LOCUS       NM_026716                557 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus syncollin (Sycn), mRNA.
ACCESSION   NM_026716
VERSION     NM_026716.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 557)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   2  (bases 1 to 557)
  AUTHORS   Scavuzzo,M.A., Chmielowiec,J., Yang,D., Wamble,K., Chaboub,L.S.,
            Duraine,L., Tepe,B., Glasgow,S.M., Arenkiel,B.R., Brou,C.,
            Deneen,B. and Borowiak,M.
  TITLE     Pancreatic Cell Fate Determination Relies on Notch Ligand
            Trafficking by NFIA
  JOURNAL   Cell Rep 25 (13), 3811-3827 (2018)
   PUBMED   30590051
REFERENCE   3  (bases 1 to 557)
  AUTHORS   Li,Z., Parlakian,A., Coletti,D., Alonso-Martin,S., Hourde,C.,
            Joanne,P., Gao-Li,J., Blanc,J., Ferry,A., Paulin,D., Xue,Z. and
            Agbulut,O.
  TITLE     Synemin acts as a regulator of signalling molecules during skeletal
            muscle hypertrophy
  JOURNAL   J Cell Sci 127 (Pt 21), 4589-4601 (2014)
   PUBMED   25179606
REFERENCE   4  (bases 1 to 557)
  AUTHORS   Soggia,A., Ramond,C., Akiyama,H., Scharfmann,R. and Duvillie,B.
  TITLE     von Hippel-Lindau gene disruption in mouse pancreatic progenitors
            and its consequences on endocrine differentiation in vivo:
            importance of HIF1-alpha and VEGF-A upregulation
  JOURNAL   Diabetologia 57 (11), 2348-2356 (2014)
   PUBMED   25186293
REFERENCE   5  (bases 1 to 557)
  AUTHORS   Wasle,B., Turvey,M., Larina,O., Thorn,P., Skepper,J., Morton,A.J.
            and Edwardson,J.M.
  TITLE     Syncollin is required for efficient zymogen granule exocytosis
  JOURNAL   Biochem J 385 (Pt 3), 721-727 (2005)
   PUBMED   15462671
  REMARK    GeneRIF: syncollin is required for efficient exocytosis in the
            pancreatic acinar cell, and it plays a particularly important role
            in compound exocytosis
REFERENCE   6  (bases 1 to 557)
  AUTHORS   Antonin,W., Wagner,M., Riedel,D., Brose,N. and Jahn,R.
  TITLE     Loss of the zymogen granule protein syncollin affects pancreatic
            protein synthesis and transport but not secretion
  JOURNAL   Mol Cell Biol 22 (5), 1545-1554 (2002)
   PUBMED   11839820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136456.3.
            
            On Apr 30, 2009 this sequence version replaced NM_026716.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019567.1, BQ921123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC136456.3         81723-82142
            421-557             AC136456.3         82912-83048
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.83 cM"
     gene            1..557
                     /gene="Sycn"
                     /gene_synonym="0910001K16Rik; 1810038B08Rik; SYL"
                     /note="syncollin"
                     /db_xref="GeneID:68416"
                     /db_xref="MGI:MGI:1915666"
     exon            1..420
                     /gene="Sycn"
                     /gene_synonym="0910001K16Rik; 1810038B08Rik; SYL"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..430
                     /gene="Sycn"
                     /gene_synonym="0910001K16Rik; 1810038B08Rik; SYL"
                     /codon_start=1
                     /product="syncollin precursor"
                     /protein_id="NP_080992.3"
                     /db_xref="CCDS:CCDS21048.1"
                     /db_xref="GeneID:68416"
                     /db_xref="MGI:MGI:1915666"
                     /translation="MSLLCPLLLALALVAVPGAHGNCPVPADLKKSDGTRTCARLYEK
                     SDPYYDNCCQGPVLSVEPGTDLPYLPSGWSNTASSLVVGQRCEITVWSLPGKHGKTRK
                     FTAGSYPRLEEYRKGIFGDWSDSISALYCKCY"
     exon            421..557
                     /gene="Sycn"
                     /gene_synonym="0910001K16Rik; 1810038B08Rik; SYL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      533..538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sycn"
                     /gene_synonym="0910001K16Rik; 1810038B08Rik; SYL"
                     /note="hexamer: AATACA"
     polyA_site      556
                     /gene="Sycn"
                     /gene_synonym="0910001K16Rik; 1810038B08Rik; SYL"
                     /note="major polyA site"
ORIGIN      
        1 agacctctca tggttcattg tcaccatgtc cctgctgtgc ccactgctgc tggctttagc
       61 cctggtggct gtccctggtg cccatggcaa ttgcccggtg cccgcagacc tgaagaagtc
      121 agatgggacg cgtacgtgcg ccagactcta tgagaagagt gatccatact atgacaactg
      181 ctgccagggg cccgtgttgt ctgtggagcc aggtactgac ctgccctatc tgccctcggg
      241 ctggtctaac actgcatcgt ctctggtagt gggccagcgc tgtgagatca ctgtgtggtc
      301 tctccccggt aagcatggca agacccgcaa gttcaccgcg ggttcttacc ctcgcctgga
      361 agagtaccgc aaaggcatct ttggagactg gtccgactcc atctctgccc tctactgcaa
      421 gtgctattga tgccttgagg ctctgtctac ccagcctggc cttgggaatt gctgtagctc
      481 caagagccag gaggcaagat gaccccacga cctgctctca tagcttccct gtaatacagc
      541 cctttcaaag ttacaac
//
