LOCUS       NM_177191               5688 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus synaptonemal complex protein 2 (Sycp2), mRNA.
ACCESSION   NM_177191 XM_619861 XM_914292 XM_988660
VERSION     NM_177191.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5688)
  AUTHORS   Chotiner,J.Y., Leu,N.A., Yang,F., Cossu,I.G., Guan,Y., Lin,H. and
            Wang,P.J.
  TITLE     TRIP13 localizes to synapsed chromosomes and functions as a
            dosage-sensitive regulator of meiosis
  JOURNAL   Elife 12, 92195 (2024)
   PUBMED   39207914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5688)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5688)
  AUTHORS   Guan,Y., Leu,N.A., Ma,J., Chmatal,L., Ruthel,G., Bloom,J.C.,
            Lampson,M.A., Schimenti,J.C., Luo,M. and Wang,P.J.
  TITLE     SKP1 drives the prophase I to metaphase I transition during male
            meiosis
  JOURNAL   Sci Adv 6 (13), eaaz2129 (2020)
   PUBMED   32232159
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5688)
  AUTHORS   Shi,B., Xue,J., Zhou,J., Kasowitz,S.D., Zhang,Y., Liang,G.,
            Guan,Y., Shi,Q., Liu,M., Sha,J., Huang,X. and Wang,P.J.
  TITLE     MORC2B is essential for meiotic progression and fertility
  JOURNAL   PLoS Genet 14 (1), e1007175 (2018)
   PUBMED   29329290
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5688)
  AUTHORS   Feng,J., Fu,S., Cao,X., Wu,H., Lu,J., Zeng,M., Liu,L., Yang,X. and
            Shen,Y.
  TITLE     Synaptonemal complex protein 2 (SYCP2) mediates the association of
            the centromere with the synaptonemal complex
  JOURNAL   Protein Cell 8 (7), 538-543 (2017)
   PUBMED   28150150
  REMARK    GeneRIF: Using yeast two-hybrid screening, it discovered the
            surprising finding that the SYCP2 NTR associates well with the
            centromere. It was reported that the C-terminal region of mSYCP2
            was found to be responsible for the association of SYCP3 and SYCP1
            for synaptonemal complex (SC) formation.
REFERENCE   6  (bases 1 to 5688)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
  REMARK    GeneRIF: SYCP2 are not required for centromere cohesion at the
            metaphase-I stage in male germ cells.
REFERENCE   7  (bases 1 to 5688)
  AUTHORS   Kolas,N.K., Yuan,L., Hoog,C., Heng,H.H., Marcon,E. and Moens,P.B.
  TITLE     Male mouse meiotic chromosome cores deficient in structural
            proteins SYCP3 and SYCP2 align by homology but fail to synapse and
            have possible impaired specificity of chromatin loop attachment
  JOURNAL   Cytogenet Genome Res 105 (2-4), 182-188 (2004)
   PUBMED   15237206
  REMARK    GeneRIF: SYCP2 and SYCP3 proteins function in the specificity of
            chromatin attachment to the chromosome core
REFERENCE   8  (bases 1 to 5688)
  AUTHORS   Pelttari,J., Hoja,M.R., Yuan,L., Liu,J.G., Brundell,E., Moens,P.,
            Santucci-Darmanin,S., Jessberger,R., Barbero,J.L., Heyting,C. and
            Hoog,C.
  TITLE     A meiotic chromosomal core consisting of cohesin complex proteins
            recruits DNA recombination proteins and promotes synapsis in the
            absence of an axial element in mammalian meiotic cells
  JOURNAL   Mol Cell Biol 21 (16), 5667-5677 (2001)
   PUBMED   11463847
REFERENCE   9  (bases 1 to 5688)
  AUTHORS   Venables,J.P., Ruggiu,M. and Cooke,H.J.
  TITLE     The RNA-binding specificity of the mouse Dazl protein
  JOURNAL   Nucleic Acids Res 29 (12), 2479-2483 (2001)
   PUBMED   11410654
REFERENCE   10 (bases 1 to 5688)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ103262.1 and AL772217.10.
            
            On or before Jun 29, 2006 this sequence version replaced
            XM_619861.3, XM_914292.2, XM_988660.1, NM_177191.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ103262.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4978              DQ103262.1         1-4978
            4979-5688           AL772217.10        103829-104538       c
FEATURES             Location/Qualifiers
     source          1..5688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 99.81 cM"
     gene            1..5688
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="synaptonemal complex protein 2"
                     /db_xref="GeneID:320558"
                     /db_xref="MGI:MGI:1933281"
     exon            1..112
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            113..171
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..4650
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="SCP-2; synaptonemal complex lateral element
                     protein"
                     /codon_start=1
                     /product="synaptonemal complex protein 2"
                     /protein_id="NP_796165.2"
                     /db_xref="CCDS:CCDS38370.1"
                     /db_xref="GeneID:320558"
                     /db_xref="MGI:MGI:1933281"
                     /translation="MPVRPDLQQLEKCIDDALRKNDFKPLLALLQIDICEDVKIKCSK
                     QFLRKLDDLICRELNKKDIQTVSSILISIGRCSKNIFILGQAGLQTMIKQGLVQKMVS
                     WFENSKEIILNQQQSKDEAVMNMIEDLFDLLMVIYDISDEGKNQVLESFIPQICALVI
                     DSRVNFCIQQEALKKMNLMLDRIPQDANKILSNQEMLTLMSNMGERILDVGDYELQVG
                     IVEALCRMTTEKRRQELAYEWFSMDFIANAFKEIKDCEFETDCRIFLNLVNGILGDKR
                     RVYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDEEDHQWEAVTVP
                     EEKVQMYNIEVRESKKLLTLTLKNIVKISKKEGKELLFYFDESLEITNVTKKVFGGNK
                     YKEFTRKQGISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSDIQKKLVNP
                     LELGNSSSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSREPLQAIN
                     SVEKAVSKTSESGMDYAASPKSRQSDGRKRWNNRANHNKTTAVIQNKQYEDNESPDQN
                     FNEIEDTLSNVSSAVGKVDKPVLPGVLDISKNTTHSRWACWTPVTTIKLCNNQRSRAL
                     PGDTCTQDTGVNKKCTKQKSVSDDDSEETQKGKYSKDVIKCNKSDEAEFCERNIQEQN
                     HPKYSQKKNTANAKKSDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDK
                     SPSRKSKRNHTKSRKELMSELTSCELEEIPVRENSKGKRFTGASESLINQISRRYNPS
                     DSMMSTRKLKEPQDGSGFSKKPDLQFNKVQRKSYRKLKATVVNVTSECPLDDVYNFSL
                     NGADEPVIKLGIQEFQATTREASMDNSLKLVKNHDEHDPFLKTKDKRMLSYEKKTLLS
                     DTETECGCDDSKTDISWLKEPKTKRLMDYSRNKNTTKYKSRKSRSSMEKGQPRPTMVL
                     NKNSMKNDYEVVVDGRTRLPRRATKTKKNYKDLSTSESESESEKECSYLFKDKLPTKE
                     ETIHSRAQTKKLPEKQQKVFNSEALKGQPSEEQKNSSRLREGREDSLCLSSASVSRSS
                     SSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAPSPEFLNGNNSVVGRGQSPRISET
                     SAMCVRKSYSPASGPPFSPRHTPTKNNSVVNMKKANSVINNQRTQHCNSYSDVSSNSS
                     EKLYMEPESPESCDNHMQNKREGNHAASPLSLSSEKIEKMWFDMPSENTHVSGPSQRG
                     SKRRMYLEDDELSNSNEAEVEEAEEREHLLSKKRCQWENSDQHTFKTSLSTPDFSVPK
                     DWQQELQGAGMFYDNISSDYKRKTDSQHKIMDDFTTKTLKLTQQHLMAMTSQAQGRRD
                     ENVEKFQVTLLDELEKVEKDSQTLRDLEKELVDIEEKLVQKMRAYHRCERERFRVLKT
                     SLDKSFLVYNSVYEESVFTSEMCLMKANMKMLQDKLLKEMHEEEVLNIRRGLQSLFKA
                     HEGNDA"
     exon            172..315
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            316..444
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            445..549
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            550..574
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..660
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            661..746
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..781
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..924
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..977
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1023
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1119
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1180
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1329
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1404
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1530
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1630
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1779
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1849
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1910
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2041
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2460
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2588
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2625
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2690
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2748
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2804
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2856
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..3019
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3057
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3234
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3433
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3639
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3825
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3916
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4072
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4182
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4277
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4278..4377
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4436
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4518
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4575
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..5688
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4708..4713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4730
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="major polyA site"
     regulatory      4952..4957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4972
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="major polyA site"
     regulatory      4998..5003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5026
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
     regulatory      5242..5247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5268
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
     regulatory      5654..5659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="hexamer: ATTAAA"
     regulatory      5672..5677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
                     /note="hexamer: AACAAA"
     polyA_site      5677
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
     polyA_site      5688
                     /gene="Sycp2"
                     /gene_synonym="3830402K23Rik; 4930518F03Rik"
ORIGIN      
        1 atcacttccg gctgacccat cgtggacagg gcaggggtca tcggaagtgg ggcaaccgac
       61 cgacccttcc cagaagcgct gcgtgtgcgc ccacagccta aagtgtctgc gggtgtttgt
      121 cttctcctat tcttaaatga gttcaaaatg ccagtgagac cagacctcca acagttagaa
      181 aagtgtattg atgatgcttt gagaaaaaat gacttcaaac ctttgttggc acttttacaa
      241 attgatattt gtgaagatgt gaagattaaa tgcagcaaac aattcctccg caagttggat
      301 gacttaatat gcagggaact taataaaaag gatatccaaa ctgtttcaag catcttgata
      361 tctattggaa gatgtagcaa gaatatcttt atattgggac aagctggact tcaaaccatg
      421 ataaaacaag gattagtcca aaagatggtt tcctggtttg aaaattccaa ggagattatt
      481 ctaaatcaac aacaatcaaa agatgaagct gttatgaata tgatagaaga cttatttgat
      541 cttttgatgg tcatatatga catcagtgat gaaggtaaaa accaagtatt ggaaagtttc
      601 atacctcaaa tctgtgccct ggttattgat tcaagagtga atttttgcat tcagcaggag
      661 gctttaaaaa aaatgaattt gatgcttgac agaatacctc aagatgccaa caaaatactt
      721 tctaatcaag aaatgttaac tctcatgagt aatatgggag aaaggatttt agatgtagga
      781 gattatgaat tacaggtagg cattgtggaa gctttgtgta gaatgaccac agaaaaacgg
      841 agacaagaac tggcatatga atggttttca atggacttta ttgctaatgc atttaaggaa
      901 attaaagact gtgaatttga aacagattgc agaatatttc tcaacttggt aaatggcatt
      961 cttggtgata aaagaagggt ctatacattt ccttgcttgt cagcatttct tggtaaatat
     1021 gagctgcaga taccatcaga tgaaaaactt gaggaattct ggatcgattt taatcttggg
     1081 agccacactc tgtcattcta cattgctgga gatgaagaag atcaccaatg ggaagctgtc
     1141 actgtacctg aagaaaaagt tcagatgtac aacattgaag tgagagaatc aaagaagcta
     1201 ctgactctaa ctttgaaaaa tatagtaaaa attagtaaaa aagaaggaaa agagttactt
     1261 ttttattttg atgaatcatt agaaatcacc aacgtgacta aaaaagtttt tggtggaaat
     1321 aagtataagg aatttaccag aaaacaaggt atttcagttg ccaaaacatc tattcatgta
     1381 ctttttgatg caagtggatc acagattcta gtaccagaaa gtcaaccatc tccagtcaaa
     1441 gaaaacctca ttcatctaaa agagaaatcc gacatccaaa agaaacttgt aaaccctcta
     1501 gaactaggca atagcagcag ccaggatgag atcactacac ctagcagaaa gaaaatgtct
     1561 gaagcatcaa tgattgttcc tgatacagac agatacactg tgcgaagccc aatactttta
     1621 atcaacacat caacaccgcg aagaagtagg gaaccactgc aagcaataaa ttctgtggag
     1681 aaagctgttt ctaaaacatc agaaagtgga atggattatg ctgcgtcacc caaatctaga
     1741 caatcagatg gaagaaaaag atggaataat agagccaacc ataacaaaac tactgctgtc
     1801 atacaaaaca aacaatacga ggataatgaa tccccagacc aaaatttcaa tgaaattgag
     1861 gacactctct ctaatgtatc ttctgcagtg ggaaaagtag acaagcctgt attgcctggt
     1921 gttttagaca tctcaaaaaa tacaacacac tccagatggg catgttggac acctgtaaca
     1981 actatcaaac tctgcaataa ccagagaagc cgtgctttac ctggagacac ttgtacccaa
     2041 gatactggtg tcaacaaaaa atgcactaaa caaaaatcag tatcagatga tgattctgaa
     2101 gaaacacaaa agggaaaata tagtaaagat gtaatcaagt gtaacaagtc agatgaagca
     2161 gaattttgtg aaagaaacat tcaagaacaa aatcatccta aatattcaca aaagaaaaat
     2221 actgcaaatg caaagaagag tgattggcat attgaatctg aaactactta taaatctgta
     2281 ctcctaaata agacaactga agaatctctc atctataaga agacatgtgt attgtcaaaa
     2341 gatgtgaata ctactatctg tgataaaagc ccttctagaa aaagcaagag gaatcataca
     2401 aaatcaagaa aggaactgat gtctgaactt acatcatgtg agctagaaga aataccagtg
     2461 agagaaaatt caaaagggaa aagatttact ggtgcatcag aatccttgat aaaccaaatt
     2521 agtaggagat ataacccaag tgatagcatg atgtcaacaa gaaaactgaa ggagcctcag
     2581 gatggcagtg gattttcaaa aaaacctgat ctgcagttca ataaggttca gagaaagagt
     2641 tacaggaaac tgaaggcaac tgttgtcaat gttacttctg aatgtccact ggatgatgta
     2701 tataatttca gcttgaatgg tgccgatgaa cctgttataa aacttggaat ccaagaattt
     2761 caagctacaa ctagagaagc cagtatggat aattcattaa aattggtaaa gaatcatgat
     2821 gaacatgacc cttttctcaa aacaaaagat aaaagaatgt taagttatga gaagaaaact
     2881 ctcttaagtg acactgaaac cgaatgtgga tgtgatgaca gcaagactga cattagctgg
     2941 ctaaaagaac caaaaacaaa aagactaatg gattatagta gaaataaaaa cacaacaaaa
     3001 tataaaagta gaaaatcaag atcatccatg gaaaaaggac aaccaagacc cacaatggta
     3061 ctcaataaaa acagtatgaa aaatgattat gaagtagttg tagatgggag aaccagactt
     3121 ccacgaagag caacaaaaac aaaaaaaaat tataaagatc tttcaacttc agaatcagaa
     3181 tcagagagtg aaaaagaatg ttcatatttg tttaaagata aactgccaac aaaggaggag
     3241 actatccatt ccagagccca aacaaagaaa ctgcccgaga aacaacagaa agtcttcaat
     3301 tcagaagcgc tgaaaggaca gccatcagaa gaacagaaaa actcctctcg gctgagagaa
     3361 gggagagaag acagtctgtg cctgtcttct gcgtctgtgt ccaggagctc gtcctctgtg
     3421 gaagtgatga gatgtacaga gaaaataaca gaaagggatt ttactcagga ttatgactat
     3481 atcacaaaat ctctttcacc ttatccaaaa gctccatcac ctgaattctt aaatggaaac
     3541 aatagcgttg taggtcgggg acaatcaccc agaattagtg agaccagtgc aatgtgtgta
     3601 agaaagagtt actcacctgc ttcaggaccg cccttttcgc caagacacac tccgaccaag
     3661 aataattctg ttgtgaatat gaaaaaagca aattcagtga taaataatca gagaacccaa
     3721 cattgtaaca gctattcaga tgtaagcagt aatagctcag agaaacttta tatggaacct
     3781 gaatctccag agagctgtga caaccatatg caaaacaaga gagagggaaa tcatgcagca
     3841 tctccattat cattgtctag tgaaaaaata gagaaaatgt ggtttgacat gcccagtgaa
     3901 aatactcatg tatcaggtcc cagtcaacgt ggtagcaaaa ggcggatgta cctagaagat
     3961 gatgagctaa gtaattccaa tgaagcagaa gtagaagagg cagaagaaag ggaacatttg
     4021 ctttccaaaa aacgatgtca atgggaaaat tctgaccagc acaccttcaa aacttcatta
     4081 tcgacaccag atttttctgt tcctaaggac tggcaacaag agttacaagg tgctggaatg
     4141 ttttatgata acatcagctc agactataaa aggaaaactg atagccaaca taaaatcatg
     4201 gatgatttta ctacaaagac attgaaattg actcaacaac atctgatggc aatgacctct
     4261 caagctcagg gacgcaggga tgaaaatgtt gagaaattcc aagtcactct cctagatgag
     4321 ctggaaaaag ttgaaaaaga ctcacagact ttgcgagact tggagaaaga gcttgtggac
     4381 atcgaggaaa agttagttca gaagatgagg gcatatcacc gatgtgagcg agagaggttt
     4441 cgtgttttga aaacttcact ggataaaagt tttcttgtct ataattctgt ttatgaagag
     4501 tctgttttta catctgagat gtgtttgatg aaagcaaaca tgaaaatgct acaagacaag
     4561 ctacttaagg agatgcatga agaggaagtt ctcaacatac gcagaggact acagtcatta
     4621 ttcaaggctc atgaaggaaa tgatgcatga aatctggctg ctgtcaatga attttatgat
     4681 tagttttttg tgtataaata aagcactaat aaagtagctt tgcaaagatg catcatctaa
     4741 gcacctctat tcttgtgtgc aagaacctcc cgactcaaat gttagagatg aaaaacatga
     4801 ctccaaatgc agcttgtatg tcctatgagc aaacagtaaa aggagctgac tttccttgga
     4861 tcatattttt atattaacta tgtctgtgaa agtagtgtct gtactaaagt atttatatat
     4921 aaagtgtaat tttaaattaa tgcagttttg gaataaaata tactgaaatt tgcatgatgg
     4981 tttgtaaata tacaagtatt aaaatattag caattctttg aaagaggaaa aggctctgct
     5041 ttaagatctt taattgttag taccttcata ctttgagata tatagagtta cagtgcacta
     5101 aaagtgttaa agtgacctaa agttatagct atttcataaa tattttatca cagtgtagaa
     5161 gtcttaacta caaagcaggc tgcttgccat ttctttctaa gcacctggta ttcacctaat
     5221 attttgttag attgtatttt aaataaatgc ttatttgagt aagtataatt actttacagt
     5281 tactattatt gtgttttatg aaccatgact tacaagccac cttcagtcag acacttgaag
     5341 gtaataccaa tctgaaggct gtagagtatt tgagcaatac cagcatttaa tattacagtg
     5401 gtgaagtagt ttcttagtca agcacaaata cattcttggt gtattcaatt gacatcagct
     5461 aagattttaa gatttatgag gaaaatgatg ggagtttcta gttttaagaa agagagagat
     5521 tttacatttt attagccctt agatgaactg tgtgtacaac aaagaactgc taagattaat
     5581 tttgtaactc ttgttttttg agacatggtc tgtgtagacc tggctaacct caaattcagt
     5641 tctgcctgca aacattaaag ccatgggccc aaacaaatgt ccttcaaa
//
