LOCUS       NM_001111015            3343 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus synapsin II (Syn2), transcript variant IIa, mRNA.
ACCESSION   NM_001111015
VERSION     NM_001111015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   Ma,Q., Yang,Z., Yang,C., Lin,M., Gong,M., Deng,P., He,M., Lu,Y.,
            Zhang,K., Pi,H., Qu,M., Yu,Z., Zhou,Z. and Chen,C.
  TITLE     A single-cell transcriptomic landscape of cadmium-hindered brain
            development in mice
  JOURNAL   Commun Biol 7 (1), 997 (2024)
   PUBMED   39147853
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Bruentgens,F., Moreno Velasquez,L., Stumpf,A., Parthier,D.,
            Breustedt,J., Benfenati,F., Milovanovic,D., Schmitz,D. and
            Orlando,M.
  TITLE     The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal
            Mossy Fibers in Male Mice
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38866497
  REMARK    Erratum:[eNeuro. 2024 Sep 13;11(9):ENEURO.0360-24.2024. doi:
            10.1523/ENEURO.0360-24.2024.. PMID: 39271241]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Stavsky,A., Parra-Rivas,L.A., Tal,S., Riba,J., Madhivanan,K.,
            Roy,S. and Gitler,D.
  TITLE     Synapsin E-domain is essential for alpha-synuclein function
  JOURNAL   Elife 12, 89687 (2024)
   PUBMED   38713200
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Longfield,S.F., Gormal,R.S., Feller,M., Parutto,P., Reingruber,J.,
            Wallis,T.P., Joensuu,M., Augustine,G.J., Martinez-Marmol,R.,
            Holcman,D. and Meunier,F.A.
  TITLE     Synapsin 2a tetramerisation selectively controls the presynaptic
            nanoscale organisation of reserve synaptic vesicles
  JOURNAL   Nat Commun 15 (1), 2217 (2024)
   PUBMED   38472171
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Forte,N., Nicois,A., Marfella,B., Mavaro,I., D'Angelo,L.,
            Piscitelli,F., Scandurra,A., De Girolamo,P., Baldelli,P.,
            Benfenati,F., Di Marzo,V. and Cristino,L.
  TITLE     Early endocannabinoid-mediated depolarization-induced suppression
            of excitation delays the appearance of the epileptic phenotype in
            synapsin II knockout mice
  JOURNAL   Cell Mol Life Sci 81 (1), 37 (2024)
   PUBMED   38214769
  REMARK    GeneRIF: Early endocannabinoid-mediated depolarization-induced
            suppression of excitation delays the appearance of the epileptic
            phenotype in synapsin II knockout mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Li,L., Chin,L.S., Greengard,P., Copeland,N.G., Gilbert,D.J. and
            Jenkins,N.A.
  TITLE     Localization of the synapsin II (SYN2) gene to human chromosome 3
            and mouse chromosome 6
  JOURNAL   Genomics 28 (2), 365-366 (1995)
   PUBMED   8530057
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   Rosahl,T.W., Spillane,D., Missler,M., Herz,J., Selig,D.K.,
            Wolff,J.R., Hammer,R.E., Malenka,R.C. and Sudhof,T.C.
  TITLE     Essential functions of synapsins I and II in synaptic vesicle
            regulation
  JOURNAL   Nature 375 (6531), 488-493 (1995)
   PUBMED   7777057
REFERENCE   8  (bases 1 to 3343)
  AUTHORS   Li,X., Rosahl,T.W., Sudhof,T.C. and Francke,U.
  TITLE     Mapping of synapsin II (SYN2) genes to human chromosome 3p and
            mouse chromosome 6 band F
  JOURNAL   Cytogenet Cell Genet 71 (3), 301-305 (1995)
   PUBMED   7587399
REFERENCE   9  (bases 1 to 3343)
  AUTHORS   Chin,L.S., Li,L. and Greengard,P.
  TITLE     Neuron-specific expression of the synapsin II gene is directed by a
            specific core promoter and upstream regulatory elements
  JOURNAL   J Biol Chem 269 (28), 18507-18513 (1994)
   PUBMED   8034599
REFERENCE   10 (bases 1 to 3343)
  AUTHORS   Oettinger,H.F., Streeter,H., Lose,E., Copeland,N.G., Gilbert,D.J.,
            Justice,M.J., Jenkins,N.A., Mohandas,T. and Bernfield,M.
  TITLE     Chromosome mapping of the murine syndecan gene
  JOURNAL   Genomics 11 (2), 334-338 (1991)
   PUBMED   1769649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147047.2, BY705489.1, BC066004.1 and AC153907.1.
            
            Transcript Variant: This variant (IIa) encodes the longer isoform
            (IIa).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085129.1, SRR7974084.9425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC147047.2         173466-173480
            16-181              BY705489.1         1-166
            182-2708            BC066004.1         1-2527
            2709-3343           AC153907.1         130612-131246
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.2 cM"
     gene            1..3343
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /note="synapsin II"
                     /db_xref="GeneID:20965"
                     /db_xref="MGI:MGI:103020"
     exon            1..559
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1940
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /note="isoform IIa is encoded by transcript variant IIa;
                     synapsin-2"
                     /codon_start=1
                     /product="synapsin-2 isoform IIa"
                     /protein_id="NP_001104485.1"
                     /db_xref="CCDS:CCDS51874.1"
                     /db_xref="GeneID:20965"
                     /db_xref="MGI:MGI:103020"
                     /translation="MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPAPGPGAAT
                     ASAATSAASPGPERRPPPAQAPAPQPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLV
                     DAPAPSAASRKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADG
                     TYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLVIGMQYAGLPSINSLE
                     SIYNFCDKPWVFAQMVAIFKTLGGEKFPLIEQTYYPNHREMLTLPTFPVVVKIGHAHS
                     GMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGNNYKAYMRTSISG
                     NWKTNTGSAMLEQIAMSDRYKLWVDACSEMFGGLDICAVKAVHGKDGKDYIFEVMDCS
                     MPLIGEHQVEDRQLITDLVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKEPDSSKTP
                     PQRPPPQGGPGQPQGMQPPGKVLPPRRLPSGPSLPSSSSSSSSSSSSSSAPQRPGGPT
                     TTHGDASSSSNSLAEAQAPQAAPAQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANED
                     EAKAETIRSLRKSFASLFSD"
     exon            560..617
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..709
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            710..866
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            867..956
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1019
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1162
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1237
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1340
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1490
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1551
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1804
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..3343
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2714
                     /gene="Syn2"
                     /gene_synonym="2900074L19Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtagtcacg ccctcggcac cgcccactgc tccctcgcta acaggctcgc tccccagacc
       61 cagagcgccg cggctgtctg ctgggctccc ggagacgcgg accaccttcg gtgtccccgc
      121 gccgtcctcc ccgcgccgct tggcccgccg cctcgagcgc cctcagcccc tcaagccaga
      181 tgatgaactt cctgaggcgc cggctgtcgg acagcagctt catcgccaac ctgcccaatg
      241 gctacatgac tgaccttcag cgcccggagc cgcagcagcc ccctcctgcc cctggccccg
      301 gtgccgctac ggcgtcggcg gccacctcag ctgcctcgcc cggtcccgag cgcaggccgc
      361 cacccgccca ggcacccgcg ccgcagccgg cgccgcagcc cgcgccgacg ccgtcggtgg
      421 gcagcagctt cttcagctcg ctgtcgcaag cggtgaagca gacggccgcc tccgccggcc
      481 tggtggacgc gcccgcacct tcggccgctt ccaggaaggc caaggtgctg ctggtggtcg
      541 acgagccgca caccgactgg gccaaatgct ttcggggcaa aaaaatcctt ggagattatg
      601 acatcaaggt ggaacaggca gaattctcag agcttaacct ggtggcccat gcagatggaa
      661 cctacgccgt ggacatgcag gtacttcgga atggcacaaa ggttgtccgg tccttcagac
      721 cagactttgt gctcatccga cagcatgcat ttggcatggc agagaatgaa gacttccgcc
      781 acctggtcat tggcatgcag tacgcaggcc tccccagcat caactctctg gagtctattt
      841 acaacttctg tgacaagccg tgggtgtttg ctcagatggt ggccatcttc aagacactgg
      901 gaggggagaa attcccactc attgagcaga catactaccc caatcaccga gagatgctta
      961 cgcttcctac gttccctgtg gtggtgaaga ttggccatgc tcactcaggc atgggcaagg
     1021 tcaaagtgga aaatcactac gacttccagg acattgccag tgtggtggcc ctcacccaaa
     1081 cttatgccac ggcagaaccc ttcatcgacg ccaagtatga catccgagtt cagaagattg
     1141 gcaacaacta caaggcctac atgaggacat ccatctcagg gaactggaag acaaacactg
     1201 gctcggcgat gctggagcaa attgccatgt cggaccggta caagctctgg gtagatgcct
     1261 gctctgaaat gtttggtggc ctggacatct gtgcagtcaa agccgtgcat ggcaaagatg
     1321 gcaaagacta catttttgag gtcatggact gcagcatgcc attgattggg gaacaccaag
     1381 tggaggacag acaactcatc actgatctag tcatcagcaa gatgaaccag ctattgtcca
     1441 ggactcctgc cctgtctcca cagagacctt taaccaccca acagccacag agtggaacac
     1501 ttaaggaacc ggactccagc aagacccctc ctcagcggcc acctccccaa gggggccctg
     1561 ggcaacccca aggaatgcag cccccaggca aggtgctgcc tccacgccgg ctcccctcgg
     1621 gaccatcact gccatcttct tcctcttcct cctcctcttc ctcctcttct tcctcggctc
     1681 ctcagaggcc gggcggcccc accaccaccc acggtgatgc atcctccagc agcaactccc
     1741 tggcagaggc ccaggcacct caggctgctc cagcacagaa gccccagcct cacccacagc
     1801 tcaacaagtc gcagtccctg acaaatgcgt tcagcttctc tgagtcctcc ttcttccggt
     1861 cttcagccaa tgaagatgaa gccaaagcgg agaccatccg gagcttgagg aagtcctttg
     1921 ccagcctctt ttcagattag ctcttcagat acacgagggc atccggccca accaggaaag
     1981 gcatctaaga cattcaccaa cagcagtctg ccatgtttgg tggcgatgtc ccatgacttg
     2041 acatgtgtgg ccccttcctc tgttcctttg tgctcagtaa tttgtgcagc ccagaaatga
     2101 ccatgtgata gtctcagggc aggtacctac cctgagaaag gcctgacagg agaggaaagg
     2161 gctctttccc tgtagtcttt aagagcttta ttctgaagtc atcattgctg tgaatttagt
     2221 ggccttattg tgacagagcc atcgtgtctt actcttccct gtgaagccag gatctctgta
     2281 acgtaggact cctggcagct tagcccagct cggaaacaga gctcagcatg tcctagtagt
     2341 cagtgctacc tgtgggaagt atgttcttac cttccaagta ctgttggctc taagttttag
     2401 gaacttctcc caaagctgga tctcctgtgg tccctgttga aagcacactc gcctgaccct
     2461 gcactcccct agactgctgt ggaggtgaag ttccttgtgt ctgttgaaac aagagaacaa
     2521 ggcctccccg cactgtctcc tctctcccct ctggagagca gttctgttgt gtgagcagca
     2581 gttaccttta cctttcagag ctgtactgta gaggagaatg catgccgcta taacagcagt
     2641 ccaccaacct ttgtgttcct caccttatga atgtcaagac cttggtgtaa taaaagcagc
     2701 agctttaacc agcatttgat tcagccctga ggttccccca tctaagatga gagcatacgt
     2761 gggcatgcag gtgtgtttgt gactaggtag ttaaaagtcc aggagggtaa agttgccgat
     2821 gccgtgtgtg tgcatgtgat ggcaggtgcg cacgtctgtg ttaagaatgt gtctgtacct
     2881 tgaatatcac atcctgatgc tcccaacaag ctccccagtg gatctgtctc ttctagaact
     2941 gtttgactgc caacagcttg gcatttctac ccatttgatt caattcacag actccaatat
     3001 tcacaacacc cctgcctgta tatcaaccaa gttagaccca tcttcccatc tttcatcaag
     3061 attctcagct aaagcccaca aggtacagcc aacaaaagaa gcaacccgtt ctgatgaatt
     3121 tggtcctaca gctgtcgtac gtagttcagg catcctaaag gcctgcggct gggtgggctc
     3181 tgagggattt tactccgaca acttcttcat ggttctctga ggataagttc cacatttgca
     3241 tatgtttgag gaaaaacagt cagtgtgtaa acatcttagc tatgtaattc cctgcgtgtg
     3301 atagatacca tgtgatataa actcaacaag tcaacacccc ttg
//
