagcac catcaggacc tcccagggcc
     8161 catttggaaa tgacttatat tctgaaaact tgtatttggt gctctggtca tcactgcttc
     8221 ccatgctaac attcagccac acacacacac acacaaacac acatgtacac atacacacat
     8281 actacatggg gcaacctaac attcatccac aaaagcatgt tctgaaatag actctagatc
     8341 aatcaaaact tcagggtgac ccctttagcc acacttaaat gaagcctaaa gcattcagtg
     8401 gacattaaga ctgtcctgta gatcatagaa acataatgtt aaaggtcaca tcacctctgg
     8461 cctctagaat atcaaacaat tttcttcact gtgatgcaaa gactcaaaac acatgtagca
     8521 aagtctcact tgcatacagg actcaaaata tccctgcagc acatattcca agccatttcc
     8581 taatatgcaa acaggttttt aaaaacagga agacattggc actattccta ttttctgcag
     8641 atgctaatag cattttattc ctgtgcagca gttccaattt aaatgtgtca ctatagcatg
     8701 ttcctatagt tatttgtatt aagtgtttgg gctttttctt gttgtagaat aaataaatgt
     8761 tgaattttga gtattttaaa aaaaaaaaaa aaaaaaa
//
