LOCUS       NM_001416542            2641 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus syntabulin (syntaxin-interacting) (Sybu), transcript
            variant s, mRNA.
ACCESSION   NM_001416542 XM_030248604
VERSION     NM_001416542.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Ragancokova,D., Rocca,E., Oonk,A.M., Schulz,H., Rohde,E.,
            Bednarsch,J., Feenstra,I., Pennings,R.J., Wende,H. and Garratt,A.N.
  TITLE     TSHZ1-dependent gene regulation is essential for olfactory bulb
            development and olfaction
  JOURNAL   J Clin Invest 124 (3), 1214-1227 (2014)
   PUBMED   24487590
  REMARK    Erratum:[J Clin Invest. 2022 Aug 15;132(16):e163087. doi:
            10.1172/JCI163087.. PMID: 35968788]
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Ying,Y., Li,L., Cao,W., Yan,D., Zeng,Q., Kong,X., Lu,L., Yan,M.,
            Xu,X., Qu,J., Su,Q. and Ma,X.
  TITLE     The microtubule associated protein syntabulin is required for
            glucose-stimulated and cAMP-potentiated insulin secretion
  JOURNAL   FEBS Lett 586 (20), 3674-3680 (2012)
   PUBMED   22975310
  REMARK    GeneRIF: syntabulin could be a novel effector of Epac2 and play a
            critical role in cAMP-enhanced insulin secretion
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Funakoshi,E., Fukui,M., Hamano,A., Okamoto,H., Sugiyama,C.,
            Nishiyama,N., Ogita,K., Hori,T., Shimizu,N. and Ito,F.
  TITLE     Expression of m-Golsyn/Syntabulin gene during mouse brain
            development
  JOURNAL   Neurosci Lett 403 (3), 244-249 (2006)
   PUBMED   16750881
  REMARK    GeneRIF: results may indicate a significant role for this protein
            in neuronal cells and other types of cells such as those of the
            choroid plexus and ciliary body
REFERENCE   8  (bases 1 to 2641)
  AUTHORS   Funakoshi,E., Hamano,A., Fukui,M., Nishiyama,N., Ogita,K.,
            Shimizu,N. and Ito,F.
  TITLE     Molecular cloning of the m-Golsyn gene and its expression in the
            mouse brain
  JOURNAL   Gene Expr 13 (1), 27-40 (2006)
   PUBMED   16572588
REFERENCE   9  (bases 1 to 2641)
  AUTHORS   Funakoshi,E., Nakagawa,K.Y., Hamano,A., Hori,T., Shimizu,A.,
            Asakawa,S., Shimizu,N. and Ito,F.
  TITLE     Molecular cloning and characterization of gene for Golgi-localized
            syntaphilin-related protein on human chromosome 8q23
  JOURNAL   Gene 344, 259-271 (2005)
   PUBMED   15656992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100730.8.
            
            On Feb 7, 2023 this sequence version replaced XM_030248604.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2135982.1,
                                           SRR17784643.1322367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC100730.8         135402-135504       c
            104-193             AC100730.8         131624-131713       c
            194-391             AC100730.8         102103-102300       c
            392-494             AC100730.8         66663-66765         c
            495-698             AC100730.8         60850-61053         c
            699-848             AC100730.8         58681-58830         c
            849-2641            AC100730.8         55171-56963         c
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.91 cM"
     gene            1..2641
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="syntabulin (syntaxin-interacting)"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
     exon            1..103
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            104..193
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            194..391
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1950
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="isoform h is encoded by transcript variant s;
                     syntaxin-1-binding protein; Golgi-localized
                     syntaphilin-related protein; Golsyn/Syntabulin"
                     /codon_start=1
                     /product="syntabulin isoform h"
                     /protein_id="NP_001403471.1"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
                     /translation="MVGEGSIQSARHKKEPKGGIIKPGSEADFSSSSSTGSISAPEVH
                     MSTTGNKRASFSRNRGPHGRSNGASSHKSGSSPPSPREKDLVSMLCRNPLSPSNIHPS
                     YAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVR
                     HLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQL
                     KQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDELCLDFSFD
                     SPEKSLPLSSTFDKLPDGLSLEEQITEEGADSELLVGDSMAEGTDLLDEMVTATTTES
                     SGLEFVHSTPGPQALKALPLVSHEEGIAVMEQAVQTDVVPFSPAISELIQSVLKLQDY
                     CPTSSASPDESGADSMESFSESISALMLDLTPRSPNSAILLSPVEIPFSKGAMEAHAN
                     RLMRELDFAAYTEERLDSVLSLSQGSVVRQYWSSNFLVDLLAVAAPVVPTVLWAFSTQ
                     RGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT"
     exon            392..494
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            495..698
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            699..848
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            849..2641
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="hexamer: AATAAA"
     polyA_site      2641
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="major polyA site"
ORIGIN      
        1 actgagagac ggcagcgctt gctcgcacag ctgataggat taggagctcg actgctttgt
       61 cagccctgat tgagtccaag acagccccgg caggcacacg caggtgcctc ctcctggacg
      121 gcggcggcgg cggcagcggc ggcgtgggga gccggcaggc agcagcgaaa tggggcccct
      181 ccgagagagc aagatgacac aggttgtccc agcagccagt cggtatcgcc tgtgaagact
      241 ccttcagaca cagggcacag tcccattggc ttttgccctg gaagcgatga agactttacc
      301 aggaagaaat gcaggattgg aatggttggt gagggaagta ttcagtcagc tcgtcataaa
      361 aaagaaccca agggaggcat cataaagcca ggcagtgaag cagattttag ctcctcgagc
      421 agcacaggca gcatctcggc tcctgaggtc cacatgtcca cgacaggaaa caagagagcc
      481 tctttctcac gcaaccgagg ccctcatggg cggagcaatg gagcatcatc ccacaagtct
      541 ggcagcagcc caccatcccc aagggaaaaa gaccttgtgt ctatgctgtg caggaatcca
      601 ctgagcccca gtaacatcca ccctagttac gccccttctt ctccaagtag cagcaactcc
      661 ggctcctaca aaggaagtga ttgtagtcca gtcatgagaa ggtctggaag atacatgtct
      721 tgtggcgaaa atcacggtgt caaaccccca aatccagaac agtatttgac tcctctgcag
      781 cagaaggagg tcacagtgag gcacctgagg accaagctga aggagtctga gcgccgactc
      841 catgagaggg aatctgaaat catggagctc aagtctcagc tggctcgaat gagggaggac
      901 tggattgagg aagagtgcca cagagtggag gctcagttgg cactcaaaga agccagaaaa
      961 gagattaaac agctcaaaca ggtcatcgag actatgagga gcagcttggc tgataaagat
     1021 aaaggcattc agaagtactt tgtggacata aacatccaaa acaagaaact ggagtctctg
     1081 cttcaaagca tggagatggc acacaatagt tccctgaggg atgaactgtg tcttgacttt
     1141 tcctttgatt ccccagagaa aagtttaccc ctgagcagca catttgacaa gttgccagat
     1201 gggttatctc tggaagaaca gataacagag gaaggtgctg acagtgagct tctggtggga
     1261 gacagcatgg ctgaaggcac agatctgtta gatgagatgg tgactgccac caccacagaa
     1321 tccagtggcc tggagtttgt tcattccact ccagggccac aagccctcaa ggctctcccc
     1381 ttggtgagcc acgaagaggg cattgcggtg atggagcaag ccgtgcagac cgacgtggtg
     1441 ccgttcagcc ctgccatctc agagctcatt cagagtgtgc taaagctgca ggactactgt
     1501 cccacaagct cagcatctcc agatgaatct ggagctgact cgatggaaag cttctcagaa
     1561 tctatctctg ccttaatgct tgatttaact ccaagaagtc ctaactcggc catccttctg
     1621 tctcctgtgg agatcccatt cagcaagggg gctatggaag cccatgcaaa tcgcctcatg
     1681 agagagctag attttgcagc ctacacagaa gaaagattgg acagtgtcct ctcactgtcc
     1741 cagggcagtg ttgtgaggca gtactggagc agcaatttct tggtggatct actggctgtg
     1801 gctgcccctg tggtacccac tgttctgtgg gcattcagta ctcagagagg gggtacagat
     1861 cctgtctaca acatcggagc tttgctccga ggttgctgtg tggtggccct acactcacta
     1921 cgccgcaccg ctttccacat gaaaacctaa ttagttgtta ctgtgtgcca atgtatctgt
     1981 gtggcctgat gccaggtaga gcaacagcag gtgatcagtg gaagtctcta ttctgtcagt
     2041 tttgcttctc gctatttgat ttgcactata gtcagttgaa gcctgttcac tgtttaaacc
     2101 agaggtattt tccaaggcat ggaaacctgg ttctggtagc tgtcccacca gagtggtgta
     2161 gaaagcatgc ttatgcccct gccgtgttgt ctgaggtgcc cgttcttata ctaatggttc
     2221 aggaagagaa aatgccgttt gcactttcac cacagccttt ctaaggctgg catgttatct
     2281 ccttgctttg ctttgtgccg tttgaaaatg tgtaattgtt ccagcattcc aatgctcttg
     2341 tgcatagcag gggactgtaa ccaaaaataa aaatgtactt gtgtaattgg ttcaaagact
     2401 tgaatagctc tttatcgtct tgaggttgat aaagtttgag tgtttagatt tttgtttttt
     2461 aacttaatgt agctccaaag tcttataaga ctcatttgct cttaaacctg tcagttagtg
     2521 atactatgta aatttacaat gtactaactt attttttgct tattatatat agtgtttttt
     2581 ggaaattgtt tgtacccaca tacttaaagc atgaaaataa aggttagtgg ttccatttaa
     2641 a
//
