LOCUS       NM_001162882             478 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus synaptonemal complex central element protein 3
            (Syce3), transcript variant 2, mRNA.
ACCESSION   NM_001162882
VERSION     NM_001162882.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Crichton,J.H., Dunce,J.M., Dunne,O.M., Salmon,L.J., Devenney,P.S.,
            Lawson,J., Adams,I.R. and Davies,O.R.
  TITLE     Structural maturation of SYCP1-mediated meiotic chromosome synapsis
            by SYCE3
  JOURNAL   Nat Struct Mol Biol 30 (2), 188-199 (2023)
   PUBMED   36635604
  REMARK    GeneRIF: Structural maturation of SYCP1-mediated meiotic chromosome
            synapsis by SYCE3.
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Liu,H., Huang,T., Li,M., Li,M., Zhang,C., Jiang,J., Yu,X., Yin,Y.,
            Zhang,F., Lu,G., Luo,M.C., Zhang,L.R., Li,J., Liu,K. and Chen,Z.J.
  TITLE     SCRE serves as a unique synaptonemal complex fastener and is
            essential for progression of meiosis prophase I in mice
  JOURNAL   Nucleic Acids Res 47 (11), 5670-5683 (2019)
   PUBMED   30949703
  REMARK    GeneRIF: SCRE interacts with synaptonemal complex protein 1 (SYCP1)
            and synaptonemal complex central element 3 (SYCE3); the function of
            SCRE is to reinforce the integrity of the central elements, thereby
            stabilizing the SC and ensuring meiotic cell cycle progression
REFERENCE   3  (bases 1 to 478)
  AUTHORS   Zhang,J., Fujiwara,Y., Yamamoto,S. and Shibuya,H.
  TITLE     A meiosis-specific BRCA2 binding protein recruits recombinases to
            DNA double-strand breaks to ensure homologous recombination
  JOURNAL   Nat Commun 10 (1), 722 (2019)
   PUBMED   30760716
  REMARK    Erratum:[Nat Commun. 2019 Feb 25;10(1):986. doi:
            10.1038/s41467-019-08995-4.. PMID: 30804343]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 478)
  AUTHORS   Ni,L., Xie,H. and Tan,L.
  TITLE     Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3
            conditional knockout mouse models
  JOURNAL   Mol Reprod Dev 83 (12), 1060-1069 (2016)
   PUBMED   27739607
REFERENCE   5  (bases 1 to 478)
  AUTHORS   Gomez-H,L., Felipe-Medina,N., Sanchez-Martin,M., Davies,O.R.,
            Ramos,I., Garcia-Tunon,I., de Rooij,D.G., Dereli,I., Toth,A.,
            Barbero,J.L., Benavente,R., Llano,E. and Pendas,A.M.
  TITLE     C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and
            is essential for mouse fertility
  JOURNAL   Nat Commun 7, 13298 (2016)
   PUBMED   27796301
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 478)
  AUTHORS   Schramm,S., Fraune,J., Naumann,R., Hernandez-Hernandez,A., Hoog,C.,
            Cooke,H.J., Alsheimer,M. and Benavente,R.
  TITLE     A novel mouse synaptonemal complex protein is essential for loading
            of central element proteins, recombination, and fertility
  JOURNAL   PLoS Genet 7 (5), e1002088 (2011)
   PUBMED   21637789
  REMARK    GeneRIF: SYCE3 is required for male and female fertility.
REFERENCE   7  (bases 1 to 478)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   8  (bases 1 to 478)
  AUTHORS   Hu,T., Wang,Z., Zeng,F., Chen,X., Gu,Z., Zheng,L. and Tong,Q.
  TITLE     Expression pattern of testis-specific expressed gene 2 in
            cryptorchidism model and its role in apoptosis of spermatogenic
            cells
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 30 (2), 193-197 (2010)
   PUBMED   20407872
  REMARK    GeneRIF: TSEG-2 may participate in the apoptosis of spermatogenic
            cells and the pathogenesis of cryptorchidism.
REFERENCE   9  (bases 1 to 478)
  AUTHORS   Wang,Z.Y., Tong,Q.S., Zeng,F.Q., Liu,Y., Gu,Z.H., Zheng,L.D.,
            Cai,J.B. and Jiang,G.S.
  TITLE     [Cloning and expression of a novel mouse testis gene TSEG-2]
  JOURNAL   Zhonghua Nan Ke Xue 15 (2), 99-105 (2009)
   PUBMED   19323366
  REMARK    GeneRIF: A novel mouse testis specific gene TSEG-2 was successfully
            cloned, which could be down-regulated by cryptorchidism-inducible
            17-beta estradiol. [TSEG-2]
REFERENCE   10 (bases 1 to 478)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029781.1 and BC048615.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029781.1, CN832352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AK029781.1         2-138
            138-478             BC048615.1         170-510
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.87 cM"
     gene            1..478
                     /gene="Syce3"
                     /gene_synonym="1700007E06Rik; TSEG-2; TSEG2"
                     /note="synaptonemal complex central element protein 3"
                     /db_xref="GeneID:75459"
                     /db_xref="MGI:MGI:1922709"
     exon            1..73
                     /gene="Syce3"
                     /gene_synonym="1700007E06Rik; TSEG-2; TSEG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..340
                     /gene="Syce3"
                     /gene_synonym="1700007E06Rik; TSEG-2; TSEG2"
                     /note="testis-specific expressed protein 2"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 3"
                     /protein_id="NP_001156354.1"
                     /db_xref="CCDS:CCDS49703.1"
                     /db_xref="GeneID:75459"
                     /db_xref="MGI:MGI:1922709"
                     /translation="MADSDPGERSYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAY
                     DMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ"
     exon            74..182
                     /gene="Syce3"
                     /gene_synonym="1700007E06Rik; TSEG-2; TSEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..448
                     /gene="Syce3"
                     /gene_synonym="1700007E06Rik; TSEG-2; TSEG2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagtccct ccttcctctg ccaccgcgtg ggctgtggag cggacccgag cgcgagcgcg
       61 ggcccagcca gagatggctg attccgatcc tggggaaaga agctatgata acatgctgaa
      121 aatgctgtct gacctgaaca aggacctgga aaagctattg gaagagatgg aaaaaatctc
      181 agtgcaggca acctggatgg cctatgatat ggtggtcatg cgtacgaacc ccacactagc
      241 agagtccatg cgccggctag aagacgcctt cctcaactgc aaagaggaga tggagaagaa
      301 ctggcaagag ctgctcactg agaccaagcg caagcagtga gctaccatct gtcagcagcc
      361 tgtgggccga agccagggac atgggtccag aagcccagac gtgtagccat gtgcatggta
      421 cttgtttctc aataaactta ttttcacgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
