LOCUS       NM_013680               3249 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus synapsin I (Syn1), transcript variant a, mRNA.
ACCESSION   NM_013680
VERSION     NM_013680.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Ma,Q., Yang,Z., Yang,C., Lin,M., Gong,M., Deng,P., He,M., Lu,Y.,
            Zhang,K., Pi,H., Qu,M., Yu,Z., Zhou,Z. and Chen,C.
  TITLE     A single-cell transcriptomic landscape of cadmium-hindered brain
            development in mice
  JOURNAL   Commun Biol 7 (1), 997 (2024)
   PUBMED   39147853
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3249)
  AUTHORS   Bruentgens,F., Moreno Velasquez,L., Stumpf,A., Parthier,D.,
            Breustedt,J., Benfenati,F., Milovanovic,D., Schmitz,D. and
            Orlando,M.
  TITLE     The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal
            Mossy Fibers in Male Mice
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38866497
  REMARK    Erratum:[eNeuro. 2024 Sep 13;11(9):ENEURO.0360-24.2024. doi:
            10.1523/ENEURO.0360-24.2024.. PMID: 39271241]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3249)
  AUTHORS   Stavsky,A., Parra-Rivas,L.A., Tal,S., Riba,J., Madhivanan,K.,
            Roy,S. and Gitler,D.
  TITLE     Synapsin E-domain is essential for alpha-synuclein function
  JOURNAL   Elife 12, 89687 (2024)
   PUBMED   38713200
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3249)
  AUTHORS   Longfield,S.F., Gormal,R.S., Feller,M., Parutto,P., Reingruber,J.,
            Wallis,T.P., Joensuu,M., Augustine,G.J., Martinez-Marmol,R.,
            Holcman,D. and Meunier,F.A.
  TITLE     Synapsin 2a tetramerisation selectively controls the presynaptic
            nanoscale organisation of reserve synaptic vesicles
  JOURNAL   Nat Commun 15 (1), 2217 (2024)
   PUBMED   38472171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3249)
  AUTHORS   Derry,J.M. and Barnard,P.J.
  TITLE     Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP
            genes on the human and mouse X chromosomes
  JOURNAL   Genomics 12 (4), 632-638 (1992)
   PUBMED   1572636
REFERENCE   7  (bases 1 to 3249)
  AUTHORS   Grant,S.G. and Chapman,V.M.
  TITLE     Detailed genetic mapping of the A-raf proto-oncogene on the mouse X
            chromosome
  JOURNAL   Oncogene 6 (3), 397-402 (1991)
   PUBMED   2011396
REFERENCE   8  (bases 1 to 3249)
  AUTHORS   Mullins,L.J., Stephenson,D.A., Grant,S.G. and Chapman,V.M.
  TITLE     Efficient linkage of 10 loci in the proximal region of the mouse X
            chromosome
  JOURNAL   Genomics 7 (1), 19-30 (1990)
   PUBMED   2110546
REFERENCE   9  (bases 1 to 3249)
  AUTHORS   Mitchell,M., Simon,D., Affara,N., Ferguson-Smith,M., Avner,P. and
            Bishop,C.
  TITLE     Localization of murine X and autosomal sequences homologous to the
            human Y located testis-determining region
  JOURNAL   Genetics 121 (4), 803-809 (1989)
   PUBMED   2721933
REFERENCE   10 (bases 1 to 3249)
  AUTHORS   Yang-Feng,T.L., DeGennaro,L.J. and Francke,U.
  TITLE     Genes for synapsin I, a neuronal phosphoprotein, map to conserved
            regions of human and murine X chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 83 (22), 8679-8683 (1986)
   PUBMED   3095840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646141.1, BC022954.1 and BI730087.1.
            
            On Nov 20, 2007 this sequence version replaced NM_013680.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BB646141.1         2-23
            23-1562             BC022954.1         1-1540
            1563-2017           BI730087.1         73-527
            2018-3249           BC022954.1         1912-3143
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.37 cM"
     gene            1..3249
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /note="synapsin I"
                     /db_xref="GeneID:20964"
                     /db_xref="MGI:MGI:98460"
     exon            1..506
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2250
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /note="isoform a is encoded by transcript variant a;
                     synapsin-1"
                     /codon_start=1
                     /product="synapsin-1 isoform a"
                     /protein_id="NP_038708.3"
                     /db_xref="CCDS:CCDS53017.1"
                     /db_xref="GeneID:20964"
                     /db_xref="MGI:MGI:98460"
                     /translation="MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATP
                     GSATASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGG
                     SGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGG
                     FSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHS
                     VYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSG
                     MGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGN
                     WKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSM
                     PLIGDHQDEDKQLIVELVVNKMTQALPRQPQRDASPGRGSHSQSSSPGALTLGRQTSQ
                     QPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRL
                     PSPTAAPQQSASQATPVTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGAPQATRQ
                     ASISGPAPTKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPGPRTGPPTTQQPRPS
                     GPGPAGRPAKPQLAQKPSQDVPPPITAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPS
                     LSQDEVKAETIRSLRKSFASLFSD"
     exon            507..564
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            565..656
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            657..813
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            814..903
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            904..966
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1109
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1184
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1287
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1434
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1522
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2114
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..3213
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /note="hexamer: AATAAA"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /note="hexamer: AACAAG"
     polyA_site      3210
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
                     /note="major polyA site"
     polyA_site      3213
                     /gene="Syn1"
                     /gene_synonym="Syn-1; Syn1-S"
ORIGIN      
        1 agtctgcagc gggcagcaga ggagtcgcgt cgtgccagag agcaccgccg tgctcctgag
       61 cccctcgcgc tccgcccccg cggcccacag acccactgcc ccttggatcc cctgccccac
      121 gccgccacca tgaactacct gcggcgccgc ctgtcggaca gcaacttcat ggccaatctg
      181 ccgaatgggt acatgacaga cctgcagcgc ccgcaaccgc ccccgccgcc tccctcggcc
      241 gccagccctg gggccacgcc cggctccgcg acagcctctg ccgagagggc ctccacagct
      301 gctccagtgg cttctccagc agcccctagt cctgggtcct cggggggcgg cggcttcttc
      361 tcgtcgctgt ctaacgcggt caagcaaacc acagcagccg cagccgccac cttcagcgag
      421 caggtgggcg gtggctctgg gggcgcaggc cgcgggggcg ccgccgccag ggtgctgctg
      481 gtcatcgacg aaccgcacac cgactgggca aaatacttca aagggaagaa gatccatgga
      541 gaaattgaca ttaaagtaga gcaagctgaa ttctctgatc tcaatcttgt ggctcatgcc
      601 aatggtggat tctctgtgga catggaagtt cttcggaatg gagtcaaagt tgtgaggtct
      661 ctgaagccag actttgtgct gatccgccag catgccttca gcatggcacg taatggagac
      721 taccgaagtt tggtcattgg gctgcagtat gctggaatcc ccagtgtaaa ctctttgcat
      781 tctgtctaca acttctgtga caaaccctgg gtgtttgccc agatggttcg actacacaag
      841 aagcttggaa cagaggaatt ccctctgatt gatcagactt tctatcctaa tcacaaagag
      901 atgctcagca gcacaacata ccctgtggtt gtgaagatgg gccacgcaca ttctgggatg
      961 ggcaaggtca aggtagacaa ccaacatgac ttccaggata ttgcaagtgt tgtggcactg
     1021 actaagacat atgccactgc tgagcccttc attgatgcta aatatgatgt gcgtgtccag
     1081 aagattgggc agaactacaa ggcctacatg aggacatcag tgtcgggtaa ctggaagacc
     1141 aatacaggtt ctgctatgct tgagcagatt gccatgtctg acaggtacaa gttgtgggta
     1201 gacacgtgct cagagatttt tgggggactt gacatctgcg cagtggaagc gctgcatggc
     1261 aaggacggaa gggatcacat tattgaggtg gtgggctcct ccatgccact cattggtgat
     1321 caccaggatg aagacaagca gctcatcgtg gaacttgtgg tcaacaagat gactcaggct
     1381 ctgcctcggc agccgcagcg ggatgcttcc cctggcaggg gctcccacag ccagtcttca
     1441 tccccaggag ccctgacctt gggccgccag acctcccagc agcctgcagg tcctcctgct
     1501 caacaacgac ccccacccca gggaggccct ccacagccag gcccaggacc tcagcgccag
     1561 ggacccccgc tgcagcagcg cccaccccca caaggccagc aacatctttc tggccttgga
     1621 ccgccagctg gcagccctct gcctcagcgc ctaccaagtc ccaccgcagc acctcagcag
     1681 tctgcctctc aggccacacc agtgacccag ggtcaaggcc gccagtcgcg gccagtggca
     1741 ggaggccctg gagcacctcc agcagcgcgc ccaccagcct ccccatctcc acagcgtcag
     1801 gcgggggccc cgcaggctac ccgtcaggca tctatctctg gtccagctcc aacgaaggcc
     1861 tcaggagccc cacccggagg gcagcagcgc cagggccctc cccaaaaacc cccaggccct
     1921 gctggtccca ctcgtcaggc cagtcaggca ggtcccggac ctcgcactgg gcctcccacc
     1981 acacagcagc cccggcccag cggcccaggt cctgctggac gtcccgccaa accacagctg
     2041 gcccagaaac ccagccagga tgtgccacca cccatcaccg ccgctgccgg gggacccccg
     2101 cacccccagc tcaacaaatc ccagtctctg accaatgcct tcaaccttcc agagccagcc
     2161 cctcccaggc ccagccttag ccaggacgag gtgaaagctg agaccatccg cagcctgagg
     2221 aagtctttcg ccagcctctt ctccgactga catcccactc tgagaacccc taaaccccta
     2281 gacagccctc tctgggtcct gagtccattt ctcacttttg gaacctccaa atcccttgag
     2341 aacccctctc ctggttctcc tagagcccac ttctcattcc tcagtatgtc ccttgagaaa
     2401 cctggtccta aatccagttc tcacatttgg gaatccccaa gtccatttag aatcctgttc
     2461 ctggtcacct ccagatctgt ttgagaacct ccaaactcct gaagacctct acttctggta
     2521 catctaaagg gtgatttctt ccctgaaagt tcctgaatgg cagaaaacct gtttctgacc
     2581 taatacatcg aatcctctcc tggagctctg aaattcctga aaaaccctat tctactcttg
     2641 gtcctgaatc tctccaacac accttgctcc taatcagaaa tttccaattc cataagaagc
     2701 ccctatcctt aaacctcttc cataggtcat ctctctggag atccacatct tcaaatgcca
     2761 cctaccatcc accaagcagt ccctcaagga cttcccttca cctcttcctc tccatcccat
     2821 tcaatatact ggaagttcct tccacttcta ggacccctaa gttccctcct ccagaaaccc
     2881 ctccccaatt tcctgcctct gacagctgtc tttaaatatg caaactccac ccatcctcag
     2941 aatcctttgc acaaggaagg cctgtggtct cccactcccc tacctttgcc aatgtgttta
     3001 tctgtgactg acttggcctc cttttgtgcc atgcttggca tatgtggtcc tcattcatgc
     3061 cgcctgtggt aatgcgtaca gtggcactgt ttttgtggtc tgcatcttcc tccaacctcc
     3121 actccttgcc tggacttgcc ccacccctca gcggctctga acccccaaga gaagagtcgg
     3181 gaagcaaaat aaacaagcaa aggcccagca gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3241 aaaaaaaaa
//
