LOCUS       NM_001166064            5495 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus synapse defective 1, Rho GTPase, homolog 2 (C.
            elegans) (Syde2), mRNA.
ACCESSION   NM_001166064 XM_001004384 XM_001479228
VERSION     NM_001166064.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5495)
  AUTHORS   Lo HF, Tsai CY, Chen CP, Wang LJ, Lee YS, Chen CY, Liang CT, Cheong
            ML and Chen H.
  TITLE     Association of dysfunctional synapse defective 1 (SYDE1) with
            restricted fetal growth - SYDE1 regulates placental cell migration
            and invasion
  JOURNAL   J Pathol 241 (3), 324-336 (2017)
   PUBMED   27917469
REFERENCE   2  (bases 1 to 5495)
  AUTHORS   Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB and
            Scheiffele P.
  TITLE     mSYD1A, a mammalian synapse-defective-1 protein, regulates
            synaptogenic signaling and vesicle docking
  JOURNAL   Neuron 78 (6), 1012-1023 (2013)
   PUBMED   23791195
  REMARK    GeneRIF: In synapse-defective-1A knockout mice synapses assemble in
            normal numbers, but there is a significant reduction in synaptic
            vescicle docking.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123684.8, AK049496.1 and CN702275.1.
            
            On or before Oct 7, 2009 this sequence version replaced
            XM_001479228.1, XM_001004384.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049496.1, SRR11927933.1509638.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-783               AC123684.8         36435-37217         c
            784-3035            AK049496.1         2-2253
            3036-3603           CN702275.1         92-659
            3604-4818           AK049496.1         2822-4036
            4819-5495           AC123684.8         3367-4043           c
FEATURES             Location/Qualifiers
     source          1..5495
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..5495
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /note="synapse defective 1, Rho GTPase, homolog 2 (C.
                     elegans)"
                     /db_xref="GeneID:214804"
                     /db_xref="MGI:MGI:3036264"
     exon            1..1300
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..4074
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /codon_start=1
                     /product="rho GTPase-activating protein SYDE2"
                     /protein_id="NP_001159536.1"
                     /db_xref="CCDS:CCDS57259.1"
                     /db_xref="GeneID:214804"
                     /db_xref="MGI:MGI:3036264"
                     /translation="MAEPLRRTLGRLRERHAPGALGLHADSVAASLSEGRSPPHELAG
                     PGMERPAWGTEQPGARVPWSRGAQEAAALGRALARASPGAWGSGDDDGEDEGADYYEN
                     LPAGCAPEGAEALRASPSRAPGSSPGMEGGRLETGRLQTQLREAYYLLIQAMHDLPPD
                     SGTRRGGPAGARAQGQQPPLPRGAAVRPACSLRGGDRPPQQVSPPRSPPTESREGRPP
                     SPRIQLSSCRSLESLRVSRRPPLLQRWASDSCIRCGAHRDRDEPQPRGGGMDGWSPGS
                     HRAATSAALLPPICHDPSGSSGRPFKDPVGTSVISSSQEDHPEDLPLKPPAVTVKKLQ
                     KWMYKGRLLSLGMKGRDRGTAPKVPGAQTTSPNLGSWKVHENHVLSVTTDQRITLTDL
                     FENVYGSPLKKREPEDVRGPAELRGHQPLNNITVSKKRNWLYQSTLRSQSLDESKRSQ
                     DRRYFSLSPVSPPKHWVSHRPHCTHAVCNAARATLSRNGSSAFSEDNDADDEGEIWYN
                     PIPEDDSLGIAHVLSLEEANTAALKLPVSMLSARDLMKAEPPSEDRGDVQTSQSNGIN
                     SADSMHSTEIMQHCKQRLGHRTQESPTAEDSPVLKSASTGPGIIVSTNRTELRAMEPS
                     SPSPSPGKKGSSITWSLPDKIKSPRTVRKLSMKMKRLPEFSRKLGARGALHYVNNPDS
                     TPPLSKWNCREIPQGVTLTSGNTTRNVISRYHLDTTVSSRHSYRKKPLGSSKYSCKGG
                     YLSDGDSPELRTRSSKHGSEHKLGKGRETVPSSCSKNELDIGAFRHYSFADQPKCSQY
                     ISGLMSVHFYGAEGLKPPRIDSKDVFCAIQVDSVNKARTALLTCRTTFLDMDHTFNIE
                     IENAQHLKLVVFSWEPTPRRNRVCCHGTVVLPALFRVTKTHQLAVKLEPRGLIYVKVT
                     LMEQWENSLHGLDKNREAVMFGVDIQKVVEKENVGLMVPLLIQKCIVEIEKRGCQVVG
                     LYRLCGSAAVKKELREAFEKDSKTVGLCENQYPDINVITGVLKDYLRELPSPLITKQL
                     YEAVLDAMAKSPLKMSSSGCENEPSDSRLTVDLLDCLPDVEKATLKMLLDHLKLVASY
                     HEVNKMTCQNLAVCFGPVLLNQRQEASTHNNRVFTDSEELASALDFKKHIEVLHYLLQ
                     LWPVQRLTVKEPRDSLCLEQSSSLNYLRRKKERPCVLNLSGPDSSGVLRTRQARLDSP
                     LSNRYAGDWSSCGESYSLNTRGNVKNLDYDDGPLEGGESRQYSKTAGAEVMTAQRIPM
                     SGGCTFQTYLTVQTIESTVDQKANLRDLQESIDTLIGNLERELNKNKLNMSV"
     exon            1301..1945
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..3036
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3163
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3345
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3577
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..5495
                     /gene="Syde2"
                     /gene_synonym="C430017H16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttatgcc aagtatgtga ggagctggcg aggaccggcc gtggtcatgg agagccgccg
       61 cctccgcccg cgcgggactc ggagcccgcc ccgcgccccg ggcgagccgg gctgctgagg
      121 gcggcgctca tggcggagcc cctgcggagg acgctcggcc ggctccgaga gcggcacgct
      181 cccggcgcgc tcgggctgca cgcggactcc gtggcggcct cgctctccga gggacgctcg
      241 ccgccccacg agctcgcggg ccccggtatg gagcggcccg catgggggac cgagcagccg
      301 ggcgcgcggg tgccatggtc tcgcggggcg caggaggccg ccgctctggg ccgcgcgctt
      361 gctcgcgcct ccccaggcgc ctggggcagc ggcgacgacg acggggagga cgagggcgcc
      421 gactactacg agaacctgcc ggcgggctgc gcgcccgagg gggcggaggc gctgcgggcc
      481 tcgccttccc gagcgccggg ctcctccccg gggatggagg gcggccgcct ggagacgggc
      541 aggctgcaga cccagttgcg agaggcctat tatctgctga tccaggccat gcacgaccta
      601 ccccctgact cgggcacgcg gcggggcgga cccgcgggag cccgggctca gggccagcag
      661 ccgcctctcc cccgcggcgc agccgtgcgc ccagcctgca gcctccgagg cggcgaccgc
      721 cctccgcagc aggtgtcccc gccccggtcg cctccgacgg agtcgagaga gggacggcct
      781 cccagtcctc ggatacaact gtccagttgc agaagtctcg agagcctccg cgtgagccgg
      841 cggccgcctc tgctccagcg gtgggcgagc gacagctgca tcaggtgcgg tgcgcaccgg
      901 gacagggacg agccccagcc acgtggaggt gggatggacg gctggagccc gggcagccac
      961 agggctgcta cgtccgccgc tctcctgcct cccatctgcc atgaccccag cgggtcctcg
     1021 ggacgaccct ttaaggatcc tgtggggacc tctgtgatat ccagcagcca agaggaccat
     1081 ccggaggatc ttcccctcaa gccacctgcg gtgactgtca agaaactgca gaagtggatg
     1141 tacaaaggac gtctgctgtc cctggggatg aagggtcgcg atcgcgggac agcacccaaa
     1201 gttcccggag cgcagacaac ctctccaaat ttgggcagtt ggaaagtgca tgaaaaccac
     1261 gtcctctcgg tgacaacgga ccaaagaatc acactgacag acttatttga gaatgtctat
     1321 ggctctccac tgaagaaacg agaacctgaa gatgtaaggg gtcccgccga gcttagaggt
     1381 caccagcccc ttaacaacat cacagtttca aagaagcgca attggctgta tcagagcacc
     1441 ctgaggtctc agagtctgga cgagagcaag cgaagccagg acagacgcta tttctccctc
     1501 tctcctgtgt ctccacccaa gcattgggta tcccacaggc cgcactgcac acatgcggtg
     1561 tgtaatgctg ccagggctac gttgtccaga aacggctctt cagcctttag cgaggacaat
     1621 gatgcggacg atgaaggaga aatatggtac aatcccatcc ctgaggatga cagcttgggc
     1681 atagcacacg tcttgagtct tgaggaggca aacaccgccg ccctgaagct tcctgtgagc
     1741 atgttgtctg ccagagatct gatgaaggcg gagcctccta gtgaagacag aggggacgtg
     1801 cagacctcac agtcaaatgg aattaattct gcagattcca tgcattctac agaaattatg
     1861 cagcactgca aacaaaggtt agggcacagg acacaagaaa gcccgacggc agaggatagc
     1921 cctgtgttga aatctgcttc tacaggtccc gggatcatag tctctacaaa taggactgaa
     1981 ctgagagcga tggagccgtc ttctccaagc cccagtcctg ggaagaaagg cagttccatt
     2041 acttggtctt taccagataa aataaagtct ccacgcactg tgaggaaact ttctatgaaa
     2101 atgaaaaggt tgccagaatt cagccgaaag ctgggggcca ggggagcttt gcactatgtg
     2161 aataatccgg atagcacccc tcctttgtct aaatggaact gtcgagaaat tcctcagggt
     2221 gtcactctga cttccgggaa caccaccagg aacgtgataa gccggtacca tcttgatacc
     2281 accgtatcct ctcggcacag ctaccggaag aaaccccttg ggagctcgaa gtattcctgc
     2341 aagggtgggt acctcagcga cggagactca cccgaactga gaactagatc tagcaagcat
     2401 ggatcggagc acaaacttgg gaaagggaga gaaactgtcc caagcagttg tagcaaaaat
     2461 gaactagaca tcggtgcctt cagacattac agctttgcgg atcaacccaa atgctcgcag
     2521 tacatatccg gcctcatgag cgtacacttc tatggagctg agggtttaaa accgccccgg
     2581 atagattcga aagatgtgtt ttgtgccatt caggtagact cagtgaacaa agccagaacg
     2641 gccctgctca cctgtcggac gaccttctta gacatggacc acacgttcaa catagagatt
     2701 gaaaatgcgc agcatctgaa gctggtggtg ttcagctggg agcccacgcc gaggaggaac
     2761 cgcgtgtgct gtcatggcac agtcgtcctg cccgctttat tcagagttac aaaaacgcat
     2821 cagctggctg tcaagctgga gcccagaggc cttatttacg tcaaggtgac cctgatggaa
     2881 cagtgggaga attctctgca cggcctggat aagaaccgcg aagcggtgat gttcggagtc
     2941 gacattcaaa aagttgtaga gaaagaaaac gtaggcttga tggtgccgct gctgatacag
     3001 aaatgcatcg tggagattga aaagaggggt tgtcaggttg taggcctgta tcgattgtgt
     3061 ggttcagcgg cggtgaagaa agagcttcga gaggcttttg agaaggacag caagactgtt
     3121 ggtctgtgtg aaaaccagta cccagatata aatgtaataa caggggttct taaggactac
     3181 ttgagagaac tcccttctcc cctaataacc aagcagctgt atgaggctgt gttggatgcc
     3241 atggcgaaga gtcctttgaa aatgtcgtcc agtggttgtg agaacgagcc cagtgactcc
     3301 aggctcactg tggacctcct ggattgcctg ccggacgttg agaaggcaac cctgaagatg
     3361 ttgttggatc atctgaaact ggtggcctcc taccacgaag tgaataagat gacctgccag
     3421 aatttggctg tgtgctttgg accagtgttg cttaaccaga ggcaagaggc ttcaacccac
     3481 aacaacagag tcttcaccga ttctgaagag cttgccagtg ctttggattt taaaaaacac
     3541 atcgaggttc ttcattactt gctccagctc tggccagtgc aacgcttaac tgtcaaagaa
     3601 cccagagaca gtttgtgcct ggagcagtcg tcttctctga attacttgag gcgaaagaaa
     3661 gagcggccgt gtgtgttaaa cctgagcggt ccggattcat caggggtgct gaggacaagg
     3721 caggcccgat tagacagtcc actcagcaac cgctatgcag gagactggag cagctgtggg
     3781 gagagctact ctttaaatac aagaggaaat gtcaagaatt tggactatga tgacggcccc
     3841 ttagaaggtg gagaaagtag acagtatagc aaaacagccg gagcggaagt catgaccgca
     3901 caacgaatcc ccatgtcagg ggggtgcacg tttcagacgt acttgacggt acagaccatt
     3961 gaatccacgg tggatcagaa agctaacctc agagatttgc aagagagcat tgatactttg
     4021 attggcaatc tggaacgtga gctcaacaaa aacaagctga acatgagtgt ttgagatgga
     4081 cggcttgttt tatttgtgat gatgtcatca agtttcatgt caatcctttt tctggggaaa
     4141 aaatatatat aacatattat atatatatat atatattgga tccttaagtt aattcttaat
     4201 aagttcatgt cattcaatta taaacactat tcattaatat ggttatttta cttgtgaact
     4261 gagctgttct gggcataaag gtaaccagac cttgggggat agtttaataa accttgccag
     4321 ttgtatggag gagacatgca gatgtttgta agggtcgggt acattattat cccgacaagg
     4381 cttcggcgag aatgttcttc tgtacgtgga gacggatgtt ctctgcagag gacactgcag
     4441 ctggactgat ttgcagtcag agtccctgtg caatgtcatt tggtcatatt tcatttgcaa
     4501 tatgaatgct gctgctataa gaaaaatttt tataaatgta aaattataca ggtattaatg
     4561 tattttgtat taacatttcg taattattta agcttataaa attaaatatt tttatggttc
     4621 tgagaatata tatttataac ttaattatgc atataggttt tagaatgagg gaaggggttg
     4681 gttacagcat tccaaatatt ttaaaaataa ggccaaagtt attagcttaa aaatgtcttt
     4741 ttcagggaaa gaatgtttaa gttaaaagac aagttacata agaccacttg aataaaaacg
     4801 caccagaact atttgagtag aagcaattgc ctttctgttt ttgctttgta gacacagtct
     4861 cccctgtgga aagttgtatt ttatgttgaa gtctttcagc ttcataaggg atcaagtgac
     4921 cagatgcctg cactagtgac ttaaaatgac tctacctgct ctgtgcatct ctgtctcctg
     4981 tgatgctcta agtatttatt tatagaggta tccttaacat gctgacttca gtaactgccc
     5041 ttgtttctaa ggaagtcatc ttgccagaat gctacaggtt acaaattttt taaatgtatt
     5101 aaaaaaaact tttatactta cagaatgtgt aattttagaa gtataaatga atatgaattg
     5161 ccaagtataa agtgtgacag ccataaaaaa aaccagtttc tcactatttt tctaaatatt
     5221 aaggtacttc tatgcaatac acataacacc catgtaattt gaaagcctaa tagtatgaag
     5281 aaaaataact atttttatat gagactttca tgttttaaaa cattgtgtaa caaatgtaac
     5341 cagaggtgat gcaggtgtac accatgggtt aacatttcaa atgttttcta gagaaagtac
     5401 ccgtgctttt tgtttgtttg attgctatgc catgtataat acataaataa gtagtatagg
     5461 ggtataagtg ctttattaaa atattataac agtga
//
