LOCUS       NM_001164495            4020 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synapsin III (Syn3), transcript variant 2, mRNA.
ACCESSION   NM_001164495
VERSION     NM_001164495.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Bruentgens,F., Moreno Velasquez,L., Stumpf,A., Parthier,D.,
            Breustedt,J., Benfenati,F., Milovanovic,D., Schmitz,D. and
            Orlando,M.
  TITLE     The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal
            Mossy Fibers in Male Mice
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38866497
  REMARK    Erratum:[eNeuro. 2024 Sep 13;11(9):ENEURO.0360-24.2024. doi:
            10.1523/ENEURO.0360-24.2024.. PMID: 39271241]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Stavsky,A., Parra-Rivas,L.A., Tal,S., Riba,J., Madhivanan,K.,
            Roy,S. and Gitler,D.
  TITLE     Synapsin E-domain is essential for alpha-synuclein function
  JOURNAL   Elife 12, 89687 (2024)
   PUBMED   38713200
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Longfield,S.F., Gormal,R.S., Feller,M., Parutto,P., Reingruber,J.,
            Wallis,T.P., Joensuu,M., Augustine,G.J., Martinez-Marmol,R.,
            Holcman,D. and Meunier,F.A.
  TITLE     Synapsin 2a tetramerisation selectively controls the presynaptic
            nanoscale organisation of reserve synaptic vesicles
  JOURNAL   Nat Commun 15 (1), 2217 (2024)
   PUBMED   38472171
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Kim,H.Y., Lee,J., Kim,H.J., Lee,B.E., Jeong,J., Cho,E.J.,
            Jang,H.J., Shin,K.J., Kim,M.J., Chae,Y.C., Lee,S.E., Myung,K.,
            Baik,J.H., Suh,P.G. and Kim,J.I.
  TITLE     PLCgamma1 in dopamine neurons critically regulates striatal
            dopamine release via VMAT2 and synapsin III
  JOURNAL   Exp Mol Med 55 (11), 2357-2375 (2023)
   PUBMED   37907739
  REMARK    GeneRIF: PLCgamma1 in dopamine neurons critically regulates
            striatal dopamine release via VMAT2 and synapsin III.
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Heeroma,J.H., Plomp,J.J., Roubos,E.W. and Verhage,M.
  TITLE     Development of the mouse neuromuscular junction in the absence of
            regulated secretion
  JOURNAL   Neuroscience 120 (3), 733-744 (2003)
   PUBMED   12895513
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Feng,J., Chi,P., Blanpied,T.A., Xu,Y., Magarinos,A.M., Ferreira,A.,
            Takahashi,R.H., Kao,H.T., McEwen,B.S., Ryan,T.A., Augustine,G.J.
            and Greengard,P.
  TITLE     Regulation of neurotransmitter release by synapsin III
  JOURNAL   J Neurosci 22 (11), 4372-4380 (2002)
   PUBMED   12040043
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   Kao,H.T., Porton,B., Hilfiker,S., Stefani,G., Pieribone,V.A.,
            DeSalle,R. and Greengard,P.
  TITLE     Molecular evolution of the synapsin gene family
  JOURNAL   J Exp Zool 285 (4), 360-377 (1999)
   PUBMED   10578110
REFERENCE   10 (bases 1 to 4020)
  AUTHORS   Kao,H.T., Porton,B., Czernik,A.J., Feng,J., Yiu,G., Haring,M.,
            Benfenati,F. and Greengard,P.
  TITLE     A third member of the synapsin gene family
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4667-4672 (1998)
   PUBMED   9539796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043854.1, AK084032.1 and AC125060.4.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding region, compared to variant 1. The encoded isoform (2) is
            shorter and has a unique C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084032.1, SRR7345562.1192359.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK043854.1         2-15
            15-767              AK084032.1         1-753
            768-2367            AK084032.1         755-2354
            2368-2370           AC125060.4         126850-126852       c
            2371-4020           AK084032.1         2355-4004
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.95 cM"
     gene            1..4020
                     /gene="Syn3"
                     /note="synapsin III"
                     /db_xref="GeneID:27204"
                     /db_xref="MGI:MGI:1351334"
     exon            1..107
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            108..564
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..985
                     /gene="Syn3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synapsin-3; synapsin IIIa"
                     /codon_start=1
                     /product="synapsin-3 isoform 2"
                     /protein_id="NP_001157967.1"
                     /db_xref="CCDS:CCDS48659.1"
                     /db_xref="GeneID:27204"
                     /db_xref="MGI:MGI:1351334"
                     /translation="MNFLRRRLSDSSFVANLPNGYMPDLQRPESSSSSPASPATERRH
                     PQPLAASFSSPGSSLFSSFSGAMKQTPQAPSGLMEPPTPVTPVVQRPRILLVIDDAHT
                     DWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKIVRSFKPDF
                     ILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLG
                     PEKFPLVEQTFFPNHKPMHFTHSLR"
     exon            565..622
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..714
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..871
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..961
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..4020
                     /gene="Syn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgcagg gcagaggcag agcgcgcaag ctgcagcgct cccgcagatc ctgtaattgg
       61 cggcgccagt ccgaggtaca cacgggccac cgtagctggc actgtcgata aacagagtcc
      121 tgggaagtcc acttctcatg gtgcagaagc tctctctgac cccaagcctc cagctccccg
      181 taactggcaa cctgagcttc aaacctcatc gagttgattc tgtgtggaag gagaattccc
      241 atctattgca gccatgaact tcctccggag gcggctgtct gacagcagct ttgtggccaa
      301 cctgcccaat ggctacatgc cggacctgca gcgcccagag agctccagta gctctccagc
      361 atccccggcc acagagagga ggcaccccca gcccctggct gcctccttct catctccagg
      421 atccagcctg ttcagctcct tctccggtgc catgaaacag accccacagg ctccctcagg
      481 gctgatggaa ccacccactc ctgtcacacc cgtggttcag agacccagga tcttgttggt
      541 tatcgatgac gcccatacag actggtcaaa gtattttcat gggaagaaag tgaatggcga
      601 cattgagatc cgagtggaac aggctgagtt ctctgagctg aacctggctg cttatgttac
      661 cggaggctgc atggtggaca tgcaagttgt gagaaatggc accaaaattg tgcggtcctt
      721 caaacctgac ttcatcctgg tccgacagca tgcctacagc atggccctgg ctgaggacta
      781 ccggagcctg gtcatcggcc tccagtatgg agggcttcct gctgtcaact ctctctactc
      841 cgtatacaac ttctgcagca agccttgggt gttttctcag ctcattaaga tcttccattc
      901 cttgggtcct gagaaatttc cactagtgga gcaaacattt ttccccaacc acaagccaat
      961 gcattttact cattccctcc gatgacatca cctgccaccg tgtcctagag agccttgaac
     1021 tggacatctc tacaagtctt tcccaccctg aatccaacct ggagaatctc cccagaccgt
     1081 gccaacagcg ccataactgg ccctgcggcc ccagtccttt tctccttctc tgtccggctc
     1141 ttctcttgct gcccatcgtc gtctcacaga tctattcata ttctgtggct ctctgaacaa
     1201 agtcttaaac tccgaagatg tacaagatcc tctctgatct gcctcttctc aacagcaccc
     1261 tgagctgcaa ctggaggtga caccactcct atagaacatc acgtgactat tacccagcag
     1321 cagacccacc cttagtgcca cctaaacctc tgttacctca gtcccatctt gccccatttt
     1381 atgccccctg ccctccctcc tccactccca tctgccagga atcaattagg accaccagct
     1441 ttggaatgtt ctctgactcc cttcagagaa cattcccttt cagctgtcca tctgggcacc
     1501 tcttatgctc tgcgccccta gtggtctaaa tgtctgtaga cccaagcaaa cctgggtgct
     1561 tctctgtgtg ccagtgcagt acctgcacac agtagacact tagaaaatac tgaagaaaga
     1621 gactaaacaa tgaactgggg gggaaagatc cagtgtatgt caatatcccc attgctaatc
     1681 caccatgaga ggctctagga cctaactcat tgaacttgag ttctcagaga gattcccaga
     1741 ggtgaacagt ctcatgggta cacccaactc aaaagggcca gcaagccagc aagccagcca
     1801 gccagccaca gtgccactgt ccttgcttct gtgagacaaa tgattaagaa gtaggcaggc
     1861 aacacatgtt catggcatac cttattatat tctgatagtg gaagagtcct atacctcctc
     1921 accagaacac tttgagttgg tgggtgtgaa attagaacat ggattgagga catcccaaga
     1981 ggaacttcta gggaaaacac cttgaaattt tctcttctca actacatgtt ttaaaaattg
     2041 attgcgtgtg tatacctgtg tgcctgagtg gtggtcagag gactggtgag agttgggtct
     2101 ctctttccaa cacatgggtt ctggatgtca aactcaggtt gtcaggcttt gtgtcaagca
     2161 cgtttactct gtaagtcatc tcagctgcct ttgaattttc tttctgatgg aagctgtgtc
     2221 cactgtcaaa agccagtctc gctggatggt gatgatggct gagctcacaa cacctactgt
     2281 ggtctctttg gtcttctcaa ttctttgttt aagattagtc atgccttcat cttcccctag
     2341 actctttttt tttttttttt tttttttttt ggccccagaa agattgcaat tcattggttt
     2401 ttctactagt ctattgtttt caggtacttt tgatagaaca aaccttatga aactgaagct
     2461 tctagtacaa cccgttcttg ccagatagat agatagatag atagatagat agatagatag
     2521 atagatagac agatctttga acttggccag tgggccttgt gtttaagagc aatgtctgtg
     2581 aagatatcct tgatgacaaa aaattgccca agaggccatt cacaaagtat gtgtagacat
     2641 gaggcagtac tagttataaa cttctacaaa gggtttgtgc tttgacgtct ccctcagtct
     2701 tccaacccta aataatagac attttacgtg agagaaagta tgtgtgttgc acacagtgag
     2761 gcgatccaag gttaacaaga tttatcttcc tctttccctc ttcaacttat tttttgagac
     2821 agtggctctc cttgaacctg gagctccctg attcgagtag gctgaccagc cagtgagctg
     2881 cagagaagag atctgcatgt ctctgttttc ccagcactga gattacgggc attgccacac
     2941 cacctttttt agacccctgc tagagctgtg acttcaggta cttaagcttg cacagcaaca
     3001 agcatctccc caccactgta tgtctgcctt ataatcaagg aaactggggc ttaaggaaga
     3061 catcttgcag acaactaaat attgtttctc tttccttcat atccatctgc taggtcttct
     3121 ttcagactct ttcttgctat aattgttttt cctcctttca tctggccacc tctggtttat
     3181 tggaatactg aagaatgggc cctaaggtcc ctggggtgta cctgagctgg ctgatagtgg
     3241 ctcagtagaa tccattgcta tattttccca gagttctcag agttacttgt aaaacatggt
     3301 catgattaaa attgtaattg caaaagtcaa caattaagtt aactttattt aaagcaatgc
     3361 aaattaacat caaacttcat catttcctaa tcatatatac tcctcaactt aaaatgagga
     3421 tatatccaag taaactcaca tgcccggcta ccattggctt aaaatatcat gatctcaaca
     3481 gcctgtaata tacttgacca gctaaacatt ggagccaagc cacagacatg ctgcaagtgt
     3541 ctctggctca ctgttttgaa ggggacctgc tggggtttgt gctcattgcc actgtccaga
     3601 atatcaggaa aggtttatag tgagtgtcag tagctcagga aatgatgaaa agtgagagat
     3661 ctggaggttg gttccaactg agtgcacata atttccccac catcttaaag ttaaaaagga
     3721 atagaatcct gagtcaaatg tctgtgtgtt tttaccatct caaggtcaat attctagagg
     3781 ttattcccac tgacttttgt ctgcgtggtg gtgacattac ataatgctct gacgttgtgg
     3841 atcgttctca ctctgtagtg agtgacatca cagtgtaatt tagaatattt acaccatgga
     3901 aattggccaa cccaacaaat caggacttct tgtctaggag agccacttgt taagtattta
     3961 caggttcact attattattt cctaactgca acaccctgga taaataactt tacctcctcg
//
