LOCUS       NM_011516               3437 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus synaptonemal complex protein 1 (Sycp1), mRNA.
ACCESSION   NM_011516 XM_131136
VERSION     NM_011516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 3437)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3437)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3437)
  AUTHORS   Cincotta,S.A., Richardson,N., Foecke,M.H. and Laird,D.J.
  TITLE     Differential susceptibility of male and female germ cells to
            glucocorticoid-mediated signaling
  JOURNAL   Elife 12, 90164 (2024)
   PUBMED   38226689
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3437)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3437)
  AUTHORS   Sage,J., Yuan,L., Martin,L., Mattei,M.G., Guenet,J.L., Liu,J.G.,
            Hoog,C., Rassoulzadegan,M. and Cuzin,F.
  TITLE     The Sycp1 loci of the mouse genome: successive retropositions of a
            meiotic gene during the recent evolution of the genus
  JOURNAL   Genomics 44 (1), 118-126 (1997)
   PUBMED   9286707
REFERENCE   7  (bases 1 to 3437)
  AUTHORS   Kondoh,N., Nishina,Y., Tsuchida,J., Koga,M., Tanaka,H., Uchida,K.,
            Inazawa,J., Taketo,M., Nozaki,M., Nojima,H., Matsumiya,K.,
            Namiki,M., Okuyama,A. and Nishimune,Y.
  TITLE     Assignment of synaptonemal complex protein 1 (SCP1) to human
            chromosome 1p13 by fluorescence in situ hybridization and its
            expression in the testis
  JOURNAL   Cytogenet Cell Genet 78 (2), 103-104 (1997)
   PUBMED   9371398
REFERENCE   8  (bases 1 to 3437)
  AUTHORS   Kerr,S.M., Taggart,M.H., Lee,M. and Cooke,H.J.
  TITLE     Ott, a mouse X-linked multigene family expressed specifically
            during meiosis
  JOURNAL   Hum Mol Genet 5 (8), 1139-1148 (1996)
   PUBMED   8842733
REFERENCE   9  (bases 1 to 3437)
  AUTHORS   Kerr,S.M., Taggart,M.H., Lee,M. and Cooke,H.J.
  TITLE     Sequence and mapping of mouse synaptonemal complex protein genes
            Sycpl and Sycpl-rs
  JOURNAL   Mamm Genome 7 (3), 209-211 (1996)
   PUBMED   8833242
REFERENCE   10 (bases 1 to 3437)
  AUTHORS   Sage,J., Martin,L., Cuzin,F. and Rassoulzadegan,M.
  TITLE     cDNA sequence of the murine synaptonemal complex protein 1 (SCP1)
  JOURNAL   Biochim Biophys Acta 1263 (3), 258-260 (1995)
   PUBMED   7548215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133229.1, AK015000.1, AK076780.1 and AV275615.2.
            
            On Jan 30, 2008 this sequence version replaced NM_011516.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z38118.1, L41069.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1168              AK133229.1         2-1169
            1169-1805           AK015000.1         1170-1806
            1806-2485           AK133229.1         1806-2485
            2486-3107           AK076780.1         577-1198
            3108-3437           AV275615.2         312-641
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..3437
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /note="synaptonemal complex protein 1"
                     /db_xref="GeneID:20957"
                     /db_xref="MGI:MGI:105931"
     exon            1..115
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..237
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3111
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /note="SCP-1"
                     /codon_start=1
                     /product="synaptonemal complex protein 1"
                     /protein_id="NP_035646.2"
                     /db_xref="CCDS:CCDS38567.1"
                     /db_xref="GeneID:20957"
                     /db_xref="MGI:MGI:105931"
                     /translation="MEKQKPFTLFVPPRLSSSQVSAVKPQTAGGDSNYFKTANKCTEG
                     DFGVPFTMSSRENIDKDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRL
                     YSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLE
                     EEIQENKDLIKENNATIHWCNLLKETCARSAEKTNKYEYEREETRQVYVDLNSNIEKM
                     ILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSELLIQSAEKE
                     NKMKDLTFLLEESRDKANQLEEKTKLQDENLKELSEKKDHLTSELEDIKMSMQRSMST
                     QKALEEDLQIATKTISQLTEVKEAQMEELNKAKTTHSFVVTELKATTCTLEELLRTEQ
                     QRLEKNEDQLKLITVELQKKSNELEEMTKFKNNKEVELEELKNILAEDQKLLDEKKQV
                     EKLAEELQEKEQELTFLLETREKEVHDLQEQVTVTKTSEQHYLKQVEEMKTELEKEKL
                     KNTELTASCDMLLLENKKFVQEASDMALELKKHQEDIINCKKQEERLLKQIENLEEKE
                     MHLRDELESVRKEFIQQGDEVKCKLDKSEENARSIECEVLKKEKQMKILESKCNNLKK
                     QVENKSKNIEELHQENKTLKKKSSAEIKQLNAYEIKVSKLELELESTKQRFEEMTNNY
                     QKEIENKKISEGKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYD
                     KIVEERDSELGLYKNREQEQSSAKIALETELSNIRNELVSLKKQLEIEKEEKEKLKMA
                     KENTAILKDKKDKKIQASLLESPEATSWKFDSKTTPSQNISRLSSSMDSGKSKDNRDN
                     LRASAKSILPTTVTKEYTVKTPTKKSIYQRENKYIPTGGSNKKRKTAFEFDVNSDSSE
                     TADLLSLVSEEDVSNRLYDNNPPDSHLLVKTPKQTPLSLSTPASFMKFGSLKKMREDR
                     WTTIAKIDRKRRLKEAEKLFS"
     exon            238..310
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..354
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..411
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..576
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..644
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..718
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..777
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..847
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..921
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1030
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1125
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1310
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1378
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1440
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1545
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1649
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1767
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1838
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1920
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1983
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2046
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2109
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2226
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2337
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2430
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2505
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2562
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2742
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2886
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2973
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3437
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /note="hexamer: AATAAA"
     polyA_site      3288
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcga gttctcgggc ttccaggagg ttctgagggg aagctcacgg ttccgttcca
       61 tgtcgtcttc ataaaggagc gcacgcgggg ccacgggccg cggagcctga caacggccca
      121 ggaggcagca tggagaagca aaagcccttc acactgttcg tcccgccgag gctgagcagc
      181 agtcaagtgt ccgccgtgaa accgcagacg gcgggaggag actccaacta cttcaagact
      241 gccaacaaat gtacagaagg tgattttggt gttccattta caatgtccag tcgggaaaac
      301 attgataaag atcctgcttt tcaaaaactt agtattttgc ccatgctcga acaggttgct
      361 aattctggca gttgtcacta tcaggaagga gtaaatgact ctgattttga gaattcagag
      421 ccaatgagca gactgtattc aaagctgtat aaagaggctg aaaagataaa aaagtggaaa
      481 gtgagcatag aatctgaact gaagcagaaa gaaaataagt tgcaagaaaa cagaaagata
      541 attgaagccc agcgaaaagc cattcaggaa cttcagtttg aaaatgaaaa agtaagcttg
      601 aaattagaag aagaaattca agaaaataaa gatttaataa aggagaataa tgctacaata
      661 cattggtgta atctactcaa ggaaacctgt gctagatctg cagaaaagac aaataaatat
      721 gaatatgagc gggaagaaac cagacaagtt tatgtggatc taaatagcaa cattgagaaa
      781 atgatactag cttttgagga acttcgtgtg caagctgaga atgccagact ggaaatgcat
      841 tttaagttaa aggaagatca tgaaaaaatc caacatcttg aagaagaata tcagaaggaa
      901 gtaaacaaca aggaaaatca ggtatcagaa ctgttgatcc aaagtgctga gaaagaaaat
      961 aaaatgaaag atttaacatt tctgttagag gaatccagag ataaagctaa tcaattagag
     1021 gaaaaaacaa aattacaaga tgaaaactta aaagaattaa gtgaaaagaa ggatcattta
     1081 acatcagaac ttgaagatat taaaatgtct atgcaaagaa gtatgagcac tcagaaagct
     1141 ttagaggaag atttgcagat agcaacaaaa acgatttctc agctcactga agtaaaagaa
     1201 gctcaaatgg aagaactcaa caaagctaaa actactcact catttgtggt gactgaactt
     1261 aaagctacta catgtacctt ggaggaatta ctgagaacag aacagcaaag gttggaaaaa
     1321 aatgaagacc aactgaaact gattactgtg gaactccaga agaaatcaaa tgaactagaa
     1381 gagatgacta aatttaaaaa taacaaagaa gtggaacttg aagaattgaa aaacatattg
     1441 gcagaagatc aaaaactttt agatgaaaag aaacaagttg agaagcttgc tgaagaatta
     1501 caagagaaag aacaagaact aactttcctt ttggaaacca gagagaaaga agtccatgat
     1561 ttgcaagaac aagtaactgt cactaaaaca agtgaacagc attatttaaa acaggttgaa
     1621 gaaatgaaaa ctgagcttga aaaagagaaa cttaagaata ctgaattaac tgcaagttgt
     1681 gacatgcttt tgcttgagaa caaaaaattt gtacaagaag caagtgatat ggccctagaa
     1741 ctcaagaaac atcaagaaga tatcattaat tgcaaaaagc aagaagaaag gctgttgaaa
     1801 caaatagaaa atttggaaga aaaagaaatg catttaaggg atgaactgga atcagtaaga
     1861 aaagagttca tacagcaagg agatgaagtt aagtgtaaat tggacaagag tgaagaaaat
     1921 gctcgaagca ttgaatgtga agttttaaag aaagaaaagc agatgaagat attagaaagc
     1981 aagtgtaata atttaaagaa acaagttgaa aataaaagca agaatattga agagcttcac
     2041 caggagaata aaaccttgaa aaaaaagagt tcagcagaaa tcaaacaact gaatgcatat
     2101 gagataaagg tcagtaaatt agagttggaa ttagaaagta ccaagcaaag atttgaagaa
     2161 atgactaaca attaccagaa ggaaattgag aacaaaaaga tatcagaagg aaagcttttg
     2221 ggagaggttg agaaagccaa agcaacagtt gatgaagctg taaagttaca gaaagaaatt
     2281 gatttacgat gccaacataa aatagctgaa atggtagcac ttatggaaaa acataagcac
     2341 caatatgata agattgttga agaaagagac tcagaattag gactttataa aaacagagag
     2401 caagaacagt catcagcgaa gattgctttg gagactgaac tatctaatat cagaaatgaa
     2461 cttgtatccc ttaagaagca acttgaaata gaaaaagaag aaaaagagaa actaaaaatg
     2521 gcaaaagaaa acacagctat tctcaaagat aaaaaagaca agaaaataca ggcatcttta
     2581 ctggaatcac ctgaagccac tagttggaag tttgattcta aaacaactcc ttcacaaaat
     2641 atatctcggc tttcctcatc aatggatagt ggcaaatcca aagataacag agataatctg
     2701 cgggcatctg ccaaaagcat tttacctaca acagttacaa aggaatatac agtgaagaca
     2761 ccaactaaaa agagtatata tcaaagagaa aacaagtata tacctactgg aggaagtaat
     2821 aaaaagagaa aaacagcctt tgaatttgat gttaattcag atagttcaga aactgctgat
     2881 ctcttgagcc tggtttcaga ggaagatgta tcaaacagac tttatgataa taatccacca
     2941 gattctcatc tattagttaa aacccccaaa cagactcctt tatcgctatc aactcctgca
     3001 tcttttatga agtttggaag tctgaaaaaa atgagagagg accgttggac aacgattgct
     3061 aaaattgata ggaaaagaag actaaaggaa gcagaaaagt tattttctta atttcagaaa
     3121 accaatgttg gttacagaga tgaaaaacat taaatagtta tctttattat ttccaagaga
     3181 gccaaacttt accaaggaat tcatatttta aaattaatta cagaaataac ttgggtttat
     3241 gttactatat ttgtggccta aaaataaaat aactatattt catctgaatt tttattgtat
     3301 tcagatactt aacattttgt tgcttttact tgcaatggat attgaagttc gaagtttttt
     3361 aacttgagct tttgatcatt agaaatgcat tattaagatt tattaatttt tctttattat
     3421 taaaatattt tgaatgc
//
