LOCUS       NM_001143765            1462 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptonemal complex central element protein 1
            (Syce1), mRNA.
ACCESSION   NM_001143765 XM_001472886 XM_001479666
VERSION     NM_001143765.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Sanchez-Saez,F., Gomez-H,L., Dunne,O.M., Gallego-Paramo,C.,
            Felipe-Medina,N., Sanchez-Martin,M., Llano,E., Pendas,A.M. and
            Davies,O.R.
  TITLE     Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1
            interactions that are disrupted in cases of human infertility
  JOURNAL   Sci Adv 6 (36) (2020)
   PUBMED   32917591
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Hernandez-Lopez,D., Geisinger,A., Trovero,M.F., Santinaque,F.F.,
            Brauer,M., Folle,G.A., Benavente,R. and Rodriguez-Casuriaga,R.
  TITLE     Familial primary ovarian insufficiency associated with an SYCE1
            point mutation: defective meiosis elucidated in humanized mice
  JOURNAL   Mol Hum Reprod 26 (7), 485-497 (2020)
   PUBMED   32402064
  REMARK    GeneRIF: Familial primary ovarian insufficiency associated with an
            SYCE1 point mutation: defective meiosis elucidated in humanized
            mice.
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Acquaviva,L., Boekhout,M., Karasu,M.E., Brick,K., Pratto,F., Li,T.,
            van Overbeek,M., Kauppi,L., Camerini-Otero,R.D., Jasin,M. and
            Keeney,S.
  TITLE     Ensuring meiotic DNA break formation in the mouse pseudoautosomal
            region
  JOURNAL   Nature 582 (7812), 426-431 (2020)
   PUBMED   32461690
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Bolcun-Filas,E., Hall,E., Speed,R., Taggart,M., Grey,C., de
            Massy,B., Benavente,R. and Cooke,H.J.
  TITLE     Mutation of the mouse Syce1 gene disrupts synapsis and suggests a
            link between synaptonemal complex structural components and DNA
            repair
  JOURNAL   PLoS Genet 5 (2), e1000393 (2009)
   PUBMED   19247432
  REMARK    GeneRIF: Mutation in the Syce1 results in disruption of synapsis.
            Erratum:[PLoS Genet. 2009 Apr;5(4). doi:
            10.1371/annotation/50260271-aed9-4316-b09a-304591b0cba5. Hall, Emma
            [added]]
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene expressed in
            female germline in addition to male germline.
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Hamer,G., Gell,K., Kouznetsova,A., Novak,I., Benavente,R. and
            Hoog,C.
  TITLE     Characterization of a novel meiosis-specific protein within the
            central element of the synaptonemal complex
  JOURNAL   J Cell Sci 119 (Pt 19), 4025-4032 (2006)
   PUBMED   16968740
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Costa,Y., Speed,R., Ollinger,R., Alsheimer,M., Semple,C.A.,
            Gautier,P., Maratou,K., Novak,I., Hoog,C., Benavente,R. and
            Cooke,H.J.
  TITLE     Two novel proteins recruited by synaptonemal complex protein 1
            (SYCP1) are at the centre of meiosis
  JOURNAL   J Cell Sci 118 (Pt 12), 2755-2762 (2005)
   PUBMED   15944401
  REMARK    GeneRIF: The localisation of Syce1 and Cesc1 (Syce2) to the central
            element depends on recruitment by Sycp1.
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Ferguson,D.A., Chiang,J.T., Richardson,J.A. and Graff,J.
  TITLE     eXPRESSION: an in silico tool to predict patterns of gene
            expression
  JOURNAL   Gene Expr Patterns 5 (5), 619-628 (2005)
   PUBMED   15939374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY081845.1, AK016694.1 and AC107815.11.
            
            On or before Jan 7, 2009 this sequence version replaced
            XM_001479666.1, XM_001472886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016694.1, BY716381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY081845.1         2-24
            24-1456             AK016694.1         24-1456
            1457-1462           AC107815.11        147638-147643
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.96 cM"
     gene            1..1462
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /note="synaptonemal complex central element protein 1"
                     /db_xref="GeneID:74075"
                     /db_xref="MGI:MGI:1921325"
     exon            1..119
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1030
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 1"
                     /protein_id="NP_001137237.1"
                     /db_xref="CCDS:CCDS52436.1"
                     /db_xref="GeneID:74075"
                     /db_xref="MGI:MGI:1921325"
                     /translation="MATRPQPLGMEPEGSADLLHGPEGARGQYGSTQKIEDLMDMVKK
                     LQKVGSLEPRIEVLINRINEVQQAKKKASEELGEAQTVWDNLQKELDLLREEKVRLKD
                     ILNRKEETLRIMQLHCQEKESEAQRKHSMLQECKERISFLNSQIDKEKAKLRKLRLDF
                     EEHLETLMSQHKDTLEFHKPEHLTKEMCVLDSSKEQLLKEEKLMKVKLEDVRQRLCAL
                     GGPEGSSSLIEGLFLRSHEAAAAMQMFKDENKKAEEFLEAAAQQHEQLQQRCHQLQQK
                     RQRLKEELEKHGVQILAHSTQNEEDSSWRMASPKPVEVHEETAQDQERPSSRT"
     exon            120..182
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            183..242
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            243..317
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            318..365
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..420
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            421..510
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..574
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..641
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            642..765
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..876
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..958
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1462
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1460
                     /gene="Syce1"
                     /gene_synonym="4933406J07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcctggaag ctgctgcggc agctgaggaa gtggagcagt atggccacca gaccgcagcc
       61 gttgggtatg gagcccgagg gctcagcaga cctgctccac gggcctgagg gggccagagg
      121 gcagtatggg tccacacaga aaattgaaga cttaatggac atggtgaaaa agttgcagaa
      181 agtgggaagc ctagagcccc ggattgaggt cctgattaac cgtattaatg aggttcagca
      241 agcaaaaaag aaagccagtg aggagcttgg agaggcccag actgtctggg acaacctgca
      301 gaaggaactg gacttactac gtgaagagaa agtacgtctg aaggatattt tgaacagaaa
      361 ggaagagacc ctgaggatta tgcagctgca ctgccaggag aaggaaagtg aggcacagag
      421 gaagcacagc atgttgcagg agtgtaaaga gagaatttct ttcctgaact cccagatcga
      481 caaagagaag gccaaactaa gaaaactgag gttggatttt gaagaacatc tggagacttt
      541 gatgagtcaa cataaggaca ccttggaatt tcataagcct gaacatctga caaaggagat
      601 gtgtgttttg gacagcagca aggagcagct gctcaaggaa gagaaactga tgaaagtaaa
      661 gctggaggat gtgagacagc ggctgtgtgc cctgggcggg cctgagggtt cttccagcct
      721 cattgaggga ctcttcctcc gaagccatga ggcagctgca gcaatgcaga tgttcaagga
      781 tgagaacaag aaagctgagg agttcctaga ggctgcagct cagcagcacg agcagctgca
      841 gcagaggtgc caccagctac agcagaaacg gcagaggctg aaggaagaac tggaaaagca
      901 tggggtacag atccttgctc atagtacgca aaacgaagaa gacagctcat ggaggatggc
      961 cagtcctaaa cctgtagaag tccacgagga gacagcccaa gaccaagagc gcccatcaag
     1021 caggacctaa taccctcctc agcctggagg acttactgac ttcagacatc acttgcggat
     1081 gttttgtgta gcctgcttca tctgagtatg tgccgagtgg aagaatgggt gttggggcca
     1141 agcccctcaa gtctttgaac ctggagatgt cttggctcaa ttttgagttt cacctagctt
     1201 agggtccaca ctgcagaccc ttagtaaatg ctttccctgt ctcttgctca ccactagtat
     1261 ctgacacacg cttcttctct tgagcagagg atgctgatct gaaccttctc acaggatctg
     1321 aagccacttg gtaatttagt tccctcatgt aggcccagaa tagcatatac tttgaaacaa
     1381 aaggaagaca catcaccagc tcttaattct cactataaac cacctcattc ttcaagcaaa
     1441 ataaatgaaa tttaagtctg ca
//
