LOCUS       NM_178765               2858 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus syntabulin (syntaxin-interacting) (Sybu), transcript
            variant c, mRNA.
ACCESSION   NM_178765
VERSION     NM_178765.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Ragancokova,D., Rocca,E., Oonk,A.M., Schulz,H., Rohde,E.,
            Bednarsch,J., Feenstra,I., Pennings,R.J., Wende,H. and Garratt,A.N.
  TITLE     TSHZ1-dependent gene regulation is essential for olfactory bulb
            development and olfaction
  JOURNAL   J Clin Invest 124 (3), 1214-1227 (2014)
   PUBMED   24487590
  REMARK    Erratum:[J Clin Invest. 2022 Aug 15;132(16):e163087. doi:
            10.1172/JCI163087.. PMID: 35968788]
REFERENCE   5  (bases 1 to 2858)
  AUTHORS   Ying,Y., Li,L., Cao,W., Yan,D., Zeng,Q., Kong,X., Lu,L., Yan,M.,
            Xu,X., Qu,J., Su,Q. and Ma,X.
  TITLE     The microtubule associated protein syntabulin is required for
            glucose-stimulated and cAMP-potentiated insulin secretion
  JOURNAL   FEBS Lett 586 (20), 3674-3680 (2012)
   PUBMED   22975310
  REMARK    GeneRIF: syntabulin could be a novel effector of Epac2 and play a
            critical role in cAMP-enhanced insulin secretion
REFERENCE   6  (bases 1 to 2858)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   7  (bases 1 to 2858)
  AUTHORS   Funakoshi,E., Fukui,M., Hamano,A., Okamoto,H., Sugiyama,C.,
            Nishiyama,N., Ogita,K., Hori,T., Shimizu,N. and Ito,F.
  TITLE     Expression of m-Golsyn/Syntabulin gene during mouse brain
            development
  JOURNAL   Neurosci Lett 403 (3), 244-249 (2006)
   PUBMED   16750881
  REMARK    GeneRIF: results may indicate a significant role for this protein
            in neuronal cells and other types of cells such as those of the
            choroid plexus and ciliary body
REFERENCE   8  (bases 1 to 2858)
  AUTHORS   Funakoshi,E., Hamano,A., Fukui,M., Nishiyama,N., Ogita,K.,
            Shimizu,N. and Ito,F.
  TITLE     Molecular cloning of the m-Golsyn gene and its expression in the
            mouse brain
  JOURNAL   Gene Expr 13 (1), 27-40 (2006)
   PUBMED   16572588
REFERENCE   9  (bases 1 to 2858)
  AUTHORS   Funakoshi,E., Nakagawa,K.Y., Hamano,A., Hori,T., Shimizu,A.,
            Asakawa,S., Shimizu,N. and Ito,F.
  TITLE     Molecular cloning and characterization of gene for Golgi-localized
            syntaphilin-related protein on human chromosome 8q23
  JOURNAL   Gene 344, 259-271 (2005)
   PUBMED   15656992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100730.8.
            
            On Feb 7, 2023 this sequence version replaced NM_178765.3.
            
            Transcript Variant: This variant (c) lacks part of the 5' coding
            region, uses an alternate 5'-terminal exon, and initiates
            translation at a downstream start codon, compared to variant a. The
            encoded isoform (c) has a shorter N-terminus, compared to isoform
            a. Both variants 3 and 4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB232449.1, AK030720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC100730.8         135402-135504       c
            104-193             AC100730.8         131624-131713       c
            194-410             AC100730.8         129561-129777       c
            411-608             AC100730.8         102103-102300       c
            609-711             AC100730.8         66663-66765         c
            712-915             AC100730.8         60850-61053         c
            916-1065            AC100730.8         58681-58830         c
            1066-2858           AC100730.8         55171-56963         c
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.91 cM"
     gene            1..2858
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="syntabulin (syntaxin-interacting)"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
     exon            1..103
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            104..193
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2167
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="isoform c is encoded by transcript variant c;
                     syntaxin-1-binding protein; Golgi-localized
                     syntaphilin-related protein; Golsyn/Syntabulin"
                     /codon_start=1
                     /product="syntabulin isoform c"
                     /protein_id="NP_848880.2"
                     /db_xref="CCDS:CCDS37071.1"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
                     /translation="MGPLRESKKEQRVQHQEKEISRSRIPRLILRPHRPQQQQQQQNK
                     VSPASESPFSEEESREFNPSSSGRSARTISSNSFCSDDTGCPSSQSVSPVKTPSDTGH
                     SPIGFCPGSDEDFTRKKCRIGMVGEGSIQSARHKKEPKGGIIKPGSEADFSSSSSTGS
                     ISAPEVHMSTTGNKRASFSRNRGPHGRSNGASSHKSGSSPPSPREKDLVSMLCRNPLS
                     PSNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQ
                     QKEVTVRHLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEA
                     RKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDEL
                     CLDFSFDSPEKSLPLSSTFDKLPDGLSLEEQITEEGADSELLVGDSMAEGTDLLDEMV
                     TATTTESSGLEFVHSTPGPQALKALPLVSHEEGIAVMEQAVQTDVVPFSPAISELIQS
                     VLKLQDYCPTSSASPDESGADSMESFSESISALMLDLTPRSPNSAILLSPVEIPFSKG
                     AMEAHANRLMRELDFAAYTEERLDSVLSLSQGSVVRQYWSSNFLVDLLAVAAPVVPTV
                     LWAFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT"
     exon            194..410
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            411..608
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            609..711
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            712..915
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1065
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2858
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2833..2838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="hexamer: AATAAA"
     polyA_site      2858
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="major polyA site"
ORIGIN      
        1 actgagagac ggcagcgctt gctcgcacag ctgataggat taggagctcg actgctttgt
       61 cagccctgat tgagtccaag acagccccgg caggcacacg caggtgcctc ctcctggacg
      121 gcggcggcgg cggcagcggc ggcgtgggga gccggcaggc agcagcgaaa tggggcccct
      181 ccgagagagc aagaaggagc agagagtgca gcatcaggag aaagagattt ccaggagccg
      241 gattccccgg ttgattctgc ggccccatcg gcctcagcag cagcaacagc agcagaacaa
      301 ggtttcccca gcctccgagt ctcccttttc ggaggaagaa agtagagagt tcaaccccag
      361 cagctctgga cgctcagcaa ggacgattag cagcaacagc ttctgctcag atgacacagg
      421 ttgtcccagc agccagtcgg tatcgcctgt gaagactcct tcagacacag ggcacagtcc
      481 cattggcttt tgccctggaa gcgatgaaga ctttaccagg aagaaatgca ggattggaat
      541 ggttggtgag ggaagtattc agtcagctcg tcataaaaaa gaacccaagg gaggcatcat
      601 aaagccaggc agtgaagcag attttagctc ctcgagcagc acaggcagca tctcggctcc
      661 tgaggtccac atgtccacga caggaaacaa gagagcctct ttctcacgca accgaggccc
      721 tcatgggcgg agcaatggag catcatccca caagtctggc agcagcccac catccccaag
      781 ggaaaaagac cttgtgtcta tgctgtgcag gaatccactg agccccagta acatccaccc
      841 tagttacgcc ccttcttctc caagtagcag caactccggc tcctacaaag gaagtgattg
      901 tagtccagtc atgagaaggt ctggaagata catgtcttgt ggcgaaaatc acggtgtcaa
      961 acccccaaat ccagaacagt atttgactcc tctgcagcag aaggaggtca cagtgaggca
     1021 cctgaggacc aagctgaagg agtctgagcg ccgactccat gagagggaat ctgaaatcat
     1081 ggagctcaag tctcagctgg ctcgaatgag ggaggactgg attgaggaag agtgccacag
     1141 agtggaggct cagttggcac tcaaagaagc cagaaaagag attaaacagc tcaaacaggt
     1201 catcgagact atgaggagca gcttggctga taaagataaa ggcattcaga agtactttgt
     1261 ggacataaac atccaaaaca agaaactgga gtctctgctt caaagcatgg agatggcaca
     1321 caatagttcc ctgagggatg aactgtgtct tgacttttcc tttgattccc cagagaaaag
     1381 tttacccctg agcagcacat ttgacaagtt gccagatggg ttatctctgg aagaacagat
     1441 aacagaggaa ggtgctgaca gtgagcttct ggtgggagac agcatggctg aaggcacaga
     1501 tctgttagat gagatggtga ctgccaccac cacagaatcc agtggcctgg agtttgttca
     1561 ttccactcca gggccacaag ccctcaaggc tctccccttg gtgagccacg aagagggcat
     1621 tgcggtgatg gagcaagccg tgcagaccga cgtggtgccg ttcagccctg ccatctcaga
     1681 gctcattcag agtgtgctaa agctgcagga ctactgtccc acaagctcag catctccaga
     1741 tgaatctgga gctgactcga tggaaagctt ctcagaatct atctctgcct taatgcttga
     1801 tttaactcca agaagtccta actcggccat ccttctgtct cctgtggaga tcccattcag
     1861 caagggggct atggaagccc atgcaaatcg cctcatgaga gagctagatt ttgcagccta
     1921 cacagaagaa agattggaca gtgtcctctc actgtcccag ggcagtgttg tgaggcagta
     1981 ctggagcagc aatttcttgg tggatctact ggctgtggct gcccctgtgg tacccactgt
     2041 tctgtgggca ttcagtactc agagaggggg tacagatcct gtctacaaca tcggagcttt
     2101 gctccgaggt tgctgtgtgg tggccctaca ctcactacgc cgcaccgctt tccacatgaa
     2161 aacctaatta gttgttactg tgtgccaatg tatctgtgtg gcctgatgcc aggtagagca
     2221 acagcaggtg atcagtggaa gtctctattc tgtcagtttt gcttctcgct atttgatttg
     2281 cactatagtc agttgaagcc tgttcactgt ttaaaccaga ggtattttcc aaggcatgga
     2341 aacctggttc tggtagctgt cccaccagag tggtgtagaa agcatgctta tgcccctgcc
     2401 gtgttgtctg aggtgcccgt tcttatacta atggttcagg aagagaaaat gccgtttgca
     2461 ctttcaccac agcctttcta aggctggcat gttatctcct tgctttgctt tgtgccgttt
     2521 gaaaatgtgt aattgttcca gcattccaat gctcttgtgc atagcagggg actgtaacca
     2581 aaaataaaaa tgtacttgtg taattggttc aaagacttga atagctcttt atcgtcttga
     2641 ggttgataaa gtttgagtgt ttagattttt gttttttaac ttaatgtagc tccaaagtct
     2701 tataagactc atttgctctt aaacctgtca gttagtgata ctatgtaaat ttacaatgta
     2761 ctaacttatt ttttgcttat tatatatagt gttttttgga aattgtttgt acccacatac
     2821 ttaaagcatg aaaataaagg ttagtggttc catttaaa
//
