LOCUS       NM_011517               1132 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus synaptonemal complex protein 3 (Sycp3), mRNA.
ACCESSION   NM_011517
VERSION     NM_011517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   Biot,M., Toth,A., Brun,C., Guichard,L., de Massy,B. and Grey,C.
  TITLE     Principles of chromosome organization for meiotic recombination
  JOURNAL   Mol Cell 84 (10), 1826-1841 (2024)
   PUBMED   38657614
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Hurtado,A., Mota-Gomez,I., Lao,M., Real,F.M., Jedamzick,J.,
            Burgos,M., Lupianez,D.G., Jimenez,R. and Barrionuevo,F.J.
  TITLE     Complete male-to-female sex reversal in XY mice lacking the
            miR-17~92 cluster
  JOURNAL   Nat Commun 15 (1), 3809 (2024)
   PUBMED   38714644
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1132)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1132)
  AUTHORS   Tanaka,S.S., Toyooka,Y., Akasu,R., Katoh-Fukui,Y., Nakahara,Y.,
            Suzuki,R., Yokoyama,M. and Noce,T.
  TITLE     The mouse homolog of Drosophila Vasa is required for the
            development of male germ cells
  JOURNAL   Genes Dev 14 (7), 841-853 (2000)
   PUBMED   10766740
REFERENCE   7  (bases 1 to 1132)
  AUTHORS   Osterlund,C., Tohonen,V., Forslund,K.O. and Nordqvist,K.
  TITLE     Mage-b4, a novel melanoma antigen (MAGE) gene specifically
            expressed during germ cell differentiation
  JOURNAL   Cancer Res 60 (4), 1054-1061 (2000)
   PUBMED   10706124
REFERENCE   8  (bases 1 to 1132)
  AUTHORS   Yuan,L., Liu,J.G., Zhao,J., Brundell,E., Daneholt,B. and Hoog,C.
  TITLE     The murine SCP3 gene is required for synaptonemal complex assembly,
            chromosome synapsis, and male fertility
  JOURNAL   Mol Cell 5 (1), 73-83 (2000)
   PUBMED   10678170
REFERENCE   9  (bases 1 to 1132)
  AUTHORS   Chen,J., Silver,D.P., Walpita,D., Cantor,S.B., Gazdar,A.F.,
            Tomlinson,G., Couch,F.J., Weber,B.L., Ashley,T., Livingston,D.M.
            and Scully,R.
  TITLE     Stable interaction between the products of the BRCA1 and BRCA2
            tumor suppressor genes in mitotic and meiotic cells
  JOURNAL   Mol Cell 2 (3), 317-328 (1998)
   PUBMED   9774970
REFERENCE   10 (bases 1 to 1132)
  AUTHORS   Klink,A., Lee,M. and Cooke,H.J.
  TITLE     The mouse synaptosomal complex protein gene Sycp3 maps to band C of
            chromosome 10
  JOURNAL   Mamm Genome 8 (5), 376-377 (1997)
   PUBMED   9133341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC138509.1 and BY386732.1.
            
            On Apr 9, 2009 this sequence version replaced NM_011517.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08485.1, BC132079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1103              BC138509.1         2-1104
            1104-1132           BY386732.1         402-430
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.94 cM"
     gene            1..1132
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /note="synaptonemal complex protein 3"
                     /db_xref="GeneID:20962"
                     /db_xref="MGI:MGI:109542"
     exon            1..126
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..844
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /note="SCP-3"
                     /codon_start=1
                     /product="synaptonemal complex protein 3"
                     /protein_id="NP_035647.2"
                     /db_xref="CCDS:CCDS24111.1"
                     /db_xref="GeneID:20962"
                     /db_xref="MGI:MGI:109542"
                     /translation="MLRGCGDSDSSPEPLSKHLKMVPGGRKHSGKSGKPPLVDQPKKA
                     FDFEKDDKDLSGSEEDVADEKAPVIDKHGKKRSAGIIEDVGGEVQNMLEKFGADINKA
                     LLAKRKRIEMYTKASFKASNQKIEQIWKTQQEEIQKLNNEYSQQFMNVLQQWELDIQK
                     FEEQGEKLSNLFRQQQKIFQQSRIVQSQRMKAIKQIHEQFIKSLEDVEKNNDNLFTGT
                     QSELKKEMAMLQKKVMMETQQQEMANVRKSLQSMLF"
     exon            127..269
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            270..333
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            334..368
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..486
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..586
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..685
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..790
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1122
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1102..1107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /note="hexamer: AATAAA"
     polyA_site      1122
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /note="major polyA site"
ORIGIN      
        1 atggcgttca gccaatcagc agagagcttg gtcggggccg gactgtattt actcctgccc
       61 aagggccagg tttcctcaga tgcttcgagg gtgtggggac agcgacagct caccggagcc
      121 gctgagcaaa catctaaaga tggtgcctgg tggaagaaag cattctggga aatctgggaa
      181 gccacctttg gttgatcagc ctaaaaaagc ctttgacttt gagaaagatg ataaagatct
      241 gtctggttca gaagaagatg ttgctgatga aaaggctcca gtaattgata aacatggaaa
      301 gaaaagatct gctgggataa ttgaagatgt tggaggtgaa gtacagaata tgctggaaaa
      361 atttggagct gacatcaaca aagctcttct tgccaagagg aaaagaatag aaatgtatac
      421 caaagcttct ttcaaagcca gtaaccagaa aattgagcaa atttggaaaa cacaacaaga
      481 ggaaatacag aagcttaaca atgaatattc tcagcaattt atgaatgtgt tgcagcagtg
      541 ggaactggat atacagaaat ttgaggaaca aggagaaaaa ctatctaatc tttttcgaca
      601 acaacaaaag atttttcagc agtctagaat tgttcagagc cagagaatga aagcaatcaa
      661 acagatacac gagcagttca taaagagttt ggaagatgtg gaaaagaata atgataatct
      721 atttactggc acacaaagtg aacttaaaaa agaaatggct atgttgcaaa aaaaagttat
      781 gatggaaact cagcagcaag agatggcaaa tgttcgaaag tctcttcaat ccatgttatt
      841 ctgatgagtc tttgaagaaa gaacttgaac ctatgtaata tgatacaatt aaaacattag
      901 ctaagaggca tgcctttagt aaattatagt ttaaactata atatccgaaa tcattagctt
      961 atttaagtgg aagatttttg ttcctgttaa cctaaaacct tataaaccta aactatgtta
     1021 agtaccagct attccaatgt atcaaacttt cagggttttt tgtttgtttg ttttaatagt
     1081 tgttctctcc acgattgtgt caataaagat gatttaaatt taaaaaaaaa aa
//
