LOCUS       NM_027954                911 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptonemal complex central element protein 2
            (Syce2), transcript variant 2, mRNA.
ACCESSION   NM_027954
VERSION     NM_027954.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Liu,H., Huang,T., Li,M., Li,M., Zhang,C., Jiang,J., Yu,X., Yin,Y.,
            Zhang,F., Lu,G., Luo,M.C., Zhang,L.R., Li,J., Liu,K. and Chen,Z.J.
  TITLE     SCRE serves as a unique synaptonemal complex fastener and is
            essential for progression of meiosis prophase I in mice
  JOURNAL   Nucleic Acids Res 47 (11), 5670-5683 (2019)
   PUBMED   30949703
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Kumar,R., Ghyselinck,N., Ishiguro,K., Watanabe,Y., Kouznetsova,A.,
            Hoog,C., Strong,E., Schimenti,J., Daniel,K., Toth,A. and de
            Massy,B.
  TITLE     MEI4 - a central player in the regulation of meiotic DNA
            double-strand break formation in the mouse
  JOURNAL   J Cell Sci 128 (9), 1800-1811 (2015)
   PUBMED   25795304
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Schucker,K., Holm,T., Franke,C., Sauer,M. and Benavente,R.
  TITLE     Elucidation of synaptonemal complex organization by
            super-resolution imaging with isotropic resolution
  JOURNAL   Proc Natl Acad Sci U S A 112 (7), 2029-2033 (2015)
   PUBMED   25646409
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Fukuda,T., Fukuda,N., Agostinho,A., Hernandez-Hernandez,A.,
            Kouznetsova,A. and Hoog,C.
  TITLE     STAG3-mediated stabilization of REC8 cohesin complexes promotes
            chromosome synapsis during meiosis
  JOURNAL   EMBO J 33 (11), 1243-1255 (2014)
   PUBMED   24797475
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Daniel,K., Lange,J., Hached,K., Fu,J., Anastassiadis,K., Roig,I.,
            Cooke,H.J., Stewart,A.F., Wassmann,K., Jasin,M., Keeney,S. and
            Toth,A.
  TITLE     Meiotic homologue alignment and its quality surveillance are
            controlled by mouse HORMAD1
  JOURNAL   Nat Cell Biol 13 (5), 599-610 (2011)
   PUBMED   21478856
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Bolcun-Filas,E., Costa,Y., Speed,R., Taggart,M., Benavente,R., De
            Rooij,D.G. and Cooke,H.J.
  TITLE     SYCE2 is required for synaptonemal complex assembly, double strand
            break repair, and homologous recombination
  JOURNAL   J Cell Biol 176 (6), 741-747 (2007)
   PUBMED   17339376
  REMARK    GeneRIF: Synaptonemal complex assembly is dependent on SYCE2.
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Hamer,G., Gell,K., Kouznetsova,A., Novak,I., Benavente,R. and
            Hoog,C.
  TITLE     Characterization of a novel meiosis-specific protein within the
            central element of the synaptonemal complex
  JOURNAL   J Cell Sci 119 (Pt 19), 4025-4032 (2006)
   PUBMED   16968740
REFERENCE   10 (bases 1 to 911)
  AUTHORS   Costa,Y., Speed,R., Ollinger,R., Alsheimer,M., Semple,C.A.,
            Gautier,P., Maratou,K., Novak,I., Hoog,C., Benavente,R. and
            Cooke,H.J.
  TITLE     Two novel proteins recruited by synaptonemal complex protein 1
            (SYCP1) are at the centre of meiosis
  JOURNAL   J Cell Sci 118 (Pt 12), 2755-2762 (2005)
   PUBMED   15944401
  REMARK    GeneRIF: The localisation of Syce1 and Cesc1 (Syce2) to the central
            element depends on recruitment by Sycp1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161765.5, BY246600.1, AK005954.1 and AK082833.1.
            
            On Dec 3, 2009 this sequence version replaced NM_027954.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005954.1, BY706088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC161765.5         139477-139544
            69-498              BY246600.1         2-431
            499-860             AK005954.1         500-861
            861-911             AK082833.1         747-797
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.25 cM"
     gene            1..911
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /note="synaptonemal complex central element protein 2"
                     /db_xref="GeneID:71846"
                     /db_xref="MGI:MGI:1919096"
     exon            1..143
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..644
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     central element synaptonemal complex 1; central element
                     synaptonemal complex protein 1"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 2
                     isoform 2"
                     /protein_id="NP_082230.2"
                     /db_xref="CCDS:CCDS22481.1"
                     /db_xref="GeneID:71846"
                     /db_xref="MGI:MGI:1919096"
                     /translation="MERHGVAAPPVELKDQEPPAIVESGEHRQSENHEETPGSVAPSA
                     SCQLPGPFSSLDSSIETLKKKAQELIENINESRQKDHALMTNFRDSLKMKVSDLTEKL
                     EERMYQVYSHHSKIIQERLQEFTQKMAKINHLEMELKQVCQTVETVYKDLCVQSEVPT
                     CEEQNYKDGEC"
     exon            144..256
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..410
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..599
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..911
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /note="hexamer: ATTAAA"
     polyA_site      861
                     /gene="Syce2"
                     /gene_synonym="1700013H19Rik; Cesc1"
                     /note="major polyA site"
ORIGIN      
        1 gagttcgccg cccccggggg ggggggggcg ggggcggggc cagggcgcgt ttcattcagc
       61 acgtgctcgg ggcggggcgt gcagggggcg tggcgtgcgc agagggcgct gaggcgggaa
      121 aagacggaat ggagcgccac ggagtggccg cgcctcccgt ggagttaaag gaccaggagc
      181 cgccggcgat tgtggagagc ggagagcatc ggcagagtga gaaccacgag gagacgcccg
      241 gctcagtggc cccgagtgcc agttgccagc tgccaggacc cttctcctct ctggactcta
      301 gcattgaaac cctgaagaag aaagcccagg aactgattga aaacatcaat gaaagcaggc
      361 agaaggacca tgcacttatg accaacttca gggacagcct caagatgaag gtctcagatc
      421 tgacagaaaa gttggaggag aggatgtacc aggtgtacag ccaccacagc aaaatcattc
      481 aggaaagact acaagaattt acccagaaga tggcaaagat caaccatctg gaaatggagc
      541 ttaaacaagt ctgccaaact gtggaaacgg tgtacaagga cctatgtgtc cagtctgagg
      601 ttcccacttg cgaagaacag aattacaaag atggtgaatg ctgacttctg ctaagaggct
      661 tccatctcaa tgtgagaagg cacagaggct gctgtttgag gcatgctgat attgtttttt
      721 atagttctgt aacccaacac aaagccacca atgctctttg tgctaattac cgtagtgtga
      781 caaggtttga ccctgccata agccttgcct tagcaaattc tcccaaccca catctgtagt
      841 tgattaaatg ttttgatttc accctggtca tactttattc cagaattgga aagactgatg
      901 atcatctatg c
//
