LOCUS       NM_011518               5148 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus spleen tyrosine kinase (Syk), transcript variant 1,
            mRNA.
ACCESSION   NM_011518
VERSION     NM_011518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5148)
  AUTHORS   Murphy,B., Miyamoto,T., Manning,B.S., Mirji,G., Ugolini,A.,
            Kannan,T., Hamada,K., Zhu,Y.P., Claiborne,D.T., Huang,L., Zhang,R.,
            Nefedova,Y., Kossenkov,A., Veglia,F., Shinde,R. and Zhang,N.
  TITLE     Myeloid activation clears ascites and reveals IL27-dependent
            regression of metastatic ovarian cancer
  JOURNAL   J Exp Med 221 (12) (2024)
   PUBMED   39570374
REFERENCE   2  (bases 1 to 5148)
  AUTHORS   Dangelmaier,C., Vari,H.R., Vajipayajula,D.N., Elzoheiry,M.,
            Wright,M., Iyer,A., Tsygankov,A.Y. and Kunapuli,S.P.
  TITLE     Phosphorylation of (Ser 291) in the linker insert of Syk negatively
            regulates ITAM signaling in platelets
  JOURNAL   Platelets 35 (1), 2369766 (2024)
   PUBMED   38904212
  REMARK    GeneRIF: Phosphorylation of (Ser 291) in the linker insert of Syk
            negatively regulates ITAM signaling in platelets.
REFERENCE   3  (bases 1 to 5148)
  AUTHORS   Chen,X., Jiang,C., Chen,M., Li,X., Yu,W., Qiu,A., Sun,L., Pu,L. and
            Shi,Y.
  TITLE     SYK promotes the formation of neutrophil extracellular traps by
            inducing PKM2 nuclear translocation and promoting STAT3
            phosphorylation to exacerbate hepatic ischemia-reperfusion injury
            and tumor recurrence
  JOURNAL   Mol Med 30 (1), 146 (2024)
   PUBMED   39261768
  REMARK    GeneRIF: SYK promotes the formation of neutrophil extracellular
            traps by inducing PKM2 nuclear translocation and promoting STAT3
            phosphorylation to exacerbate hepatic ischemia-reperfusion injury
            and tumor recurrence.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5148)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5148)
  AUTHORS   Zhang,J., Tu,Y., Wei,J., Zheng,R., Shao,J., Chen,Q., Liang,G.,
            Ying,H., Han,X. and Shi,Q.
  TITLE     Dectin1 contributes to hypertensive vascular injury by promoting
            macrophage infiltration through activating the Syk/NF-kappaB
            pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166911 (2024)
   PUBMED   37813169
  REMARK    GeneRIF: Dectin1 contributes to hypertensive vascular injury by
            promoting macrophage infiltration through activating the
            Syk/NF-kappaB pathway.
REFERENCE   6  (bases 1 to 5148)
  AUTHORS   Katagiri,T., Ogimoto,M., Hasegawa,K., Mizuno,K. and Yakura,H.
  TITLE     Selective regulation of Lyn tyrosine kinase by CD45 in immature B
            cells
  JOURNAL   J Biol Chem 270 (47), 27987-27990 (1995)
   PUBMED   7499277
REFERENCE   7  (bases 1 to 5148)
  AUTHORS   Cheng,A.M., Rowley,B., Pao,W., Hayday,A., Bolen,J.B. and Pawson,T.
  TITLE     Syk tyrosine kinase required for mouse viability and B-cell
            development
  JOURNAL   Nature 378 (6554), 303-306 (1995)
   PUBMED   7477353
REFERENCE   8  (bases 1 to 5148)
  AUTHORS   Turner,M., Mee,P.J., Costello,P.S., Williams,O., Price,A.A.,
            Duddy,L.P., Furlong,M.T., Geahlen,R.L. and Tybulewicz,V.L.
  TITLE     Perinatal lethality and blocked B-cell development in mice lacking
            the tyrosine kinase Syk
  JOURNAL   Nature 378 (6554), 298-302 (1995)
   PUBMED   7477352
REFERENCE   9  (bases 1 to 5148)
  AUTHORS   Fluck,M., Zurcher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     Molecular characterization of the murine syk protein tyrosine
            kinase cDNA, transcripts and protein
  JOURNAL   Biochem Biophys Res Commun 213 (1), 273-281 (1995)
   PUBMED   7639745
REFERENCE   10 (bases 1 to 5148)
  AUTHORS   Negishi,I., Motoyama,N., Nakayama,K., Nakayama,K., Senju,S.,
            Hatakeyama,S., Zhang,Q., Chan,A.C. and Loh,D.Y.
  TITLE     Essential role for ZAP-70 in both positive and negative selection
            of thymocytes
  JOURNAL   Nature 376 (6539), 435-438 (1995)
   PUBMED   7630421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U36776.1, BB629720.1 and BC065121.1.
            
            On Dec 10, 2004 this sequence version replaced NM_011518.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U36776.1, AK143564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               U36776.1           1-132
            133-731             BB629720.1         55-653
            732-5148            BC065121.1         664-5080
FEATURES             Location/Qualifiers
     source          1..5148
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.41 cM"
     gene            1..5148
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /note="spleen tyrosine kinase"
                     /db_xref="GeneID:20963"
                     /db_xref="MGI:MGI:99515"
     exon            1..173
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            174..630
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            631..791
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            792..930
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1012
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1044
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1113
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1201
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1379
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1589
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1779
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1920
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2033
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..5103
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3781..3786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /note="hexamer: AATACA"
     polyA_site      3812
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /note="major polyA site"
     regulatory      5077..5082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syk"
                     /gene_synonym="Sykb"
                     /note="hexamer: AATAAA"
     polyA_site      5094
                     /gene="Syk"
                     /gene_synonym="Sykb"
ORIGIN      
        1 ccacttccct agttacagac accacttaac agcaggaaac ctccacttgc tctcctctgc
       61 cttctctcca ttgcagccat tcccattttc aagactgcca gtctggtcct ttcaacgttc
      121 catgctgcct ggtgcccggg agcccaggcc ttctgtgact ccaggacagg aaggtacttc
      181 tccatacact tcccagaact ctgaaggggt gcagacatgg cgggaagtgc tgtggacagc
      241 gccaaccacc tgacctactt ttttggcaac atcacccggg aagaggctga agactacctg
      301 gtccagggag gcatgaccga tgggctctac ctgctacgcc agagccgcaa ttacctgggt
      361 ggttttgctt tgtcggtggc tcacaacagg aaggcacacc actacaccat cgagagggaa
      421 cttaatggca cctacgccat ctccgggggc agggcccatg ccagcccagc agacctctgc
      481 cattaccact cccaggaacc tgatggcctt atctgcctcc ttaagaagcc cttcaaccgg
      541 cccccgggag tacagcccaa gaccggaccc tttgaggacc tgaaggagaa cctcatcagg
      601 gaatatgtga aacagacctg gaaccttcag ggccaggctc tggagcaagc catcatcagc
      661 cagaagcccc agctggagaa gctgatcgcc accacggccc atgagaagat gccctggttc
      721 catggcaaca tctccagaga tgaatcagag cagacggtcc tcatagggtc aaagaccaat
      781 ggaaaattcc tgatcagggc cagagacaac agcggctcct atgctctgtg cctgctgcac
      841 gaagggaaag tattgcacta ccgcattgac agggacaaga ccgggaagct ctccattcct
      901 gaggggaaga agtttgacac cctctggcag ctagtggaac attactctta caagccagat
      961 gggctactaa gagtcctcac ggtaccatgc caaaagattg gtgcacagat gggccaccca
     1021 ggaagcccaa atgcccatcc cgtgacttgg tcaccgggtg gaataatctc aaggatcaaa
     1081 tcctactcct tcccaaagcc tggccacaaa aagcctgccc caccccaagg gagccgtcca
     1141 gagagcactg tgtccttcaa cccctatgag ccaacgggag ggccctgggg cccagacaga
     1201 ggccttcaga gagaagccct gcccatggac acagaggtgt acgagagccc ttatgctgac
     1261 cctgaagaga tccggcccaa agaggtctac ctggacagga gcctgctgac cctggaggac
     1321 aatgaactgg gctccggtaa cttcgggact gtgaaaaagg gatactacca aatgaaaaaa
     1381 gttgtgaaaa ccgtggctgt gaaaatcctg aagaacgagg ccaacgaccc ggctttgaag
     1441 gacgagctgc tggcagaggc gaacgtcatg cagcagctgg acaaccccta cattgtgcgc
     1501 atgatcggaa tctgcgaggc ggagtcctgg atgctggtga tggagatggc ggagctgggg
     1561 ccgctcaaca agtacctgca gcagaacagg cacattaagg ataagaacat catagagctg
     1621 gttcaccagg tttccatggg gatgaagtat ttggaagaga gcaactttgt gcacagagat
     1681 ctggctgcgc ggaacgtgct tctggtcaca cagcactatg ccaagatcag cgatttcggt
     1741 ctttccaaag ccctgcgtgc tgatgaaaac tactacaagg cccagaccca cgggaagtgg
     1801 cccgtgaagt ggtacgcccc cgaatgcatc aactactaca agttctccag taagagtgac
     1861 gtctggagct tcggagtcct gatgtgggaa gcgttctcct atgggcagaa gccctacaga
     1921 gggatgaaag ggagcgaagt gaccgccatg ctggagaaag gagagcggat ggggtgccct
     1981 gcaggatgcc cgagagagat gtacgacctg atgaacctgt gctggactta cgatgtggag
     2041 aacaggccag gattcacagc tgtggaactg aggcttcgca attactacta cgacgtggtt
     2101 aactaacagc tccggcgcct gtccgtgcac accacggatt cccaagcgat cacaggaaat
     2161 tcattcagat gaactggctc tcagagtttc atctccctct gcccggagtg agagctaagc
     2221 taacatagga ctcaccctca caacaggtct ggtgcccaga gacagacaag cagcaagacc
     2281 ttggggcctg tggagtcgtc tctctggtct ttgtttccat ctgtgtggtc ttcgctatcg
     2341 gtcacgtttg ggagccattt ccaaattctc ttgacatcat tccgttcctc tgggtccagg
     2401 atttcagtgt cccctgaaga tcagaaaaga aaagtgcttt gccactccag caaaggacat
     2461 aaagagaaac ctcgctggtg cagtcagcaa gctggaaggt ggttaaggac aatgacaagc
     2521 ctggacactg gttttactct cagcgctgag acagagatac tgtgtggatg acatgctgag
     2581 atgtgctggc ttggctgaca cgcccctgga gtccacctcc ctgcagtcgt gtgtgtttgc
     2641 tggaggaggt gtgaataacg ttctgtgtgg aggctgccgg gggaggtgag ctcccatgat
     2701 cctctgcgac tgagcagaag tgtgtcaggc aagggtcaga ctcccctctc tgcagaggga
     2761 atgcatccag gactccttgt tgctgccact aaaaaattgc caaccagcaa cttaagggag
     2821 gaatggctca tttgagctca cagttggagg ggataggcca tcatggtgga aaagacaaca
     2881 ggcaggaaag gcttggtggc atgaaaagga agctggaagg tcacatggca tccacattca
     2941 ggaaacaaag aatgaacagg aagtggggcc aggctataag gccctaaagg ccacctccgg
     3001 tgacccagtt ccttcagatc catctatcaa agattccaca ggcctctcag acactgaatg
     3061 ccaacagctg gggaccaaat gttcaagcac acaaggtgca gtgccaggca ggggccttcc
     3121 tgaatgatta cacagtgtgg tatcctgaca gagcgggtga gccatctcag gtctgtcccc
     3181 ttatgagccc cgtttaccat cccagattcc cccttgggac ccccctcatc tggatcattc
     3241 ccctcccccc aggccctatc tccaaacacc taggtactaa gtgaacctag gtactaagtc
     3301 ttcaacacat gaattctgag gggacacatt catactggag ccgatggcag cctggtgacc
     3361 aagaccatct caggatgagt ttctgaatgg aatcttcatt cgccataaaa ccagagatgt
     3421 gaccttcccc acaaggaagc cttgctaagt gcgacattga gctgaggaca cacaagctga
     3481 gaattccccc tctgtcctcc tagccttggc taactactga ccatacaccg aatgtcaccc
     3541 attcacggca cttttgctga ggacctaaaa gctacaaagg ctgcatagcc ttccatctag
     3601 gtctagggac atgtacagat gggagcatct caccttcacc tctgagacac tgggacattc
     3661 acagccaggg atggtacagg agtccctgct ggtggtgggc tcaatgaaca gagacgatgg
     3721 tgaaatgggt gcctctcttt agaccagtgg ttctcaacct tcctaatgct gagatctttc
     3781 aatacaggtc cttgcgttgt ggcgactccc aaccatgaag ttattttgtt gctacattgt
     3841 cactgtaatt ttgctactat gatgaatcgt agtgtagata tctgatatgc aggatatcgg
     3901 atatgtaaat atctggtatg caggatatgt gaaatgaggg cacatcccac aggttgggaa
     3961 ccactgcctt tgatagggag gcactatgct tagagcatgg ttaggaagta tttagaagct
     4021 attggtgtgt cttggaattg tgttagtagg tcaaccgtcc tgtggaggga aggaaggggg
     4081 tggaggaaat ccctgtatgt tgaattcatt gagcagacct gcagaacaca gccttggtga
     4141 ggaagtccca tgggtcagac cacctgtaga tttagtcagg agaggaaggg ccactgtata
     4201 gttatggaga caggactgtc tgctctgagc aagaagttct ctgctgagct cctagcctac
     4261 cttcccttgt ccccagggct atagaaaggc cacctcgaag accagggagc atgtgtgaga
     4321 agtctgtgga ggcctctgcc ttcttcctgg cctctctagc agtgcctctc cttcccaggg
     4381 atttgggact gaccgttatc tggctatgac tgagcagagt ggagggatgg gctttgcccc
     4441 ccttcagaaa gccgaaaccg gttcccatgt gcagagtcac atgtggccat cgaccagggc
     4501 tctcatctgg tgaaaactgt gtcttactgt caagattaat tctctcccct gggccactga
     4561 ggagggcaga tggcaagagg atcctcccta gaggatttag actatgaatg cccactaaat
     4621 ttgcaaggtc agaaactagc caaggtcctt ctcaggcatc tatccttaac ttggtctctc
     4681 cacaagctgc ctctgatgct ccgagcccct tctgcctggc agctgggctc cctgtgtgct
     4741 tttacctatg acccttggtc agcagagtac aaggagcacc taagctgcct cgccacctcc
     4801 cactgactgc aaacaccaca tacctcatgc ggaaccgaat gtctctccag taaacacccc
     4861 agccagccat tcataaaaac ctgtctctgt gtgcgctggg acatgtcctc cctgtacccc
     4921 gggcctgctt tgtgtgccag acagtgactc cacagggatg ccaggtctgt gattgcattg
     4981 ctccttgcag agggaagccc tcggttgtcc ttctctggga atgctgccac ccagagcagc
     5041 acacagtgat tccctgttat ttcagaaatt attttaaata aagatctact attagtcttg
     5101 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
